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Dietary supplement

Phenylethylamine HCL (PEA) Ingredients & Drug Interactions

by BulkSupplements.com

Phenylethylamine HCL (PEA) label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phenylethylamine HCL (PEA) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phenylethylamine HCL (PEA) is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for mood support, focus and concentration, energy and pre-workout boost.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phenylethylamine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phenylethylamine HCL (PEA) by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Phenylethylamine HCL (PEA) by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phenylethylamine HCL (PEA) by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phenylethylamine hydrochloride, a compound your body naturally produces in small amounts, especially when you're feeling upbeat or after exercise. The powder form contains no other inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Phenethylamine (pea) product and its label doesn't state a use — see Phenethylamine (pea)'s own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish that PEA works for athletic performance, depression, or weight management — each of these is rated insufficient reliable evidence to rate. That doesn't mean it doesn't work; it means solid clinical trials in humans are lacking for these uses.

The evidence, ingredient by ingredient Phenethylamine (pea)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

PEA may affect your heart rate and blood pressure, and human safety data for supplements is limited. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe for you or your baby.

Isolated case reports mention anxiety, agitation, and rapid heartbeat in people taking weight-loss products that contained PEA along with several other active ingredients — so it's unclear whether PEA alone was responsible.

Side effects, ingredient by ingredient Phenethylamine (pea)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phenethylamine (pea).
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before using if you take serotonergic drugs (like antidepressants and anti-anxiety medications) or monoamine oxidase inhibitors (MAOIs) — both carry a moderate risk of amplified effects. Use the medication search tool on this page to verify your exact prescriptions, and confirm with your doctor or pharmacist before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PEA is a single-ingredient powder with limited human safety data. If you're on an antidepressant, anti-anxiety medication, or an MAOI, talk with your doctor or pharmacist before using it.

If you're pregnant, planning to become pregnant, or breastfeeding, the safety data advises against it. Anyone considering it should discuss it with their own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phenylethylamine HCL (PEA), straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000HHSWHP
Net contents 500 Gram(s); 17.6 Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294575
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phenylethylamine HCL (PEA) by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
150 Milligram(s)
Maximum serving Sizes:
150 Milligram(s)
Servings per container
3333
UPC/BARCODE
X000HHSWHP
IngredientAmount% DV
Phenylethylamine Hydrochloride150 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

Precautions

Phenylketonurics: Contains phenylalanine

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Free of: Added sugar, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 150 mg once daily, or as directed by a physician. Individual needs may vary. Do not exceed recommended dose. Use an accurate milligram scale to measure.

Storage

Store in a dry, cool place

General Statements

New

Formula

Phenylethylamine HCL (Pea) Powder

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phenylethylamine HCL (PEA) by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phenylethylamine HCL (PEA) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phenylethylamine HCL (PEA) by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size150 Milligram(s) Dosage formPowder Servings per container3333 Amounts shown are per serving.

Phenylethylamine Hydrochloride

Interacts with
187 drugs
150 mg per serving

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. R...

Phenylethylamine Hydrochloride monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phenylethylamine HCL (PEA) by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Phenylethylamine HCL (PEA)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

Phenylethylamine Hydrochloride 187

Individual Drug Interactions

The ingredients in Phenylethylamine HCL (PEA) interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phenylethylamine HCL (PEA) interact with drugs. Each result below shows which ingredient is responsible. Phenylethylamine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Phenylethylamine HCL (PEA) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phenylethylamine Hydrochloride2 drug types · 187 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking phenethylamine concomitantly with MAOIs may increase adverse effects.
In humans, phenethylamine is oxidized by MAO-B to form the inactive metabolite phenylacetic acid. Animal research shows that administering an MAOI prior to phenethylamine increases the amphetamine-like effects of phenethylamine. However, low-quality clinical research has used phenethylamine with selegiline, an MAOI, with apparent safety.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.
Animal research shows that phenethylamine increases levels of serotonin, norepinephrine, and dopamine. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of additive serotonergic adverse effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, low-quality clinical research has used phenethylamine with selegiline, a monoamine oxidase inhibitor (MAOI), with apparent safety.

Likelihood Possible Evidence D
Phenylethylamine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phenylethylamine HCL (PEA), from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Road
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Phenylethylamine HCL (PEA) by BulkSupplements.com: Common Questions

Does Phenylethylamine HCL (PEA) by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Phenylethylamine HCL (PEA) has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phenylethylamine HCL (PEA) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phenylethylamine do in the body?
PEA is a compound your body makes naturally that increases levels of serotonin, norepinephrine, and dopamine — neurotransmitters involved in mood and energy. The supplement form is the hydrochloride salt of phenylethylamine.
Is PEA safe to take if I'm pregnant or breastfeeding?
The safety data advises against it during both pregnancy and breastfeeding because there isn't enough information to know whether it's safe. Talk with your doctor or pharmacist about your specific situation.
Can I take PEA with my antidepressant?
PEA interacts with serotonergic drugs — including many antidepressants — at moderate severity, meaning it could add to their effects on serotonin and raise the risk of unwanted side effects. Check your exact medication with your doctor or pharmacist before starting.
Does PEA help with weight loss or athletic performance?
The evidence we hold does not establish that PEA works for weight management or athletic performance. Both are rated insufficient reliable evidence to rate, meaning solid human trials are lacking.
What side effects has PEA been reported to cause?
Case reports mention anxiety, agitation, and rapid heartbeat; however, these came from people taking weight-loss products with PEA plus many other ingredients, so it's unclear whether PEA alone was the cause. PEA may affect heart rate and blood pressure, and human safety data is limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phenylethylamine HCL (PEA) label
Go deeper

The Full Monographs Behind Phenylethylamine HCL (PEA)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phenethylamine (pea)

Interacts with 187 drugs

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement...

Read the full Phenethylamine (pea) monograph →
Sources

Sources & How We Checked

Phenylethylamine HCL (PEA)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenethylamine (pea) 9 references
  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
  3. Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
  4. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
  5. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
  6. Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
  7. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
  8. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
  9. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

See these in context on the Phenethylamine (pea) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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