Interactions on record — worth a quick check against your medications. Based on 7 of 8 ingredients. Check your meds →
Dietary supplement

Nightly Restore Ingredients & Drug Interactions

by Gaia Herbs Adrenal Health

Nightly Restore label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nightly Restore against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nightly Restore is a dietary supplement by Gaia Herbs Adrenal Health with 8 active ingredients. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 1,431 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha Root Extract, Cinnamon bark extract, Reishi Mushroom Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nightly Restore by Gaia Herbs Adrenal Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Nightly Restore by Gaia Herbs Adrenal Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Nightly Restore by Gaia Herbs Adrenal Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 8 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (750 mg) without saying how much of each component you get.

Nightly Restore contains 8 ingredients, 7 of which are active herbal extracts. The main ones are ashwagandha root extract (used traditionally for stress and sleep), lemon balm aerial parts extract (traditionally for calm and mood), reishi mushroom fruiting body extract (used in sleep and immune support), and magnolia bark extract (traditionally for relaxation).

You'll also find cinnamon bark extract, cordyceps mushroom fruiting body extract, and mimosa tree bark extract. One ingredient, vervain aerial parts extract, we could not verify in our data.

The product is filled with glycerin, water, and a plant-based capsule material (hypromellose); there are no other inactive fillers added.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: stress support and adrenal health while resting.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Fatigue, sleep quality, nervous system support, relaxation.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Magnolia is rated "Insufficient Reliable Evidence To Rate" for Anxiety.
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

Ashwagandha is rated possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder — the conditions this product seems designed for — though the research is preliminary. Lemon balm is also rated possibly effective for stress and possibly effective for depression.

Reishi mushroom and magnolia bark don't have established evidence for the uses in this sleep-support product. The other ingredients lack effectiveness ratings in our data.

The product as a whole hasn't been tested as a combination, so we can't say how well these ingredients work together.

The evidence, ingredient by ingredient Cassia Cinnamon Lemon Balm Magnolia Albizia Julibrissin Ashwagandha Reishi Mushroom Cordyceps

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ashwagandha is generally well tolerated short-term in healthy adults, though long-term safety data are limited. The most common side effects are diarrhea, nausea, and gastrointestinal upset, though these don't usually happen at typical doses.

Serious but rare cases of liver damage have been reported. Ashwagandha is traditionally thought to risk miscarriage, so avoid it during pregnancy; there isn't enough safety information for breastfeeding either.

Cinnamon bark at food amounts is likely safe, though medicinal doses high in coumarin (a compound it contains) may harm the liver over time — avoid high-dose supplements in pregnancy and breastfeeding. Lemon balm is generally well tolerated short-term but is best avoided in pregnancy without a doctor's okay.

Reishi, magnolia, mimosa tree bark, and cordyceps all lack sufficient pregnancy and breastfeeding safety data and should be avoided during these periods. Common side effects across these ingredients include dizziness, dry mouth, nausea, and gastrointestinal upset — all generally mild and uncommon.

Side effects, ingredient by ingredient Cassia Cinnamon Lemon Balm Magnolia Albizia Julibrissin Ashwagandha Reishi Mushroom Cordyceps

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Magnolia, Lemon Balm, Cordyceps, Reishi Mushroom, Ashwagandha, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,432 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Nightly Restore, check with your pharmacist if you use CNS depressants (sedatives, sleep aids, alcohol), blood pressure medications, benzodiazepines (like Valium or Klonopin), diabetes drugs, blood thinners (anticoagulants or antiplatelet drugs), thyroid hormone supplements, immune-suppressing medications, or drugs that affect your liver. These are the medication types with documented interactions in this product — the ashwagandha and other ingredients may change how these drugs work or raise your risk of side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is built around ashwagandha and other herbs traditionally used for sleep and stress, with preliminary evidence supporting a few of them. If you take any blood pressure medication, diabetes drug, sedative, blood thinner, thyroid hormone, immune-suppressing medication, or any drug that stresses your liver, you need to check your specific medications with the tool on this page — the interactions are real.

Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or managing any chronic condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nightly Restore, straight from the product label.

Brand Gaia Herbs Adrenal Health
Net contents 60 Vegan Liquid Phyto-Cap(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 309546
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nightly Restore by Gaia Herbs Adrenal Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Proprietary Extract Blend750 mg--
Ashwagandha Root Extract80 mg--
Cinnamon bark extract0 NP--
Lemon Balm Aerial Parts Extract0 NP--
Reishi Mushroom Fruiting Body Extract20 mg--
Magnolia Bark Extract0 NP--
Mimosa Tree Bark Extract0 NP--
Cordyceps Mushroom Fruiting Body Extract50 mg--
Vervain Aerial Parts Extract0 NP--

Other ingredients: Glycerin, Water, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

A balanced approach Our stress support formulas contain an expert blend of adaptogens and nervines. Together, these herbs work harmoniously to support different facets of the stress response and bring your body into balance. Stress & nervous system response Hypothalamus Pituitary Adrenals Vagus nerve

The Gaia difference Sustainably sourced 6 distinct quality tests

Vegan

Gluten free

Stress support Adrenal health Supports adrenal function while you rest Concentrated formula Full spectrum

Natural separation may occur. This does not affect product quality.

Extracted without harsh solvents

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Vegan Certified B Corporation

General Statements

Gaia herbs delivers unprecedented tradeability by screening every product and sharing results online. To learn more, enter the unique ID # below at meetyourherbs.com.

Formula rooted in traditional herbalism

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested use Adults take 2 capsules daily in the evening after dinner. Best results obtained with long-term use.

Precautions

Not for use during pregnancy or lactation. If you have a medical condition or take medications, please consult with your doctor before use.

Store away from children.

Use only as directed on label. Safety-sealed for your protection.

Storage

Keep bottle capped at all times and store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nightly Restore by Gaia Herbs Adrenal Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nightly Restore label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nightly Restore by Gaia Herbs Adrenal Health

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

750 mg per serving

Ashwagandha Root Extract

Interacts with
1,373 drugs
80 mg per serving Form: Withania somnifera Root Extract

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Ashwagandha Root Extract monograph & interactions

Reishi Mushroom Fruiting Body Extract

Interacts with
375 drugs
20 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom Fruiting Body Extract monograph & interactions

Cordyceps Mushroom Fruiting Body Extract

Interacts with
249 drugs
50 mg per serving Form: Cordyceps militaris Mushroom Fruiting Body Extract

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Cordyceps Mushroom Fruiting Body Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nightly Restore by Gaia Herbs Adrenal Health Drug Interactions

Want to check YOUR meds against Nightly Restore?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,431Drugs
1,004 Moderate 427 Minor

Ingredients driving the most interactions

Ashwagandha Root Extract 1,373
Cinnamon bark extract 444
Reishi Mushroom Fruiting Body Extract 375
Magnolia Bark Extract 351
Lemon Balm Aerial Parts Extract 264

Individual Drug Interactions

The ingredients in Nightly Restore interact with 1,431 drugs. Click any drug to see the details.

7 of the 8 ingredients in Nightly Restore interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Root Extract Cinnamon bark extract Reishi Mushroom Fruiting Body Extract Magnolia Bark Extract Lemon Balm Aerial Parts Extract Cordyceps Mushroom Fruiting Body Extract Mimosa Tree Bark Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Nightly Restore with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ashwagandha Root Extract10 drug types · 1,373 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Ashwagandha Root Extract full monograph & interactions

Cinnamon bark extract2 drug types · 444 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon bark extract full monograph & interactions

Reishi Mushroom Fruiting Body Extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom Fruiting Body Extract full monograph & interactions

Magnolia Bark Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia Bark Extract full monograph & interactions

Lemon Balm Aerial Parts Extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm Aerial Parts Extract full monograph & interactions

Cordyceps Mushroom Fruiting Body Extract3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps Mushroom Fruiting Body Extract full monograph & interactions

Mimosa Tree Bark Extract1 drug type · 248 drugs

Cns Depressants

Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mice. Theoretically, Albizia julibrissin might enhance the therapeutic and adverse effects of CNS depressants.
Some CNS depressants include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), clonazepam (Klonopin), lorazepam (Ativan), zolpidem (Ambien), and others.

Likelihood Possible Evidence D
Mimosa Tree Bark Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nightly Restore, from the product label.

Gaia Herbs Adrenal Health

Name
GAIA HERBS, INC.
Street Address
101 Gaia Herbs Dr.
City
Brevard
State
NC
ZipCode
28712
Pharmacist Counseling Corner

Nightly Restore by Gaia Herbs Adrenal Health: Common Questions

Does Nightly Restore by Gaia Herbs Adrenal Health interact with any medications?
Yes. Based on its ingredients, Nightly Restore has a known interaction with 1,431 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nightly Restore contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me sleep?
Ashwagandha and lemon balm in this product are both rated possibly effective for insomnia and stress, which can keep you awake. The research is preliminary, though, so results vary. Reishi mushroom and magnolia don't have established evidence for sleep yet in our data.
Is this safe to take every night?
Ashwagandha and lemon balm are generally well tolerated short-term, but long-term safety hasn't been thoroughly studied. If you plan to use it nightly for months, talk to your pharmacist or doctor first.
Can I take this while pregnant?
No. Ashwagandha is traditionally thought to risk miscarriage and is best avoided in pregnancy. Lemon balm, reishi, magnolia, mimosa tree bark, and cordyceps all lack enough safety data for pregnancy — avoid them too unless your doctor says otherwise.
What are the most common side effects?
Ashwagandha may cause diarrhea, nausea, or stomach upset, though these are uncommon at normal doses. Cordyceps can cause similar digestive effects. Dizziness, dry mouth, and mild nausea have been reported with reishi and other ingredients in this formula.
Can I breastfeed while taking this?
The safety data aren't there. Ashwagandha, reishi, magnolia, mimosa tree bark, and cordyceps all lack enough information for breastfeeding — it's best to avoid them. Talk to your doctor about whether this product is right for you during nursing.
Does this contain caffeine or stimulants?
No stimulants are listed in the active ingredients. This is formulated as a calming product, not an energy booster.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nightly Restore label
Go deeper

The Full Monographs Behind Nightly Restore’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cassia Cinnamon

Interacts with 444 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph → Herb & supplement monograph

Albizia Julibrissin

Interacts with 248 drugs

Albizia julibrissin (Persian silk tree, He Huan) is a plant used in traditional Chinese medicine, mainly the flower and bark, for calming the mind, lifting mood, and easing sleep problems. H...

Read the full Albizia Julibrissin monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,373 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph →
Sources

Sources & How We Checked

Nightly Restore's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 105 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
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See these in context on the Ashwagandha monograph →

Cassia Cinnamon 20 references
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See these in context on the Cassia Cinnamon monograph →

Lemon Balm 12 references
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See these in context on the Lemon Balm monograph →

Reishi Mushroom 17 references
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  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
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  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
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See these in context on the Magnolia monograph →

Albizia Julibrissin 1 reference
  1. Kang, T. H., Jeong, S. J., Kim, N. Y., Higuchi, R., and Kim, Y. C. Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz. J Ethnopharmacol 2000;71(1-2):321-323. PubMed

See these in context on the Albizia Julibrissin monograph →

Cordyceps 14 references
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  2. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
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  10. Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
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  14. Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.

See these in context on the Cordyceps monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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