Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Black Elderberry plus Probiotics & Zinc Ingredients & Drug Interactions

by Enzymedica

Black Elderberry plus Probiotics & Zinc label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Elderberry plus Probiotics & Zinc against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Black Elderberry plus Probiotics & Zinc is a dietary supplement by Enzymedica with 3 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 332 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis DE111, ElderCraft, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Black Elderberry plus Probiotics & Zinc by Enzymedica

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Elderberry plus Probiotics & Zinc by Enzymedica — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Black Elderberry plus Probiotics & Zinc by Enzymedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 3 active ingredients.
  • “ElderCraft” is listed as a grouped ingredient — the label gives one combined amount (425 mg) without saying how much of each component you get.

This powder contains 3 active ingredients: zinc, the probiotic Bacillus subtilis DE111, and anthocyanins (the pigments in black elderberries that give them their color and potential health effects). Zinc is a mineral your body needs for immune function and wound healing.

Bacillus subtilis is a beneficial bacterium — a live probiotic — that's meant to support your gut. The product also contains several inactive ingredients like xylitol, sorbitol, and citric acid for texture and flavor.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune function, sinus and respiratory health.
  • We looked for evidence on: Allergic rhinitis (hay fever), Bronchiolitis, Coronavirus disease 2019 (COVID-19), Lower respiratory tract infections, cough, sore throat — and 2 related terms.
  • The strongest evidence on file: Zinc is rated "Possibly Effective" for Coronavirus disease 2019 (COVID-19) (Natural Medicines).
  • Also on file: Zinc is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Postoperative sore throat, Bronchiolitis.

For zinc, there's solid evidence it works for zinc deficiency and likely works for Wilson disease (a rare copper-storage disorder). It's possibly effective for acne, age-related macular degeneration (AMD), and diabetes, though the evidence is less certain.

For the probiotic Bacillus subtilis, there's possibly reliable evidence it may help with antibiotic-associated diarrhea, but the evidence for constipation, eczema, diabetes, and athletic performance is insufficient to rate. We hold no effectiveness data for the anthocyanins in this product.

The evidence, ingredient by ingredient Zinc Bacillus Subtilis Elderberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zinc is generally well tolerated when you stay within the recommended daily limit of 40 mg — the powder's dose will determine whether you're under that ceiling, so check the label. The most common side effects from oral zinc are mild: nausea, diarrhea, abdominal cramps, and a metallic taste.

High-dose zinc over the long term can lead to copper deficiency, which is why your doctor might suggest adding copper if you take zinc long-term. Bacillus subtilis is generally well tolerated in healthy adults, though safety data is limited; in very rare cases, people have reported headache or diarrhea.

There is not enough pregnancy and lactation safety data for Bacillus subtilis — talk with your doctor or pharmacist before using if you're pregnant or nursing.

Side effects, ingredient by ingredient Zinc Bacillus Subtilis Elderberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Zinc, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 213 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use any antibiotic drugs — especially quinolones (ciprofloxacin, levofloxacin), tetracyclines (doxycycline), cephalexin, or penicillamine — because zinc will reduce their absorption if taken together. Also check if you're on ritonavir, integrase inhibitors like dolutegravir, bictegravir/emtricitabine/tenofovir alafenamide, or cisplatin.

If any of these apply, spacing out doses by several hours is necessary — your pharmacist can help you plan that timing.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product makes sense if you're looking to cover a zinc deficiency or support your digestion with a probiotic. If you take antibiotics — especially quinolones, tetracyclines, cephalexin, or penicillamine — you'll need to time this supplement carefully to avoid reducing how well your antibiotic works.

Check your medications with the tool on this page before you start, and talk to your pharmacist if you take any HIV drugs or cancer treatments.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Elderberry plus Probiotics & Zinc, straight from the product label.

Brand Enzymedica
Barcode (UPC) 670480101124
Net contents 30 Powder Pack(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 296458
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Elderberry plus Probiotics & Zinc by Enzymedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Stick Pack(s)
Maximum serving Sizes:
1 Stick Pack(s)
Servings per container
30
UPC/BARCODE
670480101124
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Total Sugars0 Gram(s)--
Sugar Alcohol0.5 Gram(s)--
Zinc11 mg100%
Bacillus subtilis DE1110 NP--
Anthocyanins30 mg--
ElderCraft425 mg--

Other ingredients: Xylitol, Sorbitol, Tapioca Maltodextrin, Natural Flavors, Citric Acid, Malic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Enzymedica Natural Digestive Health & Wellness

DE111 is a registered trademark of Deerland Probiotics & Enzymes, Inc. ElderCraft is a registered trademark, exclsuively licensed to Iprona AG/SPA

Formula

With a Clinically studied probiotic

Equal to 80 berries per serving

Not just any elderberry Grown in Styria, Austria, ElderCraft European Black Elderberry Extract is considered by many as the finest in the world. This fertile region is known most for exquisite groves of Haschberg-variety elderberry trees, which may have been nurtured by farmers for genreations. Once fully ripe, big clusters of berries naturally rich in anthocyanins, polysaccharides and berry micronutrients are harvested. After completing a journey to a state-of-the-art facility, the berries undergo a solvent-free extraction & ultra-filtration process, which creates an active blend rich in beneficial compounds to support immune health.

Formulation

On-The-Go Immune Packs Boosts immune, sinus & respiratory health Great testing quick melt

Sugar Free Non GMO

Vegetarian

Dual-Action Support Elderberry + 5 billion CFUs of DE111 probiotic work together to promote immune function. Throat & Chest Supplement ElderCraft elderberry has been shown to help warm & soothe scratchy throats. Breathe Freely ElderCraft elderberry helps to support upper respiratory tract health. Nutrition Powerhouse Antioxidants in elderberry + Zinc naturally provide fuel for your body's immune functions.

Contains no: gluten, milk, casein, soy, egg, artificial colors or flavors

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

How to Enjoy On-The-Go Immune Packs Place the delicious powder directly on your tongue & let it quickly dissolve. Sprinkle on your favorite foods, such as ice cream and yogurt.

Recommended Use: One stick pack daily. For adults and children ages 4+, place powder on tongue or sprinkle on favorite food. Children must take under supervision of an adult.

Storage

Keep closed in dry place; avoid excessive heat.

Precautions

Do not use if packet is opened.

Please keep out of reach of children & pets

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Elderberry plus Probiotics & Zinc by Enzymedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Elderberry plus Probiotics & Zinc label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Elderberry plus Probiotics & Zinc by Enzymedica

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Stick Pack(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
11 mg per serving Form: Zinc Citrate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Bacillus subtilis DE111

Interacts with
182 drugs
0 NP per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis DE111 monograph & interactions

ElderCraft

Interacts with
121 drugs
425 mg per serving Form: European Black Elderberry Fruit Extract

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

ElderCraft monograph & interactions
  • › Anthocyanins

Other (inactive) ingredients: Xylitol, Sorbitol, Tapioca Maltodextrin, Natural Flavors, Citric Acid, Malic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Elderberry plus Probiotics & Zinc by Enzymedica Drug Interactions

Want to check YOUR meds against Black Elderberry plus Probiotics & Zinc?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
332Drugs
328 Moderate 4 Minor

Ingredients driving the most interactions

Bacillus subtilis DE111 182
ElderCraft 121
Zinc 67

Individual Drug Interactions

The ingredients in Black Elderberry plus Probiotics & Zinc interact with 332 drugs. Click any drug to see the details.

3 of the 3 ingredients in Black Elderberry plus Probiotics & Zinc interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis DE111 ElderCraft Zinc

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Elderberry plus Probiotics & Zinc with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis DE1111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis DE111 full monograph & interactions

ElderCraft2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
ElderCraft full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Black Elderberry plus Probiotics & Zinc, from the product label.

Enzymedica

See all Enzymedica products
Name
Enzymedica, Inc.
Street Address
771 Commerce Drive
City
Venice
State
FL
ZipCode
34292-1731
Phone Number
1-888-918-1118
Web Address
www.enzymedica.com
Pharmacist Counseling Corner

Black Elderberry plus Probiotics & Zinc by Enzymedica: Common Questions

Does Black Elderberry plus Probiotics & Zinc by Enzymedica interact with any medications?
Yes. Based on its ingredients, Black Elderberry plus Probiotics & Zinc has a known interaction with 332 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Elderberry plus Probiotics & Zinc contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Zinc is likely safe during pregnancy and lactation at normal doses. But we don't have enough safety data on the probiotic Bacillus subtilis to know either way — talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.
What's the main difference between this and just taking zinc alone?
This adds a live probiotic (Bacillus subtilis) and anthocyanins from black elderberry. The probiotic is possibly effective for antibiotic-associated diarrhea, while the anthocyanins — the plant pigments that give elderberries their color — are included for their antioxidant effects, though we hold no effectiveness data for them in this product.
What side effects should I expect from the zinc?
Most people don't have issues, but the most common ones are nausea, diarrhea, stomach cramps, and a metallic taste — all dose-related. Stay within the recommended daily limit on the label (ideally not above 40 mg per day) to keep side effects minimal.
Will this upset my stomach if I have a sensitive gut?
Zinc can cause nausea and diarrhea, especially at higher doses. The probiotic itself is generally well tolerated, and diarrhea from it is rare. Start with a smaller dose and see how you feel, and reach out to your pharmacist if you notice issues.
Does this contain any fillers?
Yes — the inactive ingredients include xylitol, sorbitol, tapioca maltodextrin, natural flavors, citric acid, malic acid, and silica. If you have a sweetener sensitivity or preference, check the label to see if these work for you.
Can I take this long-term?
Zinc is well tolerated below 40 mg daily over the long term, but very high-dose zinc for prolonged periods might increase the risk of copper deficiency — some doctors recommend adding a small amount of copper if you're on high-dose zinc long-term. Talk with your pharmacist about your specific dose and timeline.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Elderberry plus Probiotics & Zinc label
Go deeper

The Full Monographs Behind Black Elderberry plus Probiotics & Zinc’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph →
Sources

Sources & How We Checked

Black Elderberry plus Probiotics & Zinc's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 104 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zinc 88 references
  1. Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
  2. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
  3. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
  4. Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
  5. Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
  6. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  8. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
  9. Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
  10. Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990;51:225-7.
  11. Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. PubMed
  12. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  13. Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14. PubMed
  14. Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976;11:45-54.. PubMed
  15. Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial. Ear Nose Throat J 2000;79:778-82.. DOI
  16. Simkin PA. Oral zinc sulphate in rheumatoid arthritis. Lancet 1976;2:539-42. PubMed
  17. Wray D. A double-blind trial of systemic zinc sulfate in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1982;53:469-72. PubMed
  18. Douglas RM, Miles HB, Moore BW, et al. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987;31:1263-5. PubMed
  19. Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology 1999;54:284-90. PubMed
  20. Ewing CI, Gibbs AC, Ashcroft C, David TJ. Failure of oral zinc supplementation in atopic eczema. Eur J Clin Nutr 1991;45:507-10.
  21. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  22. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Oph
  23. Greenberg JE, Lynn M, Kirsner RS, et al. Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol 2002;29:613-5. PubMed
  24. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.
  25. Turner RB. Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. Clin Infect Dis 2001;33:1865-70. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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