Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Peppermint Soothe Ingredients & Drug Interactions

by Nature's Way

Peppermint Soothe label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Peppermint Soothe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Peppermint Soothe is a dietary supplement by Nature's Way with 3 active ingredients. Its ingredients are commonly taken for memory and concentration, digestive upset, hair growth.Based on those ingredients, 1,058 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Peppermint whole plant Oil, Thyme whole plant Oil, Rosemary leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Peppermint Soothe by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Peppermint Soothe by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Peppermint Soothe by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Peppermint Soothe contains 3 active ingredients: rosemary leaf extract, peppermint whole plant oil, and thyme whole plant oil. These are delivered in a softgel capsule along with inactive ingredients—gelatin, glycerin, ethylcellulose, silica, sodium alginate, medium-chained triglycerides, oleic acid, and stearic acid—that serve as the capsule structure and to help mix the oils evenly.

Rosemary is a culinary herb used in traditional medicine for memory support. Peppermint is well studied for digestive comfort, particularly irritable bowel syndrome symptoms.

Thyme is included for its traditional uses, though less clinical evidence supports its specific applications in this formulation.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive comfort.
  • We looked for evidence on: Abdominal pain, Dyspepsia, Irritable bowel syndrome (IBS), Postoperative ileus, Indigestion, Gas — and 1 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Peppermint is rated "Possibly Effective" for Dyspepsia.
  • Also on file: Peppermint is rated "Insufficient Reliable Evidence To Rate" for Abdominal pain, Postoperative ileus.

Peppermint oil in this product has the strongest evidence: it's likely effective for irritable bowel syndrome (IBS) and possibly effective for indigestion (dyspepsia), nausea from chemotherapy, and reducing spasm during medical procedures. Rosemary is possibly effective for memory, though the evidence for age-related cognitive decline and other uses is insufficient.

The evidence for thyme's effectiveness in this product is not established in the data we hold—studies haven't reliably shown it works for bronchitis, skin aging, or hair loss.

The evidence, ingredient by ingredient Rosemary Peppermint Thyme

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rosemary is safe in normal culinary amounts, but concentrated extracts and essential oils require caution. Peppermint tea and food amounts are generally well tolerated; concentrated peppermint oil should be used carefully because it can cause abdominal pain, anal burning, heartburn, nausea, and diarrhea, and in large amounts may cause chemical burns.

Thyme is safe as a food and in tea, but the concentrated essential oil can be toxic if swallowed. One case of severe allergic reaction (anaphylaxis) to peppermint has been reported, and topical use of any of these oils can cause contact dermatitis or skin irritation in sensitive people.

For pregnancy, rosemary is rated possibly unsafe—medicinal or large doses should be avoided, though culinary amounts are likely fine. Peppermint is likely safe in pregnancy and lactation.

Thyme is likely safe in pregnancy and lactation, though concentrated essential oil doses should be avoided. If you're pregnant, breastfeeding, or planning to become pregnant, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Rosemary Peppermint Thyme

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Rosemary, Peppermint, Thyme.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,059 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Peppermint Soothe, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (Moderate risk of increased bleeding), diabetes medications (Moderate risk of low blood sugar), aspirin or salicylate-containing pain relievers (Moderate risk of additive effects), cyclosporine (Moderate risk of higher levels and side effects), medications broken down by CYP2C19, CYP2C9, or CYP3A4 enzymes (Moderate risk of raised drug levels), estrogen replacement therapy (Moderate risk of reduced effectiveness), or anticholinergic or cholinergic drugs for neurological conditions (Moderate risk of reduced or additive effects). No interactions are documented in our data for the inactive ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Peppermint Soothe may help with IBS and indigestion, and it's generally well tolerated at food and tea amounts. If you take blood thinners, diabetes medications, cyclosporine, estrogen replacement, or drugs for Parkinson's disease or myasthenia gravis—or any prescription medication—run this product through the interaction checker on this page before you start.

Discuss it with your doctor or pharmacist to confirm it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Peppermint Soothe, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948084661
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251975
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Peppermint Soothe by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
763948084661
IngredientAmount% DV
Rosemary leaf extract0.02 mL--
Peppermint whole plant Oil0.2 mL--
Thyme whole plant Oil0.02 mL--

Other ingredients: Gelatin, Glycerin, Ethylcellulose, Silica, Sodium Alginate, Medium-Chained Triglycerides, Oleic Acid, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Digestive comfort

Gluten free. No yeast-derived ingredients, corn, wheat, soy, dairy products, or artificial colors, flavors, or preservatives.

Premium extract

General Statements

At Nature's Way, we believe nature knows best. That's why our mission is to seek out the best herbs the earth has to give. We will go to any continent or country to find where herbs grow best, so we can bring you the purest botanicals possible. It's the way we deliver uncompromising quality and the way to help you live healthier. It's not just our way, it's Nature's Way.

Nature's Way - Since 1969

Bottles made from 97% post-consumer recycled plastic

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 softgel three times daily between meals.

Precautions

Warning: Do not use this product if you are pregnant or nursing. If you are taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Brand IP Statement(s)

Copyright 2020 Distributed by Nature's Way Brands, LLC (previously branded Enzymatic Therapy, LLC)

Seals/Symbols

Quality Global Sourcing - Bottled & Tested in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Peppermint Soothe by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Peppermint Soothe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Peppermint Soothe by Nature's Way

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rosemary leaf extract

Interacts with
372 drugs
0.02 mL per serving

Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory...

Rosemary leaf extract monograph & interactions

Peppermint whole plant Oil

Interacts with
796 drugs
0.2 mL per serving

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...

Peppermint whole plant Oil monograph & interactions

Thyme whole plant Oil

Interacts with
379 drugs
0.02 mL per serving

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found i...

Thyme whole plant Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Ethylcellulose, Silica, Sodium Alginate, Medium-Chained Triglycerides, Oleic Acid, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Peppermint Soothe by Nature's Way Drug Interactions

Want to check YOUR meds against Peppermint Soothe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,058Drugs
1,009 Moderate 49 Minor

Ingredients driving the most interactions

Peppermint whole plant Oil 796
Thyme whole plant Oil 379
Rosemary leaf extract 372

Individual Drug Interactions

The ingredients in Peppermint Soothe interact with 1,058 drugs. Click any drug to see the details.

3 of the 3 ingredients in Peppermint Soothe interact with drugs. Each result below shows which ingredient is responsible. Peppermint whole plant Oil Thyme whole plant Oil Rosemary leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Peppermint Soothe with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Peppermint whole plant Oil5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint whole plant Oil full monograph & interactions

Thyme whole plant Oil4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Thyme whole plant Oil full monograph & interactions

Rosemary leaf extract6 drug types · 372 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Aspirin

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.

Likelihood Possible Evidence D
Choline Magnesium Trisalicylate (Trilisate)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Salsalate (Disalcid)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Unlikely Evidence D
Rosemary leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Peppermint Soothe, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC (previously branded Enzymatic Therapy, LLC)
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Peppermint Soothe by Nature's Way: Common Questions

Does Peppermint Soothe by Nature's Way interact with any medications?
Yes. Based on its ingredients, Peppermint Soothe has a known interaction with 1,058 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Peppermint Soothe contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually work for IBS?
Peppermint oil in this product is likely effective for irritable bowel syndrome. The evidence is strongest for this use compared to the other ingredients and conditions in the formula.
Is it safe to take if I'm pregnant or breastfeeding?
Peppermint and thyme are likely safe during pregnancy and lactation. Rosemary, though, is rated possibly unsafe—medicinal or large doses should be avoided during pregnancy, though culinary amounts are probably fine. Talk with your doctor or pharmacist about whether this specific product is appropriate for you.
What are the most common side effects?
Peppermint oil most commonly causes abdominal pain, anal burning, belching, diarrhea, dry mouth, heartburn, nausea, and vomiting. Topically, all three oils can cause burning, irritation, dermatitis, and redness. Allergic reactions are rare but have been reported.
Can I take this if I'm on aspirin?
Rosemary contains salicylates and might add to aspirin's effects. This is a Moderate-severity interaction—check with your doctor or pharmacist before combining them.
What is rosemary extract in here supposed to do?
Rosemary is included for memory support and is rated possibly effective for that use. The evidence for other purposes like liver health or hair loss is not established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Peppermint Soothe is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Peppermint Soothe label
Go deeper

The Full Monographs Behind Peppermint Soothe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rosemary

Interacts with 372 drugs

Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...

Read the full Rosemary monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph →
Sources

Sources & How We Checked

Peppermint Soothe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 79 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rosemary 20 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  6. Cartier LC, Lehrer A, Malo JL. Occupational asthma caused by aromatic herbs. Allergy 1996;51:647-9. DOI
  7. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  8. Swain AR, Dutton SP, Truswell AS. Salicylates in foods. J Am Diet.Assoc 1985;85(8):950-60. DOI
  9. Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-7. PubMed
  10. Debersac P, Heydel JM, Amiot MJ, et al. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39(9):907-18. PubMed
  11. Debersac P, Vernevaut MF, Amiot MJ, et al. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39(2):109-17. PubMed
  12. Lee JJ, Jin YR, Lee JH, et al. Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Planta Med 2007;73(2):121-7.
  13. Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
  14. Naemura A, Ura M, Yamashita T, et al. Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 2008;122(4):517-22. PubMed
  15. Lee JJ, Jin YR, Lim Y, et al. Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. Vascul Pharmacol 2006;45:148-53. PubMed
  16. Bakirel, T., Bakirel, U., Keles, O. U., Ulgen, S. G., and Yardibi, H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 2-28-2008;116(1):64-73. PubMed
  17. Erenmemisoglu, A., Saraymen, R., and Ustun, S. Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice. Pharmazie 1997;52(8):645-646.
  18. Valones MAA, Silva ICG, Gueiros LAM, Leão JC, Caldas AF Jr, Carvalho AAT. Clinical assessment of rosemary-based toothpaste (Rosmarinus officinalis Linn.): A randomized controlled double-blind study. Braz Dent J. 2019;30(2):146-151. PubMed
  19. Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, et al. A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD). J Popul Ther Clin Pharmacol. 2019;26(4):e18-e28.
  20. Al Jamal A. Effect of rosemary (Rosmarinus officinalis) on lipid profiles and blood glucose in human diabetic patients (type-2). African J. Biochem. Res. 2014;8(8):147-50. DOI

See these in context on the Rosemary monograph →

Peppermint 41 references
  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
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See these in context on the Peppermint monograph →

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See these in context on the Thyme monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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