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Dietary supplement

Platinum Phosphatiidyl Seriine Ingredients & Drug Interactions

by MuscleTech Essential Series

Platinum Phosphatiidyl Seriine label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Platinum Phosphatiidyl Seriine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Platinum Phosphatiidyl Seriine is a dietary supplement by MuscleTech Essential Series with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Platinum Phosphatiidyl Seriine by MuscleTech Essential Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Platinum Phosphatiidyl Seriine by MuscleTech Essential Series — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Platinum Phosphatiidyl Seriine by MuscleTech Essential Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Phosphatidylserine” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

This product contains a single active ingredient: phosphatidylserine, supplied at 150 mg per capsule. Phosphatidylserine is a naturally occurring fat-like substance found in cell membranes that your body uses to help support brain function and cell communication.

The product also contains inactive ingredients — magnesium stearate, silicon dioxide, and dicalcium phosphate — which serve as binders and flow agents in the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, mental performance — and 2 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

Phosphatidylserine is rated possibly effective for age-related cognitive decline and Alzheimer's disease based on available research. For athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia, the evidence isn't established enough in our data to rate it one way or the other.

Talk with your doctor about what the current research suggests for your particular situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Insomnia is more likely at higher doses (around 600 mg), and stomach upset can occur at doses of 200–300 mg per day. There is not enough safety information to use this supplement during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use anticholinergic drugs (for overactive bladder, certain poisonings, or movement disorders) or cholinergic drugs (for myasthenia gravis or some Alzheimer's treatments). Both interactions are rated Moderate, meaning phosphatidylserine may decrease the anticholinergic's effectiveness or add to the cholinergic drug's effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phosphatidylserine may be worth considering if you're interested in supporting age-related cognitive decline or Alzheimer's disease based on possibly effective evidence. However, if you take anticholinergic or cholinergic medications, check with your doctor or pharmacist first — this supplement could interfere with how they work.

Most people tolerate it well, though stomach upset and insomnia are possible. Discuss it with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Platinum Phosphatiidyl Seriine, straight from the product label.

Brand MuscleTech Essential Series
Barcode (UPC) 631656604610
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41724
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Platinum Phosphatiidyl Seriine by MuscleTech Essential Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
631656604610
IngredientAmount% DV
Phosphatidylserine300 mg--
supplying 150mg of Phosphatatidylserine150 mg--

Other ingredients: Magnesium Stearate, Capsule, Silicon Dioxide, Dicalcium Phosphate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

MT(TM) THE MOST POWERFUL SUPPLEMENTS ON EARTH.(TM)

At MuscleTech(R), our researchers are passionate about supplements.

MuscleTech(R) invests millions in product research and development, and quality control – and our supplement facts always tell you EXACTLY what you are getting: The Most Powerful Supplements on Earth!

MuscleTech(R) is the Leader in Science with a Multi-Million Dollar Research Budget A portion of every dollar spent on MuscleTech(R) supplements is allocated toward scientific research to discover new and more effective ways to increase lean muscle and strength, and improve athletic performance. In fact, Team MuscleTech(R) researchers have collaborated with researchers at over 20 universities and research facilities around the world to study the various key ingredients found in our powerful formulas.

MuscleTech(R) is America's #1 Selling Bodybuilding Supplement Brand based on cumulative wholesale dollar sales 2001 to present.

(C) 2014.

General Statements

Our mission is to develop the most scientifically advanced and effective supplements to help you build muscle and strength, lose weight, and improve athletic performance. Thanks to our millions of loyal customers, we are fortunate to be the most-awarded and best-selling sports nutrition brand over the past 20 years. Many supplement companies do not disclose their ingredients, and don’t invest in science and research, or quality control. We are different.

This precise dose was shown in a 10-day clinical study to help subjects suppress cortisol levels by 39% more than when they used a placebo. It also significantly improved subjects testosterone to cortisol ratio which can help combat exercise-induced stress for improved recovery post-workout.1 Researchers believe phosphatidylserine could increase the rate of glucose transported into muscle cells and, therefore, enhance recovery of muscle glycogen following strenuous exercise.,2 What’s more, Platinum Phosphatidylserine is completely free of stimulants, and is an excellent addition to your musclebuilding stack.

ESSENTIALSERIES

REDUCES CORTISOL TO SUPPORT MUSCLE RECOVERY IMPROVES TESTOSTERONE TO CORTISOL RATIO

60 COUNT

Twitter @MuscleTech Facebook.com/MuscleTech

1. Starks et al,. 2008. J Int Soc Sports Nutr. 5:11. 2. Jäger et al,. 2007. J Int Soc Sports Nutr. 4:5.

Research & development

Seals/Symbols

#1 MOST AWARD WINNING SPORTS NUTRITION BRAND

AMERICA'S #1 SELLING BODY BUILDING SUPPLEMENT BRAND

#1FASTEST GROWING SPORTS NUTRITION BRAND TOTAL AVERAGE YEARLY SALES GROWTH SINCE 1995

20 YEARS of EXCELLENCE

U.S. MILITARY #1 SELLING BODYBUILDING SUPPLEMENT BRAND Cumulative Sales

Tens of Millions of CUSTOMERS

MADE IN THE USA FROM DOMESTIC & INTERNATIONAL INGREDIENTS

MOST CLINICAL STUDIES #1 IN SCIENCE

FORMULATED WITH CLINICALLY DOSED KEY INGREDIENTS

LEADER IN SCIENCE A PORTION OF EVERY DOLLAR TO MORE RESEARCH $

NO. 1 PATENTS MOST PATENTS AWARDED & PENDING

#1 IN QUALITY CONTROL Over $10 Million INVESTED

cGMP MANUFACTURED Manufactured according to cGMP standards, as is required for all dietary supplements.

GUARANTEED BANNED SUBSTANCE FREE

FULLY DISCLOSED INGREDIENTS No Proprietary Blends

Formula

Platinum Phosphatidylserine – Platinum Phosphatidylserine is the world’s most powerful phosphatidylserine supplement that delivers a daily clinically studied 600mg dose of phosphatidylserine.

NEW

HIGH POTENCY PHOSPHATIDYLSERINE 150mg PHOSPHATIDYL SERINE

CONTAINS SOY INGREDIENTS

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 1 serving (1 capsule) up to 4 times daily with a glass of water. Read the entire label before use and follow directions provided.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

Precautions

Do not use if pregnant or nursing.

Consult a medical doctor before starting a diet or exercise program.

Do not use if packaging has been tampered with.

WARNING: For adult use only.

KEEP OUT OF REACH OF CHILDREN

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

9500US 0214

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Platinum Phosphatiidyl Seriine by MuscleTech Essential Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Platinum Phosphatiidyl Seriine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Platinum Phosphatiidyl Seriine by MuscleTech Essential Series

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
300 mg per serving Form: Soy Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Capsule, Silicon Dioxide, Dicalcium Phosphate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Platinum Phosphatiidyl Seriine by MuscleTech Essential Series Drug Interactions

Want to check YOUR meds against Platinum Phosphatiidyl Seriine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Platinum Phosphatiidyl Seriine interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Platinum Phosphatiidyl Seriine interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Platinum Phosphatiidyl Seriine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Platinum Phosphatiidyl Seriine, from the product label.

MuscleTech Essential Series

See all MuscleTech Essential Series products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 North Market Street, Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Pharmacist Counseling Corner

Platinum Phosphatiidyl Seriine by MuscleTech Essential Series: Common Questions

Does Platinum Phosphatiidyl Seriine by MuscleTech Essential Series interact with any medications?
Yes. Based on its ingredients, Platinum Phosphatiidyl Seriine has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Platinum Phosphatiidyl Seriine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylserine actually do?
Phosphatidylserine is a fat-like substance that helps with cell communication in your brain. It's studied mainly for age-related cognitive decline and Alzheimer's disease, where it shows possibly effective evidence. For other uses like athletic performance or ADHD, the evidence isn't strong enough yet to rate.
Will this give me a headache or stomach problems?
Phosphatidylserine is generally well tolerated, but some people do report flatulence, nausea, headache, insomnia, and other stomach upset. Insomnia is more likely at higher doses (around 600 mg), and stomach issues can show up at 200–300 mg per day.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information to know either way. The facts advise against use during pregnancy and recommend avoiding it while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in these situations.
How long until I notice a difference?
The product facts don't specify a timeframe for when you might see results. That's a question for your doctor or pharmacist, who can discuss what the research shows for your particular goal.
Does this product have any fillers or binders?
Yes — it contains magnesium stearate, silicon dioxide, and dicalcium phosphate as inactive ingredients. These are standard binders and flow agents used in capsules to hold the supplement together and help it flow during manufacturing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Platinum Phosphatiidyl Seriine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Platinum Phosphatiidyl Seriine label
Go deeper

The Full Monographs Behind Platinum Phosphatiidyl Seriine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Platinum Phosphatiidyl Seriine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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