Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Para-Safe Ingredients & Drug Interactions

by Terry Naturally

Para-Safe label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Para-Safe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Para-Safe is a dietary supplement by Terry Naturally with 6 active ingredients. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 1,408 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Clove (Eugenia caryophyllata) bud Oil, Peppermint (Mentha piperita) aerial oil, Coriander (Coriandrum sativum) fruit oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Para-Safe by Terry Naturally

Ask about any prescription or over-the-counter medication and we check it for interactions with Para-Safe by Terry Naturally — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Para-Safe by Terry Naturally

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Formula” is a proprietary blend — the label gives one combined amount (150 mg) without saying how much of each component you get.

Para-Safe is a softgel capsule with six active ingredients in a proprietary blend: cinnamon bark oil, oregano flower oil, clove bud oil, coriander fruit oil, peppermint aerial oil, and savory flower oil. These are concentrated herbal oils meant to deliver the bioactive compounds from each plant.

The product also contains inactive ingredients—extra virgin olive oil, gelatin, glycerin, and water—that serve as the oil carrier and capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive tract protection and intestinal flora balance.
  • We looked for evidence on: Abdominal pain, Constipation, Diarrhea, Dyspepsia, Flatulence, Gastritis — and 4 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Peppermint is rated "Possibly Effective" for Chemotherapy-induced nausea and vomiting (CINV), Dyspepsia.
  • Also on file: Coriander is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Dyspepsia, Flatulence.

The evidence for these ingredients' effectiveness is limited in the data we hold. Peppermint has the strongest support, with ratings of Likely Effective for irritable bowel syndrome and Possibly Effective for indigestion, chemotherapy-induced nausea, and certain endoscopy-related effects.

Clove is Possibly Effective for ventilator-associated pneumonia. The rest of the ingredients—cinnamon, oregano, coriander, and savory—carry Insufficient Reliable Evidence ratings for the conditions listed in our data, meaning the evidence is not yet established well enough to make a clear claim.

The evidence, ingredient by ingredient Cassia Cinnamon Oregano Clove Coriander Peppermint Winter Savory

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Peppermint, clove, and cinnamon are all rated Likely Safe in pregnancy and lactation when used in food amounts; the safety notes advise against medicinal doses without medical approval. Oregano is rated Possibly Unsafe in pregnancy, so it should be avoided at medicinal doses during pregnancy, though food amounts are likely fine.

For savory and coriander, pregnancy and lactation safety data are not on file, so it's wise to avoid medicinal doses unless cleared by your provider. Common side effects reported with these oils are mild—gastrointestinal upset (nausea, diarrhea, abdominal pain, heartburn), contact dermatitis when applied topically, and dry mouth.

Rare but serious allergic reactions including anaphylaxis have been documented with oregano and coriander; a few case reports also exist of CNS depression and seizure in children who ingested large amounts of clove oil by accident. Clove oil in doses as small as 5–10 mL can be toxic in children.

Side effects, ingredient by ingredient Cassia Cinnamon Oregano Clove Coriander Peppermint Winter Savory

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Coriander, Winter Savory, Clove, Oregano, Peppermint, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,409 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Para-Safe, double-check the following medication types: drugs processed by liver enzymes (CYP2D6, CYP1A2, CYP3A4, CYP2C9, CYP2C19), diabetes medications, blood pressure drugs, blood thinners, cyclosporine, lithium, sedatives, and sun-sensitizing drugs. The heaviest load of interactions comes from clove and peppermint's effects on liver enzyme metabolism.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Para-Safe is designed for someone interested in herbal support using culinary-strength oils. If you take diabetes medications, blood thinners, blood pressure drugs, cyclosporine, lithium, sedatives, or drugs processed by liver enzymes, you need to check your exact medications with the tool on this page before starting.

Talk with your doctor or pharmacist about whether this product is right for you, especially if you're pregnant, breastfeeding, or caring for a young child.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Para-Safe, straight from the product label.

Brand Terry Naturally
Barcode (UPC) 367703106065
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Nov 25, 2014
DSLD ID 39762
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Para-Safe by Terry Naturally, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
367703106065
IngredientAmount% DV
Proprietary Formula150 mg--
Cinnamon (Cinnamomum cassia) bark Oil0 NP--
Oregano (Origanum compactum) flower oil0 NP--
Clove (Eugenia caryophyllata) bud Oil0 NP--
Coriander (Coriandrum sativum) fruit oil0 NP--
Peppermint (Mentha piperita) aerial oil0 NP--
Savory (Satureja montana) flower oil0 NP--

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Product of Belgium

UNCONDITIONALLY GUARANTEED

Unique formulation provides protection for your digestive tract and helps maintain a healthy balance of intestinal flora.*

Bio-Typed Plant Oils are 75 to 100 times more concentrated than herbal extracts.

Supports Healthy Intestinal Balance*

For Your Good Health

{signature} Terry

NON-GMO

Suggested/Recommended/Usage/Directions

Recommendations: 1 softgel daily to maintain good health. If you are unsure of the quality of the food you are consuming, take 1 softgel with each meal or beverage, not to exceed 4 capsules daily.

Precautions

If pregnant or nursing, consult a healthcare practitioner before using.

If pregnant or nursing, consult a healthcare practitioner before use.

FDA Disclaimer Statement

* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

General

JC 34 91 + 3(5,6)EP L10606.03

Seals/Symbols

Terry Naturally(R)

Terry Naturally EuroPharma(R)

FDA Statement of Identity

DIETARY SUPPLEMENT

Formulation

No sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or artificial preservatives.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Para-Safe by Terry Naturally label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Para-Safe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Para-Safe by Terry Naturally

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Para-Safe by Terry Naturally Drug Interactions

Want to check YOUR meds against Para-Safe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,408Drugs
1,408 Moderate

Ingredients driving the most interactions

Clove (Eugenia caryophyllata) bud Oil 977
Peppermint (Mentha piperita) aerial oil 796
Coriander (Coriandrum sativum) fruit oil 717
Cinnamon (Cinnamomum cassia) bark Oil 442
Oregano (Origanum compactum) flower oil 208

Individual Drug Interactions

The ingredients in Para-Safe interact with 1,408 drugs. Click any drug to see the details.

6 of the 6 ingredients in Para-Safe interact with drugs. Each result below shows which ingredient is responsible. Clove (Eugenia caryophyllata) bud Oil Peppermint (Mentha piperita) aerial oil Coriander (Coriandrum sativum) fruit oil Cinnamon (Cinnamomum cassia) bark Oil Oregano (Origanum compactum) flower oil Savory (Satureja montana) flower oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Para-Safe with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove (Eugenia caryophyllata) bud Oil7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove (Eugenia caryophyllata) bud Oil full monograph & interactions

Peppermint (Mentha piperita) aerial oil5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint (Mentha piperita) aerial oil full monograph & interactions

Coriander (Coriandrum sativum) fruit oil4 drug types · 717 drugs

Antidiabetes Drugs

Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Evidence from animal research suggests that coriander fruit and coriander extract can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Evidence from animal research suggests that coriander fruit can lower blood pressure.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Evidence from animal research suggests that coriander fruit extract has sedative effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Evidence from in vitro research suggests that coriandrin, a constituent of coriander, has photosensitizing effects.

Likelihood Possible Evidence D
Coriander (Coriandrum sativum) fruit oil full monograph & interactions

Cinnamon (Cinnamomum cassia) bark Oil2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon (Cinnamomum cassia) bark Oil full monograph & interactions

Oregano (Origanum compactum) flower oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
Oregano (Origanum compactum) flower oil full monograph & interactions

Savory (Satureja montana) flower oil1 drug type · 1 drug

Lithium

Winter savory is thought to have diuretic properties. Theoretically, winter savory might reduce the excretion of lithium and increase plasma levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Savory (Satureja montana) flower oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Para-Safe, from the product label.

Terry Naturally

See all Terry Naturally products
Name
EuroPharma, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
(866) 807-2731
Web Address
www.EuroPharmaUSA.com
Pharmacist Counseling Corner

Para-Safe by Terry Naturally: Common Questions

Does Para-Safe by Terry Naturally interact with any medications?
Yes. Based on its ingredients, Para-Safe has a known interaction with 1,408 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Para-Safe contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is peppermint in this product effective for digestive issues?
Yes—peppermint is rated Likely Effective for irritable bowel syndrome and Possibly Effective for indigestion. It may also help with nausea and certain endoscopy-related effects. The other oils in the blend, though, have insufficient evidence to claim they're effective for digestive support.
Can I take this if I'm pregnant?
Oregano is rated Possibly Unsafe in pregnancy, so medicinal doses should be avoided. Peppermint, clove, and cinnamon are Likely Safe in food amounts but should not be used at medicinal or supplement doses during pregnancy without your doctor's approval. Safety data for coriander and savory during pregnancy aren't on file, so check with your provider before taking this product while pregnant.
What's the main risk with clove in this product?
Clove contains eugenol, which can slow how your liver processes several types of medications. In theory, this could raise the blood levels of drugs broken down by liver enzymes (CYP2D6, CYP1A2, CYP3A4, or CYP2C9), potentially increasing their effects or side effects. This hasn't been proven in humans, but it's important to check your specific medications.
Can this product cause side effects?
Most common side effects are mild—upset stomach, nausea, diarrhea, heartburn, or abdominal pain. Skin irritation can occur with topical exposure. Rare allergic reactions including anaphylaxis have been reported with oregano and coriander in sensitive people. Clove oil is toxic in large amounts, especially in children.
Does this interact with blood sugar medications?
Yes—three of the oils (cinnamon, oregano, and coriander) may lower blood sugar and could have additive effects with diabetes drugs, increasing the risk of low blood sugar. If you take insulin or diabetes pills, check with your doctor or pharmacist before starting this product.
Can I take this with blood thinners like warfarin?
Both oregano and clove may theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs. Use the medication checker on this page to see if your specific blood thinner is listed, and talk with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Para-Safe label
Go deeper

The Full Monographs Behind Para-Safe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph → Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph → Herb & supplement monograph

Coriander

Interacts with 717 drugs

Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints. As a food it is generally safe for most people,...

Read the full Coriander monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Winter Savory

Interacts with 1 drug

Winter savory is a culinary herb in the mint family used mainly to flavor food and, in folk medicine, to ease digestion and sore throats. Solid human research is very limited, so it should n...

Read the full Winter Savory monograph →
Sources

Sources & How We Checked

Para-Safe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 114 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
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See these in context on the Cassia Cinnamon monograph →

Oregano 12 references
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See these in context on the Oregano monograph →

Clove 26 references
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Coriander 12 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
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See these in context on the Coriander monograph →

Peppermint 41 references
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See these in context on the Peppermint monograph →

Winter Savory 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Sansalone S, Russo GI, Mondaini N, Cantiello F, Antonini G, Cai T. A combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts is able to improve sexual quality of life in patient with premature ejaculation. Arch Ital PubMed

See these in context on the Winter Savory monograph →

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