Perfect Mushroom Immunity 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Perfect Mushroom Immunity 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Perfect Mushroom Immunity 500 mg is a dietary supplement by Perfect Supplements with 3 active ingredients. Its ingredients are commonly taken for immune support, antioxidant support, general wellness/tonic.Based on those ingredients, 494 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Blend, Chaga. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Perfect Mushroom Immunity 500 mg by Perfect Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Perfect Mushroom Immunity 500 mg by Perfect Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Perfect Mushroom Immunity 500 mg by Perfect Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Perfect Mushroom Immunity contains three active mushroom ingredients: Turkey Tail, Chaga, and Reishi Blend — each 500 mg per capsule. These are whole or extracted mushroom materials traditionally used in foods and supplements to support immune function.
The capsule itself is made from pullulan, an inactive ingredient that forms the capsule shell.
Does it work?
Not established
The evidence for what these mushrooms can actually do is limited. Chaga has been studied for heart disease, diabetes, and COVID-19, but we don't have enough reliable evidence yet to rate how well it works for any of those.
Reishi Blend shows possibly ineffective evidence for lowering cholesterol, and insufficient evidence for altitude sickness, Alzheimer's disease, and athletic performance. None of the three ingredients have established effectiveness ratings for immune support itself in our data.
How safe is it?
Well-documented data
Chaga and Reishi Blend are generally well tolerated when used short-term, though long-term safety isn't well studied. Reishi can cause dizziness, dry mouth, itching, nausea, rash, stomach upset, sore throat, and runny nose in some people, and rarely insomnia or headache.
Chaga is generally used in foods and teas, but human safety data are limited. In rare cases, very high amounts of chaga have caused kidney problems because chaga contains high concentrations of oxalate.
For pregnancy and breastfeeding, the safety data aren't there — both chaga and reishi have insufficient information, so it's best to avoid them during pregnancy and while breastfeeding unless your doctor says otherwise.
Meds to double-check
Moderate interaction found
Before taking this product, double-check any blood thinners (anticoagulants or antiplatelet drugs) you're on — both chaga and reishi may increase bleeding risk at Moderate severity. Also check blood pressure medications (reishi may lower blood pressure further) and diabetes drugs (both chaga and reishi may lower blood sugar).
We could not check Turkey Tail for interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product is for people interested in mushroom supplements for immune support, but effectiveness isn't proven in our data. If you take blood thinners, blood pressure medications, or diabetes drugs, check your specific medications with the tool below before starting — the risks are theoretical but documented.
Talk with your pharmacist or doctor before use, especially if you're pregnant, breastfeeding, or have kidney concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Perfect Mushroom Immunity 500 mg, straight from the product label.
| Brand | Perfect Supplements |
|---|---|
| Barcode (UPC) | 793888502932 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 329222 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Perfect Mushroom Immunity 500 mg by Perfect Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Turkey Tail | 500 mg | -- |
| Chaga | 500 mg | -- |
| Reishi Blend | 500 mg | -- |
Other ingredients: Pullulan
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Three Simple ingredients: made with mycelial biomass & fruit body of 100% pure chaga, reishi, and turkey tail. Perfect health benefits: These mushrooms strengthen the body's natural defenses & healing mechanisms, and can increase general well being. Mushroom Immunity is lab tested for a minimum of 225 mg of beta glucans per serving.
Chaga, reishi, & turkey tail Mushroom trio blend Perfect Mushroom Immunity 500 mg each
Formulation
Sustainable, ethical transparent: Grown without toxic pesticides, fertilizers, or GMOs.
Sustainable, ethical, transparent: Grown without toxic pesticides, fertilizers, or GMOs. Each batch is independently lab tested.
Made with organic mushrooms
Vegan
Gluten free Non-GMO
This product has been certified organic by Organic Certifiers Inc., under NOP Final Rule 7, CFR Part 205. www.organiccertifiers.com
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Vegan Lab tested USA grown
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Usage: Take 3 capsules daily.
Storage
Store in a cool dry place.
Precautions
Manufactured in a facility that processes milk, egg, soy, tree nuts, fish, & shellfish.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Perfect Mushroom Immunity 500 mg by Perfect Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Perfect Mushroom Immunity 500 mg by Perfect Supplements
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Turkey Tail
Chaga
Interacts with327 drugs
Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...
Chaga monograph & interactionsReishi Blend
Interacts with375 drugs
Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...
Reishi Blend monograph & interactionsOther (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.
Perfect Mushroom Immunity 500 mg by Perfect Supplements Drug Interactions
HelloPharmacist Interaction Report
Perfect Mushroom Immunity 500 mg contains three mushroom ingredients, and two of them carry documented interactions.
Chaga and Reishi Blend both interact with blood thinners (anticoagulants and antiplatelet drugs) at Moderate severity — they may theoretically increase bleeding risk, though this hasn't been seen in people.
Read the full breakdown — every affected drug type, severity by severity
Chaga also interacts with immune-suppressing medications (Moderate severity) and diabetes drugs (Moderate severity). The immune interaction could theoretically interfere with how those medications work.
The diabetes concern is a theoretical risk of low blood sugar (hypoglycemia) if chaga lowers blood glucose on its own.
Reishi Blend shares the diabetes interaction (Moderate severity) — animal work suggests it lowers blood sugar, though human studies are mixed. It also interacts with blood pressure medications (Moderate severity); reishi has shown blood pressure-lowering activity in animals and in some people with high blood pressure, so taking it with a blood pressure drug could theoretically lower your pressure too much.
Turkey Tail is the third ingredient, but we could not check it — we hold no interaction data for it. Altogether, these interactions span 487 individual medications.
Use the medication checker below to see if any of your exact drugs are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Perfect Mushroom Immunity 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Perfect Mushroom Immunity 500 mg interact with 494 drugs. Click any drug to see the details.
2 of the 3 ingredients in Perfect Mushroom Immunity 500 mg interact with drugs. Each result below shows which ingredient is responsible. Reishi Blend Chaga
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Abciximab interactionChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Abrocitinib interactionChagaAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
ChagaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Chaga + Acarbose interactionReishi BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Blend + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Reishi BlendAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Blend + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Acenocoumarol interactionChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
ChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Acetaminophen, Aspirin interactionReishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Acetaminophen, Aspirin, Caffeine interactionChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Acetaminophen, Ibuprofen interactionChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Reishi BlendAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Blend + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
ChagaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Chaga + Acetohexamide interactionReishi BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Blend + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
ChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Acetylsalicylic Acid interactionReishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
ChagaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Chaga + Albiglutide interactionReishi BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Blend + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
ChagaImmunosuppressants Moderate
Interaction Summary
Theoretically, chaga might interfere with immunosuppressive therapy.
Read the full Chaga + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Reishi BlendAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Blend + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Blend + Alogliptin interactionChagaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Chaga + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
ChagaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Chaga + Alogliptin, Metformin interactionReishi BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Blend + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Blend + Alogliptin, Pioglitazone interactionChagaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Chaga + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Alteplase, Tpa interactionChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
ChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionReishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Perfect Mushroom Immunity 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Reishi BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Blend + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionChagaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chaga + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Perfect Mushroom Immunity 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Reishi BlendAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Blend + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Perfect Mushroom Immunity 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Reishi Blend
Anticoagulant/Antiplatelet Drugs
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.
Antidiabetes Drugs
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.
Antihypertensive Drugs
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.
Chaga
Anticoagulant/Antiplatelet Drugs
Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.
Antidiabetes Drugs
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.
Immunosuppressants
Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.
Brand information
Manufacturer and brand details for Perfect Mushroom Immunity 500 mg, from the product label.
Perfect Supplements
See all Perfect Supplements products- Name
- Perfect Supplements, LLC
- Street Address
- PO Box 60070
- City
- Florence
- State
- MA
- ZipCode
- 01062
- Phone Number
- 1-866-802-3860
- Web Address
- www.perfectsupplements.com
Perfect Mushroom Immunity 500 mg by Perfect Supplements: Common Questions
Does Perfect Mushroom Immunity 500 mg by Perfect Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the side effects?
Does this actually boost immunity?
How much chaga is in each capsule?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Perfect Mushroom Immunity 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Perfect Mushroom Immunity 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Chaga
Interacts with 327 drugsChaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...
Read the full Chaga monograph → Herb & supplement monographReishi Mushroom
Interacts with 375 drugsReishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...
Read the full Reishi Mushroom monograph →Sources & How We Checked
Perfect Mushroom Immunity 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Chaga 9 references
- Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008;118(1):7-13. PubMed
- Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. PubMed
- Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. PubMed
- Kikuchi Y, Seta K, Ogawa Y, et al. Chaga mushroom-induced oxalate nephropathy. Clin Nephrol 2014;81(6):440-4. PubMed
- Lee S, Lee HY, Park Y, et al. Development of end stage renal disease after long-term ingestion of chaga mushroom: case report and review of literature. J Korean Med Sci. 2020;35(19):e122.
- Kwon O, Kim Y, Paek JH, et al. Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report. Medicine (Baltimore) 2022;101(10):e28997. PubMed
- Su L, Xin C, Yang J, et al. A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus. Int J Biol Macromol 2022;214:312-323. PubMed
- Chen S, Ma Y, Li H, et al. Anti-diabetic e?ects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice. Nutr Hosp 2022;39(6):1256-1263. PubMed
- Ye X, Wu K, Xu L, et al. Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora. Front Endocrinol (Lausanne) 2023;13:1103972. PubMed
Reishi Mushroom 17 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
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