Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Probiotic 40 Billion CFU Ingredients & Drug Interactions

by BioSchwartz

Probiotic 40 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic 40 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic 40 Billion CFU is a dietary supplement by BioSchwartz with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus (La-14). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic 40 Billion CFU by BioSchwartz

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic 40 Billion CFU by BioSchwartz — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic 40 Billion CFU by BioSchwartz

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 5 active ingredients: a proprietary blend of four live probiotic strains (Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus paracasei, and Lactobacillus plantarum) plus prebiotic fructooligosaccharides. Probiotics are beneficial bacteria; the prebiotic acts as food for them to thrive.

The capsule also contains inactive ingredients including cellulose, rice dextrin, L-leucine, and polysaccharides complex.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Lactobacillus Acidophilus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Lactobacillus Acidophilus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It is possibly ineffective for atopic disease (allergic conditions), and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome.

We have no effectiveness data on file for the other three probiotic strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Uncommonly, taking it with other probiotics may cause mild gastrointestinal side effects — epigastric discomfort, abdominal pain, indigestion, gas, bloating, diarrhea, vomiting, or burping.

In rare cases, live probiotic organisms have been linked to serious infections (bacteremia, sepsis, abscess, endocarditis) primarily in patients with weakened immune systems or disrupted gut barriers; most experts believe these occur when the bacteria spread from places in the body where they naturally live. Pregnancy is rated possibly safe, but data are limited — talk with your doctor or pharmacist about whether it's right for you.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Separate your doses of antibiotics and this probiotic by a few hours — taking them at the same time can reduce the probiotic's effectiveness. We could not check the interaction data for three of the four probiotic strains in this product, so there may be other interactions we're unaware of.

Run your medications through the search tool on this page before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-associated diarrhea, and certain infections, but the evidence is still developing. If you take antibiotics, time your doses a few hours apart from this supplement.

Check with your doctor or pharmacist before starting, especially if you have a compromised immune system, serious illness, or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic 40 Billion CFU, straight from the product label.

Brand BioSchwartz
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 249935
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic 40 Billion CFU by BioSchwartz, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Proprietary Blend0 NP--
Lactobacillus acidophilus (La-14)0 NP--
Bifidobacterium lactis (Bl-04)0 NP--
Lactobacillus paracasei Lpc-370 NP--
Lactobacillus plantarum (Lp-115)0 NP--
Prebiotic Fructooligosaccharides0 NP--

Other ingredients: Cellulose, Rice Dextrin, L-Leucine, Polysaccharides complex

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take two (2) capsules once daily. For best results, take one (1) capsule during the day and one (1) capsule in the evening. Repeat the process daily. Do not exceed two capsules per day.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

This statements has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

No refrigeration required

Shelf stable

Formulation

Professional Grade

Advanced strength Shelf life potency guaranteed Survives stomach acids and bile fluids

Proudly made in the USA Third-party tested

Non-GMO ingredients 100% Allergen free

No GMOs, soy, gluten, wheat, tree nuts, peanuts, sugar, preservatives or artificial colorants.

Gluten free ingredients

General Statements

Best seller

New name, same product & quality

FDA Statement of Identity

Natural Dietary Supplement

Formula

This product guarantees a minimum potency of 20 Billion CFU per serving until expiration date.

Seals/Symbols

Made in USA GMP Good Manufacturing Practice 3rd Party Certified 100% Natural Highest Quality

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic 40 Billion CFU by BioSchwartz label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic 40 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic 40 Billion CFU by BioSchwartz

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Prebiotic Fructooligosaccharides

0 NP per serving

Other (inactive) ingredients: Cellulose, Rice Dextrin, L-Leucine, Polysaccharides complex. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic 40 Billion CFU by BioSchwartz Drug Interactions

Want to check YOUR meds against Probiotic 40 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus (La-14) 182

Individual Drug Interactions

The ingredients in Probiotic 40 Billion CFU interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in Probiotic 40 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus (La-14)

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic 40 Billion CFU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus (La-14)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (La-14) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic 40 Billion CFU, from the product label.

BioSchwartz

See all BioSchwartz products
Name
BioSchwartz
Street Address
9450 SW Gemini Dr #50492
City
Beaverton
State
OR
ZipCode
97008
Phone Number
+1 (855) 739-2206
Web Address
http://www.bioschwartz.com
Pharmacist Counseling Corner

Probiotic 40 Billion CFU by BioSchwartz: Common Questions

Does Probiotic 40 Billion CFU by BioSchwartz interact with any medications?
Yes. Based on its ingredients, Probiotic 40 Billion CFU has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic 40 Billion CFU contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm taking an antibiotic?
Taking them simultaneously can reduce how well the probiotic works, since the antibiotic may kill the live organisms. The standard advice is to space them out by a few hours — ask your doctor or pharmacist for the best timing for your specific antibiotic and dose.
Can this cause stomach upset?
Mild gastrointestinal side effects like gas, bloating, or abdominal discomfort are uncommon but possible, especially if you're taking multiple probiotics together. These usually settle down over time.
Is it safe during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but the data are limited. Talk with your doctor or pharmacist to decide if it's right for you during pregnancy.
What does the prebiotic fructooligosaccharides do?
It acts as food for the probiotic bacteria, helping them grow and thrive in your gut.
How many live organisms does each capsule contain?
The product is labeled 40 Billion CFU (colony-forming units), which is the standard measure of live organisms, though the facts on file don't break down how much of each strain is included.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic 40 Billion CFU is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic 40 Billion CFU label
Go deeper

The Full Monographs Behind Probiotic 40 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic 40 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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