Organic Skullcap Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Organic Skullcap against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Organic Skullcap is a dietary supplement by Five Flavors Herbs with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Organic Skullcap by Five Flavors Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Skullcap by Five Flavors Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Organic Skullcap by Five Flavors Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: skullcap aerial parts extract, which comes from the flowering parts of the skullcap plant. The liquid also includes cane alcohol and purified water as inactive ingredients.
Does it work?
Not established
The evidence we hold shows insufficient reliable data to rate skullcap for any of the uses on file — epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD). That means we don't have solid proof it works for these purposes, though it doesn't mean it doesn't; the research just isn't there yet.
How safe is it?
Well-documented data
Skullcap is often used only short-term, but we have limited safety data and product quality varies, so use it with care. The most common side effects reported are sedation, cognitive impairment (fuzzy thinking), and mild digestive disturbances — about 9% of people in one study reported stomach upset at higher doses.
One person taking a large dose reported vivid dreams, though it's unclear if skullcap caused it. The safety data advises against using skullcap during pregnancy or while breastfeeding because there isn't enough information to know it's safe.
Meds to double-check
Moderate interaction found
Before taking this product, double-check anything that makes you drowsy: sedatives, sleep aids, anti-anxiety medications, opioids, and some antihistamines. Skullcap can have an additive effect (Moderate severity), potentially deepening sedation or impairing your thinking.
Use the medication checker on this page with your full list.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Skullcap might be worth considering if you're looking for a traditional herbal remedy for stress or sleep, but the evidence to back those uses isn't established in our data. Because it can add to the drowsiness of other medications, check with your pharmacist before you start — especially if you take anything for anxiety, sleep, or pain.
Pregnancy and breastfeeding are off-limits based on the safety data available.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Organic Skullcap, straight from the product label.
| Brand | Five Flavors Herbs |
|---|---|
| Barcode (UPC) | 635983568829 |
| Net contents | 2 Fluid Ounce(s); 59 mL |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2024 |
| DSLD ID | 320708 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Organic Skullcap by Five Flavors Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Skullcap Aerial Parts Extract | 1 mL | -- |
Other ingredients: Cane Alcohol, Water, Purified
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use 1 ml, 2 - 3 times daily in water, or as directed. Shake well before using.
Precautions
Caution Consult with your physician or a qualified herbalist before using if pregnant or nursing.
Keep out of reach of children.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Integrating Traditions for Wellness Five Flavors Herbs creates and delivers effective, sustainable herbal remedies by integrating East Asian medicine principles with Western herbs and modern research. Calms the Mind & Quiets the spirit
USDA Organic Certified Organic by CCOF
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
USDA Organic
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Organic Skullcap by Five Flavors Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Organic Skullcap by Five Flavors Herbs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Milliliter(s) Dosage formLiquid Servings per container59 Amounts shown are per serving.
Skullcap Aerial Parts Extract
Interacts with248 drugs
American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...
Skullcap Aerial Parts Extract monograph & interactionsOther (inactive) ingredients: Cane Alcohol, Water, Purified. These complete the product’s ingredient list but are not active constituents.
Organic Skullcap by Five Flavors Herbs Drug Interactions
HelloPharmacist Interaction Report
Organic Skullcap by Five Flavors Herbs contains one active ingredient — skullcap aerial parts extract — that does interact with medications.
The main concern is with CNS depressants (drugs that slow your brain and nervous system), a group that includes sedatives, sleep aids, anti-anxiety medications, opioids, and some antihistamines. Skullcap can add to their effect, potentially deepening sedation or impairing how clearly you think.
Read the full breakdown — every affected drug type, severity by severity
Animal and clinical research suggests skullcap itself causes sedation and cognitive impairment, especially at higher doses. A 100 mg dose in research didn't show obvious brain-related side effects, but 200 mg and higher doses did trigger sedation and fuzzy thinking.
Altogether, these interactions span 248 individual medications.
Before you start this product, run your exact medications — especially anything that makes you drowsy — through the search tool on this page. We hold no other interaction data for the ingredients we could check.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Organic Skullcap?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Organic Skullcap interact with 248 drugs. Click any drug to see the details.
1 of the 1 ingredient in Organic Skullcap interact with drugs. Each result below shows which ingredient is responsible. Skullcap Aerial Parts Extract
Dyphylline, Ephedrine, Guaifenesin, PhenobarbitalLufyllin-EPG
How Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionEphedrine, Guaifenesin, Phenobarbital, TheophyllineMudrane GG
How Ephedrine, Guaifenesin, Phenobarbital, Theophylline interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEphedrine, Phenobarbital, Potassium Iodide, TheophyllineMudrane, Quadrinal
How Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Ephedrine, Phenobarbital, Theophylline interactionErgotamine, Belladonna, PhenobarbitalBellamine, Bellaspas, Eperbel-S
How Ergotamine, Belladonna, Phenobarbital interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Ergotamine, Belladonna, Phenobarbital interactionEstazolamProsom
How Estazolam interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Estazolam interactionEszopicloneLunesta
How Eszopiclone interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Eszopiclone interactionEthosuximideZarontin
How Ethosuximide interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Ethosuximide interactionEthotoinPaganone
How Ethotoin interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Ethotoin interactionFelbamateFelbatol
How Felbamate interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Felbamate interactionFenfluamineFintepla
How Fenfluamine interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Fenfluamine interactionFentanylAbstral, Duragesic, Fentora, Lazanda, Sublimaze, Subsys
How Fentanyl interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Fentanyl interactionFentanyl Citrate, Oral Transmucosal Fentanyl CitrateActiq
How Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate interactionFentanyl CitrateInnovar
How Fentanyl Citrate interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Fentanyl Citrate interactionFesoterodine FumarateToviaz
How Fesoterodine Fumarate interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Fesoterodine Fumarate interactionFlibanserinAddyi
How Flibanserin interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Flibanserin interactionFlupenthixolFluanxol
How Flupenthixol interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Flupenthixol interactionFlurazepamApo-Flurazepam, Bio-Flurazepam, Dalmane, Novo-Flurazepam, PMS-Flurazepam, Som Pam +1 more
How Flurazepam interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Flurazepam interactionFosphenytoinCerebyx
How Fosphenytoin interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Fosphenytoin Sodium interactionGabapentinGralise, Neurontin
How Gabapentin interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Gabapentin interactionGabapentin EnacarbilHorizant
How Gabapentin Enacarbil interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Gabapentin Enacarbil interactionGamma Hydroxybutyrate (prescription Drug)GHB
How Gamma Hydroxybutyrate (prescription Drug) interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Gamma Hydroxybutyrate (prescription Drug) interactionGanaxoloneZtalmy
How Ganaxolone interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Ganaxolone interactionGlutethimideDoriden
How Glutethimide interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Glutethimide interactionGuaifenesin, HydrocodoneEntuss, Pneumotussin
How Guaifenesin, Hydrocodone interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Guaifenesin, Hydrocodone interactionGuaifenesin, Hydrocodone BitartrateFlowtuss, Obredon
How Guaifenesin, Hydrocodone Bitartrate interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Guaifenesin, Hydrocodone Bitartrate interactionGuaifenesin, Hydrocodone Bitartrate, Pseudoephedrine HydrochlorideHycofenix
How Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride interactionGuaifenesin, Hydrocodone, PseudoephedrineEntuss-D, Tussi-Organidin DM NR
How Guaifenesin, Hydrocodone, Pseudoephedrine interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Guaifenesin, Hydrocodone, Pseudoephedrine interactionHeroinHeroin
How Heroin interacts with Organic Skullcap — through 1 ingredient. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Heroin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Organic Skullcap with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Skullcap Aerial Parts Extract
Cns Depressants
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.
Brand information
Manufacturer and brand details for Organic Skullcap, from the product label.
Five Flavors Herbs
See all Five Flavors Herbs products- Name
- Five Flavors Herbs, Inc.
- Street Address
- 344 40th St.
- City
- Oakland
- State
- CA
- ZipCode
- 94609
- Web Address
- www,fiveflavorsherbs.com
Organic Skullcap by Five Flavors Herbs: Common Questions
Does Organic Skullcap by Five Flavors Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant or breastfeeding?
What are the most common side effects?
Is this safe to take long-term?
What is skullcap supposed to do?
Will this make me drowsy?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Organic Skullcap is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Organic Skullcap’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Organic Skullcap's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Skullcap 3 references
- Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
- Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
- Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC