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Dietary supplement

Phosphatidylserine Plus Phosphatidic Acid Ingredients & Drug Interactions

by Lipogen PS Plus

Phosphatidylserine Plus Phosphatidic Acid label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phosphatidylserine Plus Phosphatidic Acid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phosphatidylserine Plus Phosphatidic Acid is a dietary supplement by Lipogen PS Plus with 1 active ingredient.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus

Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (690 mg) without saying how much of each component you get.
  • “Phospholipids Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Phosphatidylserine” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

Lipogen PS Plus contains 6 active ingredients in a proprietary phospholipid blend: phosphatidylserine, phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, phosphatidic acid, and other soy phospholipids. These are all naturally occurring fats found in cell membranes that support brain and nerve function.

The softgel also contains gelatin, glycerol, and iron oxide as inactive ingredients (the capsule shell and colorant).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Phosphatidylcholine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Memory, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Dementia, Alzheimer disease — and 4 related terms.
  • The closest evidence on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Memory, Dementia.

Evidence for this product's effectiveness is limited. Phosphatidylcholine, one of the active ingredients, is possibly effective for ulcerative colitis (inflammation of the colon and rectum).

For Alzheimer disease, anxiety, nonalcoholic fatty liver disease, and alcohol-related liver disease, the evidence we hold is insufficient to say whether it works. The other ingredients in the blend don't have effectiveness ratings in our data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylcholine is generally well tolerated when taken orally. Common side effects from oral use include altered taste, bloating, diarrhea, nausea, sweating, itching, and vomiting—most often at high doses (30 grams per day or more).

A small number of people have reported these effects at smaller doses. During pregnancy, choline (which phosphatidylcholine provides) is needed, but supplement safety beyond food sources hasn't been well studied; talk with your doctor about whether this product is right for you.

There isn't enough data on use while breastfeeding; check with your healthcare provider first.

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. Still, ask your pharmacist to run your exact medications through our interaction checker on this page before you start—it's your best tool for confirming this product is safe with your drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

Lipogen PS Plus is a phospholipid blend aimed at brain and nerve support, with the most evidence behind phosphatidylcholine for ulcerative colitis. If you're pregnant, breastfeeding, or have any digestive conditions, talk it over with your doctor or pharmacist first.

Most people tolerate it well, but watch for digestive upset, especially at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidylserine Plus Phosphatidic Acid, straight from the product label.

Brand Lipogen PS Plus
Barcode (UPC) 994922802248
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 240221
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
994922802248
IngredientAmount% DV
Proprietary Blend690 mg--
Phosphatidylinositol0 NP--
Phosphatidylethanolamine0 NP--
Polyenylphosphatidycholine0 NP--
Phosphatidic Acid590 mg--
Other Soy Phospholipids0 NP--
Phospholipids Complex0 NP--
Phosphatidylserine100 mg--
other Glycerides0 NP--

Other ingredients: Gelatin, Glycerol, Iron Oxide E172

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel up to three times daily, preferably with meals.

Precautions

As a reminder discuss the supplement and medication you take with your health care providers.

Warning: Pregnant or lactating women should consult a doctor before using any product. Consult your doctor before use if you have or have had any health condition or if you are taking any medications or remedies including OTC medications, or are planning any medical procedure.

Discontinue use and consult your doctor if any adverse reaction occurs, such as gastrointestinal discomfort.

Not intended for use by persons under age of 18. Keep out of reach of children.

Tamper resistant. Do not use if seal under cap is broken or missing.

Storage

Store in a dry place and avoid excessive heat.

FDA Statement of Identity

Dietary Supplement

Formulation

No yeast, milk or milk derivatives, lactose, sugar, preservatives or artificial flavor

Seals/Symbols

GMP Good Manufacturing Practices

General Statements

To reorder and for customer service call 1-888-748-6955

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phosphatidylserine Plus Phosphatidic Acid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Proprietary Blend

690 mg per serving
  • › Phospholipids Complex

Other (inactive) ingredients: Gelatin, Glycerol, Iron Oxide E172. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus Drug Interactions

Want to check YOUR meds against Phosphatidylserine Plus Phosphatidic Acid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Phosphatidylserine Plus Phosphatidic Acid interact with 219 drugs. Click any drug to see the details.

0 of the 1 ingredient in Phosphatidylserine Plus Phosphatidic Acid interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidylserine Plus Phosphatidic Acid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Phosphatidylserine Plus Phosphatidic Acid, from the product label.

Lipogen PS Plus

See all Lipogen PS Plus products
Name
Lipogen Products (9000) Ltd.
City
Haifa
State
Israel
ZipCode
31078
Pharmacist Counseling Corner

Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus: Common Questions

Does Phosphatidylserine Plus Phosphatidic Acid by Lipogen PS Plus interact with any medications?
Yes. Based on its ingredients, Phosphatidylserine Plus Phosphatidic Acid has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidylserine Plus Phosphatidic Acid contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylcholine do?
Phosphatidylcholine is a fat found in cell membranes that helps your brain and nerve cells function. It's the ingredient in this product with the most research behind it, and the evidence strongest for ulcerative colitis.
Can I take this if I'm pregnant?
Choline (which phosphatidylcholine provides) is needed during pregnancy, but supplement safety beyond what you get in food hasn't been well studied. Talk with your doctor to decide whether this product is right for you during pregnancy.
Can I take this while breastfeeding?
There isn't enough reliable data on supplement use while breastfeeding. Speak with your healthcare provider first to get personalized advice.
What side effects might I notice?
The most common side effects from oral use are altered taste, bloating, diarrhea, nausea, sweating, itching, and vomiting—usually at high doses (30 grams per day or more), but sometimes at smaller doses too. Watch for digestive upset especially.
Does this treat Alzheimer disease or anxiety?
Phosphatidylcholine has been studied for both, but we don't have enough reliable evidence to say whether it works for either condition. If you're interested in it for those reasons, discuss it with your doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phosphatidylserine Plus Phosphatidic Acid is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidylserine Plus Phosphatidic Acid label
Sources

Sources & How We Checked

Phosphatidylserine Plus Phosphatidic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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