Interactions on record — worth a quick check against your medications. Based on 2 of 12 ingredients. Check your meds →
Dietary supplement

Oral Health Probiotics WiseBiotics Mint Ingredients & Drug Interactions

by NatureWise

Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Oral Health Probiotics WiseBiotics Mint is a dietary supplement by NatureWise with 12 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are B. breve. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Oral Health Probiotics WiseBiotics Mint by NatureWise

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Oral Health Probiotic Blend” is a proprietary blend — the label gives one combined amount (110 mg) without saying how much of each component you get.

This tablet contains 12 active probiotic ingredients—mostly beneficial bacteria strains meant to support oral health. The two we could verify are Bifidobacterium breve and Streptococcus thermophilus; the others (including several Lactobacillus and Bifidobacterium species, plus two Streptococcus salivarius strains) are part of what's called an Oral Health Probiotic Blend.

The inactive ingredients are standard tablet binders and fillers like inulin, dicalcium phosphate, and stevia leaf extract for sweetness—plus natural peppermint flavor.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: oral health and upper respiratory support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Respiratory tract infections, Otitis media, Dental health, Gum health, Oral microbiome balance — and 1 related terms.
  • The closest evidence on file: Streptococcus Thermophilus is rated "Insufficient Reliable Evidence To Rate" for Otitis media (Natural Medicines).
  • Also on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Respiratory tract infections.

The evidence for what these probiotics actually do is limited. For Bifidobacterium breve, studies suggest it's possibly ineffective for age-related cognitive decline and sepsis, but there isn't enough reliable data to rate it for antibiotic-associated diarrhea, hay fever, or other allergic conditions.

Streptococcus thermophilus shows insufficient evidence for antibiotic-associated diarrhea, bacterial vaginosis, constipation, diabetes, and other conditions listed. We don't have effectiveness ratings on file for the other strains in the blend.

The evidence, ingredient by ingredient Bifidobacterium Breve Streptococcus Thermophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both B. breve and S. thermophilus are generally well tolerated in healthy people, but probiotics do come with caveats. Caution is needed if you're very ill, immunocompromised, or a preterm infant—there are rare but documented cases of these bacteria causing bloodstream infections in critically ill patients and newborns.

Bloating and flatulence have been reported with probiotic use generally. The safety data on probiotic supplements is limited, so check with your doctor before you start, especially if you have a weakened immune system or are facing critical illness.

Side effects, ingredient by ingredient Bifidobacterium Breve Streptococcus Thermophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bifidobacterium Breve.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern—they can reduce how well this probiotic works by killing the live bacteria in it. Separate your doses and talk to your pharmacist about timing.

We couldn't verify interactions for most of the other probiotic strains in the blend, so run your medications through the checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a probiotic blend aimed at oral health, but the evidence for its effectiveness isn't strong yet. The main thing to watch is if you're taking antibiotics—they'll interfere with the live bacteria in this supplement.

If you're healthy and not on antibiotics, it's generally well tolerated, but it's worth a quick conversation with your pharmacist or doctor first, especially if you have any immune system concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Oral Health Probiotics WiseBiotics Mint, straight from the product label.

Brand NatureWise
Barcode (UPC) 858081006356
Net contents 50 Chewable Mint Tablet(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 327773
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Oral Health Probiotics WiseBiotics Mint by NatureWise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
Servings per container
50
UPC/BARCODE
858081006356
IngredientAmount% DV
L. plantarum0 NP--
B. breve0 NP--
L. paracasei LPC-370 NP--
L. reuteri0 NP--
L. salivarius0 NP--
S. thermophilus0 NP--
L. casei0 NP--
B. longum infantis0 NP--
L. rhamnosus GG0 NP--
B. animalis lactis BL-040 NP--
Oral Health Probiotic Blend110 mg--
S. salivarius BLIS M180 NP--
S. salivarius BLIS-K120 NP--

Other ingredients: Isomalt, Inulin, Behenoyl Polyoxyl-8 Glycerides, Dicalcium Phosphate, Peppermint Flavor, Natural, Stevia leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free

Advanced oral care

Advanced protection for teeth & gums + better breath & upper resiratory immune support for healthy ears nose & throat

This product does not contain: Wheat, gluten, soy, eggs, tree nuts, peanuts, fish, or shellfish.

Suggested/Recommended/Usage/Directions

Suggested use: After brushing teeth or using mouthwash, chew or suck 1 tablet once or twice daily, or as recommended by your healthcare provider. NatureWise Oral Health Probiotics should always be taken in conjunction with a healthy diet.

Precautions

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Contains trace amounts of milk protein from the fermentation process.

Keep out of the reach of children, except under adult supervision.

Do not use if safety seal is damaged or missing.

Formula

NatureWise Oral Health Probiotics is intelligently formulated with 12 strains of probiotics, including BLIS K12 & BLIS M18, that have been researched for their potential benefits for dental and upper respiratory system, which may contribute to the overall health of the ear, nose, and throat wellness.

For children & adults

General Statements

To learn more about NatureWise Oral Health Probiotics and our other great products, please visit us at naturewise.com.

Brand IP Statement(s)

Copyright 2023 NatureWise. All rights reserved.

BLIS and BLIS K12 are trademarks of Blis Technologies Limited and the subject of USA patent no. 6772912. BLIS and BLIS M18 are trademarks of Blis Technologies Limited and the subject of USA patent no. 7226590.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

See for yourself

Oral Health Probiotics WiseBiotics Mint by NatureWise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Oral Health Probiotics WiseBiotics Mint by NatureWise

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Oral Health Probiotic Blend

110 mg per serving
  • › L. plantarum
  • B. breve
  • › L. paracasei LPC-37
  • › L. reuteri
  • › L. salivarius
  • S. thermophilus
  • › L. casei
  • › B. longum infantis
  • › L. rhamnosus GG
  • › B. animalis lactis BL-04
  • › S. salivarius BLIS M18
  • › S. salivarius BLIS-K12

Other (inactive) ingredients: Isomalt, Inulin, Behenoyl Polyoxyl-8 Glycerides, Dicalcium Phosphate, Peppermint Flavor, Natural, Stevia leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Oral Health Probiotics WiseBiotics Mint by NatureWise Drug Interactions

Want to check YOUR meds against Oral Health Probiotics WiseBiotics Mint?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

B. breve 182

Each ingredient & the kinds of drugs it affects

For each ingredient in Oral Health Probiotics WiseBiotics Mint with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

B. breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Oral Health Probiotics WiseBiotics Mint, from the product label.

NatureWise

See all NatureWise products
Name
NatureWise
City
Costa Mesa
State
CA
ZipCode
92626
Phone Number
800-510-7207
Web Address
naturewise.com
Pharmacist Counseling Corner

Oral Health Probiotics WiseBiotics Mint by NatureWise: Common Questions

Does Oral Health Probiotics WiseBiotics Mint by NatureWise interact with any medications?
Yes. Based on its ingredients, Oral Health Probiotics WiseBiotics Mint has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Oral Health Probiotics WiseBiotics Mint contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm on an antibiotic?
No, not as well. Antibiotics kill bacteria, including the beneficial ones in this supplement. If you're on an antibiotic, space out your doses—take the antibiotic at one time of day and the probiotic several hours apart—and ask your pharmacist for the best timing.
Is it safe for me if I have a weak immune system?
Caution is needed. While probiotics are generally well tolerated in healthy people, those with weakened immune systems should check with their doctor first. There are rare reports of these bacteria causing infections in people who are critically ill or immunocompromised.
Can I take this while pregnant or breastfeeding?
The data on file for these specific strains doesn't cover pregnancy or breastfeeding clearly. Probiotics from food are usually considered safe, but ask your doctor before taking a probiotic supplement—they can advise you based on your situation.
What does 'oral health' mean for these probiotics?
The blend includes several Streptococcus and Lactobacillus strains traditionally thought to support mouth and gum health, but the evidence that they actually work for this purpose isn't established in the data we have.
Will this cause bloating or gas?
Bloating and flatulence have been reported with probiotic use in general, though we don't have specific reports tied to the strains in this blend. Start with a lower dose if you're concerned and see how you feel.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Oral Health Probiotics WiseBiotics Mint is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Oral Health Probiotics WiseBiotics Mint label
Sources

Sources & How We Checked

Oral Health Probiotics WiseBiotics Mint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Streptococcus Thermophilus 21 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Dolatkhah N, Hajifaraji M, Abbasalizadeh F, Aghamohammadzadeh N, Mehrabi Y, Abbasi MM. Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial. J Health Popul Nutr. 2015;33:25. PubMed
  12. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  13. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  14. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  15. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  16. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  17. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  18. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  19. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  20. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  21. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Streptococcus Thermophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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