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Dietary supplement

Potassium Gluconate 99 mg Ingredients & Drug Interactions

by up&up

Potassium Gluconate 99 mg label
See full label image
Other (e.g. Tea Bag) Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potassium Gluconate 99 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potassium Gluconate 99 mg is a dietary supplement by up&up with 1 active ingredient. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Potassium Gluconate 99 mg by up&up

Ask about any prescription or over-the-counter medication and we check it for interactions with Potassium Gluconate 99 mg by up&up — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Potassium Gluconate 99 mg by up&up

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: potassium, supplied as potassium gluconate at 99 mg per serving. Potassium is an electrolyte your body needs for heart rhythm, muscle function, and nerve signals.

The inactive ingredients listed are potassium gluconate itself (the form the potassium takes), stearic acid (a thickener), and minor components at 2% or less.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: helps maintain proper heart function.
  • We looked for evidence on: Arrhythmia, Hypertension, Cardiovascular health, Electrolyte balance.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold no effectiveness data for this product in our records. That doesn't mean it doesn't work — potassium is essential for your body — but we don't have clinical evidence on file for what this specific dose and form is meant to do.

If you're considering it for a particular reason, ask your doctor or pharmacist whether supplementing makes sense for you and at what dose.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is fine, but supplements can build up to dangerously high levels in your blood, especially if you have kidney disease. Most people tolerate it well, but common side effects include belly pain, belching, diarrhea, gas, nausea, and vomiting.

In rare cases, very high potassium levels can cause irregular heartbeat, heart block, low blood pressure, or confusion — these are serious and require immediate medical attention. During pregnancy, dietary potassium is appropriate, and supplements are rated likely safe, but use them only under medical guidance.

While breastfeeding, dietary potassium is fine; check with your doctor before taking supplements.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take a potassium-sparing diuretic, ACE inhibitor, or angiotensin receptor blocker, check with your doctor or pharmacist before using this product. All three classes carry a Moderate risk of high blood potassium when combined with potassium supplements and will need dose review or blood tests to stay safe.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Potassium supplements are not a casual add-on if you take blood pressure or heart medications. If you're on an ACE inhibitor, ARB, or potassium-sparing diuretic, you need your doctor or pharmacist to clear this first and monitor your blood potassium.

Talk with them about whether you actually need supplemental potassium — many people get enough from food.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potassium Gluconate 99 mg, straight from the product label.

Brand up&up
Barcode (UPC) 079524874817
Net contents 250 Caplet(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 240336
Product type Mineral
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potassium Gluconate 99 mg by up&up, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
UPC/BARCODE
079524874817
IngredientAmount% DV
Potassium99 mg2%

Other ingredients: Potassium Gluconate, Stearic Acid, Contains 2% or less of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Helps maintain proper heart function Restore

Gluten free

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested use: Adults, take one (1) caplet daily with food as a dietary supplement.

Brand IP Statement(s)

2017 Target Brands, Inc.

Formula

Restore Potassium is a major mineral needed for well-being. As an essential nutrient, potassium is important for muscle and nerve health and works with sodium to promote fluid balance within the body.

Precautions

Caution: Pregnant or nursing women, individuals taking medication(s) or persons who have a health condition should consult their physician before using this product.

Keep out of reach of children.

Storage

Store at 15 degrees - 30 degrees C (59 degrees - 86 degrees F).

General Statements

Caplet color may vary.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potassium Gluconate 99 mg by up&up label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potassium Gluconate 99 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potassium Gluconate 99 mg by up&up

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Potassium

Interacts with
62 drugs
99 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other (inactive) ingredients: Potassium Gluconate, Stearic Acid, Contains 2% or less of. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potassium Gluconate 99 mg by up&up Drug Interactions

Want to check YOUR meds against Potassium Gluconate 99 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Potassium Gluconate 99 mg interact with 62 drugs. Click any drug to see the details.

1 of the 1 ingredient in Potassium Gluconate 99 mg interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Potassium Gluconate 99 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potassium Gluconate 99 mg, from the product label.

up&up

See all up&up products
Name
Target Corporation
City
Minneapolis
State
MN
ZipCode
55403
Phone Number
1-800-910-6874
Pharmacist Counseling Corner

Potassium Gluconate 99 mg by up&up: Common Questions

Does Potassium Gluconate 99 mg by up&up interact with any medications?
Yes. Based on its ingredients, Potassium Gluconate 99 mg has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potassium Gluconate 99 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Why can't I just take this with my blood pressure meds?
Medications like ACE inhibitors, ARBs, and potassium-sparing diuretics already make your kidneys hold onto potassium. Adding a supplement can push levels too high and cause heart problems. Your doctor needs to know about both and may need to monitor your blood potassium or adjust doses.
What are the most common side effects?
Stomach upset — belly pain, diarrhea, gas, nausea, or vomiting. These tend to be mild, but if they're bothersome or paired with chest pain, irregular heartbeat, or confusion, stop and call your doctor right away.
Can I take this while pregnant?
Dietary potassium is fine during pregnancy. Supplements are rated likely safe, but only use them under medical guidance — your doctor should know and may want to monitor your levels.
Can I take this while breastfeeding?
Dietary potassium is appropriate. If you're thinking about supplements, check with your doctor first to make sure it's the right choice for you.
What does potassium do in my body?
Potassium is an electrolyte that keeps your heartbeat steady, helps your muscles work, and sends nerve signals. Your body needs it, which is why it's in many foods — but whether you need a supplement is a question for your doctor.
Is this product safe if I have kidney disease?
No — potassium supplements can build up to dangerous levels in people with kidney problems because damaged kidneys can't clear it properly. If you have any kidney issues, talk to your doctor before taking this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potassium Gluconate 99 mg label
Go deeper

The Full Monographs Behind Potassium Gluconate 99 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Potassium Gluconate 99 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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