Octacosanol 5000 mcg Ingredients & Drug Interactions
by NOW Sports
What is this page for?
First and foremost: checking Octacosanol 5000 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Octacosanol 5000 mcg is a dietary supplement by NOW Sports with 1 active ingredient. Its ingredients are commonly taken for physical performance and endurance, cholesterol support, parkinson's and movement concerns.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Octacosanol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Octacosanol 5000 mcg by NOW Sports
Ask about any prescription or over-the-counter medication and we check it for interactions with Octacosanol 5000 mcg by NOW Sports — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Octacosanol 5000 mcg by NOW Sports
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: octacosanol 5000 mcg per capsule. Octacosanol is a waxy substance derived from plant oils and is the main component of policosanol, which is studied for its potential effects on cholesterol and athletic performance.
The inactive ingredients are cellulose, gelatin, silica, and magnesium stearate — the standard capsule fillers and binders.
Does it work?
Couldn't assess
The evidence for octacosanol isn't established in the data we hold. The studies reviewed classify its effectiveness for athletic performance, high cholesterol (hyperlipidemia), ALS, and Parkinson disease as having insufficient reliable evidence to rate — meaning there isn't enough solid research yet to confirm it works for these uses.
How safe is it?
Well-documented data
Octacosanol is generally well tolerated in the amounts that have been studied, but long-term safety data are limited. Uncommon side effects from the research include headache, mild dizziness, drowsiness, irritability, insomnia, and skin rash or itching — though it's not entirely clear if octacosanol itself is responsible for these.
There isn't enough safety information to recommend octacosanol during pregnancy or breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.
Meds to double-check
Moderate interaction found
Before taking NOW Sports Octacosanol, double-check with your doctor or pharmacist if you take blood pressure medications (especially beta-blockers or propranolol), diabetes medications, blood thinners or antiplatelet drugs (like warfarin), or levodopa/carbidopa for Parkinson disease — octacosanol may enhance or add to their effects in ways that need monitoring.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Octacosanol may be worth considering if you're interested in its potential effects, but it does interact with several common medication types — particularly blood pressure drugs and diabetes medications. If you take any prescription medications, especially for high blood pressure, diabetes, or Parkinson disease, or if you take blood thinners, check with your doctor or pharmacist before adding this supplement.
Long-term safety data are limited, so this is something to discuss with your healthcare provider for your individual situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Octacosanol 5000 mcg, straight from the product label.
| Brand | NOW Sports |
|---|---|
| Barcode (UPC) | 733739018205 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 24, 2013 |
| DSLD ID | 28389 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Octacosanol 5000 mcg by NOW Sports, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Octacosanol | 5 mg | -- |
Other ingredients: Cellulose, Gelatin, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
SUGGESTED USAGE: As a dietary supplement, take 1 capsule daily with food. Consider taking this product in combination with NOW(R) ENERGY, B-12 and L-Carnitine.
General Statements
Octacosanol is a naturally occurring substance found in sugar cane, wheat germ oil, spinach and other natural sources. Our Octacosanol is derived from spinach.
Please Recycle.
CAPSULE SIZE
Made in the USA
For more product information visit www.nowfoods.com/1820
Formula
Our Octacosanol is derived from spinach.
from Spinach Extract
Storage
Store in a cool, dry place after opening.
Precautions
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
FDA Statement of Identity
A Dietary Supplement
Seals/Symbols
GMP QUALITY ASSURED
Formulation
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
General
CODE 1820B V4
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Octacosanol 5000 mcg by NOW Sports label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Octacosanol 5000 mcg by NOW Sports
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Octacosanol
Interacts with248 drugs
Octacosanol is a waxy long-chain alcohol from plant sources that is most often promoted for exercise endurance and cholesterol support, but solid huma...
Octacosanol monograph & interactionsOther (inactive) ingredients: Cellulose, Gelatin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Octacosanol 5000 mcg by NOW Sports Drug Interactions
HelloPharmacist Interaction Report
NOW Sports Octacosanol 5000 mcg does interact with several medication types through its octacosanol content.
The most serious concern is with blood pressure medications: octacosanol might add to the blood-pressure-lowering effects of beta-blockers and certain other blood pressure drugs, potentially causing your blood pressure to drop too far.
Read the full breakdown — every affected drug type, severity by severity
Octacosanol may also interact with blood thinners and antiplatelet drugs (anticoagulant/antiplatelet drugs), though research suggests the effect may not be clinically significant in practice. If you take diabetes medications (antidiabetes drugs), octacosanol might lower your blood sugar further, and if you're on levodopa/carbidopa (Sinemet) for Parkinson disease, it could worsen involuntary movements and increase nervous tension.
Altogether, these interactions span 248 individual medications.
Before you start octacosanol, run through your exact medications with the search tool on this page or talk with your doctor or pharmacist — especially if you take any blood pressure or diabetes drug, or levodopa/carbidopa.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Octacosanol 5000 mcg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Octacosanol 5000 mcg interact with 248 drugs. Click any drug to see the details.
1 of the 1 ingredient in Octacosanol 5000 mcg interact with drugs. Each result below shows which ingredient is responsible. Octacosanol
AbciximabReoPro
How Abciximab interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolBeta-blockers Moderate
Interaction Summary
Theoretically, concomitant use of octacosanol with beta-blockers might result in additive hypotensive effects.
Read the full Octacosanol + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Octacosanol 5000 mcg — through 1 ingredient. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Butalbital, Caffeine, Phenacetin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Octacosanol 5000 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Octacosanol
Anticoagulant/Antiplatelet Drugs
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Octacosanol is the main component of policosanol. Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. However, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to initiating warfarin does not affect warfarin pharmacokinetics or warfarin response. Furthermore, a study in patients undergoing percutaneous coronary intervention with a drug-eluting stent found that taking policosanol 40 mg plus clopidogrel and aspirin daily for 30 days modestly reduced the risk for minor bleeding events when compared with taking clopidogrel and aspirin alone.
Antidiabetes Drugs
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Octacosanol is the main component of policosanol. In humans, policosanol can decrease blood glucose. It is not clear if these effects occur with the use of octacosanol.
Beta-Blockers
Theoretically, concomitant use of octacosanol with beta-blockers might result in additive hypotensive effects.
Octacosanol is the main component of policosanol. Clinical research shows that policosanol 5 mg daily can have additive blood pressure-lowering effects in patients with hypertension who are taking beta-blockers. Also, animal research shows that policosanol can increase the hypotensive effects of propranolol. It is not clear if these effects occur with the use of octacosanol.
Levodopa/Carbidopa (Sinemet)
Concomitant use may worsen symptoms of Parkinson disease.
One small clinical study suggests that octacosanol might worsen dyskinesias and increase nervous tension in some patients being treated with levodopa/carbidopa.
Nitroprusside (Nitropress)
Theoretically, octacosanol might enhance the hypotensive effects of nitroprusside.
Octacosanol is the main component of policosanol. Animal research shows that taking policosanol along with nitroprusside can increase the hypotensive effects of nitroprusside. It is not clear if these effects occur with the use of octacosanol.
Propranolol (Inderal)
Theoretically, octacosanol might enhance the hypotensive effects of propranolol.
Octacosanol is the main component of policosanol. Animal research shows that taking policosanol along with propranolol can increase the blood pressure-lowering effects of propranolol. It is not clear if these effects occur with the use of octacosanol.
Warfarin (Coumadin)
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Octacosanol is the main component of policosanol. Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. Therefore, there is concern that taking policosanol with warfarin might increase the risk of bruising and bleeding. However, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response. It is not clear if these effects occur with the use of octacosanol.
Brand information
Manufacturer and brand details for Octacosanol 5000 mcg, from the product label.
Octacosanol 5000 mcg by NOW Sports: Common Questions
Does Octacosanol 5000 mcg by NOW Sports interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is octacosanol, and what is it supposed to do?
Can I take this if I'm on blood pressure medication?
What side effects might I experience?
Is this safe to take while pregnant or breastfeeding?
Does this product have any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Octacosanol 5000 mcg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Octacosanol 5000 mcg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Octacosanol 5000 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 16 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Octacosanol 16 references
- Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
- Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
- Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
- Snider S. Octacosanol in parkinsonism. Ann Neurol 1984;16:723. PubMed
- Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
- Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
- Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
- Menendez, R., Mas, R., Amor, A. M., Gonzalez, R. M., Fernandez, J. C., Rodeiro, I., Zayas, M., and Jimenez, S. Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modificat
- Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
- Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
- Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
- Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
- Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
- Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
- Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed
- Li C, Ding Y, Si Q, Li K, Xu K. Multiple functions of policosanol in elderly patients with dyslipidemia. J Int Med Res. 2020;48(7):300060520936082. PubMed
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