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Dietary supplement

Phosphatidyl Serine Complex 500 mg Ingredients & Drug Interactions

by Wonder Laboratories

Phosphatidyl Serine Complex 500 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phosphatidyl Serine Complex 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phosphatidyl Serine Complex 500 mg is a dietary supplement by Wonder Laboratories with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Neuro-PS. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phosphatidyl Serine Complex 500 mg by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidyl Serine Complex 500 mg by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phosphatidyl Serine Complex 500 mg by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylserine (Neuro-PS brand), a naturally occurring compound found in cell membranes that plays a role in brain cell communication. The supplement is delivered in a softgel capsule that also contains gelatin, vegetable glycerin, caramel color, titanium dioxide, and a food glaze as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, mental performance — and 2 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease based on the evidence we hold. For athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia, the evidence isn't established enough to rate it reliably.

If you're considering this for memory or focus, talk with your doctor about whether the evidence fits your situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated by most people in studies, though long-term safety data is incomplete. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea—with insomnia more likely at higher doses (600 mg or above) and stomach upset possible at lower doses (200–300 mg daily).

The safety data advises against use during pregnancy and recommends avoiding it while breastfeeding because there isn't enough information to know it's safe in either situation.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check any anticholinergic drugs you take—these include medications for urinary symptoms, motion sickness, and certain eye conditions—since phosphatidylserine may make them less effective. Also confirm any cholinergic drugs (used for myasthenia gravis, Parkinson disease, or glaucoma), because this supplement could add to their effects.

Altogether, these interactions span 219 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phosphatidyl Serine Complex may be worth considering if you're concerned about age-related memory loss or early cognitive decline and your doctor agrees—but it's not proven for sharper focus or ADHD in general. If you take any anticholinergic or cholinergic medication, check with your doctor or pharmacist before starting, since this ingredient may interfere with how those drugs work.

Start with a lower dose if you're prone to stomach upset or insomnia. Have a conversation with your own healthcare provider to make sure it's the right choice for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidyl Serine Complex 500 mg, straight from the product label.

Brand Wonder Laboratories
Net contents 250 Softgel(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 262429
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidyl Serine Complex 500 mg by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
250
IngredientAmount% DV
Neuro-PS500 mg--

Other ingredients: Gelatin, Vegetable Glycerin, natural Caramel color, Titanium Dioxide color, Food Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 softgel daily.

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Contains soy ingredients.

Storage

Keep tightly closed. Store at room temperature: 59 degrees-86 degrees F (15 degrees-30 degrees C).

Brand IP Statement(s)

Neuro-PS is a trademark of Capsule Works.

Formulation

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs) Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Gluten free

Made in USA

General Statements

Formula 443

Formula

Neuro PS Phosphatidylserine

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phosphatidyl Serine Complex 500 mg by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phosphatidyl Serine Complex 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phosphatidyl Serine Complex 500 mg by Wonder Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container250 Amounts shown are per serving.

Neuro-PS

Interacts with
219 drugs
500 mg per serving Form: Phosphatidylserine, Soy Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Neuro-PS monograph & interactions

Other (inactive) ingredients: Gelatin, Vegetable Glycerin, Natural Caramel color, Titanium Dioxide color, Food Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidyl Serine Complex 500 mg by Wonder Laboratories Drug Interactions

Want to check YOUR meds against Phosphatidyl Serine Complex 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Neuro-PS 219

Individual Drug Interactions

The ingredients in Phosphatidyl Serine Complex 500 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phosphatidyl Serine Complex 500 mg interact with drugs. Each result below shows which ingredient is responsible. Neuro-PS

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidyl Serine Complex 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Neuro-PS2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Neuro-PS full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phosphatidyl Serine Complex 500 mg, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Phosphatidyl Serine Complex 500 mg by Wonder Laboratories: Common Questions

Does Phosphatidyl Serine Complex 500 mg by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, Phosphatidyl Serine Complex 500 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidyl Serine Complex 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
The safety data advises against use during pregnancy because there isn't enough information to know it's safe. For breastfeeding, safety is also unknown, so avoidance is recommended. Talk with your doctor or pharmacist about whether this product is right for you in these situations.
What side effects might I experience?
Most common are flatulence, stomach upset, headache, insomnia, and nausea. Insomnia is more likely if you take a higher dose (600 mg), and stomach problems can show up even at lower doses (200–300 mg daily). Start low and see how you feel.
Does phosphatidylserine actually work for memory and focus?
It's possibly effective for age-related cognitive decline and Alzheimer disease. For general focus, ADHD, and athletic performance, we don't have reliable evidence yet. If you're exploring it for memory, discuss your goals with your doctor first.
Why does this interact with anticholinergic and cholinergic drugs?
Phosphatidylserine is thought to raise acetylcholine levels in your brain. Anticholinergic drugs block acetylcholine activity, so phosphatidylserine may undo their effect. Cholinergic drugs boost acetylcholine, so together they could create stronger effects than you'd want.
Is this supplement safe long-term?
It's generally well tolerated in studies, but long-term safety hasn't been fully established. If you're planning to take it regularly, it's a good reason to check in with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidyl Serine Complex 500 mg label
Go deeper

The Full Monographs Behind Phosphatidyl Serine Complex 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Phosphatidyl Serine Complex 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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