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Dietary supplement

Phosphatidylserine Complex 500 mg Ingredients & Drug Interactions

by BIOVEA

Phosphatidylserine Complex 500 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phosphatidylserine Complex 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phosphatidylserine Complex 500 mg is a dietary supplement by BIOVEA with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidyl Serine Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phosphatidylserine Complex 500 mg by BIOVEA

Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidylserine Complex 500 mg by BIOVEA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phosphatidylserine Complex 500 mg by BIOVEA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Phosphatidyl Serine Complex” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This softgel contains 3 active ingredients: phosphatidylserine, phosphatidylethanolamine, and phosphatidylcholine — all phospholipids, which are fatty compounds found naturally in cell membranes. Phosphatidylserine is thought to play a role in brain function and has been studied for age-related memory and Alzheimer's disease.

The other two phospholipids support cellular health and have been investigated for liver and digestive conditions. The capsule also holds gelatin, glycerin, polyglycitol syrup, and purified water as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Memory, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Mental clarity, Focus — and 1 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Memory, Aging.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

Phosphatidylserine is rated possibly effective for slowing age-related cognitive decline and possibly effective for Alzheimer's disease. However, the evidence for its use in general cognitive function, ADHD, dementia, and athletic performance is insufficient to make a reliable rating.

Phosphatidylcholine is possibly effective for ulcerative colitis, but evidence is insufficient for its use in fatty liver disease, alcohol-related liver damage, Alzheimer's, and anxiety. We hold no effectiveness data for phosphatidylethanolamine.

The evidence, ingredient by ingredient Phosphatidylserine Phosphatidylcholine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea — insomnia is more likely at higher doses around 600 mg.

Phosphatidylcholine is also generally well tolerated at typical doses, but high amounts can cause digestive upset including bloating, diarrhea, nausea, and vomiting; it may also increase sweating and itching. During pregnancy, there isn't enough safety information for phosphatidylserine, so avoidance is recommended.

For phosphatidylcholine, choline itself is needed in pregnancy, but supplement safety beyond food sources isn't well studied — talk with your doctor. Safety during breastfeeding is unknown for both phosphatidylserine and phosphatidylcholine; speak with your healthcare provider before use.

Side effects, ingredient by ingredient Phosphatidylserine Phosphatidylcholine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check with your own doctor or pharmacist if you're on anticholinergic drugs (for overactive bladder or Parkinson's symptoms) or cholinergic drugs (for Alzheimer's or myasthenia gravis) — phosphatidylserine may change how well they work. We could not check phosphatidylethanolamine for interactions.

Use the medication search tool on this page to verify your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're concerned about age-related memory loss or early Alzheimer's changes, this product may be worth discussing with your doctor — phosphatidylserine has some evidence behind it for those uses. But if you take medications for bladder control, Parkinson's disease, or Alzheimer's treatment (cholinergic or anticholinergic drugs), you'll need to check those specific prescriptions against the medication list on this page before you start.

Pregnant or breastfeeding? Talk it over with your own doctor or pharmacist first, since safety data is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidylserine Complex 500 mg, straight from the product label.

Brand BIOVEA
Barcode (UPC) 818423023595
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 278634
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidylserine Complex 500 mg by BIOVEA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
818423023595
IngredientAmount% DV
Phosphatidylserine100 mg--
Phosphatidylethanolamine2.5 mg--
Phosphatidylcholine25 mg--
Phosphatidyl Serine Complex500 mg--

Other ingredients: Gelatin, Glycerin, Polyglycitol Syrup, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

GMP Compliant

Formulation

Gluten free

Guaranteed premium quality

General Statements

Premium quality guaranteed since 2001. BIOVEA is committed to product quality to support you and your family's wellness goals. Because we feel so strongly about the quality, potency and purity of our products, we 100% guarantee your satisfaction with every purchase.

Phospholipid

Suggested/Recommended/Usage/Directions

Suggested Daily Intake: Take 1 softgel, 3 times daily with meals.

Precautions

Warning: If you are pregnant or lactating, consult a healthcare professional before using this product.

Keep out of reach of children.

Do not use this product if the safety seal on the bottle is broken.

Contains: Soy.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Sharp-PS is a registered trademark of Enzymotec Ltd.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phosphatidylserine Complex 500 mg by BIOVEA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phosphatidylserine Complex 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phosphatidylserine Complex 500 mg by BIOVEA

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Phosphatidyl Serine Complex

Interacts with
219 drugs
500 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidyl Serine Complex monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Polyglycitol Syrup, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidylserine Complex 500 mg by BIOVEA Drug Interactions

Want to check YOUR meds against Phosphatidylserine Complex 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidyl Serine Complex 219

Individual Drug Interactions

The ingredients in Phosphatidylserine Complex 500 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phosphatidylserine Complex 500 mg interact with drugs. Each result below shows which ingredient is responsible. Phosphatidyl Serine Complex

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidylserine Complex 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidyl Serine Complex2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidyl Serine Complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phosphatidylserine Complex 500 mg, from the product label.

BIOVEA

See all BIOVEA products
Name
BIOVEA
Street Address
9160 E. Bahia Dr.
City
Scottsdale
State
AZ
ZipCode
85260
Web Address
www.biovea.com
Pharmacist Counseling Corner

Phosphatidylserine Complex 500 mg by BIOVEA: Common Questions

Does Phosphatidylserine Complex 500 mg by BIOVEA interact with any medications?
Yes. Based on its ingredients, Phosphatidylserine Complex 500 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidylserine Complex 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are phospholipids and why are they in this supplement?
Phospholipids are fatty compounds that naturally make up cell membranes. The three in this product — phosphatidylserine, phosphatidylethanolamine, and phosphatidylcholine — are thought to support brain and cellular health. Phosphatidylserine has the most research backing for memory and Alzheimer's concerns.
Can I take this if I'm pregnant or breastfeeding?
No for pregnancy — there isn't enough safety data, so avoidance is recommended. For breastfeeding, safety is unknown for phosphatidylserine, and we don't have enough reliable data on phosphatidylcholine supplements during nursing. Talk with your doctor or pharmacist first.
What side effects might I notice?
The most common ones are flatulence, stomach upset, headache, trouble sleeping, and nausea. Insomnia is more likely if you take a higher dose around 600 mg. Most people tolerate it well, but long-term safety hasn't been fully studied.
Does this really help with memory and thinking?
Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer's disease — meaning there's some supporting evidence, but it's not definitive. For general memory, ADHD, dementia, and athletic performance, we don't have enough reliable evidence to rate it. Talk with your doctor about what to expect.
Is this safe to take long-term?
It's generally well tolerated in studies, but long-term safety isn't fully established. If you're thinking about taking it regularly, check with your pharmacist or doctor, especially if you're on other medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidylserine Complex 500 mg label
Go deeper

The Full Monographs Behind Phosphatidylserine Complex 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph →
Sources

Sources & How We Checked

Phosphatidylserine Complex 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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