Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Papaya Digestive Support Pineapple Papaya Flavor Ingredients & Drug Interactions

by Country Life

Papaya Digestive Support Pineapple Papaya Flavor label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Papaya Digestive Support Pineapple Papaya Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Papaya Digestive Support Pineapple Papaya Flavor is a dietary supplement by Country Life with 5 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 93 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya, Papain, Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Papaya Digestive Support Pineapple Papaya Flavor by Country Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Papaya Digestive Support Pineapple Papaya Flavor by Country Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Papaya Digestive Support Pineapple Papaya Flavor by Country Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Digestive Support Blend” is a proprietary blend — the label gives one combined amount (98 mg) without saying how much of each component you get.

This product contains 5 active ingredients: glycine, papain, protease, alpha-amylase, and papaya. They're packaged together as a digestive blend — papain and protease are enzymes that help break down proteins in food, while alpha-amylase breaks down carbohydrates.

Glycine is an amino acid, and papaya is the whole fruit. The inactive ingredients are fructose, cellulose, mannitol, starch, maltodextrin, pineapple and papaya flavoring, stearic acid, silica, and magnesium stearate.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive enzyme support for nutrient absorption.
  • We looked for evidence on: Indigestion, Bloating, Protein digestion.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold doesn't establish that this product works for digestive support. Glycine is rated possibly effective for schizophrenia, but that's unrelated to digestion.

Papain, protease, papaya, and alpha-amylase all have insufficient reliable evidence in our data for any health claim — we simply don't have enough quality studies to rate them. If you're looking for digestive enzyme support, talk with your pharmacist about what the research actually shows for your situation.

The evidence, ingredient by ingredient Glycine Papain Proteolytic Enzymes (proteases) Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycine is generally well tolerated at typical doses, though long-term safety data are limited; rarely, it can cause mild sedation, and GI upset like soft stools, nausea, or vomiting have been reported. Papain supplements may irritate your digestive tract or trigger allergic reactions — high doses could potentially cause severe gastritis or esophageal perforation, though this is rare.

Protease is generally well tolerated but may cause digestive upset or allergies in some people. We don't have pregnancy or lactation safety information on file for glycine, protease, or alpha-amylase.

For papain, concentrated forms and unripe papaya are best avoided in pregnancy; papain supplements aren't recommended while breastfeeding without medical advice. For papaya itself, ripe fruit is likely safe in pregnancy, but unripe papaya, papaya latex, and seeds should be avoided.

Side effects, ingredient by ingredient Glycine Papain Proteolytic Enzymes (proteases) Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Papain, Papaya, Glycine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 93 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take clozapine (Clozaril) for schizophrenia, warfarin (Coumadin) or other blood thinners, diabetes medications, amiodarone (Cordarone) for heart rhythm, or levothyroxine (Synthroid) or other thyroid hormones. Moderate interactions are documented for all of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're on clozapine, warfarin, diabetes medication, amiodarone, or levothyroxine, talk to your pharmacist before using this product — the interaction risk is real. If you're pregnant or breastfeeding, check with your doctor or pharmacist first, especially about the papain and papaya content.

For anyone else considering it, the evidence for digestive benefit isn't established in our data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Papaya Digestive Support Pineapple Papaya Flavor, straight from the product label.

Brand Country Life
Barcode (UPC) 015794053873
Net contents 200 Chewable Wafer(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 326831
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Papaya Digestive Support Pineapple Papaya Flavor by Country Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Wafer(s)
Maximum serving Sizes:
4 Wafer(s)
Servings per container
50
UPC/BARCODE
015794053873
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Glycine40 mg--
Added Sugars1 Gram(s)2%
Total Sugars1 Gram(s)--
Digestive Support Blend98 mg--
Papain0 NP--
Protease0 NP--
Alpha-Amylase0 NP--
Papaya0 NP--

Other ingredients: Fructose, Cellulose, Mannitol, Starch, Maltodextrin, Pineapple Flavor, Natural, Stearic Acid, natural Fruit flavors, Papaya Flavor, Natural, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Digestive enzymes, such as those naturally found in papaya, papain and protease, are essential to the body's absorption of food nutrients. This chewable wafer has a delicious pineapple-papaya flavor -great after any meal.

Yes Kosher

Papaya Digestive Support From whole papaya fruit Pineapple Papaya Flavor with other natural flavors

General Statements

Available in 200 and 500 wafers.

Yes Recyclable Packaging

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Yes Certified Gluten-Free by GFCO.org No yeast or wheat No soy, milk or salt No artificial colors, flavors or sweeteners

Yes Certified Vegan by the AVA

Yes Manufacturing supports wind power

USP - United States Pharmacopoeia. This product has been manufactured at a GMP Registered facility.

This product does not contain common GE genes or proteins. Visit igenprogram.com Non-GMO Tested Certified Gluten-Free

Digestive enzyme support

Our Pledge of Integrity Authenticity Cleanliness Freshness Consistency Accuracy

Precautions

Do not accept if seal is broken.

Keep out of the reach of children.

As a reminder, discuss the supplements and medications that you take with your health care providers. Caution: If you are pregnant, nursing, or taking medication, have a medical condition or planning surgery, consult a doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur.

Storage

Store in a dry place between 59 degrees - 86 degrees F.

Seals/Symbols

IGEN Non-GMO Tested Certified B Corporation Certified Gluten Free GFCO.org K (Kosher)

Brand IP Statement(s)

Established 1971 Country Life

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults chew four (4) wafers after each meal, up to three times a day.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Papaya Digestive Support Pineapple Papaya Flavor by Country Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Papaya Digestive Support Pineapple Papaya Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Papaya Digestive Support Pineapple Papaya Flavor by Country Life

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Wafer(s) Dosage formOther (e.g. Tea Bag) Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycine

Interacts with
1 drug
40 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine monograph & interactions

Digestive Support Blend

98 mg per serving

Other (inactive) ingredients: Fructose, Cellulose, Mannitol, Starch, Maltodextrin, Pineapple Flavor, Natural, Stearic Acid, Natural Fruit flavors, Papaya Flavor, Natural, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Papaya Digestive Support Pineapple Papaya Flavor by Country Life Drug Interactions

Want to check YOUR meds against Papaya Digestive Support Pineapple Papaya Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
93Drugs
93 Moderate

Ingredients driving the most interactions

Papaya 92
Papain 2
Glycine 1

Individual Drug Interactions

The ingredients in Papaya Digestive Support Pineapple Papaya Flavor interact with 93 drugs. Click any drug to see the details.

3 of the 5 ingredients in Papaya Digestive Support Pineapple Papaya Flavor interact with drugs. Each result below shows which ingredient is responsible. Papaya Papain Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in Papaya Digestive Support Pineapple Papaya Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Papaya4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Papaya Digestive Support Pineapple Papaya Flavor, from the product label.

Country Life

See all Country Life products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

Papaya Digestive Support Pineapple Papaya Flavor by Country Life: Common Questions

Does Papaya Digestive Support Pineapple Papaya Flavor by Country Life interact with any medications?
Yes. Based on its ingredients, Papaya Digestive Support Pineapple Papaya Flavor has a known interaction with 93 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Papaya Digestive Support Pineapple Papaya Flavor contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
No — not without talking to your doctor first. Papain and papaya in this product may increase warfarin's effects and thin your blood too much. A case report showed a patient's blood-clotting level spike dangerously after taking papain while on warfarin. Your doctor needs to know before you take this.
Does this help with digestion?
We don't have reliable evidence in our data that it does. The enzymes papain and protease break down proteins, and alpha-amylase breaks down carbs, but we don't have enough quality studies to rate whether this product actually improves digestion for you.
Is it safe to take while pregnant?
It depends on which ingredients concern you most. Ripe papaya fruit is likely safe, but concentrated papain and unripe papaya should be avoided in pregnancy. We don't have safety information on file for glycine, protease, or alpha-amylase in pregnancy. Talk with your doctor or pharmacist before starting.
Can I take this if I'm on thyroid medication?
Check with your pharmacist first. Papaya in large amounts may reduce how well levothyroxine (Synthroid) works. A case report documented one person who developed hypothyroidism after eating 5–6 papaya fruits daily for two weeks while on levothyroxine.
What are the side effects?
Most people tolerate the enzymes well, but glycine can rarely cause mild sedation or GI upset like soft stools and nausea. Papain may trigger allergic reactions — itching, runny nose, or diarrhea — in people sensitive to it. High doses of papain are potentially unsafe and can cause severe stomach damage.
Is this safe while breastfeeding?
The safety data for breastfeeding are limited. Papain supplements aren't recommended while breastfeeding without medical advice. We don't have safety information on file for glycine, protease, or alpha-amylase during breastfeeding. Talk to your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Papaya Digestive Support Pineapple Papaya Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Papaya Digestive Support Pineapple Papaya Flavor label
Go deeper

The Full Monographs Behind Papaya Digestive Support Pineapple Papaya Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Papaya Digestive Support Pineapple Papaya Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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