Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Peppermint Smooth Move Senna Ingredients & Drug Interactions

by Traditional Medicinals

Peppermint Smooth Move Senna label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Peppermint Smooth Move Senna against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Peppermint Smooth Move Senna is a dietary supplement by Traditional Medicinals with 5 active ingredients. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 1,099 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic licorice, organic Peppermint, organic bitter Fennel. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Peppermint Smooth Move Senna by Traditional Medicinals

Ask about any prescription or over-the-counter medication and we check it for interactions with Peppermint Smooth Move Senna by Traditional Medicinals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Peppermint Smooth Move Senna by Traditional Medicinals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (920 mg) without saying how much of each component you get.

Peppermint Smooth Move Senna contains 5 ingredients total. The active herbal components are organic senna, organic bitter fennel, organic peppermint, and organic licorice.

We don't hold detailed data on senna or the proprietary blend, though the product notes all its herbal ingredients are organic. There are no inactive fillers or other ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: herbal stimulant laxative for bowel regularity.
  • We looked for evidence on: Constipation, Postoperative ileus, bowel movement, digestive regularity.
  • The closest evidence on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Constipation (Natural Medicines).
  • Also on file: Peppermint is rated "Insufficient Reliable Evidence To Rate" for Postoperative ileus.

Peppermint is the strongest evidence here — it's likely effective for irritable bowel syndrome (IBS) and possibly effective for indigestion, nausea from chemotherapy or colonoscopy prep, and related digestive discomfort. Fennel is possibly effective for period pain (dysmenorrhea) but evidence is insufficient to rate it for cough, anxiety, bedwetting, or cholera.

Licorice is possibly effective for eczema and canker sores but evidence is insufficient for Addison disease or asthma. We don't hold effectiveness ratings for senna.

The evidence, ingredient by ingredient Fennel Peppermint Licorice

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Peppermint and senna are the key players here. Peppermint tea in food amounts is generally well tolerated, though concentrated oil needs care — the most common side effects are stomach pain, burning near the anus, bloating, diarrhea, dry mouth, heartburn, nausea, and vomiting.

Rare allergic reactions including anaphylaxis have been reported. Fennel is generally safe as a food but concentrated supplements need caution; it may cause stomach upset, sun sensitivity, or allergic reactions, and rare seizures have been reported.

Licorice in small food amounts is usually fine, but high doses or long-term use can cause headache, nausea, vomiting, contact rash, and serious effects tied to its glycyrrhizin content. All three ingredients are not recommended in pregnancy due to limited safety data or known hormone-like effects.

For breastfeeding, peppermint tea in food amounts is likely safe; fennel and licorice concentrated supplements are not well studied — talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Fennel Peppermint Licorice

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Fennel, Peppermint, Licorice.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; heart-rhythm medications.
  • For scale: 1,100 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your own doctor or pharmacist if you take any blood thinners (including warfarin or aspirin-type drugs), birth control pills, hormone replacement therapy, heart medications (especially digoxin), the antibiotic ciprofloxacin, the cancer drugs tamoxifen, cisplatin, or paclitaxel, the immunosuppressant cyclosporine, water pills (loop diuretics), the sedative midazolam, or any drug your liver processes through the CYP2C19, CYP2C9, CYP3A4, CYP2B6, or CYP1A2 pathways — all carry Moderate or Minor interaction risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a digestive tea blend, and peppermint is well established for IBS and indigestion. But the combination of fennel, peppermint, and especially licorice brings real medication interactions — particularly with birth control, blood thinners, heart drugs, and cancer treatments.

If you take any prescription medication, check it against the full interaction list before you start, and have that conversation with your own doctor or pharmacist. Pregnant or breastfeeding?

The safety data advises caution or avoidance — ask your provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Peppermint Smooth Move Senna, straight from the product label.

Brand Traditional Medicinals
Net contents 16 Wrapped Tea Bag(s); 1.13 oz.; 32 g
Market status On market
Date entered into DSLD Jan 25, 2012
DSLD ID 4819
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Peppermint Smooth Move Senna by Traditional Medicinals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tea Bag(s)
Maximum serving Sizes:
1 Tea Bag(s)
Servings per container
16
IngredientAmount% DV
Calories2 {Calories}--
Proprietary Blend920 mg--
All Herbal Ingredients0 NP--
organic Senna1080 mg--
organic bitter Fennel0 NP--
organic Peppermint0 NP--
organic licorice0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

HERBAL DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Duration of use: Stimulant laxatives should not be taken for a period longer than 1 week unless directed by a doctor.

Precautions

Keep out of the reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.

Ask a doctor or pharmacist prior to use if you are taking any other drug.

Cautions: Ask a doctor before use if you have stomach pain, nausea, vomiting, or have noticed a sudden change in bowel habits that continue over a period of 2 weeks.

Contraindications: Ileus, acute intestinal inflammation (e.g. Crohn’s disease, ulcerative colitis), appendicitis, abdominal pain of unknown origin, severe dehydration states with water and electrolyte depletion.

NOTICE: This product contains senna leaf. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because senna leaf may worsen these conditions and be harmful to your health.

Stop use and ask a doctor if you have rectal bleeding or fail to have a bowel movement after use of a laxative. These may indicate a serious condition.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

General Statements

BEST IF USED BY EXPIRATION DATE/LOT: Use this number on all correspondence related to this product

herbal Stimulant Laxative* Tea

NEW

Brand IP Statement(s)

What will Peppermint Smooth Move(R) SENNA do for me? Peppermint Smooth Move(R) SENNA provides gentle, overnight relief of occasional constipation (irregularity). Senna leaf promotes bowel movement by direct action on the intestine.* How do I know it works? A single serving provides an effective dose of sennosides from senna leaf, which have proven stimulant laxative action. Peppermint, licorice and fennel are traditionally combined with senna to ease discomfort and reduce cramping.* When should I use it? Drink one cup preferably before bedtime. Repeat the next day if needed. Peppermint Smooth Move(R) SENNA will generally produce bowel movements in 6 to 12 hours. How does it taste? Pleasantly aromatic and bittersweet.

Formulation

Caffeine Free Herbal Tea

Certified by the California Certified Organic Farmers (CCOF). 100% organic ingredients.

Seals/Symbols

California Certified Organic Farmers CCOF

K

USDA ORGANIC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Peppermint Smooth Move Senna by Traditional Medicinals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Peppermint Smooth Move Senna label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Peppermint Smooth Move Senna by Traditional Medicinals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tea Bag(s) Dosage formOther (e.g. Tea Bag) Servings per container16 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

920 mg per serving

All Herbal Ingredients

0 NP per serving

Organic Senna

1080 mg per serving
Interaction report

Peppermint Smooth Move Senna by Traditional Medicinals Drug Interactions

Want to check YOUR meds against Peppermint Smooth Move Senna?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,099Drugs
1,039 Moderate 60 Minor

Ingredients driving the most interactions

organic licorice 1,040
organic Peppermint 796
organic bitter Fennel 740

Individual Drug Interactions

The ingredients in Peppermint Smooth Move Senna interact with 1,099 drugs. Click any drug to see the details.

3 of the 5 ingredients in Peppermint Smooth Move Senna interact with drugs. Each result below shows which ingredient is responsible. organic licorice organic Peppermint organic bitter Fennel

Each ingredient & the kinds of drugs it affects

For each ingredient in Peppermint Smooth Move Senna with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic licorice18 drug types · 1,040 drugs

Antihypertensive Drugs

Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.

Likelihood Possible Evidence B
Cisplatin (Platinol-Aq)

Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.

Likelihood Possible Evidence D
Corticosteroids

Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.

Likelihood Possible Evidence D
Estrogens

Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.

Likelihood Possible Evidence D
Loop Diuretics

Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.

Likelihood Possible Evidence D
Paclitaxel (Abraxane, Onxol)

Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.

Likelihood Unlikely Evidence D
organic licorice full monograph & interactions

organic Peppermint5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
organic Peppermint full monograph & interactions

organic bitter Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
organic bitter Fennel full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Peppermint Smooth Move Senna, from the product label.

Traditional Medicinals

See all Traditional Medicinals products
Web Address
www.TraditionalMedicinals.com
Pharmacist Counseling Corner

Peppermint Smooth Move Senna by Traditional Medicinals: Common Questions

Does Peppermint Smooth Move Senna by Traditional Medicinals interact with any medications?
Yes. Based on its ingredients, Peppermint Smooth Move Senna has a known interaction with 1,099 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Peppermint Smooth Move Senna contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
The safety data advises against it in pregnancy — fennel and licorice have possible hormone-like effects with limited safety data, and licorice is flagged as unsafe. For breastfeeding, peppermint tea in food amounts is likely safe, but concentrated fennel and licorice supplements aren't well studied. Talk with your doctor or pharmacist about what's right for you.
What is this product actually supposed to help with?
Peppermint is well established for irritable bowel syndrome and indigestion. Fennel may help with period pain. The senna component (a stimulant laxative) is included for bowel regularity, though we don't have detailed effectiveness data for it on file. The licorice and other herbs are supporting players.
What are the most common side effects I might feel?
From peppermint, you might notice stomach pain, bloating, diarrhea, dry mouth, heartburn, nausea, or a burning sensation near the anus. Fennel can cause stomach upset, sun sensitivity, or allergic reactions in sensitive people. Licorice in this blend is likely in small amounts, but high-dose licorice can cause headache, nausea, or vomiting.
Can I take this with my blood thinner or birth control?
Both fennel and licorice have documented interactions with blood thinners at Moderate severity, and fennel may reduce how well birth control works. Don't guess — use the medication checker on this page with your exact drugs, or talk to your pharmacist or doctor before starting.
How much licorice is actually in this tea?
The product label lists organic licorice as an ingredient, but we don't have the exact amount on file. Since licorice's safety and interactions depend heavily on dose, ask the manufacturer or your pharmacist how much is in each serving.
Is peppermint safe for my digestive problems?
Peppermint is likely effective for IBS and possibly effective for indigestion — it's one of the better-studied herbs for these issues. Peppermint tea in food amounts is generally well tolerated, though concentrated oil needs care. If you have severe reflux or other conditions, check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Peppermint Smooth Move Senna label
Go deeper

The Full Monographs Behind Peppermint Smooth Move Senna’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Licorice

Interacts with 1,040 drugs

Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...

Read the full Licorice monograph →
Sources

Sources & How We Checked

Peppermint Smooth Move Senna's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 150 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
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See these in context on the Licorice monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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