Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Panzyme-HCL Ingredients & Drug Interactions

by DC

Panzyme-HCL label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Panzyme-HCL against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Panzyme-HCL is a dietary supplement by DC with 6 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Panzyme-HCL by DC

Ask about any prescription or over-the-counter medication and we check it for interactions with Panzyme-HCL by DC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Panzyme-HCL by DC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (97 mg) without saying how much of each component you get.

Panzyme-HCL contains 6 active ingredients — a blend of digestive enzymes and stomach-acid helpers. Betaine hydrochloride is an acidifying agent meant to raise stomach acid.

The other actives are digestive enzymes: amylase (breaks down carbs), protease (breaks down protein), lipase (breaks down fat), pepsin (a protein-digesting enzyme), and pancreatin (a multi-enzyme blend from pancreas tissue). The tablet also contains inactive ingredients — calcium carbonate, vegetable cellulose, vegetable stearic acid, silica, and vanillin — that serve as fillers, binders, and flavorings.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Pancreatic insufficiency, Indigestion, Bloating and gas.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence on betaine hydrochloride for dyspepsia, hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, and hay fever is insufficient — we don't have reliable data to say whether it works. Lipase is similarly unproven for inflammatory bowel disease, dyspepsia, or prematurity.

No effectiveness ratings are available for protease or pepsin in the data we hold.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride may irritate your stomach and is not safe if you have ulcers, gastritis, or true acid reflux — it could trigger heartburn or even interfere with ulcer healing. The data advises against betaine hydrochloride in pregnancy and breastfeeding due to insufficient safety information.

Protease and pepsin are generally well tolerated but may cause digestive upset or, rarely, allergic reactions — occupational exposure to pepsin has caused asthma and allergic rhinitis in some cases. Lipase is generally well tolerated in supplement form, but no serious adverse effects have been reported in adults; however, a thorough safety review hasn't been done.

People with serious digestive conditions should use lipase only under medical guidance.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any acid-reducing medication — H2-blockers (like famotidine), antacids, or proton pump inhibitors (like omeprazole) — check with your pharmacist before taking this product. Betaine hydrochloride increases stomach acid, which can weaken those drugs' effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Panzyme-HCL is a multi-enzyme digestive aid with betaine hydrochloride to increase stomach acid. It's not right for you if you have ulcers, gastritis, or acid reflux, and it can reduce how well acid-reducing medications work.

Talk with your doctor or pharmacist before you start — especially if you take H2-blockers, antacids, or PPIs — to make sure it's appropriate for you and won't interfere with your other medicines.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Panzyme-HCL, straight from the product label.

Brand DC
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 266620
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Panzyme-HCL by DC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
IngredientAmount% DV
Betaine Hydrochloride178 mg--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Ammonium Chloride10 mg--
Pepsin97 mg--
Pancreatin97 mg--

Other ingredients: Calcium Carbonate, Vegetable Cellulose, Vegetable Stearic Acid, Silica, Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a food enzyme dietary supplement, take 1 tablet with each meal and if necessary at bedtime. Don't hesitate to use two servings (two tablets) with each meal and at bedtime if needed.

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing do not take this product.

Contains milk ingredients.

Formulation

Manufactured in our own state-of-the-art FDA Registered Facility (Registration #1023013) using Good Manufacturing Practices (GMPs) assuring correct potencies, freshness, quality and purity.

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Made in USA

Gluten free

Nutritionally supports digestive health

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Quali Pure

Formula

Pancreatin, Pepsin, Betaine HCI and Ammonium Chloride

FDA Statement of Identity

Food Enzyme Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Panzyme-HCL by DC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Panzyme-HCL label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Panzyme-HCL by DC

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
178 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Ammonium Chloride

10 mg per serving

Pepsin

No known
interactions
97 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Pancreatin

97 mg per serving

Other (inactive) ingredients: Calcium Carbonate, Vegetable Cellulose, Vegetable Stearic Acid, Silica, Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Panzyme-HCL by DC Drug Interactions

Want to check YOUR meds against Panzyme-HCL?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Panzyme-HCL interact with 36 drugs. Click any drug to see the details.

1 of the 6 ingredients in Panzyme-HCL interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Panzyme-HCL with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Panzyme-HCL, from the product label.

DC

See all DC products
Name
Dee Cee Laboratories, Inc.
Street Address
304 Dee Cee Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Panzyme-HCL by DC: Common Questions

Does Panzyme-HCL by DC interact with any medications?
Yes. Based on its ingredients, Panzyme-HCL has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Panzyme-HCL contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux or heartburn?
No — betaine hydrochloride is not safe for people with true acid reflux, gastritis, or ulcers. It raises stomach acid and could trigger or worsen heartburn and may even interfere with ulcer healing. Talk with your doctor if you have reflux before starting this product.
Is it safe to take during pregnancy?
The data advises against it in pregnancy. There isn't enough safety information to know whether it's okay, so talk with your doctor or pharmacist for personalized guidance before taking it while pregnant.
Can I breastfeed while taking this?
The data advises against it during breastfeeding as well — safety hasn't been established. Check with your doctor or pharmacist before using it if you're nursing.
What do the enzymes in this product actually do?
They're digestive helpers: amylase breaks down carbs, protease breaks down protein, lipase breaks down fat, pepsin helps digest protein, and pancreatin is a multi-enzyme blend that supports overall digestion. Betaine hydrochloride is there to increase stomach acid, which aids these enzymes.
Does it work for upset stomach or digestion problems?
The evidence isn't clear — there's insufficient reliable data on betaine hydrochloride for upset stomach, and we don't have effectiveness ratings for the enzymes in our records. If you're considering it for a digestive issue, talk with your doctor first.
Could this cause allergic reactions?
Protease and pepsin may cause allergic reactions in rare cases — occupational exposure to pepsin has triggered asthma and allergy symptoms in some people. If you have enzyme sensitivities or a history of allergy, mention it to your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Panzyme-HCL is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Panzyme-HCL label
Go deeper

The Full Monographs Behind Panzyme-HCL’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

Panzyme-HCL's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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