Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Primadophilus Reuteri Ingredients & Drug Interactions

by Nature's Way

Primadophilus Reuteri label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Primadophilus Reuteri against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Primadophilus Reuteri is a dietary supplement by Nature's Way with 4 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus DDS-1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Primadophilus Reuteri by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Primadophilus Reuteri by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Primadophilus Reuteri by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (78 mg) without saying how much of each component you get.

Primadophilus Reuteri is a probiotic capsule with 4 active ingredients: two strains of Lactobacillus (rhamnosus and acidophilus), Lactobacillus reuteri, and NutraFlora scFOS—a prebiotic fiber that may feed the beneficial bacteria. The capsule itself is plant-derived, and the inactive ingredients are rice dextrin, magnesium stearate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestion and immunity support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Colic, Clostridioides difficile infection, Common cold, Constipation — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Necrotizing enterocolitis (NEC).

The Lactobacillus acidophilus in this product is rated possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. For atopic disease (allergies and eczema-like conditions) it's rated possibly ineffective, and for acute respiratory distress syndrome the evidence isn't strong enough to rate.

The effectiveness data we hold doesn't cover the other strains or the prebiotic blend in this formulation.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. A small number of trial participants taking combinations of probiotics reported gastrointestinal side effects like bloating, gas, and mild abdominal discomfort; these events are uncommon.

Rarely, in people with weakened immunity or certain underlying conditions, L. acidophilus has been linked to serious infections—though most cases appear to involve bacteria that relocated from elsewhere in the body. Pregnancy is rated possibly safe; data for lactation isn't on file.

Because the safety picture is still developing, check with your doctor before use.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Primadophilus Reuteri, double-check antibiotic drugs with your doctor or pharmacist—taking them at the same time as this probiotic may lower its effectiveness. Separate them by several hours if possible.

We could not check three other ingredients in this product for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with gut issues, traveler's diarrhea, or after antibiotic use, but you'll need to time it carefully—doses should be separated from antibiotics by several hours. If you have a weakened immune system or are pregnant, talk it over with your doctor or pharmacist before starting.

Run your full medication list through the checker on this page so you and your healthcare provider can spot any conflicts.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Primadophilus Reuteri, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674142400
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 242945
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Primadophilus Reuteri by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
033674142400
IngredientAmount% DV
Lactobacillus rhamnosus UALr-180 NP--
Lactobacillus acidophilus DDS-10 NP--
NutraFlora scFOS100 mg--
Lactobacillus reuteri UALre-160 NP--
Proprietary Probiotic Blend78 mg--

Other ingredients: Rice Dextrin, plant-derived Capsule, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Digestion & immunity

Gluten free. No wheat, dairy, or artificial colors, or flavors.

Primadophilus Reuteri fortifies the intestinal tract with active Lactobacillus cultures. Delayed-release capsules resist stomach acid to help deliver probiotics to the intestines

Delayed-release

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Formula

Enhanced with NutraFlora

Superior probiotic Multi-strain formula 5 billion CFU

Primadophilus Reuteri is a multi-strain probiotic formula with Latobacillus reuteri UALre-16, L. acidophilus and L. rhamnosus that can help: Support healthy immune function Support healthy digestion

What is Reuteri? Lactobacillus reuteri is a unique probiotic strain.

5 billion CFU per serving Multi-strain formula with L. reuteri UALre-16, L. acidophilus and L. rhamnosus Prebiotic support with NutraFlora scFOS (short-chain fructooligosaccharides) to support growth of probiotic bacteria

True potency guarantee Primadophilus Reuteri contains at least 5 billion CFU through to the date of expiration on this box. Most other probiotic brands claim their potency as of time of manufacture.

Multistrain with scFOS

Brand IP Statement(s)

NutraFlora and scFOS are registered trademarks of Ingredion. DDS is a registered trademark of UAS Laboratories LLC and used under license.

Copyright 2020 Distributed by Nature's Way Brands, LLC

FDA Disclaimer Statement

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 capsule daily, with or without food.

Storage

Keep refrigerated to maintain maximum potency.

General Statements

Why take Primadophilus Reuteri?

LBN14240.D01 B711937D

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Primadophilus Reuteri by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Primadophilus Reuteri label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Primadophilus Reuteri by Nature's Way

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

NutraFlora scFOS

100 mg per serving

Proprietary Probiotic Blend

78 mg per serving

Other (inactive) ingredients: Rice Dextrin, Plant-derived Capsule, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Primadophilus Reuteri by Nature's Way Drug Interactions

Want to check YOUR meds against Primadophilus Reuteri?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus DDS-1 182

Individual Drug Interactions

The ingredients in Primadophilus Reuteri interact with 182 drugs. Click any drug to see the details.

1 of the 4 ingredients in Primadophilus Reuteri interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus DDS-1

Each ingredient & the kinds of drugs it affects

For each ingredient in Primadophilus Reuteri with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus DDS-11 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus DDS-1 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Primadophilus Reuteri, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Primadophilus Reuteri by Nature's Way: Common Questions

Does Primadophilus Reuteri by Nature's Way interact with any medications?
Yes. Based on its ingredients, Primadophilus Reuteri has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Primadophilus Reuteri contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm on antibiotics?
Not well if you take them together. Antibiotics kill the live organisms in the probiotic, making it less effective. If you're prescribed an antibiotic, ask your doctor or pharmacist whether you should wait a few hours between doses or start the probiotic after your course ends.
What are these bacteria supposed to do for me?
Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, bacterial vaginosis, and H. pylori infection—though results vary from person to person. The prebiotic (NutraFlora scFOS) may help feed beneficial bacteria already in your gut.
Is this safe if I'm pregnant?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but data are limited. Talk with your doctor or pharmacist before starting to make sure it's right for you right now.
Can this cause side effects?
Most people tolerate it well, but some experience mild gas, bloating, or abdominal discomfort—these are uncommon. Rarely, in people with very weak immunity, serious infections have been reported, so mention this product to your doctor if you have any immune concerns.
What's NutraFlora scFOS?
It's a prebiotic fiber—a food for the beneficial bacteria already in your gut. Unlike the live organisms, we don't have interaction data on file for it, so check with your pharmacist if you're taking other medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Primadophilus Reuteri is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Primadophilus Reuteri label
Go deeper

The Full Monographs Behind Primadophilus Reuteri’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Primadophilus Reuteri's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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