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Dietary supplement

Organic Lion's Mane 50:1 Extract Ingredients & Drug Interactions

by Micro Ingredients

Organic Lion's Mane 50:1 Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Lion's Mane 50:1 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Lion's Mane 50:1 Extract is a dietary supplement by Micro Ingredients with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Lion's Mane extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Lion's Mane 50:1 Extract by Micro Ingredients

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Lion's Mane 50:1 Extract by Micro Ingredients — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Organic Lion's Mane 50:1 Extract by Micro Ingredients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a 50:1 extract of organic lion's mane mushroom. A 50:1 extract means the powder is concentrated — 50 grams of raw mushroom is reduced into 1 gram of extract, so you get a potent dose in a small amount.

There are no inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lion's Mane Mushroom product and its label doesn't state a use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for lion's mane is incomplete. Our data shows insufficient reliable evidence to rate it for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment.

That doesn't mean it doesn't work — it means large, well-designed human trials haven't been published yet. If you're considering this for a specific health goal, talk it over with your doctor or pharmacist to see whether the emerging research fits your situation.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when taken by mouth. The most common side effects in people who used it are gastrointestinal discomfort, nausea, and occasionally a skin rash.

Long-term safety as a supplement hasn't been studied thoroughly, so there's an element of unknowing there. There isn't enough safety data to recommend this during pregnancy or breastfeeding.

If you're pregnant or nursing and interested in lion's mane, talk with your doctor or pharmacist — they can help you weigh what's known against your personal situation.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin) — lion's mane may increase bleeding risk. Also flag any diabetes medications, since lion's mane may lower blood sugar further.

And if you take immunosuppressants after a transplant or for an autoimmune condition, that's another reason to clear it first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane is a single-ingredient extract that some people take hoping for cognitive support, though the evidence in humans remains thin. If you take blood thinners, diabetes medications, or immunosuppressants, you'll need to check with your own doctor or pharmacist before adding this — the interactions are documented and worth a conversation.

It's generally well tolerated, but long-term safety data is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Lion's Mane 50:1 Extract, straight from the product label.

Brand Micro Ingredients
Barcode (UPC) X0022HTKKB
Net contents 8 Oz(s); 227 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231740
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Lion's Mane 50:1 Extract by Micro Ingredients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
227
UPC/BARCODE
X0022HTKKB
IngredientAmount% DV
organic Lion's Mane extract1000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

USDA Organic

Formulation

Vegan

Non-GMO

Free of: soy, dairy, yeast, gluten & additives.

Certified organic by Organic Certifiers

FDA Statement of Identity

Dietary Supplement Powder

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 scoop 2 times daily. For best results, please consult your physician.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

If pregnant/lactating or taking any medications, please consult your physician prior to use.

Keep out of the reach of children.

Storage

Keep in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Lion's Mane 50:1 Extract by Micro Ingredients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Lion's Mane 50:1 Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Lion's Mane 50:1 Extract by Micro Ingredients

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container227 Amounts shown are per serving.

Organic Lion's Mane extract

Interacts with
327 drugs
1000 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Organic Lion's Mane extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Lion's Mane 50:1 Extract by Micro Ingredients Drug Interactions

Want to check YOUR meds against Organic Lion's Mane 50:1 Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

organic Lion's Mane extract 327

Individual Drug Interactions

The ingredients in Organic Lion's Mane 50:1 Extract interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Lion's Mane 50:1 Extract interact with drugs. Each result below shows which ingredient is responsible. organic Lion's Mane extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Lion's Mane 50:1 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Lion's Mane extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Lion's Mane 50:1 Extract, from the product label.

Micro Ingredients

See all Micro Ingredients products
Name
Micro Ingredients
Street Address
21660 Copley Dr.
City
Diamond Bar
State
CA
ZipCode
91765
Phone Number
1-844-836-8200
Web Address
www.microingredients.com
Pharmacist Counseling Corner

Organic Lion's Mane 50:1 Extract by Micro Ingredients: Common Questions

Does Organic Lion's Mane 50:1 Extract by Micro Ingredients interact with any medications?
Yes. Based on its ingredients, Organic Lion's Mane 50:1 Extract has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Lion's Mane 50:1 Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's a 50:1 extract?
It means 50 grams of raw lion's mane mushroom has been concentrated into 1 gram of extract. You get a more potent dose in less powder — so a small scoop gives you what you'd get from a much larger amount of the whole mushroom.
Can I take this if I'm pregnant?
There isn't enough safety data to recommend lion's mane during pregnancy. Talk with your doctor or pharmacist before taking it — they can help you decide what's right for your situation.
Can I take this while breastfeeding?
There isn't enough safety data for breastfeeding either. Check with your doctor or pharmacist first.
What side effects might I see?
Most people tolerate it well. The side effects that have been reported are gastrointestinal discomfort, nausea, and rarely a skin rash. If any of those happen, stop and let your pharmacist or doctor know.
Does it actually improve memory or focus?
The evidence in humans isn't strong enough yet to say for sure. Our data shows insufficient reliable evidence to rate it for cognitive function, memory, or brain health — which means larger human studies need to be done. Animal research is promising, but that's not the same as proof in people.
Are there any fillers in this?
No — the ingredient list shows no inactive ingredients, so you're getting the extract and nothing else.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Lion's Mane 50:1 Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Lion's Mane 50:1 Extract label
Go deeper

The Full Monographs Behind Organic Lion's Mane 50:1 Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Organic Lion's Mane 50:1 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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