Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Nugenix Estro-Regulator Ingredients & Drug Interactions

by Nugenix

Nugenix Estro-Regulator label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nugenix Estro-Regulator against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nugenix Estro-Regulator is a dietary supplement by Nugenix with 4 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 960 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polygonum cuspidatum extract, Vitamin E, Chrysin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nugenix Estro-Regulator by Nugenix

Ask about any prescription or over-the-counter medication and we check it for interactions with Nugenix Estro-Regulator by Nugenix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nugenix Estro-Regulator by Nugenix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Nugenix Estro-Regulator contains four active ingredients. Diindolylmethane is a compound found in cruciferous vegetables thought to support hormone balance.

Chrysin is a flavonoid derived from plants like passionflower. Vitamin E is a fat-soluble antioxidant.

Polygonum cuspidatum extract (also called hu zhang) comes from a traditional Chinese plant and contains resveratrol. The capsules also contain inactive ingredients: gelatin and cellulose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support estrogen regulation and hormonal balance.
  • We looked for evidence on: Menopausal symptoms, Dysmenorrhea, Infertility, Male infertility, Benign prostatic hyperplasia (BPH), Testosterone balance — and 2 related terms.
  • The strongest evidence on file: Vitamin E is rated "Possibly Effective" for Dysmenorrhea (Natural Medicines).
  • Also on file: Vitamin E is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms, Polycystic ovary syndrome (PCOS), Infertility.
  • Also on file: Chrysin is rated "Insufficient Reliable Evidence To Rate" for Male infertility.

The evidence we hold does not establish that any of these four ingredients is effective for their intended uses. Diindolylmethane has insufficient evidence for benign prostate enlargement, breast cancer, colorectal cancer, cervical precancerous changes, and breast pain.

Chrysin likewise shows insufficient evidence for anxiety, athletic performance, cancer, HIV/AIDS, muscle strength, and gout. Polygonum cuspidatum extract shows insufficient evidence for hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina.

Vitamin E is established as effective only for vitamin E deficiency and a rare condition called ataxia with vitamin E deficiency; it is possibly effective for Alzheimer disease and a few other conditions, but that's separate from this product's intended hormone-support purpose.

The evidence, ingredient by ingredient Diindolylmethane Chrysin Vitamin E Hu Zhang

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated in short-term studies, but long-term safety is not established. Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting; a very rare serious reaction called DRESS (drug rash with eosinophilia and systemic symptoms) has been reported.

Chrysin appears well tolerated short-term, but long-term safety is not well studied and there are no reported adverse effects in the data we hold. Vitamin E from food and normal doses is safe, but high-dose supplements may increase bleeding risk and other harms.

Polygonum cuspidatum extract has limited human safety data; its emodin content may cause digestive upset. All four ingredients should be avoided in pregnancy, and diindolylmethane and polygonum cuspidatum extract should be avoided while breastfeeding due to insufficient safety information.

Chrysin has no safety data for pregnancy or lactation. For vitamin E, amounts from food and prenatal vitamins are appropriate in pregnancy, but high-dose supplements need doctor approval.

Side effects, ingredient by ingredient Diindolylmethane Chrysin Vitamin E Hu Zhang

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Vitamin E, Chrysin, Diindolylmethane, Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 961 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Nugenix Estro-Regulator, double-check with your doctor or pharmacist if you take birth control pills or estrogen replacement therapy (chrysin and diindolylmethane may reduce their effects), blood thinners or antiplatelet drugs like warfarin or aspirin (chrysin, vitamin E, and polygonum cuspidatum extract may increase bleeding risk), seizure medications like carbamazepine or mephenytoin (interactions documented), chemotherapy or alkylating agents (vitamin E may interfere), or any medications your liver processes—including heart drugs, blood pressure medications, antidepressants, and many others.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is not established to be effective for hormone support based on the evidence we hold. More importantly, its four ingredients interact with a large number of medications—particularly birth control, hormone therapies, blood thinners, seizure drugs, and many others processed by your liver.

If you're considering this product, talk with your doctor or pharmacist first, especially if you take any prescription medications, hormone therapy, or blood thinners; they can review your specific situation and help you decide whether it's safe for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nugenix Estro-Regulator, straight from the product label.

Brand Nugenix
Barcode (UPC) 855710002383
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 199814
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nugenix Estro-Regulator by Nugenix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
855710002383
IngredientAmount% DV
Diindolylmethane100 mg--
Chrysin500 mg--
Vitamin E6.7 mg45%
Polygonum cuspidatum extract300 mg--

Other ingredients: Gelatin, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Nugenix Estro-Regulator is a powerful, cutting-edge supplement that can be stacked with Nugenix Free Testosterone Booster in order to maximize results.

Formula

One of the key super ingredients found in Nugenix Estro-Regulator is Diindolylmethane (DIM), which is an aromatase inhibitor that can help support estrogen balance - a critical factor for anyone wanting hardcore gains.

Featuring: Chrysin & DIM

Precautions: Only for adult males over 18 years.

General Statements

In vitro evidence demonstrates DIM’s anti-estrogen activity. Through its interaction with estrogen binding sites, it can help inhibit the reaction that converts testosterone into estrogen. Overall, this activity can diminish the impact estrogen has in the body!

Powerful anti-aromastase modulator

Helps to: Support estrogen regulation Reduce aromatization or testosterone Support hormonal balance

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Adult Men: Take two (2) capsules in the morning, with or without food.

Precautions

Use only as directed.

Consult your healthcare practitioner if you have or suspect a medical condition or if you use any medications as extracts may alter the potency and/or side effects of certain medications.

Discontinue use two weeks prior to surgery or if any serious adverse reaction occurs. Do not use if safety seal is missing.

Keep out of the reach of children.

Storage

Keep product at room temperature and humidity [59-86(0)F (15-30(0)C), 40% RH].

General

R1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nugenix Estro-Regulator by Nugenix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nugenix Estro-Regulator label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nugenix Estro-Regulator by Nugenix

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diindolylmethane

Interacts with
269 drugs
100 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

Chrysin

Interacts with
358 drugs
500 mg per serving

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not show...

Chrysin monograph & interactions

Vitamin E

Interacts with
764 drugs
6.7 mg per serving Form: D-Alpha-Tocopherol Succinate

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Polygonum cuspidatum extract

Interacts with
826 drugs
300 mg per serving Form: Trans-Resveratrol

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and ear...

Polygonum cuspidatum extract monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nugenix Estro-Regulator by Nugenix Drug Interactions

Want to check YOUR meds against Nugenix Estro-Regulator?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
960Drugs
931 Moderate 29 Minor

Ingredients driving the most interactions

Polygonum cuspidatum extract 826
Vitamin E 764
Chrysin 358
Diindolylmethane 269

Individual Drug Interactions

The ingredients in Nugenix Estro-Regulator interact with 960 drugs. Click any drug to see the details.

4 of the 4 ingredients in Nugenix Estro-Regulator interact with drugs. Each result below shows which ingredient is responsible. Polygonum cuspidatum extract Vitamin E Chrysin Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in Nugenix Estro-Regulator with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Polygonum cuspidatum extract7 drug types · 826 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Estrogens

Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Polygonum cuspidatum extract full monograph & interactions

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Chrysin9 drug types · 358 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that chrysin might inhibit platelet aggregation.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, chrysin might increase the effects and adverse effects of aromatase inhibitors.
In vitro research suggests that chrysin might decrease estrogen synthesis by acting as an aromatase (estrogen synthetase) inhibitor..

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, chrysin might reduce the efficacy of estrogen-containing contraceptive drugs.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D
Diclofenac (Voltaren, Others)

Theoretically, chrysin might increase the effects and adverse effects of diclofenac.
In vitro research suggests that chrysin and its sulfate conjugate inhibit diclofenac metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of diclofenac by inhibiting cytochrome P450 2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, chrysin might decrease the effects of estrogen therapy.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D
Mephenytoin (Mesantoin)

Theoretically, chrysin might increase the effects and adverse effects of mephenytoin.
In vitro research suggests that chrysin and its sulfate and glucuronide conjugates inhibit S-mephenytoin metabolism. It is speculated that chrysin and its conjugates reduce the metabolism of S-mephenytoin by inhibiting cytochrome P450 2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
In vitro research suggests that chrysin inhibits CYP1A2 isozymes. However, chrysin does not appear to inhibit CYP1A2-dependent caffeine metabolism in animals. Due to chrysin's low bioavailability and rapid metabolism to glucuronide and sulfate conjugates, this interaction is unlikely.

Likelihood Unlikely Evidence D
Glucuronidated Drugs

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).

Likelihood Unlikely Evidence D
Testosterone

Theoretically, chrysin might increase the effects and adverse effects of testosterone.
In vitro research suggests that chrysin and its sulfate conjugate inhibit testosterone metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of testosterone by inhibiting cytochrome P450 3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Chrysin full monograph & interactions

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nugenix Estro-Regulator, from the product label.

Nugenix

Name
Direct Digital, LLC
City
Charlotte
State
NC
ZipCode
28202
Phone Number
1-855-714-3234
Web Address
www.Nugenix.com
Pharmacist Counseling Corner

Nugenix Estro-Regulator by Nugenix: Common Questions

Does Nugenix Estro-Regulator by Nugenix interact with any medications?
Yes. Based on its ingredients, Nugenix Estro-Regulator has a known interaction with 960 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nugenix Estro-Regulator contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product contain any fillers or binders I should know about?
Yes. Beyond the four active ingredients, the capsules contain gelatin and cellulose, which are inactive ingredients used to form and stabilize the capsule.
Is it safe to take this product while pregnant?
No. All four active ingredients should be avoided in pregnancy according to the safety data. Talk with your doctor or pharmacist about what's appropriate for you.
Can I take this while breastfeeding?
The data advises against it. Diindolylmethane and polygonum cuspidatum extract have insufficient safety information for breastfeeding, and chrysin and vitamin E also lack adequate breastfeeding safety data. Check with your doctor or pharmacist for personalized guidance.
What are the most common side effects?
Diindolylmethane can cause diarrhea, gas, headache, nausea, rash, and vomiting. Chrysin and polygonum cuspidatum extract have no adverse effects listed in the data we hold. Vitamin E from normal food sources is well tolerated, though high-dose supplements carry a bleeding risk.
Does this product actually work for hormone balance?
The evidence we hold does not establish that any of these four ingredients is effective for hormone support. Each one has insufficient evidence for its intended uses.
Why does this product interact with so many medications?
Three of the four ingredients—vitamin E, chrysin, and polygonum cuspidatum extract—affect liver enzymes (cytochrome P450 pathways) that break down hundreds of common medications. When those enzymes are slowed or sped up, drug levels in your blood can change, potentially making medications less effective or causing buildup. That's why it's important to check with your pharmacist before adding this product to your routine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nugenix Estro-Regulator label
Go deeper

The Full Monographs Behind Nugenix Estro-Regulator’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Chrysin

Interacts with 358 drugs

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the bo...

Read the full Chrysin monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Hu Zhang

Interacts with 826 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph →
Sources

Sources & How We Checked

Nugenix Estro-Regulator's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 120 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
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