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Dietary supplement

Potassium Gluconate Ingredients & Drug Interactions

by H-E-B

Potassium Gluconate label
See full label image
Other (e.g. Tea Bag) Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potassium Gluconate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potassium Gluconate is a dietary supplement by H-E-B with 1 active ingredient. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Potassium Gluconate by H-E-B

Ask about any prescription or over-the-counter medication and we check it for interactions with Potassium Gluconate by H-E-B — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Potassium Gluconate by H-E-B

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: potassium, a mineral your body needs for nerve signaling, muscle contraction, and heart rhythm. It's delivered as potassium gluconate in a tea bag or similar form.

The product also contains cellulose and trace inactive ingredients that help hold it together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports healthy cell and muscle function.
  • We looked for evidence on: muscle cramps, electrolyte balance, nerve transmission.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts don't include effectiveness data for potassium gluconate as a supplement. The evidence we hold doesn't establish whether this product works to raise potassium levels or prevent deficiency in the way you'd expect.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is fine, but supplements can cause dangerously high blood levels in some people, especially those with kidney problems — so this isn't something to take on your own without your doctor's say-so. Common side effects taken by mouth include belly pain, belching, diarrhea, bloating, nausea, and vomiting.

Rarely, very high potassium levels can trigger irregular heartbeats, low blood pressure, mental confusion, or even cardiac arrest. During pregnancy, dietary potassium is appropriate, but use supplements only under medical guidance.

The same goes for breastfeeding — check with your doctor before taking potassium supplements.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on potassium-sparing diuretics (a type of water pill), ACE inhibitors, or angiotensin receptor blockers (ARBs) — these are all Moderate-severity interactions with potassium supplements. The risk is dangerously high blood potassium levels, which can trigger serious heart rhythm problems.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Potassium supplements can be necessary if you're deficient or on certain medications, but they're not a casual add-on — especially if you take blood pressure or heart medications. The three major drug classes that interact with it (potassium-sparing diuretics, ACE inhibitors, and ARBs) are very common, and the risk of high blood potassium is real.

Talk it over with your own doctor or pharmacist before you start, and bring a list of all your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potassium Gluconate, straight from the product label.

Brand H-E-B
Barcode (UPC) 041220818396
Net contents 180 Caplet(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62892
Product type Mineral
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potassium Gluconate by H-E-B, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
UPC/BARCODE
041220818396
IngredientAmount% DV
Potassium99 mg3%

Other ingredients: Cellulose, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Mineral Supplement

Formula

Potassium Gluconate (equivalent to 99 mg Potassium)

Formulation

Gluten free

General Statements

Supports healthy cell and muscle function Potassium is essential for muscle activity and nerve transmission.

4615-1604

Actual size

Brand IP Statement(s)

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

H-E-B 100% Guarantee promise If you aren't completely pleased with this product, we'll be happy to replace it or refund your money. You have our word on it.

Precautions

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children

Storage

Store at room temperature (59(0)-86(0) F).

General

Prod No. 1110 B51486 03C

Suggested/Recommended/Usage/Directions

Suggested Use: For adults, take one (1) caplet daily, preferably with a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potassium Gluconate by H-E-B label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potassium Gluconate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potassium Gluconate by H-E-B

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Potassium

Interacts with
62 drugs
99 mg per serving Form: Potassium Gluconate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other (inactive) ingredients: Cellulose, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potassium Gluconate by H-E-B Drug Interactions

Want to check YOUR meds against Potassium Gluconate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Potassium Gluconate interact with 62 drugs. Click any drug to see the details.

1 of the 1 ingredient in Potassium Gluconate interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Potassium Gluconate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potassium Gluconate, from the product label.

H-E-B

See all H-E-B products
Name
H-E-B
City
San Antonio
State
Texas
ZipCode
78204
Phone Number
1-800-432-3113
Pharmacist Counseling Corner

Potassium Gluconate by H-E-B: Common Questions

Does Potassium Gluconate by H-E-B interact with any medications?
Yes. Based on its ingredients, Potassium Gluconate has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potassium Gluconate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take potassium supplements if I have kidney disease?
No — check with your doctor first. Potassium from a normal diet is fine, but supplements can cause dangerously high blood levels in people with kidney problems, since damaged kidneys can't excrete potassium properly. This is a conversation you need to have with your own doctor or pharmacist before taking this product.
What are the most common side effects?
When taken by mouth, potassium is generally well-tolerated, but you may experience belly pain, belching, diarrhea, bloating, nausea, or vomiting. If these bother you or don't go away, let your doctor know.
Is it safe to take potassium supplements while pregnant or breastfeeding?
Dietary potassium is fine in both pregnancy and breastfeeding, but supplements require medical guidance. Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing — they'll advise you based on your individual situation.
What exactly is potassium gluconate?
It's potassium, an essential mineral your body needs for nerve and muscle function and a healthy heartbeat, combined with gluconic acid to make it easier to absorb. It's one of several potassium salt forms used in supplements.
What happens if potassium levels get too high?
High blood potassium (hyperkalemia) is serious and can cause irregular heartbeats, heart block, low blood pressure, and mental confusion. In rare severe cases, it can even stop the heart. This is why mixing potassium supplements with certain blood pressure or heart medications carries a Moderate interaction risk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Potassium Gluconate is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potassium Gluconate label
Go deeper

The Full Monographs Behind Potassium Gluconate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Potassium Gluconate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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