Pancreatin Select Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pancreatin Select against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pancreatin Select is a dietary supplement by Moss Nutrition with 7 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 385 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke leaf & inflorescence extract, Gentian root & rhizome extract, Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pancreatin Select by Moss Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Pancreatin Select by Moss Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pancreatin Select by Moss Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Pancreatin Select contains 7 active ingredients that work together as digestive aids. Three are pancreatic enzymes — amylase, protease, and lipase — which help break down carbohydrates, proteins, and fats during digestion.
Pancreatin 4X is a blend of additional pancreatic enzymes. Betaine HCl is a compound that increases stomach acid to support the digestion process.
The product also includes desiccated ox bile powder (dried bile from cattle) to help with fat digestion, plus artichoke leaf extract and gentian root extract, both bitter plant compounds traditionally used to support digestive function. Inactive ingredients include the capsule shell itself, microcrystalline cellulose, vegetable stearate, and silicon dioxide — standard fillers and binders used to form and stabilize the capsule.
Does it work?
Moderate evidence
The evidence for these ingredients is mixed. Artichoke leaf extract is rated possibly effective for high cholesterol (hyperlipidemia) and indigestion (dyspepsia), meaning some clinical evidence supports it.
For protease, lipase, betaine HCl, and gentian root, the evidence we have rates them as insufficient — meaning the data doesn't yet establish how well they work for their intended purposes. You won't find a clear yes-or-no answer about whether this product will solve your digestive symptoms from the research currently on file.
How safe is it?
Well-documented data
Pancreatin Select is generally well tolerated by most adults. The main cautions are digestive upset (nausea, diarrhea, bloating, or stomach pain) and the small risk of allergic reaction, especially if you're sensitive to plants in the ragweed family (for artichoke) or have celery allergies (for gentian).
Betaine HCl specifically isn't safe if you have ulcers, gastritis, or true acid reflux, since it irritates the stomach. During pregnancy, the safety data advises against all active ingredients in this product — avoid it unless your doctor prescribes it.
During breastfeeding, there isn't enough data to know either way for most ingredients, so talk with your doctor or pharmacist before using it. If you take medications for blood pressure, blood sugar, or stomach acid, flag this product with your healthcare provider first.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this product if you're on blood pressure medications (antihypertensives), blood sugar medications (antidiabetes drugs), H2-blockers or proton pump inhibitors for acid reflux, antacids, or drugs processed through CYP2B6 or CYP2C19 liver pathways — your healthcare provider can tell you if any of your medications fall into those categories.
The bottom line
Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Pancreatin Select is a digestive enzyme blend that may help if your body doesn't break down food efficiently — but the evidence for how well it works is incomplete. The real concern is whether it'll interfere with your medications, especially blood pressure drugs, blood sugar medications, or acid-reflux treatments.
Talk it over with your doctor or pharmacist before starting, and bring a list of everything you take.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pancreatin Select, straight from the product label.
| Brand | Moss Nutrition |
|---|---|
| Barcode (UPC) | M072 |
| Net contents | 90 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2019 |
| DSLD ID | 188856 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pancreatin Select by Moss Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Betaine HCl | 150 mg | -- |
| Pancreatin 4X | 200 mg | -- |
| desiccated Ox Bile powder | 60 mg | -- |
| Artichoke leaf & inflorescence extract | 50 mg | -- |
| Gentian root & rhizome extract | 50 mg | -- |
Other ingredients: Capsule, Microcrystalline Cellulose, Vegetable Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: 1 capsule per meal or as directed by your healthcare professional.
Precautions
Warning: If taking medication, pregnant or nursing, consult a physician before using.
Keep out of reach of children.
Storage
Store sealed in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
M Professional Supplements
General Statements
Comprehensive digest support
FDA Statement of Identity
Dietary Supplement
Formulation
Does not contain gluten.
General
V.1117.12
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pancreatin Select by Moss Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pancreatin Select by Moss Nutrition
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Betaine HCl
Interacts with36 drugs
Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...
Betaine HCl monograph & interactionsDesiccated Ox Bile powder
Artichoke leaf & inflorescence extract
Interacts with363 drugs
Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...
Artichoke leaf & inflorescence extract monograph & interactionsGentian root & rhizome extract
Interacts with172 drugs
Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...
Gentian root & rhizome extract monograph & interactionsOther (inactive) ingredients: Capsule, Microcrystalline Cellulose, Vegetable Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Pancreatin Select by Moss Nutrition Drug Interactions
HelloPharmacist Interaction Report
Pancreatin Select by Moss Nutrition contains several ingredients with documented drug interactions.
The most serious concerns come through its betaine HCl, artichoke leaf extract, and gentian root content, which affect stomach-acid–lowering drugs, blood pressure medications, blood sugar medications, and certain drug-metabolizing pathways.
Read the full breakdown — every affected drug type, severity by severity
Betaine HCl increases stomach acidity, which can reduce how well H2-blockers (acid-reflux medications), antacids, and proton pump inhibitors (PPIs) work — all Minor interactions. Artichoke leaf extract carries Moderate interactions with blood pressure medications (antihypertensives), blood sugar medications (antidiabetes drugs), and drugs processed through two liver pathways (CYP2B6 and CYP2C19 substrates).
Gentian root extract also has a Moderate interaction with blood pressure medications. Altogether, these interactions span 385 individual medications.
Two ingredients — amylase and desiccated ox bile powder — we could not check, so we hold no interaction data for them. Protease and lipase, the other enzyme components, have no interactions documented in our data.
Use the medication search tool on this page to check your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pancreatin Select?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pancreatin Select interact with 385 drugs. Click any drug to see the details.
3 of the 7 ingredients in Pancreatin Select interact with drugs. Each result below shows which ingredient is responsible. Artichoke leaf & inflorescence extract Gentian root & rhizome extract Betaine HCl
Chlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Chlorothiazide, Reserpine interactionArtichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Chlorothiazide, Reserpine interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Chlorpropamide interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Chlorthalidone interactionGentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Chlorthalidone interactionChlorthalidone, ClonidineClorpres, Combipres
How Chlorthalidone, Clonidine interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Chlorthalidone, Clonidine interactionArtichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Chlorthalidone, Clonidine interactionCilazaprilInhibace
How Cilazapril interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Cilazapril interactionGentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Cilazapril interactionCilostazolPletal
How Cilostazol interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf & Inflorescence Extract + Cilostazol interactionCitalopramCelexa
How Citalopram interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf & Inflorescence Extract + Citalopram interactionClevidipineCleviprex
How Clevidipine interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Clevidipine interactionGentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Clevidipine interactionClomipramineAnafranil, Anafranil SR
How Clomipramine interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf & Inflorescence Extract + Clomipramine interactionClonidineCatapres
How Clonidine interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Clonidine interactionArtichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Clonidine interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Cryptenamine, Methyclothiazide interactionArtichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Cryptenamine, Methyclothiazide interactionCyclophosphamideCytoxan, Neosar
How Cyclophosphamide interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf & Inflorescence Extract + Cyclophosphamide interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Cyclothiazide interactionGentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Cyclothiazide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Dasiglucagon Hydrochloride interactionDehydrocholic Acid, Homatropine Methylbromide, PhenobarbitalG.B.S.
How Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Leaf & Inflorescence Extract + Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interactionDeserpidineHarmonyl
How Deserpidine interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Deserpidine interactionArtichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Deserpidine interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Deserpidine, Hydrochlorothiazide interactionGentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Deserpidine, Methyclothiazide interactionArtichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Deserpidine, Methyclothiazide interactionDesipramineDesipramine, Norpramin, Pertofrane
How Desipramine interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf & Inflorescence Extract + Desipramine interactionDexamethasoneDecadron, Dexone, Dextenza, Dexycu, Hemady, Hexadrol +1 more
How Dexamethasone interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Leaf & Inflorescence Extract + Dexamethasone interactionDexlansoprazoleDexilant Solutab
How Dexlansoprazole interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf & Inflorescence Extract + Dexlansoprazole interactionBetaine HclProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hcl + Dexlansoprazole interactionDiazepamDiastat AcuDial, Valium, Valium injection, Valtoco
How Diazepam interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf & Inflorescence Extract + Diazepam interactionDicyclomine, PhenobarbitalBentyl w/ Pb
How Dicyclomine, Phenobarbital interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Leaf & Inflorescence Extract + Dicyclomine, Phenobarbital interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Diltiazem interactionArtichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Diltiazem, Enalapril interactionGentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Diltiazem, Enalapril interactionDoxazosin MesylateCardura
How Doxazosin Mesylate interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root & Rhizome ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root & Rhizome Extract + Doxazosin Mesylate interactionArtichoke Leaf & Inflorescence ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf & Inflorescence Extract + Doxazosin Mesylate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pancreatin Select with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Artichoke leaf & inflorescence extract
Antidiabetes Drugs
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.
Antihypertensive Drugs
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.
Gentian root & rhizome extract
Antihypertensive Drugs
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.
Betaine HCl
Antacids
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.
H2-Blockers
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.
Proton Pump Inhibitors (Ppis)
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs
Brand information
Manufacturer and brand details for Pancreatin Select, from the product label.
Moss Nutrition
See all Moss Nutrition products- Name
- Moss Nutrition Products, Inc.
- Street Address
- 380 Russell Street
- City
- Hadley
- State
- MA
- ZipCode
- 01035
- Phone Number
- 800-851-5444
- Web Address
- www.mossnutrition.com
Pancreatin Select by Moss Nutrition: Common Questions
Does Pancreatin Select by Moss Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Pancreatin Select if I'm pregnant?
What if I'm breastfeeding?
Is artichoke safe for people with ragweed allergies?
What side effects might I notice?
Does this product actually work for indigestion?
Can I take this with my acid-reflux medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pancreatin Select is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pancreatin Select’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Betaine Hydrochloride
Interacts with 36 drugsBetaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...
Read the full Betaine Hydrochloride monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographArtichoke
Interacts with 363 drugsArtichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...
Read the full Artichoke monograph → Herb & supplement monographGentian
Interacts with 172 drugsGentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...
Read the full Gentian monograph →Sources & How We Checked
Pancreatin Select's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Betaine Hydrochloride 2 references
- Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
- Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed
See these in context on the Betaine Hydrochloride monograph →
Artichoke 16 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
- Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
- Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
- Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
- Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
- Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
- Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
- Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
- Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
- Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
- Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
- Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
- Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
- Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
- Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed
Gentian 5 references
- Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
- Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
- Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
- Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
- Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC