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Dietary supplement

Organic Skullcap Ingredients & Drug Interactions

by Five Flavors Herbs

Organic Skullcap label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Skullcap against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Skullcap is a dietary supplement by Five Flavors Herbs with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Skullcap by Five Flavors Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Skullcap by Five Flavors Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Organic Skullcap by Five Flavors Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: skullcap aerial parts extract, which comes from the flowering parts of the skullcap plant. The liquid also includes cane alcohol and purified water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Calms the mind and quiets the spirit.
  • We looked for evidence on: Anxiety, Stress, Insomnia, Nervousness, Sleep quality, Mental restlessness.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence we hold shows insufficient reliable data to rate skullcap for any of the uses on file — epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD). That means we don't have solid proof it works for these purposes, though it doesn't mean it doesn't; the research just isn't there yet.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used only short-term, but we have limited safety data and product quality varies, so use it with care. The most common side effects reported are sedation, cognitive impairment (fuzzy thinking), and mild digestive disturbances — about 9% of people in one study reported stomach upset at higher doses.

One person taking a large dose reported vivid dreams, though it's unclear if skullcap caused it. The safety data advises against using skullcap during pregnancy or while breastfeeding because there isn't enough information to know it's safe.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check anything that makes you drowsy: sedatives, sleep aids, anti-anxiety medications, opioids, and some antihistamines. Skullcap can have an additive effect (Moderate severity), potentially deepening sedation or impairing your thinking.

Use the medication checker on this page with your full list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap might be worth considering if you're looking for a traditional herbal remedy for stress or sleep, but the evidence to back those uses isn't established in our data. Because it can add to the drowsiness of other medications, check with your pharmacist before you start — especially if you take anything for anxiety, sleep, or pain.

Pregnancy and breastfeeding are off-limits based on the safety data available.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Skullcap, straight from the product label.

Brand Five Flavors Herbs
Barcode (UPC) 635983568829
Net contents 2 Fluid Ounce(s); 59 mL
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 320708
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Skullcap by Five Flavors Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Milliliter(s)
Maximum serving Sizes:
1 Milliliter(s)
Servings per container
59
UPC/BARCODE
635983568829
IngredientAmount% DV
Skullcap Aerial Parts Extract1 mL--

Other ingredients: Cane Alcohol, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use 1 ml, 2 - 3 times daily in water, or as directed. Shake well before using.

Precautions

Caution Consult with your physician or a qualified herbalist before using if pregnant or nursing.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Integrating Traditions for Wellness Five Flavors Herbs creates and delivers effective, sustainable herbal remedies by integrating East Asian medicine principles with Western herbs and modern research. Calms the Mind & Quiets the spirit

USDA Organic Certified Organic by CCOF

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

USDA Organic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Skullcap by Five Flavors Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Skullcap label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Skullcap by Five Flavors Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Milliliter(s) Dosage formLiquid Servings per container59 Amounts shown are per serving.

Skullcap Aerial Parts Extract

Interacts with
248 drugs
1 mL per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Cane Alcohol, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Skullcap by Five Flavors Herbs Drug Interactions

Want to check YOUR meds against Organic Skullcap?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap Aerial Parts Extract 248

Individual Drug Interactions

The ingredients in Organic Skullcap interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Skullcap interact with drugs. Each result below shows which ingredient is responsible. Skullcap Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Skullcap with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap Aerial Parts Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Skullcap, from the product label.

Five Flavors Herbs

See all Five Flavors Herbs products
Name
Five Flavors Herbs, Inc.
Street Address
344 40th St.
City
Oakland
State
CA
ZipCode
94609
Web Address
www,fiveflavorsherbs.com
Pharmacist Counseling Corner

Organic Skullcap by Five Flavors Herbs: Common Questions

Does Organic Skullcap by Five Flavors Herbs interact with any medications?
Yes. Based on its ingredients, Organic Skullcap has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Skullcap contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against skullcap in pregnancy and while breastfeeding because there isn't enough information to know it's safe for you or your baby. Talk with your doctor or pharmacist about what's right for your situation.
What are the most common side effects?
Sedation, fuzzy thinking (cognitive impairment), and mild digestive disturbances are the most common. About 9% of people in one study reported stomach upset at higher doses. One person reported vivid dreams, though we can't say for certain skullcap caused it.
Is this safe to take long-term?
Skullcap is typically used short-term, and the evidence we have is limited. Product quality also varies. Use with care, and talk with your pharmacist about how long you're planning to take it.
What is skullcap supposed to do?
Skullcap has been used traditionally for stress, sleep, epilepsy, and other conditions, but we don't have solid evidence proving it works for any of them. The research just isn't there yet.
Will this make me drowsy?
Yes, sedation is one of the most common side effects. Research shows a 100 mg dose may not cause obvious drowsiness, but 200 mg and higher doses can trigger sedation and cognitive impairment. If you take other medications that make you drowsy, the effect could be stronger.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Skullcap is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Skullcap label
Go deeper

The Full Monographs Behind Organic Skullcap’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Organic Skullcap's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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