Organic Schisandra Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Organic Schisandra Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Organic Schisandra Extract is a dietary supplement by Micro Ingredients with 1 active ingredient. Its ingredients are commonly taken for fatigue and low energy, stress and adaptogen support, liver health.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Schisandra extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Organic Schisandra Extract by Micro Ingredients
Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Schisandra Extract by Micro Ingredients — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Organic Schisandra Extract by Micro Ingredients
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: organic schisandra extract. Schisandra is a berry used in traditional medicine, and this powder form delivers the concentrated extract with no other active compounds.
There are no inactive fillers listed.
Does it work?
Couldn't assess
The data we hold shows insufficient reliable evidence to rate schisandra for asthma, athletic performance, cough, diabetes, or diarrhea. It's also listed for hepatitis with insufficient evidence.
In short, we don't have enough quality research on file to say whether this product works for any of these uses.
How safe is it?
Well-documented data
Schisandra is generally well tolerated in the short term in healthy adults, though high-quality long-term safety data are limited. The most common side effects are decreased appetite, heartburn, stomach upset, and urticaria (a type of skin rash).
The safety data advises against schisandra during pregnancy because traditional sources suggest it may stimulate the uterus. There isn't enough reliable safety information to use it while breastfeeding—talk with your doctor or pharmacist about your personal situation.
Meds to double-check
Moderate interaction found
Before taking schisandra, double-check with your pharmacist or doctor if you take an immunosuppressant like tacrolimus, a blood thinner like warfarin, an antifungal like voriconazole, a sedative like midazolam, or any medication metabolized by your liver (CYP3A4, CYP2C9, or CYP2C19 enzymes). Schisandra can raise or lower levels of these drugs, sometimes significantly, and adjust your dose or timing—or choose a different supplement.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Schisandra extract might be worth considering if you're interested in traditional uses, but the evidence on file doesn't establish that it works for the common claims. Much more importantly, it interacts with a large number of medications—especially immunosuppressants, blood thinners, and drugs processed by your liver.
If you take any prescription medication, check it against our tool before you start. Discuss this product with your doctor or pharmacist to make sure it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Organic Schisandra Extract, straight from the product label.
| Brand | Micro Ingredients |
|---|---|
| Barcode (UPC) | X001UNNT1T |
| Net contents | 227 Gram(s); 8 Oz(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2020 |
| DSLD ID | 231950 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Organic Schisandra Extract by Micro Ingredients, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Supports internal well-being
Vegan
Non-GMO Gluten-free
Free of: soy, dairy, yeast, gluten & additives.
Certified organic by Organic Certifiers
Seals/Symbols
USDA Organic
FDA Statement of Identity
Dietary Supplement Powder
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 1 scoop two times daily. For best results, please consult your physician.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
If pregnant/lactating or taking any medications, please consult your physician prior to use.
Keep out of the reach of children.
General Statements
B
Storage
Keep in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Organic Schisandra Extract by Micro Ingredients label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Organic Schisandra Extract by Micro Ingredients
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Gram(s) Dosage formPowder Servings per container227 Amounts shown are per serving.
Organic Schisandra extract
Interacts with803 drugs
Schisandra is a traditional Chinese medicine berry used as an adaptogen for stress, fatigue, and liver support. Human evidence is limited and most cla...
Organic Schisandra extract monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Organic Schisandra Extract by Micro Ingredients Drug Interactions
HelloPharmacist Interaction Report
Organic Schisandra Extract by Micro Ingredients contains one active ingredient—schisandra—that interacts with a significant number of medications.
The most serious finding is a Moderate-severity interaction with tacrolimus (an immunosuppressant), where schisandra can raise tacrolimus levels by 183% to 268%, potentially causing toxicity. This is backed by clinical evidence in transplant and other patients.
Read the full breakdown — every affected drug type, severity by severity
Schisandra also has Moderate interactions with several other drug groups. It can increase levels of drugs broken down by the CYP3A4 enzyme (affecting medications like midazolam and others), inhibit the CYP2C19 enzyme (raising levels of drugs like voriconazole), and theoretically decrease levels of CYP2C9 substrates.
Additionally, it may increase levels of drugs that depend on P-glycoprotein transport, and it may reduce the effectiveness of warfarin (a blood thinner).
Altogether, these interactions span 804 individual medications. Before you start schisandra, check your exact prescriptions with the search tool on this page—especially if you take an immunosuppressant, blood thinner, antifungal, sedative, or any medication metabolized by your liver.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Organic Schisandra Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Organic Schisandra Extract interact with 803 drugs. Click any drug to see the details.
1 of the 1 ingredient in Organic Schisandra Extract interact with drugs. Each result below shows which ingredient is responsible. organic Schisandra extract
Aspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.
Read the full Organic Schisandra Extract + Aspirin, Omeprazole interactionAtazanavirReyataz
How Atazanavir interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Atogepant interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Atorvastatin Calcium interactionAtovaquone, ProguanilMalarone
How Atovaquone, Proguanil interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.
Read the full Organic Schisandra Extract + Atovaquone, Proguanil interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.
Read the full Organic Schisandra Extract + Atropine, Morphine Sulfate interactionAvacopanTavneos
How Avacopan interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Avacopan interactionAvanafilStendra
How Avanafil interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Avanafil interactionAvapritinibAyvakit
How Avapritinib interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Avapritinib interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.
Read the full Organic Schisandra Extract + Avatrombopag Maleate interactionAxitinibInlyta
How Axitinib interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Axitinib interactionAzelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Azelastine Hydrochloride, Fluticasone Propionate interactionAzilsartanEdarbi
How Azilsartan interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, schisandra might decrease the levels and clinical effects of CYP2C9 substrates.
Read the full Organic Schisandra Extract + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, schisandra might decrease the levels and clinical effects of CYP2C9 substrates.
Read the full Organic Schisandra Extract + Azilsartan, Chlorthalidone interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.
Read the full Organic Schisandra Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Beclomethasone Dipropionate interactionBedaquilineSirturo
How Bedaquiline interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Bedaquiline interactionBelinostatBeleodaq
How Belinostat interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.
Read the full Organic Schisandra Extract + Belinostat interactionBelladonna Alkaloids, Chlorpheniramine, Phenylephrine, PhenylpropanolamineRespa ARM
How Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Belladonna, Ergotamine, Phenobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionBelumosudil MesylateRezurock
How Belumosudil Mesylate interacts with Organic Schisandra Extract — through 1 ingredient. Tap an ingredient for the detail:
Organic Schisandra ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Organic Schisandra Extract + Belumosudil Mesylate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Organic Schisandra Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Schisandra extract
Cyclophosphamide
Theoretically, schisandra might increase the levels and clinical effects of cyclophosphamide.
In vitro research shows that schisandra increases the concentration of cyclophosphamide, likely through inhibition of cytochrome P450 3A4. After multiple doses of the schisandra constituents schisandrin A and schisantherin A, the maximum concentration of cyclophosphamide was increased by 7% and 75%, respectively, while the overall exposure to cyclophosphamide was increased by 29% and 301%, respectively.
Cyclosporine (Neoral, Sandimmune)
Schisandra can increase the levels and clinical effects of cyclosporine.
A small observational study in children with aplastic anemia found that taking schisandra with cyclosporine increased cyclosporine trough levels by 93% without increasing the risk of adverse events. However, the dose of cyclosporine was reduced in 9% of children to maintain appropriate cyclosporine blood concentrations.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.
In vitro research shows that schisandra inhibits CYP2C19, and animal research shows that schisandra increases the concentration of voriconazole, a CYP2C19 substrate. Theoretically, schisandra may also inhibit the metabolism of other CYP2C19 substrates. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, schisandra might decrease the levels and clinical effects of CYP2C9 substrates.
In vitro and animal research suggests that schisandra induces CYP2C9 enzymes. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Most clinical and laboratory research shows that schisandra, administered either as a single dose or up to twice daily for 14 days, inhibits CYP3A4 and increases the concentration of CYP3A4 substrates such as cyclophosphamide, midazolam, tacrolimus, and talinolol. Although one in vitro and animal study shows that schisandra may induce CYP3A4 metabolism, this effect appears to be overpowered by schisandra's CYP3A4 inhibitory activity and has not been reported in humans.
Midazolam (Versed)
Schisandra can increase the levels and clinical effects of midazolam.
A small pharmacokinetic study in healthy adults shows that taking schisandra extract (Hezheng Pharmaceutical Co.) containing deoxyschizandrin 33.75 mg twice daily for 8 days and a single dose of midazolam 15 mg on day 8 increases the overall exposure to midazolam by about 119%, increases the peak plasma level of midazolam by 86%, and decreases midazolam clearance by about 52%. This effect has been attributed to inhibition of CYP3A4 by schisandra.
P-Glycoprotein Substrates
Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that schisandra extracts and constituents such as schisandrin B inhibit P-glycoprotein mediated efflux in intestinal cells and in P-glycoprotein over-expressing cell lines. Additionally, a small clinical study shows that schisandra increases the peak concentration and overall exposure to talinolol, a P-glycoprotein probe substrate. Theoretically, schisandra might inhibit the efflux of other P-glycoprotein substrates.
Sirolimus (Rapamune)
Schisandra can increase the levels and clinical effects of sirolimus.
A small pharmacokinetic study in healthy volunteers shows that taking 3 capsules of schisandra (Hezheng Pharmaceutical Company) containing a total of 33.75 mg deoxyschizandrin twice daily for 13 days and then taking a single dose of sirolimus 2 mg increases the overall exposure and peak level of sirolimus by two-fold. This effect is thought to be due to inhibition of cytochrome P450 3A4 by schisandra, as well as possible inhibition of the P-glycoprotein drug transporter.
Tacrolimus (Prograf)
Schisandra can increase the levels and clinical effects of tacrolimus.
Clinical research in healthy children and adults, transplant patients, and patients with nephrotic syndrome and various rheumatic immunologic disorders shows that taking schisandra with tacrolimus increases tacrolimus peak levels by 183% to 268%, prolongs or delays time to peak tacrolimus concentrations, increases overall exposure to tacrolimus by 126% to 343%, and decreases tacrolimus clearance by 19% to 73%. This effect is thought to be due to inhibition of P-glycoprotein drug transporter and CYP3A4 and CYP3A5 by schisandra. Some clinical and observational studies suggest that schisandra increases tacrolimus levels similarly in both expressors and non-expressors of CYP3A5, while other studies suggest it does so to a greater degree in CYP3A5 expressors than non-expressors. Animal research suggests that the greatest increase in tacrolimus levels occurs when schisandra is taken either concomitantly or up to 2 hours before tacrolimus, and clinical and observational research in humans suggests that schisandra may increase whole blood levels of tacrolimus and decrease clearance of tacrolimus in a dose-dependent manner.
Talinolol
Schisandra can increase the levels and clinical effects of talinolol.
A small pharmacokinetic study in healthy volunteers shows that taking schisandra extract 300 mg twice daily for 14 days with a single dose of talinolol 100 mg on day 14 increases the peak talinolol level by 51% and the overall exposure to talinolol by 47%. This effect is thought to be due to the possible inhibition of cytochrome P450 3A4 and P-glycoprotein by schisandra.
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Voriconazole (Vfend)
Theoretically, schisandra might increase the levels and clinical effects of voriconazole.
Animal research shows that oral schisandra given daily for 1 or 14 days increases levels of intravenously administered voriconazole, a cytochrome P450 (CYP) 2C19 substrate. This effect is thought to be due to inhibition of CYP2C19 by schisandra. However, this interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, schisandra might decrease the levels and clinical effects of warfarin.
Animal research suggests that oral schisandra extract, given daily for 6 days, reduces levels of intravenously administered warfarin. This effect might be due to the induction of cytochrome P450 (CYP) 2C9 metabolism by schisandra. However, this interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Organic Schisandra Extract, from the product label.
Micro Ingredients
See all Micro Ingredients products- Name
- Micro Ingredients
- Street Address
- 21660 Copley Dr.
- City
- Diamond Bar
- State
- CA
- ZipCode
- 91765
- Phone Number
- 1-844-836-8200
- Web Address
- www.microingredients.com
Organic Schisandra Extract by Micro Ingredients: Common Questions
Does Organic Schisandra Extract by Micro Ingredients interact with any medications?
How can one product interact with so many drugs?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Organic Schisandra Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Organic Schisandra Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Organic Schisandra Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Schisandra 26 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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