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Dietary supplement

Pantethine Vitamin B5 Co-Enzyme Ingredients & Drug Interactions

by Cardiovascular Research

Pantethine Vitamin B5 Co-Enzyme label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pantethine Vitamin B5 Co-Enzyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pantethine Vitamin B5 Co-Enzyme is a dietary supplement by Cardiovascular Research with 2 active ingredients. Its ingredients are commonly taken for general nutrition and energy, skin and hair health, acne (topical and oral).Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: pantothenic acid and pantethine. Pantothenic acid (vitamin B5) is a water-soluble B vitamin your body needs for energy production and stress response; it's also used to address pantothenic acid deficiency.

Pantethine is a form of pantothenic acid that's been studied for its effects on cholesterol and fat levels in the blood. Both are forms of vitamin B5, but pantethine carries the documented drug interaction noted above.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Cholesterol and heart health support.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia, Heart failure, High triglycerides, Cardiovascular disease, Dyslipidemia.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantothenic Acid is rated "Insufficient Reliable Evidence To Rate" for Heart failure.
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

Pantothenic acid is effective for treating pantothenic acid deficiency. For other uses — including radiation-induced skin damage, hay fever, hair loss, and alcoholism — the evidence is either limited or suggests it's not effective; we don't have strong data to support those claims.

Pantethine appears possibly effective for high cholesterol and high triglycerides (hyperlipoproteinemia), but evidence for other uses such as athletic performance is insufficient. The data on file doesn't establish whether it works for those purposes.

The evidence, ingredient by ingredient Pantothenic Acid Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantothenic acid is generally well tolerated at typical supplement doses; the main caution is to check with your doctor before taking high-dose supplements. Pregnancy and lactation ratings for pantothenic acid are likely safe.

Pantethine is also generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild stomach complaints — nausea, vomiting, diarrhea, bloating, gas, and discomfort — and rarely, mild itching.

Safety during breastfeeding hasn't been well studied, so caution is advised. Because pregnancy and lactation safety data aren't on file for pantethine, talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Pantothenic Acid Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood thinners and antiplatelet drugs before taking this product. Pantethine may increase the risk of bleeding with medications like warfarin, aspirin, clopidogrel, and similar drugs — a moderate concern.

Use the medication checker on this page to confirm your specific medications aren't affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're deficient in pantothenic acid or if you're exploring options for high cholesterol under your doctor's guidance. If you take any blood thinners or antiplatelet medications, check your exact drugs before starting — the pantethine in this product may increase bleeding risk.

Talk it over with your doctor or pharmacist before you begin, especially if you're pregnant, breastfeeding, or on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pantethine Vitamin B5 Co-Enzyme, straight from the product label.

Brand Cardiovascular Research
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22985
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
60
IngredientAmount% DV
Pantothenic Acid135 mg1350%
Pantethine165 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, modified Cellulose Gum, Magnesium Stearate, Povidone, Film coating ingredients

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A DIETARY SUPPLEMENT

Dietary Supplement

Formula

PANTETHINE is a biologically active intermediate form of pantothenic acid (Vitamin B5) containing an equimolar amount of Pantethine (165mg) and Pantothenic Acid (135mg).

General Statements

Pantethine occurs as viscous liquid within the tablet.

11010727 EXP0114

Formulation

Contains no corn, soy, yeast, wheat or other common food or chemical allergens.

Yeast Free

FDA Disclaimer Statement

This product has not been evaluated by the FDA. This product is not intended to diagnose, cure, treat or prevent any disease.

Seals/Symbols

ECOLOGICAL FORMULAS

Suggested/Recommended/Usage/Directions

DIRECTIONS Take one to three tablets daily, or as directed by a physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pantethine Vitamin B5 Co-Enzyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pantothenic Acid

No known
interactions
135 mg per serving Form: Calcium Pantothenate

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

Pantethine

Interacts with
122 drugs
165 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Modified Cellulose Gum, Magnesium Stearate, Povidone, Film coating ingredients. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research Drug Interactions

Want to check YOUR meds against Pantethine Vitamin B5 Co-Enzyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in Pantethine Vitamin B5 Co-Enzyme interact with 122 drugs. Click any drug to see the details.

1 of the 2 ingredients in Pantethine Vitamin B5 Co-Enzyme interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pantethine Vitamin B5 Co-Enzyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pantethine Vitamin B5 Co-Enzyme, from the product label.

Cardiovascular Research

See all Cardiovascular Research products
Name
CARDIOVASCULAR RESEARCH, LTD.
Street Address
1061-B SHARY CIRCLE
City
CONCORD
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research: Common Questions

Does Pantethine Vitamin B5 Co-Enzyme by Cardiovascular Research interact with any medications?
Yes. Based on its ingredients, Pantethine Vitamin B5 Co-Enzyme has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pantethine Vitamin B5 Co-Enzyme contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is pantothenic acid the same thing as pantethine?
Both are forms of vitamin B5, but they're not identical. Pantothenic acid is the basic form your body uses for energy and stress response. Pantethine is a modified version that's been studied separately for cholesterol and fat management. This product contains both.
Can I take this if I'm pregnant or breastfeeding?
Pantothenic acid is likely safe during pregnancy and breastfeeding. However, pantethine's safety during breastfeeding hasn't been well studied, and we don't have pregnancy data on file for it. Talk with your doctor or pharmacist before taking this product while pregnant or nursing — they can give you personalized advice based on your situation.
What are the most common side effects?
Mild stomach complaints are the most common — nausea, vomiting, diarrhea, bloating, gas, and epigastric discomfort. Pantothenic acid alone can cause diarrhea. These effects are generally mild, and pantethine is generally well tolerated overall.
Does this product actually work for high cholesterol?
Pantethine is possibly effective for high cholesterol and high triglycerides, meaning there's some evidence to support it — but it's not proven. The pantothenic acid in this product, however, doesn't have strong evidence for that purpose. Talk with your doctor about whether it fits into your cholesterol management plan.
What are the inactive ingredients?
The tablet contains microcrystalline cellulose, stearic acid, silicon dioxide, modified cellulose gum, magnesium stearate, povidone, and film coating ingredients. These are binders, fillers, and coating materials that help hold the tablet together — they're not active ingredients.
Can I take this long-term?
Pantothenic acid is considered safe at typical doses. Pantethine is generally well tolerated in studies, but long-term safety data are limited — that's why it's best to discuss long-term use with your doctor before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pantethine Vitamin B5 Co-Enzyme label
Go deeper

The Full Monographs Behind Pantethine Vitamin B5 Co-Enzyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Pantethine Vitamin B5 Co-Enzyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantothenic Acid 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  4. Schmuth, M., Wimmer, M. A., Hofer, S., Sztankay, A., Weinlich, G., Linder, D. M., Elias, P. M., Fritsch, P. O., and Fritsch, E. Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br.J.Dermatol. 2 PubMed
  5. Schreck, U., Paulsen, F., Bamberg, M., and Budach, W. Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? Strahlenther.Onkol. 2002;178(6):321-329. PubMed
  6. Herbst, R. A., Uter, W., Pirker, C., Geier, J., and Frosch, P. J. Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period. Contact Dermatitis 2004;51(1):13-1 PubMed
  7. Champault, G. and Patel, J. C. [Treatment of constipation with Bepanthene]. Med.Chir Dig. 1977;6(1):57-59.
  8. Scott LN, Fiume M, Bergfeld WF, et al. Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Int J Toxicol 2022;41(3_suppl):77-128. PubMed
  9. Han J, Warshaw EM. Allergic Contact Dermatitis to Panthenol in "Hypoallergenic" Products. Dermatitis 2023;34(1):62-63. PubMed
  10. Blanchard G, Kerre S, Walker A, et al. Allergic contact dermatitis from pantolactone and dexpanthenol in wound healing creams. Contact Dermatitis 2022;87(5):468-471. PubMed
  11. Peltier E, Trapp S, de Salvo R, et al. A new dexpanthenol-containing liquid cleanser for atopic-prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function. J Cosme PubMed

See these in context on the Pantothenic Acid monograph →

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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