Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Nitric Charge Ingredients & Drug Interactions

by NutraChamps

Nitric Charge label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nitric Charge against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nitric Charge is a dietary supplement by NutraChamps with 5 active ingredients. Its ingredients are commonly taken for high blood pressure, erectile dysfunction, athletic performance.Based on those ingredients, 1,198 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape Seed Extract, L-Arginine Alpha-Ketoglutarate, Pine bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nitric Charge by NutraChamps

Ask about any prescription or over-the-counter medication and we check it for interactions with Nitric Charge by NutraChamps — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Nitric Charge by NutraChamps

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Nitric Charge contains 5 active ingredients, three of which are forms of L-arginine — L-Arginine Alpha-Ketoglutarate and L-Arginine Hydrochloride — plus L-Citrulline Malate, Grape Seed Extract, and Pine Bark Extract. All five work to support nitric oxide production and blood vessel function.

The product also contains inactive ingredients including hypromellose, silica, rice flour, and magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Pumps power and athletic performance.
  • We looked for evidence on: Athletic performance, Erectile Dysfunction (ED), Exercise-induced muscle soreness, Muscle soreness, Muscle strength, Sexual dysfunction — and 3 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Grape is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Erectile Dysfunction (ED), Muscle soreness.
  • Also on file: Maritime Pine is rated "Insufficient Reliable Evidence To Rate" for Antidepressant-induced sexual dysfunction, Athletic performance, Erectile dysfunction (ED).

The evidence for these ingredients is mixed. Grape seed extract is possibly effective for chronic venous insufficiency (poor circulation in the legs), but the data suggests it's possibly ineffective for chemotherapy nausea, hay fever, and obesity.

L-Citrulline Malate is possibly effective for athletic performance but possibly ineffective for sarcopenia (age-related muscle loss); the evidence for heart failure, cardiovascular disease, and diabetes is insufficient. Pine bark extract is possibly effective for osteoarthritis, chronic venous insufficiency, and asthma, but possibly ineffective for high cholesterol.

For L-arginine itself, the facts don't include effectiveness ratings in our data. The evidence overall is preliminary, and much rests on small or theoretical studies.

The evidence, ingredient by ingredient L-arginine Grape L-citrulline Maritime Pine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-arginine is generally well tolerated short-term but can lower blood pressure and may not be safe for everyone; it should only be used under medical supervision because safety for self-treatment isn't well established. Common side effects from oral L-arginine include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.

Grape seed extract appears generally well tolerated; common oral side effects are abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea (anaphylaxis to grape skin is rare). L-Citrulline is generally well tolerated in healthy adults, with gastrointestinal discomfort and heartburn reported most often.

Pine bark extract is generally well tolerated, with gastrointestinal complaints, dizziness, and vertigo most common. There isn't enough safety data on L-Citrulline and pine bark extract during pregnancy or breastfeeding, so these should be avoided unless your doctor advises otherwise.

Side effects, ingredient by ingredient L-arginine Grape L-citrulline Maritime Pine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Grape, L-arginine, Maritime Pine, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,199 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you're on any blood pressure medication (especially ACE inhibitors or ARBs), blood thinners, potassium-sparing diuretics, diabetes drugs, sildenafil or other PDE-5 inhibitors, cyclosporine, midazolam, or any medication your liver processes via CYP2D6, CYP3A4, CYP2E1, or CYP1A2 enzymes. All of these carry Moderate interactions.

The sheer number of affected medications makes a personalized check essential.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Nitric Charge is aimed at people wanting to boost blood vessel function and circulation, but it's not a casual over-the-counter add-on. If you take any blood pressure medication, blood thinner, diabetes drug, or medications processed by your liver, you need to check this product against your exact drugs before starting.

Even then, use it only under your doctor's or pharmacist's guidance — L-arginine needs supervision.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nitric Charge, straight from the product label.

Brand NutraChamps
Barcode (UPC) 621983999701
Net contents 150 Vegan Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 338140
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nitric Charge by NutraChamps, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Capsule(s)
Maximum serving Sizes:
5 Capsule(s)
Servings per container
30
UPC/BARCODE
621983999701
IngredientAmount% DV
L-Arginine Alpha-Ketoglutarate500 mg--
L-Arginine Hydrochloride1000 mg--
Grape Seed Extract50 mg--
L-Citrulline Malate1000 mg--
Pine bark extract150 mg--

Other ingredients: Hypromellose, Silica, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Do not exceed 2 servings per day.

Caution: Pregnant or nursing mothers, children under the age of 18, or individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Caution: Pregnant or nursing mothers, children under the age of 18, or individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Storage

Store at room temperature.

Formulation

Pumps & power

Powerful nitric oxide booster Energy Circulation Stamina Support Boosts strength & performance

Vegan

Non GMO

Zero gluten, soy, eggs, dairy, nuts or animal products

Formula

Enhanced with pine bark & grape seed

L-Arginine HCl, AAKG & L-Citrulline

General Statements

It's time to take charge

This bottle supports a child or mother in need. Every product you purchase from us makes a difference by providing life-changing vitamins to those in need. Vitamin Angels Proud supporter

Made with love

Suggested/Recommended/Usage/Directions

Suggested use: Take 5 capsules before working out, or as directed by your healthcare professional. On non-workout days, take 5 capsules in the morning.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Consistent Quality Tested Lab Verified Vegan

Made in the USA global ingredients

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nitric Charge by NutraChamps label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nitric Charge label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nitric Charge by NutraChamps

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Arginine Alpha-Ketoglutarate

Interacts with
403 drugs
500 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Alpha-Ketoglutarate monograph & interactions

L-Arginine Hydrochloride

Interacts with
403 drugs
1000 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Hydrochloride monograph & interactions

Grape Seed Extract

Interacts with
910 drugs
50 mg per serving Form: Proanthocyanidins

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...

Grape Seed Extract monograph & interactions

L-Citrulline Malate

Interacts with
178 drugs
1000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline Malate monograph & interactions

Pine bark extract

Interacts with
327 drugs
150 mg per serving Form: Proanthocyanidins

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...

Pine bark extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Silica, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nitric Charge by NutraChamps Drug Interactions

Want to check YOUR meds against Nitric Charge?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,198Drugs
1,173 Moderate 25 Minor

Ingredients driving the most interactions

Grape Seed Extract 910
L-Arginine Alpha-Ketoglutarate 403
Pine bark extract 327
L-Citrulline Malate 178

Individual Drug Interactions

The ingredients in Nitric Charge interact with 1,198 drugs. Click any drug to see the details.

4 of the 5 ingredients in Nitric Charge interact with drugs. Each result below shows which ingredient is responsible. Grape Seed Extract L-Arginine Alpha-Ketoglutarate Pine bark extract L-Citrulline Malate

Each ingredient & the kinds of drugs it affects

For each ingredient in Nitric Charge with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Grape Seed Extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Grape Seed Extract full monograph & interactions

L-Arginine Alpha-Ketoglutarate9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine Alpha-Ketoglutarate full monograph & interactions

Pine bark extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Pine bark extract full monograph & interactions

L-Citrulline Malate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline Malate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nitric Charge, from the product label.

NutraChamps

See all NutraChamps products
Name
NutraChamps
Street Address
701-90 Sheppard Ave E.
City
North York
State
ON
ZipCode
M2N0A4
Phone Number
1-866-272-6888
Web Address
NutraChamps.com
Pharmacist Counseling Corner

Nitric Charge by NutraChamps: Common Questions

Does Nitric Charge by NutraChamps interact with any medications?
Yes. Based on its ingredients, Nitric Charge has a known interaction with 1,198 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nitric Charge contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Nitric Charge safe to take if I'm pregnant or breastfeeding?
The safety data doesn't support it. L-Arginine Alpha-Ketoglutarate and L-Arginine Hydrochloride are rated possibly safe in pregnancy but have no lactation data. L-Citrulline Malate and Pine Bark Extract have insufficient data for both pregnancy and breastfeeding — they should be avoided unless your doctor advises otherwise. Talk with your doctor or pharmacist before using any supplement during pregnancy or while nursing.
What are the most common side effects?
From the L-arginine ingredients, expect possible abdominal pain, bloating, nausea, diarrhea, headache, insomnia, or flushing. Grape seed extract may cause abdominal pain, diarrhea, dry mouth, indigestion, headache, or joint pain. L-Citrulline can cause gastrointestinal discomfort or heartburn. Pine bark extract may bring dizziness or vertigo. Most people tolerate the product in short-term use, but if side effects bother you, stop and talk to us.
Does this product actually work?
The evidence is incomplete. Grape seed extract is possibly effective for poor leg circulation. L-Citrulline is possibly effective for athletic performance. Pine bark extract is possibly effective for osteoarthritis, poor circulation, and asthma. For the other claimed benefits, the science either isn't there or is only preliminary. Talk to your pharmacist about what you're hoping to achieve and whether Nitric Charge is the right fit.
Why are there two forms of L-arginine in one product?
L-Arginine Alpha-Ketoglutarate and L-Arginine Hydrochloride are two different salt forms of the same amino acid. The product uses both to increase the total L-arginine dose. They have the same interactions and safety profile.
Can I take this with my blood pressure medication?
Theoretically, L-arginine widens blood vessels and can lower blood pressure on its own, so taking it with blood pressure drugs carries a Moderate risk of your pressure dropping too far. This is especially true for ACE inhibitors and ARBs. Do not take this without checking with your pharmacist or doctor first — they need to know your exact medication and may need to monitor your blood pressure or adjust doses.
What's in the capsule besides the active ingredients?
The capsule itself is made of hypromellose, and it contains silica, rice flour, and magnesium stearate as binders and flow agents. These are standard inactive ingredients and are present in small amounts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nitric Charge label
Go deeper

The Full Monographs Behind Nitric Charge’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Maritime Pine

Interacts with 327 drugs

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...

Read the full Maritime Pine monograph →
Sources

Sources & How We Checked

Nitric Charge's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 122 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
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Grape 34 references
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L-citrulline 8 references
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Maritime Pine 14 references
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