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Dietary supplement

Potassium Iodide 130 mg Ingredients & Drug Interactions

by Safrel

Potassium Iodide 130 mg label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potassium Iodide 130 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potassium Iodide 130 mg is a dietary supplement by Safrel with 1 active ingredient. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium Iodide. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Potassium Iodide 130 mg by Safrel

Ask about any prescription or over-the-counter medication and we check it for interactions with Potassium Iodide 130 mg by Safrel — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Potassium Iodide 130 mg by Safrel

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Safrel Potassium Iodide contains one active ingredient: potassium iodide at 130 mg per tablet. The product also holds several inactive ingredients — dicalcium phosphate, hypromellose, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, silicon dioxide, and stearic acid — which are fillers and binders that help form and stabilize the tablet.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Potassium product and its label doesn't state a use — see Potassium's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness ratings for potassium iodide in our data, so I can't tell you what the evidence shows for its intended use from our facts alone. That said, if you're taking this under a doctor's orders — for instance, for thyroid protection during radiation or to treat iodine deficiency — your prescriber has already weighed the evidence for your situation.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is fine, but supplements carry real risk, especially if you have kidney disease — they can push your potassium to harmful levels even at normal doses. The most common side effects from oral potassium are stomach upset: abdominal pain, nausea, vomiting, diarrhea, and gas.

Rarely, very high potassium causes serious problems — irregular heartbeats, heart block, low blood pressure, and mental confusion. During pregnancy, dietary potassium is appropriate, but supplements should only be used under medical guidance.

If you're breastfeeding, check with your doctor before taking this supplement. The safety data rates it likely safe in pregnancy and lactation, but personalized advice from your care team matters here.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Safrel Potassium Iodide, double-check with your pharmacist if you're on potassium-sparing diuretics, ACE inhibitors, or ARBs — all carry Moderate risk of dangerously high blood potassium when combined with this supplement. These are common blood pressure drugs, so it's worth a quick conversation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is for people whose doctors have prescribed it for a specific reason — usually thyroid protection or iodine deficiency. If you take any blood pressure medication, especially potassium-sparing diuretics, ACE inhibitors, or ARBs, you must talk to your pharmacist or doctor before starting.

Even if you have no drug interactions, kidney problems or certain conditions make potassium supplements risky.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potassium Iodide 130 mg, straight from the product label.

Brand Safrel
Barcode (UPC) 371309000122
Net contents 240 Tablet(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328950
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potassium Iodide 130 mg by Safrel, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
120
UPC/BARCODE
371309000122
IngredientAmount% DV
Potassium Iodide130 mg--

Other ingredients: Dicalcium Phosphate, Hypromellose, Microcrystalline Cellulose, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, yeast, artificial colors.

Made in U.S.A.

Dairy free Non GMO Gluten free

Immunity & thyroid support

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Consult your doctor if you are pregnant, nursing, taking any medications or have a medical condition.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

For short-term use

Storage

Store at room temperature.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take two (2) tablets daily, preferably with food.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potassium Iodide 130 mg by Safrel label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potassium Iodide 130 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potassium Iodide 130 mg by Safrel

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Potassium Iodide

Interacts with
62 drugs
130 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium Iodide monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Hypromellose, Microcrystalline Cellulose, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potassium Iodide 130 mg by Safrel Drug Interactions

Want to check YOUR meds against Potassium Iodide 130 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium Iodide 62

Individual Drug Interactions

The ingredients in Potassium Iodide 130 mg interact with 62 drugs. Click any drug to see the details.

1 of the 1 ingredient in Potassium Iodide 130 mg interact with drugs. Each result below shows which ingredient is responsible. Potassium Iodide

Each ingredient & the kinds of drugs it affects

For each ingredient in Potassium Iodide 130 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium Iodide3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium Iodide full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potassium Iodide 130 mg, from the product label.

Safrel

See all Safrel products
Name
Safrel Pharmaceuticals
Street Address
1200 Route 22 East, Suite 2000
City
Bridgewater
State
NJ
ZipCode
08807
Phone Number
(844) 384-3723
Web Address
www.safrel.com
Pharmacist Counseling Corner

Potassium Iodide 130 mg by Safrel: Common Questions

Does Potassium Iodide 130 mg by Safrel interact with any medications?
Yes. Based on its ingredients, Potassium Iodide 130 mg has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potassium Iodide 130 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's in this tablet besides potassium iodide?
The tablet has several inactive ingredients that help form and stabilize it: dicalcium phosphate, hypromellose, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, silicon dioxide, and stearic acid. They're fillers and binders, not active medicine.
Can I take this if I have kidney disease?
Our data flags potassium supplements as risky for people with kidney disease — they can't clear potassium well, so levels can climb to dangerous heights. Talk to your doctor or pharmacist before taking this product if you have any kidney problems.
What are the most common side effects?
The typical ones are stomach-related: abdominal pain, nausea, vomiting, diarrhea, and gas. These usually appear when you take it by mouth. Serious side effects from very high potassium — like irregular heartbeats or confusion — are rare but possible.
Is it safe to take this while breastfeeding?
Our data rates potassium iodide likely safe during breastfeeding, but the safety notes say to check with your doctor first. Since it's a supplement — not something you need for regular nutrition — a personalized conversation with your healthcare provider makes sense.
Can I take this if I'm pregnant?
Our data rates it likely safe in pregnancy. That said, our notes advise using supplements only under medical guidance during pregnancy, not on your own. Talk to your doctor about whether you actually need it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Potassium Iodide 130 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potassium Iodide 130 mg label
Go deeper

The Full Monographs Behind Potassium Iodide 130 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Potassium Iodide 130 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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