Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Pharmepa Maintain Ingredients & Drug Interactions

by Igennus Healthcare Nutrition

Pharmepa Maintain label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pharmepa Maintain against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pharmepa Maintain is a dietary supplement by Igennus Healthcare Nutrition with 6 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 996 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Vitamin D3, Omega-3 rTG concentrated Fish Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pharmepa Maintain by Igennus Healthcare Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Pharmepa Maintain by Igennus Healthcare Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pharmepa Maintain by Igennus Healthcare Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “Fat” is listed as a grouped ingredient — the label gives one combined amount (2,082 mg) without saying how much of each component you get.
  • “Omega-3 rTG concentrated Fish Oil” is listed as a grouped ingredient — the label gives one combined amount (1,365 mg) without saying how much of each component you get.
  • “virgin Evening Primrose Oil” is listed as a grouped ingredient — the label gives one combined amount (717 mg) without saying how much of each component you get.

Pharmepa Maintain contains 7 active ingredients centered on essential fatty acids and fat-soluble vitamins. You get eicosapentaenoic acid and docosahexaenoic acid (omega-3 fatty acids from fish oil), gamma-linolenic acid (an omega-6 from evening primrose oil), vitamin D3, and vitamin E, along with polyunsaturated and monounsaturated fats.

The product also includes inactive ingredients — the capsule shell, lemon oil for flavoring, and additional vitamin E as a preservative.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Omega-3 and omega-6 fatty acid support.
  • We looked for evidence on: Age-related cognitive decline, Age-related macular degeneration (AMD), Alzheimer disease, Anxiety, Atherosclerosis, Atrial fibrillation — and 4 related terms.
  • The strongest evidence on file: Vitamin E is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Vitamin D is rated "Possibly Ineffective" for Cardiovascular disease (CVD).
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Age-related macular degeneration (AMD), Atherosclerosis.

Vitamin D3 in this product is effective for treating vitamin D deficiency states: familial hypophosphatemia, osteomalacia (soft bones), renal bone disease, rickets, and hypoparathyroidism. Vitamin E is effective for vitamin E deficiency itself and ataxia caused by vitamin E deficiency; it's possibly effective for Alzheimer disease, beta-thalassemia, G6PD deficiency, and intracranial hemorrhage.

We do not hold effectiveness data for the fish oil fatty acids or evening primrose oil in this product.

The evidence, ingredient by ingredient Vitamin D Vitamin E Docosahexaenoic Acid (dha)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses, though very high doses taken over time can cause toxicity with symptoms of high blood calcium (hypercalcemia), kidney damage, and anemia. It's likely safe in pregnancy at recommended amounts and likely safe while breastfeeding, though pregnancy use should be under your doctor's guidance; the data flags a possibly unsafe rating as well, so discuss your specific situation with your doctor.

Vitamin E is also generally well tolerated at dietary amounts, but high-dose long-term supplements may increase bleeding risk and other harms. It's possibly safe in pregnancy (avoid high doses unless directed by your doctor) and likely safe while breastfeeding at normal dietary amounts, though there is a possibly unsafe rating for breastfeeding at higher doses.

We do not hold safety data on file for the fish oil components or evening primrose oil.

Side effects, ingredient by ingredient Vitamin D Vitamin E Docosahexaenoic Acid (dha)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin D, Vitamin E.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; heart-rhythm medications.
  • For scale: 833 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pharmepa Maintain, double-check these medication types with your doctor or pharmacist: heart rhythm drugs (digoxin, verapamil, diltiazem), blood thinners and antiplatelet agents (including warfarin), thiazide diuretics, atorvastatin or other CYP3A4 substrates, chemotherapy (alkylating agents and antitumor antibiotics), cyclosporine, calcipotriene, and niacin. No interactions are documented for the fish oil or evening primrose oil ingredients we hold data for.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pharmepa Maintain may suit someone looking to support omega-3 intake and vitamin D and E status, especially if they have a documented deficiency in vitamin D. If you take any heart medications (digoxin, verapamil, diltiazem), blood thinners (warfarin), chemotherapy, or thiazide diuretics, you'll want to discuss this product with your doctor or pharmacist before starting.

Pregnancy and breastfeeding both require personalized guidance — check with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pharmepa Maintain, straight from the product label.

Brand Igennus Healthcare Nutrition
Net contents 60 Easy-To-Swallow Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 249526
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pharmepa Maintain by Igennus Healthcare Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
IngredientAmount% DV
Eicosapentaenoic Acid750 mg--
Docosahexaenoic Acid250 mg--
Polyunsaturated Fat1964 mg--
Monounsaturated Fat54 mg--
Gamma-Linolenic Acid60 mg--
Saturated Fat65 mg--
Vitamin D330 mcg--
Vitamin E9 mg--
Fat2082 mg--
Omega-3 rTG concentrated Fish Oil1365 mg--
Energy0 NP--
virgin Evening Primrose Oil717 mg--

Other ingredients: rTG, Capsule Shell, cold-pressed virgin Evening Primrose Oil, Lemon Oil, Vitamin E

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Food Supplement

Formula

Super-strength wild fish oil & virgin evening primrose oil Omega-3 EPA 750 mg & DHA 250 mg per serving plus omega-6 GLA & vitamins D3 & E 80% super-absorbable triglyceride (rTG) Lemon oil prevents fish reflux

Advanced Omega-3 nutrition for intensive support The body requires regular intake of certain fatty acids to maintain omeg-3 and omega-6 balance. Each daily dose of Pharmepa Maintain provides an optimum ratio of 750 mg EPA, 250 mg DHA and 60 mg GLA for lifelong health, with additional support from vitamins D3 and E. Pharmaceutical-grade 80% Omega-3 concentrate is sourced from wild deep-sea fish and purified to produce an ultra-pure fish oil. The combination of high concentration, strong stability and bioavailability of nature-identical triglyceride (rTG) fish oil makes it the most effective form of omega-3 at delivering EPA and DHA directly into cells where they are needed most.

Halal & kosher

Halal & kosher

Formulation

Sustainable fish oil

Free from PCBs, dioxins & heavy metals

Capsules are small and support split-dosing for optimal absorption. GLA is sourced from virgin cold-pressed evening primrose oil, rich in supportive phytonutrients. Intensive support Omega-3 EPA and DHA support normal heart function with a daily intake of at least 250 mg DHA contributes to the maintenance of normal brain function and normal vision Replacing saturated fats with unsaturated fats in the diet contributes to the maintenance of normal blood LDL cholesterol concentrations DHA intake during pregnancy and breastfeeding contributes to the normal development of the brain eyes of the fetus and breastfed infants, with a daily intake of at least 200 mg Safe & well tolerated

Free from: dairy, gluten, lactose, soya & yeast Not tested on animals, non-GMO, no artificial colours, flavours or preservatives

Independently batch-tested Vitamin E, protective capsules and blister packaging protect the oil against oxidation from air and light

Suggested/Recommended/Usage/Directions

Directions for use Adults: 3 capsules daily Children 12 to 16 years: 2-3 capsules daily Children 4-11 years: 1-2 capsule daily It is not advisable to exceed the recommended dose unless advised by a healthcare practitioner. Take Pharmepa Maintain as a split dose with food for optimum absorption.

Precautions

Seek professional advice before taking any food supplement if are taking medication, pregnant or breastfeeding.

This product should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Keep out of reach of young children.

Storage

Store in a cool, dry place away from direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pharmepa Maintain by Igennus Healthcare Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pharmepa Maintain label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pharmepa Maintain by Igennus Healthcare Nutrition

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D3

Interacts with
715 drugs
30 mcg per serving

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Vitamin E

Interacts with
764 drugs
9 mg per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Fat

2082 mg per serving

Omega-3 rTG concentrated Fish Oil

Interacts with
375 drugs
1365 mg per serving

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and gen...

Omega-3 rTG concentrated Fish Oil monograph & interactions
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Energy

0 NP per serving

Virgin Evening Primrose Oil

717 mg per serving
  • › Gamma-Linolenic Acid

Other (inactive) ingredients: RTG, Capsule Shell, Cold-pressed virgin Evening Primrose Oil, Lemon Oil, Vitamin E. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pharmepa Maintain by Igennus Healthcare Nutrition Drug Interactions

Want to check YOUR meds against Pharmepa Maintain?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
996Drugs
995 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 764
Vitamin D3 715
Omega-3 rTG concentrated Fish Oil 375

Individual Drug Interactions

The ingredients in Pharmepa Maintain interact with 996 drugs. Click any drug to see the details.

3 of the 6 ingredients in Pharmepa Maintain interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Vitamin D3 Omega-3 rTG concentrated Fish Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Pharmepa Maintain with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions

Omega-3 rTG concentrated Fish Oil3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
In people with type 2 diabetes, including those taking oral hypoglycemic medications, DHA seems to increase fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B
Omega-3 rTG concentrated Fish Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pharmepa Maintain, from the product label.

Igennus Healthcare Nutrition

See all Igennus Healthcare Nutrition products
Name
Igennus Healthcare Nutrition
Street Address
St John's Innovation Centre Cowley Road
City
Cambridge
ZipCode
CB4 0WS
Web Address
www.igennus.com
Pharmacist Counseling Corner

Pharmepa Maintain by Igennus Healthcare Nutrition: Common Questions

Does Pharmepa Maintain by Igennus Healthcare Nutrition interact with any medications?
Yes. Based on its ingredients, Pharmepa Maintain has a known interaction with 996 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pharmepa Maintain contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any fillers or just the active ingredients?
The capsule contains the active oils and vitamins plus some inactive ingredients: the capsule shell itself, lemon oil for flavor, and vitamin E as a preservative. No unnecessary fillers are listed.
Can I take this if I'm pregnant or breastfeeding?
Vitamin D3 is likely safe in pregnancy at recommended doses but should be used under your doctor's guidance; there's also a possibly unsafe rating, so discuss your individual situation. Vitamin E is possibly safe in pregnancy at normal amounts — avoid high doses unless directed by your doctor. For breastfeeding, both are rated likely safe at recommended dietary amounts, though vitamin E carries a possibly unsafe rating at higher doses. Talk with your doctor or pharmacist about what's right for you.
What is vitamin D3 in this product actually for?
Vitamin D3 is effective for treating vitamin D deficiency and related bone and calcium disorders: familial hypophosphatemia, osteomalacia (very soft bones), renal bone disease, rickets, and hypoparathyroidism.
Is vitamin E safe to take long term?
At recommended dietary amounts, yes — vitamin E is generally well tolerated. High-dose long-term supplements, though, may raise the risk of bleeding and other complications. Stick to recommended doses and discuss any concerns with your pharmacist or doctor.
What are the fish oil and evening primrose ingredients for?
The product contains omega-3 fatty acids from fish oil and gamma-linolenic acid from evening primrose oil — essential fatty acids that support general health. We don't hold effectiveness data specific to this formulation for those components in our monographs.
What are the serious side effects I should watch for?
Vitamin D toxicity is rare but can occur at very high doses, causing high blood calcium with bone loss in adults or slowed growth in children. Vitamin E at high doses may rarely cause bleeding. Both are well tolerated at recommended amounts; if you experience unusual symptoms, contact your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pharmepa Maintain label
Go deeper

The Full Monographs Behind Pharmepa Maintain’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Docosahexaenoic Acid (dha)

Interacts with 375 drugs

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the stronges...

Read the full Docosahexaenoic Acid (dha) monograph →
Sources

Sources & How We Checked

Pharmepa Maintain's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 139 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
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See these in context on the Docosahexaenoic Acid (dha) monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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