Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Permeability Factors Ingredients & Drug Interactions

by Integrative Therapeutics

Permeability Factors label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Permeability Factors against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Permeability Factors is a dietary supplement by Integrative Therapeutics with 6 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin E, NAG, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Permeability Factors by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Permeability Factors by Integrative Therapeutics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Permeability Factors by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Permeability Factors contains 6 active ingredients. L-glutamine is an amino acid that supports gut health and is used in clinical settings for conditions like sickle cell disease and recovery from surgery or critical illness.

Vitamin E is a fat-soluble antioxidant. NAG (N-acetyl glucosamine) supports joint and connective tissue health and is commonly used for osteoarthritis.

Gamma-linolenic acid is an omega-6 fatty acid. Sunflower lecithin is a phospholipid derived from sunflower seeds that supports cell membrane function.

Gamma-oryzanol, extracted from rice bran, is used for cholesterol support. The product is delivered as a softgel capsule with inactive ingredients including gelatin, safflower oil, glycerin, purified water, beeswax, caramel color, and titanium dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Glutamine) (Natural Medicines).
  • On file: Vitamin E deficiency — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Ataxia with vitamin E deficiency (AVED) — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Osteoarthritis — rated "Likely Effective" (Glucosamine) (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Glutamine) (Natural Medicines).

The evidence for these ingredients varies. L-glutamine is rated effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting and recovery after surgery or critical illness.

Vitamin E is effective for vitamin E deficiency and a rare genetic condition called AVED (ataxia with vitamin E deficiency), and possibly effective for Alzheimer disease, beta-thalassemia, and G6PD deficiency. NAG is rated likely effective for osteoarthritis.

Gamma-oryzanol is possibly effective for high cholesterol (dyslipidemia). Sunflower lecithin shows insufficient evidence for most uses we hold data on—it's rated likely ineffective for Alzheimer disease but evidence is unclear for age-related cognitive decline and other conditions.

Gamma-linolenic acid's effectiveness ratings are not on file.

The evidence, ingredient by ingredient Glutamine Vitamin E Lecithin Glucosamine Gamma-oryzanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults but should be used only under medical supervision if you have kidney or liver disease. People with bipolar disorder should be aware that in rare reports, glutamine has been associated with mania or hypomania.

The most common side effects are gastrointestinal—belching, bloating, constipation, flatulence, nausea, vomiting, and diarrhea. Vitamin E at dietary amounts is safe, but high-dose supplements may increase bleeding risk, especially over the long term, and have been associated with rare serious effects including hemorrhagic stroke.

NAG is generally well tolerated but quality varies between products. Common side effects include bloating, constipation, cramps, diarrhea, heartburn, and nausea.

Rare allergic reactions have been reported, particularly in people with egg or soy allergies, and a small number of cases of asthma worsening have been linked to glucosamine-chondroitin products. Sunflower lecithin is generally well tolerated; common side effects are abdominal pain, diarrhea, fullness, and nausea.

Gamma-oryzanol is generally well tolerated in studies, though long-term safety is not well established. For pregnancy: L-glutamine and sunflower lecithin are rated likely safe.

Vitamin E from food and prenatal vitamins is appropriate, but high-dose supplements should be avoided unless your doctor recommends them. NAG and gamma-oryzanol lack sufficient safety data and should be avoided unless advised by your doctor.

For breastfeeding: L-glutamine lacks sufficient data—check with your clinician before taking supplement doses. Vitamin E at normal dietary amounts is fine, but high-dose supplements require your doctor's approval.

NAG and gamma-oryzanol should be avoided unless your doctor advises otherwise.

Side effects, ingredient by ingredient Glutamine Vitamin E Lecithin Glucosamine Gamma-oryzanol

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Glucosamine, Glutamine, Vitamin E.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 922 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take warfarin or other blood thinners (anticoagulants) or antiplatelet drugs—both vitamin E and NAG may increase bleeding risk. If you're on chemotherapy, especially alkylating agents, antitumor antibiotics, or topoisomerase II inhibitors, vitamin E and NAG may interfere with effectiveness.

Anticonvulsants (seizure medications) may be antagonized by L-glutamine, though this hasn't been documented in humans. If you take cyclosporine, CYP3A4 substrates (a large class of drugs), niacin, diabetes medications, or acetaminophen, discuss this product with your healthcare provider beforehand.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product may be considered by people looking to support gut permeability and joint health, particularly those with osteoarthritis. However, it's not for everyone—if you take warfarin, anticoagulants, antiplatelet drugs, chemotherapy, cyclosporine, niacin, diabetes medications, or acetaminophen regularly, you'll need to clear it with your doctor or pharmacist first because of documented interactions.

Pregnant or breastfeeding individuals should discuss it with their healthcare provider before starting, as safety data varies by ingredient.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Permeability Factors, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791000520
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 265948
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Permeability Factors by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
45
UPC/BARCODE
871791000520
IngredientAmount% DV
Calories20 Calorie(s)--
L-Glutamine500 mg--
Vitamin E7.5 mg50%
Total Fat1.5 Gram(s)2%
Saturated Fat0 Gram(s)--
Trans Fat0 Gram(s)--
Gamma-Linolenic Acid133 mg--
Sunflower Lecithin170 mg--
NAG250 mg--
Gamma Oryzanol66 mg--

Other ingredients: Gelatin, Safflower Oil, Glycerin, Water, Purified, Beeswax, Caramel color, Titanium Dioxide color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For more information, please visit integrativepro.com.

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Contains shellfish (crab and shrimp).

Caution: If you are pregnant, nursing, have active liver disease, or are taking prescription drugs, consult a healthcare professional prior to use.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Seals/Symbols

Quality Global Sourcing Bottled & Tested in the USA

Formulation

Contains no wheat, gluten, or dairy.

Intestinal permeability complex

Brand IP Statement(s)

Copyright 2021 Distributed by Integrative Therapeutics, LLC

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults swallow 1 or 2 softgels three times daily, or as recommended by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Permeability Factors by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Permeability Factors label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Permeability Factors by Integrative Therapeutics

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Vitamin E

Interacts with
764 drugs
7.5 mg per serving Form: D-Alpha-Tocopheryl Acetate

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Gamma-Linolenic Acid

133 mg per serving Form: Borage Seed Oil

Sunflower Lecithin

No known
interactions
170 mg per serving Form: Phosphatidylcholine

Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting...

Sunflower Lecithin monograph & interactions

NAG

Interacts with
170 drugs
250 mg per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

NAG monograph & interactions

Gamma Oryzanol

No known
interactions
66 mg per serving Form: Rice Bran Oil

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The...

Gamma Oryzanol monograph & interactions

Other (inactive) ingredients: Gelatin, Safflower Oil, Glycerin, Water, Purified, Beeswax, Caramel color, Titanium Dioxide color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Permeability Factors by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Permeability Factors?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
921Drugs
2 Major 805 Moderate 114 Minor

Ingredients driving the most interactions

Vitamin E 764
NAG 170
L-Glutamine 50

Individual Drug Interactions

The ingredients in Permeability Factors interact with 921 drugs. Click any drug to see the details.

3 of the 6 ingredients in Permeability Factors interact with drugs. Each result below shows which ingredient is responsible. Vitamin E NAG L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Permeability Factors with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

NAG4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
NAG full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Permeability Factors, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
800.931.1709
Web Address
integrativepro.com
Pharmacist Counseling Corner

Permeability Factors by Integrative Therapeutics: Common Questions

Does Permeability Factors by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Permeability Factors has a known interaction with 921 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Permeability Factors contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is NAG, and why is it in this product?
NAG stands for N-acetyl glucosamine, a form of glucosamine that supports joint and connective tissue health. It's rated likely effective for osteoarthritis, which is why it's included in a permeability-support formula—healthy connective tissue supports healthy barriers in your body.
Can I take this if I'm pregnant?
It depends on which ingredient you're concerned about. L-glutamine and sunflower lecithin are rated likely safe in pregnancy. Vitamin E from food and prenatal vitamins is appropriate, but high-dose supplements should be avoided unless your doctor recommends them. NAG and gamma-oryzanol lack sufficient safety data in pregnancy, so talk with your doctor first.
What are the most common side effects?
The most common side effects are gastrointestinal and mild: bloating, constipation, diarrhea, nausea, and flatulence—mostly from the L-glutamine and NAG. These usually settle as your body adjusts, but if they persist or worsen, lower your dose or stop and check with your pharmacist.
Will this interfere with my diabetes medication?
NAG was once thought to worsen diabetes, but current evidence suggests it's unlikely to interfere with how diabetes drugs work. Still, because individual responses vary, mention this product to your doctor or pharmacist before starting, especially if your blood sugar is already hard to control.
Is vitamin E in this product safe?
Vitamin E at the dietary amounts found in food and typical supplements is generally safe. However, this product contains a softgel, and high-dose vitamin E supplements over the long term may raise bleeding risk, especially if you're already on blood thinners. Check the label for the exact dose, and discuss it with your doctor if you take anticoagulants or have bleeding concerns.
What does gamma-oryzanol do?
Gamma-oryzanol is a compound from rice bran that's rated possibly effective for high cholesterol (dyslipidemia). Evidence for other uses is unclear or insufficient, so it's mainly included here for its potential cholesterol support as part of a broader permeability-support formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Permeability Factors label
Go deeper

The Full Monographs Behind Permeability Factors’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Lecithin

Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting most of its health claims is limited, t...

Read the full Lecithin monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Gamma-oryzanol

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...

Read the full Gamma-oryzanol monograph →
Sources

Sources & How We Checked

Permeability Factors's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 142 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
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Glucosamine 58 references
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