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Dietary supplement

Pantethine-300 Ingredients & Drug Interactions

by Cardiovascular Research

Pantethine-300 label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pantethine-300 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pantethine-300 is a dietary supplement by Cardiovascular Research with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pantethine-300 by Cardiovascular Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Pantethine-300 by Cardiovascular Research — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pantethine-300 by Cardiovascular Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pantethine-300 contains one active ingredient: pantethine, a form of pantothenic acid (vitamin B5) that your body can use directly. The softgel capsule also holds rice bran oil, gelatin, glycerin, water, yellow beeswax, soy lecithin, and carob color as inactive ingredients to hold and deliver the pantethine.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: heart health and cholesterol support.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia, triglycerides, cardiovascular health.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

Pantethine is possibly effective for hyperlipoproteinemia (elevated blood fats). For athletic performance and general high cholesterol (hyperlipidemia), the evidence we hold is insufficient — meaning we don't have enough reliable data to say whether it works.

For pantothenate kinase-associated neurodegeneration, the same goes: not enough data in our records.

The evidence, ingredient by ingredient Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild gastrointestinal complaints: nausea, vomiting, diarrhea, bloating, flatulence, and epigastric discomfort (stomach upset).

Mild itching has been reported but is uncommon. Because long-term safety isn't well established and pregnancy safety data are not on file, it's best to avoid pantethine-300 unless your doctor advises otherwise.

Safety during breastfeeding has not been well studied, so caution is advised — talk with your doctor or pharmacist about whether this is right for you if you're nursing.

Side effects, ingredient by ingredient Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start pantethine-300, check with your doctor or pharmacist if you take any anticoagulants (blood thinners like warfarin, apixaban, rivaroxaban) or antiplatelet drugs (such as aspirin, clopidogrel, or ticlopidine). The moderate risk of increased bleeding means timing and dosing matter — your prescriber needs to know.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pantethine-300 may help with high blood fats, but the evidence for general cholesterol is still unclear. If you take blood thinners or antiplatelet drugs, check your medications with your doctor or pharmacist before starting — this product could increase your bleeding risk.

Long-term safety data are limited, so discuss it with your own healthcare provider to see if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pantethine-300, straight from the product label.

Brand Cardiovascular Research
Barcode (UPC) 696859132650
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 271513
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pantethine-300 by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
696859132650
IngredientAmount% DV
Pantethine300 mg--

Other ingredients: Rice Bran Oil, Gelatin, Glycerin, Water, yellow Beeswax, Soy Lecithin, carob color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Dietary Supplement

Formula

Pantethine-300 is a biologically active intermediate form of pantothenic acid (Vitamin B5) and a major precursor of coenzyme A.

Vitamin B5 Coenzyme

Suggested/Recommended/Usage/Directions

Directions As a dietary supplement, take one softgel daily with meals, or as directed by your healthcare practitioner.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Ecological Formulas

Formulation

Yeast Free

Non-GMO Contains no yeast, gluten, wheat, casein, corn, dairy, egg, fish/shellfish, tree nuts

Precautions

Contain: Soy

Brand IP Statement(s)

Pantesin is a registered trademark of Kyowa Pharma Chemical Co. Ltd.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pantethine-300 by Cardiovascular Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pantethine-300 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pantethine-300 by Cardiovascular Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Pantethine

Interacts with
122 drugs
300 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Other (inactive) ingredients: Rice Bran Oil, Gelatin, Glycerin, Water, Yellow Beeswax, Soy Lecithin, Carob color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pantethine-300 by Cardiovascular Research Drug Interactions

Want to check YOUR meds against Pantethine-300?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in Pantethine-300 interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pantethine-300 interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pantethine-300 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pantethine-300, from the product label.

Cardiovascular Research

See all Cardiovascular Research products
Name
Cardiovascular Research, LTD.
Street Address
1061-B Shary Circle
City
Concord
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Pantethine-300 by Cardiovascular Research: Common Questions

Does Pantethine-300 by Cardiovascular Research interact with any medications?
Yes. Based on its ingredients, Pantethine-300 has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pantethine-300 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pantethine and why is it in this product?
Pantethine is a form of pantothenic acid, a B vitamin your body can absorb and use directly. It's included because research suggests it may help with elevated blood fats, particularly a condition called hyperlipoproteinemia.
Can I take pantethine-300 if I'm pregnant?
Pregnancy safety data for pantethine are not on file, so we don't know either way. Talk with your doctor or pharmacist before taking it during pregnancy — they can weigh your individual situation and advise you.
What side effects might I get from this?
The most common side effects are mild stomach and digestive complaints: nausea, vomiting, diarrhea, bloating, gas, and stomach discomfort. Mild itching has been reported but is rare. Most people tolerate it well.
Does pantethine-300 work for high cholesterol?
The evidence we hold shows pantethine is possibly effective for hyperlipoproteinemia (elevated blood fats), but for general high cholesterol, we don't have enough reliable data to say whether it works.
Can I breastfeed while taking this?
Safety during breastfeeding hasn't been well studied, so caution is advised. Check with your doctor or pharmacist before taking pantethine-300 if you're nursing — they can help you decide if it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pantethine-300 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pantethine-300 label
Go deeper

The Full Monographs Behind Pantethine-300’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Pantethine-300's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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