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Dietary supplement

Potassium Orotate 175 mg Ingredients & Drug Interactions

by Advanced Research

Potassium Orotate 175 mg label
See full label image
Capsule Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potassium Orotate 175 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potassium Orotate 175 mg is a dietary supplement by Advanced Research with 1 active ingredient. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Potassium Orotate 175 mg by Advanced Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Potassium Orotate 175 mg by Advanced Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Potassium Orotate 175 mg by Advanced Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Potassium” is listed as a grouped ingredient — the label gives one combined amount (175 mg) without saying how much of each component you get.

This supplement contains one active ingredient: potassium. Potassium is a mineral your body needs for heart rhythm, nerve signals, and muscle function.

The remaining ingredients are inactive — cellulose, silicon dioxide, and other materials that form the capsule and help it hold together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Potassium product and its label doesn't state a use — see Potassium's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts we hold don't include effectiveness ratings for potassium orotate, so we can't tell you from our data whether it works for any particular purpose.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is fine, but supplements can cause dangerously high blood levels in some people — especially those with kidney disease. The most common side effects from taking potassium by mouth are stomach upset: abdominal pain, nausea, vomiting, diarrhea, and gas.

Serious but rare effects of very high potassium include irregular heartbeat, heart block, low blood pressure, and confusion. During pregnancy and breastfeeding, dietary potassium is appropriate, but check with your doctor or pharmacist before using potassium supplements — the safety data we hold is rated as likely safe, but personalized guidance matters given the risks of high blood potassium.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your doctor or pharmacist if you're on a potassium-sparing diuretic, an ACE inhibitor, or an angiotensin receptor blocker (ARB). All three types raise the risk of dangerously high blood potassium when combined with potassium supplements.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Potassium supplements are worth considering if your doctor has told you that you're low in potassium and you're not on a diuretic or blood pressure medication. If you take any heart or blood pressure pill — or have kidney problems — you need to check with your doctor or pharmacist before starting this, because the interaction risks are real and potentially serious.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potassium Orotate 175 mg, straight from the product label.

Brand Advanced Research
Barcode (UPC) 605164341831
Net contents 200 Veggie Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 273944
Product type Mineral
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potassium Orotate 175 mg by Advanced Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
605164341831
IngredientAmount% DV
Potassium35 mg--
Potassium175 mg1%

Other ingredients: Silicified Microcrystaline Cellulose, natural Glaze, Cellulose, Silicon Dioxide, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As an addition to the daily diet, take one capsule daily or as directed by your health care professional.

Precautions

If you are pregnant or a nursing mother, consult your health care professional before using this or any dietary supplement.

Children: Consult your health care professional before giving this or any dietary supplement to children. Keep out of the reach of children

Storage

Keep bottle tightly closed and store in a cool, dry place.

General Statements

Formulated by Hans A. Nieper, M.D. of Hannover, Germany

FDA Statement of Identity

Dietary Supplement

Formulation

Made in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potassium Orotate 175 mg by Advanced Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potassium Orotate 175 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potassium Orotate 175 mg by Advanced Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Potassium

Interacts with
62 drugs
175 mg per serving Form: Potassium Orotate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other (inactive) ingredients: Silicified Microcrystaline Cellulose, Natural Glaze, Cellulose, Silicon Dioxide, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potassium Orotate 175 mg by Advanced Research Drug Interactions

Want to check YOUR meds against Potassium Orotate 175 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Potassium Orotate 175 mg interact with 62 drugs. Click any drug to see the details.

1 of the 1 ingredient in Potassium Orotate 175 mg interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Potassium Orotate 175 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potassium Orotate 175 mg, from the product label.

Advanced Research

See all Advanced Research products
Name
Advanced Research
Street Address
PO Box 11
City
Santa Teresa
State
NM
ZipCode
88008
Phone Number
1-800-222-7153
Web Address
www.NCIadvancedresearch.com
Pharmacist Counseling Corner

Potassium Orotate 175 mg by Advanced Research: Common Questions

Does Potassium Orotate 175 mg by Advanced Research interact with any medications?
Yes. Based on its ingredients, Potassium Orotate 175 mg has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potassium Orotate 175 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's potassium orotate, and why would I take it?
Potassium orotate is potassium bound to orotic acid. We don't have effectiveness data in our records for this specific form, so we can't tell you from our facts what it's meant to do. Talk to your doctor about whether you need a potassium supplement and which form is right for you.
Can I take this if I have kidney disease?
No — not without talking to your doctor first. Kidney disease makes it harder for your body to clear excess potassium, so supplements are riskier. Your doctor or pharmacist needs to know about your kidney function before you start.
What are the most common side effects?
Stomach upset: abdominal pain, nausea, vomiting, diarrhea, and gas. These are usually mild, but if they're bothersome or don't go away, let your doctor know.
Is it safe to take while pregnant or breastfeeding?
Dietary potassium during pregnancy and breastfeeding is fine, but supplements need to be cleared with your doctor first. Talk it over before you start — they can weigh whether you actually need a supplement and whether it's right for you right now.
What's in the capsule besides potassium?
The capsule contains cellulose, silicon dioxide, and related inactive ingredients — basically fillers and binders that hold the supplement together. None of these are active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Potassium Orotate 175 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potassium Orotate 175 mg label
Go deeper

The Full Monographs Behind Potassium Orotate 175 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Potassium Orotate 175 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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