Palmetto Plus Ingredients & Drug Interactions
by USANA
What is this page for?
First and foremost: checking Palmetto Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Palmetto Plus is a dietary supplement by USANA with 3 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, urinary problems, hair loss.Based on those ingredients, 174 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saw Palmetto extract, Lycopene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Palmetto Plus by USANA
Ask about any prescription or over-the-counter medication and we check it for interactions with Palmetto Plus by USANA — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Palmetto Plus by USANA
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Palmetto Plus contains 3 active ingredients. Saw palmetto extract is the traditional herbal remedy for urinary and prostate symptoms.
Lycopene is a natural red pigment found in tomatoes and other foods, studied for antioxidant effects. The product also contains soy isoflavones, though we hold no interaction data for this ingredient.
The softgel capsule also contains several inactive ingredients — gelatin, glycerin, soybean oil, beeswax, purified water, soy lecithin, natural caramel color, and titanium dioxide — that serve as fillers, thickeners, and capsule material.
Does it work?
Leans against
Saw palmetto is rated possibly effective for recovery after transurethral resection of the prostate (a surgical procedure), but possibly ineffective for benign prostatic hyperplasia (enlarged prostate). For other uses — chronic bronchitis, hair loss, and lower urinary tract symptoms — the evidence isn't strong enough to establish effectiveness in our data.
Lycopene is rated possibly effective for prostate cancer prevention, but possibly ineffective for bladder cancer and diabetes. For high cholesterol and other conditions, we don't have enough evidence to rate it.
How safe is it?
Well-documented data
Saw palmetto is generally well tolerated, but side effects can include abdominal pain, constipation, decreased libido, diarrhea, dizziness, fatigue, headache, nausea, and stuffy nose. Rarely, skin reactions (fixed drug eruption with blistering), acne worsening, or heart rhythm changes have been reported.
Lycopene supplements may cause gastrointestinal upset — diarrhea, gas, bloating, nausea, vomiting, and indigestion — though it's generally well tolerated. Saw palmetto is rated likely unsafe in pregnancy due to possible hormonal effects and lack of safety data; avoid it while breastfeeding as well.
Lycopene from food is considered safe during pregnancy and breastfeeding, but supplement doses are not well studied — talk with your doctor or pharmacist about whether a supplement is right for you. We hold no safety data for soy isoflavones in pregnancy or breastfeeding.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking Palmetto Plus if you're on blood thinners or antiplatelet drugs (like warfarin or aspirin) — both saw palmetto and lycopene may increase bleeding risk. Also confirm it with estrogens or birth control pills, since saw palmetto may reduce their effectiveness.
If you take any prescription medication, run it through the search tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Palmetto Plus is primarily used for prostate and urinary health, though evidence is mixed. If you take blood thinners, estrogens, or birth control pills, you'll want to check this product's ingredients with your doctor or pharmacist first — the interactions are real and could affect how your medications work.
Discuss it with your own healthcare provider before starting, especially if you're pregnant, breastfeeding, or have heart rhythm concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Palmetto Plus, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Palmetto Plus by USANA, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Saw Palmetto extract | 320 mg | -- |
| Lycopene | 5 mg | -- |
| Soy Isoflavones | 25 mg | -- |
Other ingredients: Gelatin, Glycerin, Soybean Oil, Beeswax, purified Water, Soy Lecithin, natural Caramel color, Titanium Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Potency Guaranteed
Laboratory tested, Quality guaranteed. Meets USP specification for uniformity, potency, and disintegration where applicable.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Adult men take one (1) capsule daily, preferably with food.
Formula
Contains: Soy.
Saw Palmetto Extract is standardized to European standards of a minimum 85% Fatty Acid content.
Precautions
Contains: Soy.
Keep out of reach of children.
Consult your physician if you are pregnant, nursing, taking a prescription drug, or have a medical condition.
There is a safety seal under the cap. Do not use if the seal is broken or missing.
Storage
Store below 25(0) C.
General
128.010101 LB.001340
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Palmetto Plus by USANA label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Palmetto Plus by USANA
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formSoftgel Capsule Servings per container28 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Saw Palmetto extract
Interacts with174 drugs
Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...
Saw Palmetto extract monograph & interactionsLycopene
Interacts with122 drugs
Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...
Lycopene monograph & interactionsSoy Isoflavones
Other (inactive) ingredients: Gelatin, Glycerin, Soybean Oil, Beeswax, Purified Water, Soy Lecithin, Natural Caramel color, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.
Palmetto Plus by USANA Drug Interactions
HelloPharmacist Interaction Report
Palmetto Plus by USANA interacts with medications through its saw palmetto and lycopene content.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — both ingredients may increase your bleeding risk, and saw palmetto is reported to prolong bleeding time. This is a Moderate severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Saw palmetto may also reduce how well estrogens and birth control pills work by interfering with their effects in your body. This is rated Moderate severity for both drug types.
Lycopene's interaction with blood thinners overlaps with saw palmetto's — if you're on any blood thinner or antiplatelet medication, both ingredients pose a bleeding risk.
We could not check soy isoflavones for interactions because we hold no data for it. Altogether, these interactions span 174 individual medications.
Use the search tool below to look up your specific prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Palmetto Plus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Palmetto Plus interact with 174 drugs. Click any drug to see the details.
2 of the 3 ingredients in Palmetto Plus interact with drugs. Each result below shows which ingredient is responsible. Saw Palmetto extract Lycopene
AbciximabReoPro
How Abciximab interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Abciximab interactionLycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Abrocitinib interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acenocoumarol interactionLycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Acetaminophen, Aspirin interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Acetaminophen, Aspirin, Caffeine interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Acetaminophen, Ibuprofen interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetaminophen, Ibuprofen interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Acetylsalicylic Acid interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetylsalicylic Acid interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Alteplase, Tpa interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Anacaulase-bcdb interactionLycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Anagrelide interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Anisindione interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Antithrombin Iii interactionLycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Apixaban interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Argatroban interactionLycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Butalbital interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Butalbital, Caffeine interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Butalbital, Caffeine, Phenacetin interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Caffeine interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Caffeine, Codeine Phosphate interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Caffeine, Dover's Pwd interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Hydrocodone interactionLycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Caffeine, Orphenadrine interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Palmetto Plus — through 2 ingredients. Tap an ingredient for the detail:
LycopeneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Lycopene + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Palmetto Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Saw Palmetto extract
Anticoagulant/Antiplatelet Drugs
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.
Contraceptive Drugs
Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.
Estrogens
Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.
Lycopene
Anticoagulant/Antiplatelet Drugs
Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.
Brand information
Manufacturer and brand details for Palmetto Plus, from the product label.
USANA
See all USANA products- Name
- USANA Health Sciences, Inc.
- Street Address
- 3838 W. Parkway Blvd.
- City
- Salt Lake City
- State
- Utah
- ZipCode
- 84120
Palmetto Plus by USANA: Common Questions
Does Palmetto Plus by USANA interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I notice?
Does this actually work for prostate problems?
What's lycopene and why is it in here?
Is it safe to take with my other medications?
Can I take this long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Palmetto Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Palmetto Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Saw Palmetto
Interacts with 174 drugsSaw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...
Read the full Saw Palmetto monograph → Herb & supplement monographLycopene
Interacts with 122 drugsLycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...
Read the full Lycopene monograph →Sources & How We Checked
Palmetto Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Saw Palmetto 22 references
- Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
- Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
- Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
- Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
- Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
- Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
- Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
- Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
- Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
- Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
- Agbabiaka, T. B., Pittler, M. H., Wider, B., and Ernst, E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009;32(8):637-647. PubMed
- Wargo, K. A., Allman, E., and Ibrahim, F. A possible case of saw palmetto-induced pancreatitis. South.Med.J. 2010;103(7):683-685. PubMed
- Lapi, F., Gallo, E., Giocaliere, E., Vietri, M., Baronti, R., Pieraccini, G., Tafi, A., Menniti-Ippolito, F., Mugelli, A., Firenzuoli, F., and Vannacci, A. Acute liver damage due to Serenoa repens: a case report. Br.J.Clin.Pharmacol. 2010;69(5):558-560.
- Mantovani, F. Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies. Minerva Urol.Nefrol. 2010;62(4):335-340.
- Hanaka, M., Yoshii, C., Yatera, K., Ito, C., Chojin, Y., Nagata, S., Yamasaki, K., Nishida, C., Kawanami, T., Kawanami, Y., Ishimoto, H., and Mukae, H. [A case of rhabdomyolysis caused by saw palmetto of healthy foods]. J.UOEH. 6-1-2012;34(2):193-199. PubMed
- Miroddi, M., Carni, A., Mannucci, C., Moleti, M., Navarra, M., and Calapai, G. Hot flashes in a young girl: a wake-up call concerning Serenoa repens use in children. Pediatrics 2012;130(5):e1374-e1376.
- Braeckman J. The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a multicenter open study. Current Therapeutic Research 1994;55(7):776-785. DOI
- Jipescu D, Patel A, Bohra H, Pientka A. Rare case of saw palmetto induced heart block. JACC 2017;69(11) supplement:2310.
- Morabito P, Miroddi M, Giovinazzo S, Spina E, Calapai G. Serenoa repens as an endocrine disruptor in a 10-year-Old young girl: a new case report. Pharmacology. 2015;96(1-2):41-3. doi: 10.1159/000431327.
- Gammoudi R, Ameur K, Ouni B, et al. Fixed drug eruption to Serenoa repens: first case report and consideration of the use of herbal medicine. Dermatol Ther 2020 Aug 29:e14247.
- Paulis G, Paulis A, Perletti G. Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials. Arch Ital Urol Androl 2021;93(4):475-480. PubMed
- Venkateswaran S, Declet-Bauzo R, Shodeinde M, Gilford P. Postoperative Retroperitoneal Hematoma: A Case of Saw Palmetto and the Importance of Primary Care Intervention. HCA Healthc J Med 2020;1(5):279-282. PubMed
Lycopene 10 references
- Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
- Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
- Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
- O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
- Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
- Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
- Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
- Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
- Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
- Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC