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Dietary supplement

Nucleotide Complex Ingredients & Drug Interactions

by Bluebonnet

Nucleotide Complex label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nucleotide Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Nucleotide Complex is a dietary supplement by Bluebonnet with 1 active ingredient.Based on those ingredients, 47 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nucleotide Complex by Bluebonnet

Ask about any prescription or over-the-counter medication and we check it for interactions with Nucleotide Complex by Bluebonnet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nucleotide Complex by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Nucleotides” is listed as a grouped ingredient — the label gives one combined amount (240 mg) without saying how much of each component you get.
  • “Nucleotide Complex” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This supplement contains 4 active nucleotide ingredients: adenosine, cytidine (the active form of citicoline), guanosine, and uridine. Nucleotides are building blocks your cells use to make and repair DNA and RNA.

The product also contains two inactive ingredients—a vegetable-based capsule and vegetable magnesium stearate (a flow agent)—to hold everything together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: RNA DNA and ATP energy molecule support.
  • We looked for evidence on: Athletic performance, cellular energy, nucleic acid synthesis, mitochondrial function.
  • The closest evidence on file: Adenosine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).

Adenosine in this product is considered effective for paroxysmal supraventricular tachycardia (a type of rapid heartbeat) and for cardiovascular disease diagnosis—but those data come from the prescription injectable form used in medical settings, not from oral supplements. Cytidine has possibly effective evidence for age-related cognitive decline and glaucoma, but the evidence for stroke is possibly ineffective, and for Alzheimer disease and traumatic brain injury, there simply isn't enough reliable data to know either way.

We hold no effectiveness ratings for guanosine or uridine.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Adenosine by mouth or injection into muscle hasn't reported adverse effects in the limited oral supplement data we have—but the evidence is thin, and safety hasn't been formally established for supplement use. The powerful prescription injectable form used in hospitals can cause chest pain, dizziness, shortness of breath, flushing, headache, low blood pressure, and in rare cases, serious heart rhythm problems or heart attack.

Avoid adenosine supplements during pregnancy and breastfeeding, as safety data isn't sufficient. Cytidine appears generally well tolerated in studies, though long-term safety isn't fully mapped out.

People taking it by mouth have reported abdominal pain, back pain, blurred vision, constipation, diarrhea, swelling, headache, trouble sleeping, nausea, and rash. Avoid cytidine during pregnancy and breastfeeding due to insufficient safety data.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Adenosine.
  • The most serious interaction on file is rated Major.
  • For scale: 47 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this supplement, double-check with your doctor or pharmacist if you take dipyridamole (Persantine)—a blood vessel dilator used in heart tests—since adenosine can amplify its effects dangerously. Also flag carbamazepine (Tegretol), an anti-seizure medication, which can increase heart block risk when combined with adenosine.

Methylxanthines like caffeine, aminophylline, and theophylline (in some asthma medicines) will block adenosine's effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is built on nucleotides, which your cells need to build DNA and RNA. Adenosine in it interacts with several heart and asthma medications—so if you take any prescription drugs, especially dipyridamole, carbamazepine, caffeine-containing products, or theophylline-based medications, check with your doctor or pharmacist before starting.

Adenosine supplement safety hasn't been fully established, and the product should be avoided in pregnancy and while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nucleotide Complex, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715012646
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 268367
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nucleotide Complex by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
743715012646
IngredientAmount% DV
Nucleotides240 mg--
Nucleotide Complex500 mg--
Adenosine60 mg--
Cytidine50 mg--
Guanosine80 mg--
Uridine50 mg--

Other ingredients: Kosher Vegetable Capsule, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily or as directed by a healthcare practitioner.

Formula

Bluebonnet’s Nucleotide Complex 500 mg Capsules contain a complete array of nucleotides, including adenosine, cytidine, guanosine and uridine, which are the necessary basic building blocks of RNA, DNA and ATP - the energy molecule. This nucleotide complex is carefully derived from torula yeast and helps support immune function.

Bluebonnet's KOF-K Certification #K-0000700

RNA/DNA

K Parve (Kosher)

Formulation

Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption.

Made with Non GMO ingredients

Vegan

Gluten free Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of corn, gluten, barley, rice and sugar.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nucleotide Complex by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nucleotide Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nucleotide Complex by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Nucleotide Complex

500 mg per serving
  • › Nucleotides

Other (inactive) ingredients: Kosher Vegetable Capsule, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nucleotide Complex by Bluebonnet Drug Interactions

Want to check YOUR meds against Nucleotide Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
47Drugs
2 Major 1 Moderate 44 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Nucleotide Complex interact with 47 drugs. Click any drug to see the details.

0 of the 1 ingredient in Nucleotide Complex interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Nucleotide Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Nucleotide Complex, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
TX
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

Nucleotide Complex by Bluebonnet: Common Questions

Does Nucleotide Complex by Bluebonnet interact with any medications?
Yes. Based on its ingredients, Nucleotide Complex has a known interaction with 47 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nucleotide Complex contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly are nucleotides, and why would I take them?
Nucleotides are the molecular building blocks your cells use to make and repair DNA and RNA—the genetic instructions that keep your body running. This supplement gives your cells those raw materials, though the evidence for specific health benefits outside of the prescription injectable form of adenosine is limited or still being studied.
Is this safe to take while I'm pregnant or breastfeeding?
No. The safety data for both adenosine and cytidine (two of the nucleotides in this blend) is not strong enough during pregnancy, and both should be avoided while breastfeeding. Talk with your doctor or pharmacist about whether this supplement fits your situation.
Can this help with brain health or memory?
Cytidine, one ingredient in this blend, has possibly effective evidence for age-related cognitive decline and glaucoma, but the evidence for stroke is possibly ineffective, and we don't have enough reliable data to say whether it helps Alzheimer disease or traumatic brain injury. Your doctor or pharmacist can help you weigh whether it's worth trying for your specific concern.
What side effects does this supplement have?
Cytidine is generally well tolerated, though some people have reported abdominal pain, back pain, blurred vision, constipation, diarrhea, swelling, headache, trouble sleeping, nausea, and rash. Adenosine supplement safety hasn't been thoroughly studied, so adverse effects at oral doses aren't fully known.
Is there caffeine in this, or should I avoid it before taking adenosine?
This product itself doesn't list caffeine as an ingredient. However, if you drink coffee, tea, energy drinks, or take any caffeine-containing medication, avoid them for 24 hours before taking this supplement, since caffeine blocks adenosine's effects.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nucleotide Complex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nucleotide Complex label
Sources

Sources & How We Checked

Nucleotide Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Adenosine 10 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
  3. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
  4. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
  5. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  6. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
  7. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
  8. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  9. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
  10. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.

See these in context on the Adenosine monograph →

Citicoline 11 references
  1. Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
  2. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
  3. Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
  4. Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
  5. Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
  6. Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
  7. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
  8. Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
  9. Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
  10. Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
  11. Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed

See these in context on the Citicoline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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