Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Omega VitaliSEA Ingredients & Drug Interactions

by Dr. Sinatra

Omega VitaliSEA label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Omega VitaliSEA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Omega VitaliSEA is a dietary supplement by Dr. Sinatra with 5 active ingredients. Its ingredients are commonly taken for preventing iodine deficiency, supporting thyroid hormone production, general energy and metabolism support.Based on those ingredients, 929 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are AstaReal Astaxanthin, Magnesium, Japanese Kelp extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Omega VitaliSEA by Dr. Sinatra

Ask about any prescription or over-the-counter medication and we check it for interactions with Omega VitaliSEA by Dr. Sinatra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Omega VitaliSEA by Dr. Sinatra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “CalaMarine Oil Concentrate” is listed as a grouped ingredient — the label gives one combined amount (2 Gram(s)) without saying how much of each component you get.

Omega VitaliSEA contains five active ingredients. Docosahexaenoic acid ethyl ester (a form of DHA, an omega-3 fatty acid) is included for its role in brain and eye health.

Iodine supports thyroid and metabolic function, especially when dietary intake is low. Astaxanthin is a carotenoid antioxidant from algae.

Magnesium aids muscle and nerve function, bone health, and digestion. Japanese kelp extract contributes iodine and trace minerals.

The softgels also contain inactive ingredients — gelatin, glycerin, silica, sunflower oil, purified water, caramel, mixed tocopherols, and sunflower lecithin — that serve as the capsule structure and preserve freshness.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: heart, brain, eyes, bones and overall health.
  • We looked for evidence on: Age-related cognitive decline, Age-related macular degeneration (AMD), Alzheimer disease, Arrhythmia, Cognitive impairment, Coronary heart disease (CHD) — and 4 related terms.
  • The strongest evidence on file: Magnesium is rated "Possibly Effective" for Arrhythmia (Natural Medicines).
  • Also on file: Magnesium is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Magnesium is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Cognitive impairment.

In our data, iodine is rated likely effective for preventing radiation-related thyroid damage and for correcting iodine deficiency, and possibly effective for mouth ulcers and gum disease. Magnesium is rated effective for indigestion, constipation, and treating low magnesium levels, and also effective for preventing pre-eclampsia in pregnancy under medical supervision.

For astaxanthin and Japanese kelp extract, the evidence we hold does not establish effectiveness — astaxanthin shows insufficient reliable evidence for cognitive decline, macular degeneration, aging skin, Alzheimer's disease, athletic performance, and carpal tunnel syndrome, while kelp shows insufficient evidence for cancer, high blood pressure, and obesity. The effectiveness of docosahexaenoic acid ethyl ester is not rated in our data.

The evidence, ingredient by ingredient Iodine Astaxanthin Magnesium Laminaria

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Magnesium is generally well tolerated at recommended doses and is generally considered safe for healthy adults from food and supplements; the most common oral side effects are diarrhea, nausea, and gastrointestinal upset. Iodine is safe in normal dietary amounts but can cause thyroid problems at high doses; common side effects include metallic taste, nausea, headache, and diarrhea, and rare severe reactions include anaphylaxis and hypersensitivity symptoms.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited; reported side effects include abdominal pain, diarrhea, and red-colored stools. Japanese kelp extract is generally well tolerated as food but can deliver very high and variable amounts of iodine that may harm the thyroid; it may also concentrate arsenic depending on where it was harvested.

Regarding pregnancy and breastfeeding: iodine is rated likely safe in pregnancy (adequate iodine is important) but use only the amount your doctor advises and avoid high-dose products; data on astaxanthin are not sufficient to recommend use in pregnancy or while breastfeeding. Magnesium is likely safe in pregnancy when medically supervised and possibly safe while breastfeeding — follow your doctor's guidance.

Japanese kelp extract is rated possibly unsafe to unsafe in pregnancy because excess iodine can harm the fetal thyroid, and should be avoided while breastfeeding because iodine passes into breast milk and high amounts may affect the infant's thyroid. No safety data are on file for docosahexaenoic acid ethyl ester in pregnancy or lactation.

Side effects, ingredient by ingredient Iodine Astaxanthin Magnesium Laminaria

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Iodine, Laminaria, Magnesium, Astaxanthin.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 930 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Omega VitaliSEA, check with your doctor or pharmacist if you take Parkinson's medication (levodopa/carbidopa) — magnesium can significantly reduce its effectiveness. Also double-check if you're on thyroid medications, antithyroid drugs, amiodarone (Cordarone), lithium, blood pressure drugs (especially calcium channel blockers), muscle relaxants, potassium-sparing water pills, ACE inhibitors, diabetes drugs, quinolone antibiotics (such as ciprofloxacin), bone medications (bisphosphonates), or digoxin.

No interactions are documented for the docosahexaenoic acid ethyl ester we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may appeal to someone seeking omega-3 and mineral support, but iodine and magnesium levels make careful consideration essential if you take thyroid, heart, diabetes, or antibiotic medications — and if you have a thyroid condition or are pregnant or breastfeeding, talk with your doctor or pharmacist before starting. The Major interaction with Parkinson's medication (levodopa/carbidopa) alone is reason to check your full medication list first.

Use the interaction checker on this page, and review the results with your own healthcare provider before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Omega VitaliSEA, straight from the product label.

Brand Dr. Sinatra
Barcode (UPC) 678829202440
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Aug 31, 2018
DSLD ID 179551
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Omega VitaliSEA by Dr. Sinatra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
678829202440
IngredientAmount% DV
Calories20 Calorie(s)--
Calories from Fat20 Calorie(s)--
Cholesterol5 mg1%
Total Fat2 Gram(s)3%
Docosahexaenoic Acid Ethyl Ester570 mg--
Iodine150 mcg100%
AstaReal Astaxanthin6 mg--
Magnesium100 mg25%
CalaMarine Oil Concentrate2 Gram(s)--
Japanese Kelp extract50 mg--

Other ingredients: Gelatin, Glycerin, Silica, Sunflower Oil, purified Water, Caramel, Mixed Tocopherols, Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Almost out? Call 1-800-304-1708 or visit drsinatra.com Choose AutoDelivery, get free shipping forever

Unconditionally guaranteed for purity and labeled potency.

Sea-based nutritional support for your heart, brain, eyes, bones and whole body

Formula

Omega VitaliSEA includes Calamarine omega-3s, sea-based minerals, and antioxidants that provide comprehensive support for your heart, brain, eyes, bones and overall health

Storage

Store bottle with cap tightly closed in a cool, dry place.

Seals/Symbols

Friend of the Sea

GF Gluten free

Brand IP Statement(s)

Calamarine is a registered trademark of Pharma Marine AS. AstaReal is a registered trademark of Fuji Chemical Industries Co., Ltd. Aquamin is a registered trademark of Marigot Ltd.

America's #1 Integrative Cardiologist

Precautions

Note: Pregnant or lactating women should consult a health care professional before taking this product.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Doctor Suggested Use: Take 2 softgels daily with a meal.

Formulation

GF Gluten free

General

SKU: OSE 02 G11000, 2017 R-1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Omega VitaliSEA by Dr. Sinatra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Omega VitaliSEA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Omega VitaliSEA by Dr. Sinatra

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Iodine

Interacts with
7 drugs
150 mcg per serving Form: Potassium Iodide

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements...

Iodine monograph & interactions

AstaReal Astaxanthin

Interacts with
671 drugs
6 mg per serving Form: Haematococcus pluvialis algae extract

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

AstaReal Astaxanthin monograph & interactions

Magnesium

Interacts with
295 drugs
100 mg per serving Form: Aquamin Magnesium Hydroxide

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

CalaMarine Oil Concentrate

2 Gram(s) per serving
  • › Docosahexaenoic Acid Ethyl Ester

Japanese Kelp extract

Interacts with
69 drugs
50 mg per serving

Laminaria is a type of brown seaweed (kelp) that is very rich in iodine and is also used in medical settings as a natural cervical dilator. Because it...

Japanese Kelp extract monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Silica, Sunflower Oil, Purified Water, Caramel, Mixed Tocopherols, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Omega VitaliSEA by Dr. Sinatra Drug Interactions

Want to check YOUR meds against Omega VitaliSEA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
929Drugs
6 Major 843 Moderate 80 Minor

Ingredients driving the most interactions

AstaReal Astaxanthin 671
Magnesium 295
Japanese Kelp extract 69
Iodine 7

Individual Drug Interactions

The ingredients in Omega VitaliSEA interact with 929 drugs. Click any drug to see the details.

4 of the 5 ingredients in Omega VitaliSEA interact with drugs. Each result below shows which ingredient is responsible. AstaReal Astaxanthin Magnesium Japanese Kelp extract Iodine

Each ingredient & the kinds of drugs it affects

For each ingredient in Omega VitaliSEA with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

AstaReal Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
AstaReal Astaxanthin full monograph & interactions

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions

Japanese Kelp extract6 drug types · 69 drugs

Ace Inhibitors (Aceis)

Theoretically, laminaria might increase the risk of hyperkalemia when taken with ACEIs.
Laminaria contains potassium.

Likelihood Possible Evidence D
Amiodarone (Cordarone)

Theoretically, combining laminaria with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with laminaria supplements, some of which may contain as much as 1000 mcg iodine, might increase the risk of adverse effects from iodine, including altered thyroid function.

Likelihood Possible Evidence D
Antithyroid Drugs

Due to its iodine content, laminaria might alter the effects of antithyroid drugs.
Some laminaria supplements contain up to 1000 mcg of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking laminaria could theoretically alter the effects of antithyroid drugs.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, laminaria might increase the risk of hyperkalemia, which could increase the effects and adverse effects of digoxin.
Laminaria contains potassium.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, laminaria might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Laminaria contains potassium.

Likelihood Possible Evidence D
Thyroid Hormone

Due to its iodine content, laminaria might alter the effects of thyroid hormone.
Some laminaria supplements contain up to 1000 mcg of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking laminaria could theoretically alter the effects of thyroid hormone.

Likelihood Possible Evidence D
Japanese Kelp extract full monograph & interactions

Iodine3 drug types · 7 drugs

Amiodarone (Cordarone)

Combining iodine with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with iodine might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.

Likelihood Probable Evidence D
Antithyroid Drugs

Iodine might alter the effects of antithyroid drugs.
Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking iodine while using antithyroid drugs could alter the effects of the antithyroid drugs.

Likelihood Probable Evidence D
Lithium

Combining iodine with lithium might have additive hypothyroid effects.
Lithium can inhibit thyroid function. Several case reports suggest that concomitant use of lithium and potassium iodide can reduce thyroid function in otherwise healthy adults. Monitor thyroid function.

Likelihood Probable Evidence D
Iodine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Omega VitaliSEA, from the product label.

Dr. Sinatra

See all Dr. Sinatra products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Phone Number
1-800-304-1708
Web Address
healthydirections.com
Pharmacist Counseling Corner

Omega VitaliSEA by Dr. Sinatra: Common Questions

Does Omega VitaliSEA by Dr. Sinatra interact with any medications?
Yes. Based on its ingredients, Omega VitaliSEA has a known interaction with 929 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Omega VitaliSEA contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product contain mercury or other heavy metals?
Our data do not address mercury or heavy metal screening for this product. Japanese kelp extract can concentrate arsenic from seawater, and the amount varies by harvest location and batch. If you have concerns about contaminants, contact the manufacturer directly or ask your pharmacist.
Can I take this while pregnant?
Iodine is needed in pregnancy, but use only the amount your doctor recommends and avoid high-dose products. Magnesium may be appropriate under medical supervision. However, the Japanese kelp extract carries a risk — excess iodine can harm the fetal thyroid — so kelp supplements are best avoided in pregnancy unless your doctor directs otherwise. Talk with your doctor or pharmacist before starting.
Can I take this while breastfeeding?
Iodine passes into breast milk and high amounts may affect the infant's thyroid, so concentrated iodine and kelp supplements should be avoided. Magnesium in normal dietary amounts is appropriate, but check with your doctor before using supplements. No breastfeeding data are on file for astaxanthin or docosahexaenoic acid ethyl ester.
What are the most common side effects?
From magnesium: diarrhea, nausea, and gastrointestinal upset. From iodine: metallic taste, nausea, headache, and diarrhea. From astaxanthin: abdominal pain, diarrhea, and red-colored stools. These are generally mild and well tolerated at recommended doses.
Is this safe for people with thyroid disease?
Not without medical guidance. Both iodine and Japanese kelp extract can alter thyroid function and may affect thyroid medications, antithyroid drugs, and amiodarone (a heart rhythm drug with high iodine content). If you have a thyroid condition or take any thyroid-related medication, talk with your doctor or pharmacist before starting.
What is astaxanthin and why is it in this product?
Astaxanthin is a red-pigmented antioxidant from algae that is included for potential eye and skin health support. However, our data show insufficient reliable evidence to confirm it works for these purposes. It is generally well tolerated, though long-term safety data are limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Omega VitaliSEA label
Go deeper

The Full Monographs Behind Omega VitaliSEA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Iodine

Interacts with 7 drugs

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements help when you are truly deficient, but...

Read the full Iodine monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Laminaria

Interacts with 69 drugs

Laminaria is a type of brown seaweed (kelp) that is very rich in iodine and is also used in medical settings as a natural cervical dilator. Because its iodine content can be high and variabl...

Read the full Laminaria monograph →
Sources

Sources & How We Checked

Omega VitaliSEA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 120 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Iodine 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
  3. Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg 1993;36:453-60.
  4. Potassium iodide for nuclear exposure. Pharmacist's Letter/Prescriber's Letter 2001;17(12):171214.
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Astaxanthin 3 references
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See these in context on the Magnesium monograph →

Laminaria 9 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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