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Dietary supplement

Oil Of Oregano Ingredients & Drug Interactions

by Planetary Herbals

Oil Of Oregano label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Oil Of Oregano against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Oil Of Oregano is a dietary supplement by Planetary Herbals with 2 active ingredients. Its ingredients are commonly taken for heart health, high blood pressure, high cholesterol.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wildcrafted Oregano leaf Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Oil Of Oregano by Planetary Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Oil Of Oregano by Planetary Herbals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Oil Of Oregano by Planetary Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “wildcrafted Oregano leaf Oil” is listed as a grouped ingredient — the label gives one combined amount (37.60 mg) without saying how much of each component you get.

This product contains 2 active ingredients: extra virgin olive oil and carvacrol (the main active compound in oregano leaf oil). Olive oil is a well-studied food source, while carvacrol is extracted from wildcrafted oregano leaves to give the supplement its potency.

No inactive fillers or binders are listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for Oil of Oregano isn't established in the data we hold. Both the olive oil and oregano components show insufficient reliable evidence for the conditions they're traditionally used for — including respiratory infections, colds, acne, and digestive upset.

That doesn't mean they don't work; it means the clinical trials backing them up aren't strong enough yet for us to rate them.

The evidence, ingredient by ingredient Olive Oregano

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oregano is well tolerated when eaten as a food seasoning, but concentrated oregano oil supplements are much stronger and less studied. The most common side effect orally is gastrointestinal upset.

Rarely, oregano can trigger allergic reactions ranging from dermatitis (skin irritation) to serious systemic reactions like anaphylaxis in sensitive people — so if you've had allergies to oregano or related herbs like thyme, be cautious. Olive oil and olives as food are very safe, but the safety of concentrated olive oil supplements isn't well known, so check with your doctor before using if you're in doubt.

One person in a trial reported skin breakouts after using olive leaf extract. Additionally, the safety data for carvacrol during pregnancy advises against medicinal amounts — food amounts are likely fine.

For breastfeeding, there isn't enough data on concentrated oregano supplements, so talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Olive Oregano

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Oregano.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — oregano may increase bleeding risk. You should also confirm it's okay if you take diabetes medications, since oregano might lower blood sugar.

These are documented moderate-severity concerns.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Oil of Oregano may be worth considering if you're looking for traditional respiratory or digestive support, but the evidence for it isn't yet solid. The main caution is if you take blood thinners, antiplatelet drugs, or diabetes medications — you'll need to clear this with your own doctor or pharmacist first.

If you have a history of allergies to oregano or thyme, be aware of the risk of allergic reactions. Talk it over with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Oil Of Oregano, straight from the product label.

Brand Planetary Herbals
Barcode (UPC) 021078105077
Net contents 1 fl. Oz.; 29.57 mL
Market status On market
Date entered into DSLD Dec 22, 2017
DSLD ID 80488
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Oil Of Oregano by Planetary Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.02675 mL
Maximum serving Sizes:
0.107 mL
Servings per container
275
UPC/BARCODE
021078105077
IngredientAmount% DV
extra virgin Olive Oil70 mg--
Carvacrol26.3 mg--
wildcrafted Oregano leaf Oil37.6 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Standardized to 70% Carvacrol

FDA Statement of Identity

Herbal Supplement

General Statements

Approved Michael Tierra L.Ac, O.M.D

Suggested/Recommended/Usage/Directions

Suggested Use: 1 to 4 drops in water, juice or milk once or twice daily. May also be used topically.

Precautions

Caution: Do not use this product in the eyes, and avoid contact with genital regions. If a rash/irritation occurs, discontinue use.

If you are pregnant, may become pregnant, or breastfeeding, consult your physician before using this product.

Do not use if tamper-evident seal is broken or missing.

Brand IP Statement(s)

Planetary Herbals, LLC

General

PF0507 REV C161

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Oil Of Oregano by Planetary Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Oil Of Oregano label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Oil Of Oregano by Planetary Herbals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.02675 mL Dosage formLiquid Servings per container275 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Extra virgin Olive Oil

No known
interactions
70 mg per serving

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Extra virgin Olive Oil monograph & interactions

Wildcrafted Oregano leaf Oil

Interacts with
208 drugs
37.6 mg per serving

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacr...

Wildcrafted Oregano leaf Oil monograph & interactions
Interaction report

Oil Of Oregano by Planetary Herbals Drug Interactions

Want to check YOUR meds against Oil Of Oregano?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

wildcrafted Oregano leaf Oil 208

Individual Drug Interactions

The ingredients in Oil Of Oregano interact with 208 drugs. Click any drug to see the details.

1 of the 2 ingredients in Oil Of Oregano interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Oregano leaf Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Oil Of Oregano with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Oregano leaf Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
wildcrafted Oregano leaf Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Oil Of Oregano, from the product label.

Planetary Herbals

See all Planetary Herbals products
Name
Planetary Herbals, LLC
Street Address
P.O. Box 1760
City
Soquel
State
CA
ZipCode
95073
Web Address
www.planetaryherbals.com
Pharmacist Counseling Corner

Oil Of Oregano by Planetary Herbals: Common Questions

Does Oil Of Oregano by Planetary Herbals interact with any medications?
Yes. Based on its ingredients, Oil Of Oregano has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Oil Of Oregano contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is oregano oil safe to use long-term?
Oregano is well tolerated as a food seasoning, but there's limited information on the safety of concentrated oregano supplements in larger doses over time. The safety data isn't as robust as it is for food amounts. Talk with your doctor about how long you plan to use it and whether it's right for you.
Can I use this if I have a food allergy to thyme or other herbs in the mint family?
Be careful — oregano belongs to the same plant family as thyme, and people allergic to one are sometimes allergic to the other. Serious allergic reactions to oregano, including anaphylaxis, have been reported in sensitive individuals. If you have known allergies to mint-family herbs, check with your doctor or pharmacist before using this product.
What does the olive oil in this product do?
Olive oil is the carrier base that delivers the oregano compounds. It's a very safe food source, though the safety of concentrated olive oil supplements specifically isn't as well understood as regular olive oil you'd use in cooking.
Is this safe during pregnancy?
Medicinal or supplement amounts of oregano are not recommended during pregnancy. Food amounts are likely fine, but the concentrated oregano in this supplement is different. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or planning to be.
Can I use this if I'm breastfeeding?
The safety of concentrated oregano supplements while breastfeeding isn't established. Food amounts of oregano are fine, but this product is much more concentrated. Check with your doctor or pharmacist before using it.
Does this product actually work for colds or respiratory infections?
The evidence for oregano against colds and upper respiratory infections isn't solid enough for us to rate it yet. That doesn't mean it doesn't help — it means clinical trials haven't proven it strongly enough so far. Your own experience may differ.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Oil Of Oregano is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Oil Of Oregano label
Go deeper

The Full Monographs Behind Oil Of Oregano’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph →
Sources

Sources & How We Checked

Oil Of Oregano's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Oregano 12 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Benito M, Jorro G, Morales C, et al. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996;76:416-8. PubMed
  3. Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
  4. Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
  5. Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
  6. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  7. Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed
  8. Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256. PubMed
  9. McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
  10. Ragi, J., Pappert, A., Rao, B., Havkin-Frenkel, D., and Milgraum, S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J.Drugs Dermatol. 2011;10(10):1168-1172.
  11. Singletary K. Oregano: overview of the literature on health benefits. Nutrition Today 2010;45(3):129-38.
  12. Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.

See these in context on the Oregano monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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