Pro-Bio Ingredients & Drug Interactions
by Enzymedica
What is this page for?
First and foremost: checking Pro-Bio against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pro-Bio is a dietary supplement by Enzymedica with 8 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis, L. acidophilus, L. bulgaricus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pro-Bio by Enzymedica
Ask about any prescription or over-the-counter medication and we check it for interactions with Pro-Bio by Enzymedica — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
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HelloPharmacist Scorecard of Pro-Bio by Enzymedica
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Pro-Bio contains 8 ingredients, including a proprietary blend with five types of live Lactobacillus bacteria (L. acidophilus, L. casei, L. paracasei, L. plantarum, L. rhamnosus, and L. salivarius), plus Bacillus subtilis and L. bulgaricus — all probiotics meant to support your gut. The inactive ingredients are gellan gum, cellulose, and water.
Does it work?
Moderate evidence
The evidence is mixed. L. acidophilus in this product is possibly effective for irritable bowel syndrome, H. pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.
Bacillus subtilis is possibly effective for antibiotic-associated diarrhea. L. bulgaricus has insufficient evidence to rate for acne, hay fever, diarrhea, asthma, fatty liver disease, and the common cold.
The other ingredients in the blend lack established evidence in our data. Since this is a blend with multiple strains, the real-world benefit depends on whether the combination works better than individual strains — something we don't have information on.
How safe is it?
Well-documented data
L. acidophilus and Bacillus subtilis are generally well tolerated in healthy adults. Side effects are uncommon but can include mild gastrointestinal symptoms like bloating, flatulence, abdominal discomfort, or diarrhea — particularly when L. acidophilus is combined with other probiotics.
One headache was reported in a trial of Bacillus subtilis. Rarely, live probiotic bacteria can cause serious bloodstream or other infections, especially in very ill or immunocompromised people; these cases are thought to result from bacteria moving from their normal locations in the body.
Safety data for L. bulgaricus are limited, and people who are severely ill or immunocompromised should be cautious. Pregnancy and lactation safety data are not well studied for this supplement — talk with your doctor if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before you start Pro-Bio, double-check any antibiotic drugs you're taking — they can reduce how well the live bacteria in this product work. Separate the timing of antibiotics and Pro-Bio by a few hours if you can.
Use the checker below with your exact medication names.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Pro-Bio may help if you have antibiotic-associated diarrhea or irritable bowel syndrome, though evidence is strongest for the L. acidophilus ingredient. If you take antibiotics, separate them from this product by a few hours.
If you're very ill, immunocompromised, pregnant, or nursing, check with your doctor first. Use the medication checker to make sure your exact drugs won't interfere.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pro-Bio, straight from the product label.
| Brand | Enzymedica |
|---|---|
| Barcode (UPC) | 670480251126 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 24, 2025 |
| DSLD ID | 328891 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pro-Bio by Enzymedica, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 0 NP | -- |
| Bacillus subtilis | 0 NP | -- |
| L. acidophilus | 0 NP | -- |
| L. casei | 0 NP | -- |
| L. paracasei | 0 NP | -- |
| L. plantarum | 0 NP | -- |
| L. rhamnosus | 0 NP | -- |
| L. bulgaricus | 0 NP | -- |
| L. salivarius | 0 NP | -- |
Other ingredients: Gellan Gum, Cellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Enzymedica supports Vitamin Angels proud supporter
#1 selling enzyme brand
Seals/Symbols
AHA Autism Hope Alliance Green Mountain Energy
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
A balanced environment of intestinal flora keeps the digestive system performing optimally, eliminating discomforts like irregularity and occasional gas and bloating. Pro-Bio capsules are formulated to survive the acidic environment of the stomach, ensuring active probiotic function in the small intestine.
No fillers added
Made in USA
Non GMO
Supportive Retains potency at room temperature
Vegetarian
Contains no egg, dairy, preservatives, salt, sucrose, soy, wheat, yeast, nuts, corn, gluten, casein, potato, rice, artificial colors or flavors.
Enzymedica does not use ingredients produced using biotechnology.
Formula
The bacterial strains contained in Pro-Bio have been shown to promote a healthy microflora balance in the intestinal tract, aiding digestion and supporting immune function.
Guaranteed-potency probiotic 8 strains of probiotics provide 10 billion CFUs per single-dose capsule
Suggested/Recommended/Usage/Directions
Recommended use: 1 capsule daily with water. Best if taken on an empty stomach one hour before or two hours after a meal.
Brand IP Statement(s)
Enzymedica Natural digestive health & wellness
FDA Statement of Identity
Dietary Supplement
Storage
Keep closed in dry place; avoid excessive heat.
Precautions
Do not use if safety seal is broken or missing.
Please keep out of reach of children
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pro-Bio by Enzymedica label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pro-Bio by Enzymedica
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Targeted Delivery Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Bacillus subtilis
- › L. acidophilus
- › L. casei
- › L. paracasei
- › L. plantarum
- › L. rhamnosus
- › L. bulgaricus
- › L. salivarius
Other (inactive) ingredients: Gellan Gum, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.
Pro-Bio by Enzymedica Drug Interactions
HelloPharmacist Interaction Report
Enzymedica Pro-Bio is a probiotic supplement with live bacteria.
It does interact with antibiotic drugs — a Moderate severity concern. Three of its checked ingredients (Bacillus subtilis, L. acidophilus, and L. bulgaricus) can be killed by antibiotics taken at the same time, which would reduce how well the probiotic works.
The fix is straightforward: separate your doses. Take antibiotics and Pro-Bio at least a few hours apart, or ask your pharmacist for the best timing for your specific situation.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 182 individual medications.
We couldn't check several other ingredients in this blend — L. casei, L. paracasei, L. plantarum, L. rhamnosus, and L. salivarius — because we hold no interaction data for them. That doesn't mean they're problem-free; it just means the information isn't on file.
Use the medication checker on this page to verify your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pro-Bio?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pro-Bio interact with 182 drugs. Click any drug to see the details.
3 of the 8 ingredients in Pro-Bio interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis L. acidophilus L. bulgaricus
Dicloxacillin SodiumDycill, Dynapen, Pathocil, Pathocil Injection
How Dicloxacillin Sodium interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Dicloxacillin Sodium interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Dicloxacillin Sodium interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Dicloxacillin Sodium interactionDirithromycinDynabac
How Dirithromycin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Dirithromycin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Dirithromycin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Dirithromycin interactionDoripenemDoribax
How Doripenem interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Doripenem interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Doripenem interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Doripenem interactionDoxycyclineDoryx, Doxy, Doxy-D, Doxycin, Doxycycline Injection, Doxylin +6 more
How Doxycycline interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Doxycycline interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Doxycycline interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Doxycycline interactionDoxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Doxycycline Hyclate interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Doxycycline Hyclate interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Doxycycline Monohydrate interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Doxycycline Monohydrate interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Doxycycline Monohydrate interactionDoxycylineDoxychel
How Doxycyline interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Doxycyline interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Doxycyline interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Doxycyline interactionEnoxacinPenetrex
How Enoxacin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Enoxacin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Enoxacin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Enoxacin interactionErtapenemInvanz
How Ertapenem interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Ertapenem interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Ertapenem interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Ertapenem interactionErythromycinE-Mycin, Ery-Tab, Eryc, EryPed Chewable, Erythro Base, Erythro E-C +6 more
How Erythromycin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Erythromycin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Erythromycin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Erythromycin interactionErythromycin EthylsuccinateE.E.S. 400, E.E.S. Chewable, Wyamycin S
How Erythromycin Ethylsuccinate interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Erythromycin Ethylsuccinate interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Erythromycin Ethylsuccinate interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Erythromycin Ethylsuccinate interactionErythromycin Ethylsuccinate, SulfisoxazolePediazole
How Erythromycin Ethylsuccinate, Sulfisoxazole interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Erythromycin Ethylsuccinate, Sulfisoxazole interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Erythromycin Ethylsuccinate, Sulfisoxazole interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Erythromycin Ethylsuccinate, Sulfisoxazole interactionErythromycin GluceptateErythromycin Gluceptate
How Erythromycin Gluceptate interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Erythromycin Gluceptate interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Erythromycin Gluceptate interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Erythromycin Gluceptate interactionErythromycin LactobionateErythromycin Lactobionate
How Erythromycin Lactobionate interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Erythromycin Lactobionate interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Erythromycin Lactobionate interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Erythromycin Lactobionate interactionErythromycin StearateErythro-S, Erythrocin, Ethril
How Erythromycin Stearate interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Erythromycin Stearate interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Erythromycin Stearate interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Erythromycin Stearate interactionErythromycin, SulfisoxazoleEryzole
How Erythromycin, Sulfisoxazole interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Erythromycin, Sulfisoxazole interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Erythromycin, Sulfisoxazole interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Erythromycin, Sulfisoxazole interactionFidaxomicinDificid
How Fidaxomicin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Fidaxomicin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Fidaxomicin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Fidaxomicin interactionFinafloxacinXtoro
How Finafloxacin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Finafloxacin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Finafloxacin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Finafloxacin interactionFlucloxacillinStaphylex
How Flucloxacillin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Flucloxacillin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Flucloxacillin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Flucloxacillin interactionFosfomycinMonurol
How Fosfomycin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Fosfomycin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Fosfomycin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Fosfomycin interactionFurazolidoneFuroxone
How Furazolidone interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Furazolidone interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Furazolidone interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Furazolidone interactionGatifloxacinTequin, Tequin Injection
How Gatifloxacin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Gatifloxacin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Gatifloxacin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Gatifloxacin interactionGemifloxacinFactive
How Gemifloxacin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Gemifloxacin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Gemifloxacin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Gemifloxacin interactionGentamicin (iv)Garamycin
How Gentamicin (iv) interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Gentamicin (iv) interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Gentamicin (iv) interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Gentamicin (iv) interactionGrepafloxacinRaxar
How Grepafloxacin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Grepafloxacin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Grepafloxacin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Grepafloxacin interactionImipenem, CilastatinPrimaxin
How Imipenem, Cilastatin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Imipenem, Cilastatin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Imipenem, Cilastatin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Imipenem, Cilastatin interactionImipenem, Cilastatin, RelebactamRecarbrio
How Imipenem, Cilastatin, Relebactam interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Imipenem, Cilastatin, Relebactam interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Imipenem, Cilastatin, Relebactam interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Imipenem, Cilastatin, Relebactam interactionIsoniazid, RifampinRifamate
How Isoniazid, Rifampin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Isoniazid, Rifampin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Isoniazid, Rifampin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Isoniazid, Rifampin interactionKanamycinKantrex
How Kanamycin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Kanamycin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Kanamycin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Kanamycin interactionLansoprazole, Amoxicillin, ClarithromycinPrevpac
How Lansoprazole, Amoxicillin, Clarithromycin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Lansoprazole, Amoxicillin, Clarithromycin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Lansoprazole, Amoxicillin, Clarithromycin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Lansoprazole, Amoxicillin, Clarithromycin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pro-Bio with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bacillus subtilis
Antibiotic Drugs
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.
L. acidophilus
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
L. bulgaricus
Antibiotic Drugs
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.
Brand information
Manufacturer and brand details for Pro-Bio, from the product label.
Enzymedica
See all Enzymedica products- Name
- Enzymedica, Inc.
- Street Address
- 771 Commerce Drive
- City
- Venice
- State
- FL
- ZipCode
- 34292-1731
- Phone Number
- 1-888-918-1118
- Web Address
- www.enzymedica.com
Pro-Bio by Enzymedica: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pro-Bio is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pro-Bio’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Bacillus Subtilis
Interacts with 182 drugsBacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...
Read the full Bacillus Subtilis monograph → Herb & supplement monographLactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph → Herb & supplement monographLactobacillus Delbrueckii
Interacts with 182 drugsLactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...
Read the full Lactobacillus Delbrueckii monograph →Sources & How We Checked
Pro-Bio's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 34 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bacillus Subtilis 10 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
- La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
- Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
- Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
- Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
- Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
- Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
- Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
- Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
- Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
- Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
- Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
- Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
- Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
- Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.
See these in context on the Lactobacillus Acidophilus monograph →
Lactobacillus Delbrueckii 9 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
- Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
- Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
- Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
- Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
- Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
- Darbro BW, Petroelje BK, Doern GV. Lactobacillus delbrueckii as the cause of urinary tract infection. J Clin Microbiol 2009;47(1):275-7.
See these in context on the Lactobacillus Delbrueckii monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC