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Dietary supplement

Probiotic-6 Ingredients & Drug Interactions

by U.S. Doctors' Clinical

Probiotic-6 label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic-6 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic-6 is a dietary supplement by U.S. Doctors' Clinical with 1 active ingredient. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Unique IS2 Bacillus Coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic-6 by U.S. Doctors' Clinical

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic-6 by U.S. Doctors' Clinical — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic-6 by U.S. Doctors' Clinical

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

Probiotic-6 contains one active ingredient: Bacillus coagulans (a proprietary strain called Unique IS2), a live microorganism that's intended to support digestive health. The softgel capsule also contains several inactive ingredients — flaxseed oil, gelatin, purified water, glycerin, MCT oil, beeswax, soy lecithin, silicon dioxide, and FD&C Red #3 — which help deliver and preserve the probiotic.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Bacillus Coagulans's overall clinical evidence instead.

Moderate

Some clinical evidence supports Bacillus Coagulans for:

Why this rating?
  • The label markets general wellness (“digestive support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Constipation — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

The data shows Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS). For other uses listed — antibiotic-associated diarrhea, athletic performance, cancer, and fatty liver disease — the evidence isn't established enough to rate whether it works.

If you're considering this product for one of those other conditions, talk with your doctor about whether there's enough evidence to try it.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, though the quality and safety evidence for probiotic products varies. There isn't enough reliable safety data on file to make a full assessment, so check with your doctor or pharmacist before starting it.

One concern is that live probiotics can theoretically cause serious infections — bacteremia (bacteria in the bloodstream) and sepsis — in people with central lines, severe illness, or weakened immune systems, including preterm infants. If you fall into that category or have any doubt, talk with your doctor first.

The product facts don't include pregnancy and breastfeeding safety information on file, so ask your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, do not take this probiotic at the same time — antibiotics can kill the live organisms and reduce its effectiveness. Separate your doses and talk with your doctor or pharmacist about the right timing for your situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with constipation and IBS symptoms. The main caution is its interaction with antibiotics — you'll need to time them separately.

Because safety data is limited and live organisms carry a small theoretical risk in certain groups, check with your doctor or pharmacist before you start, especially if you have a weakened immune system or any serious illness.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic-6, straight from the product label.

Brand U.S. Doctors' Clinical
Barcode (UPC) 851743006183
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71647
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic-6 by U.S. Doctors' Clinical, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
851743006183
IngredientAmount% DV
Unique IS2 Bacillus Coagulans0 NP--

Other ingredients: Flaxseed Oil, Gelatin, purified Water, Glycerin, MCT Oil, Bees Wax, Soy Lecithin, Silicon Dioxide, FD&C Red #3

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Probiotic-6 is one of the most potent probiotic supplements available that has a long, stable shelf life.

Unique IS2 Bacillus Coagulans is a registered trademark of Unique Biotech Ltd.

Formula

It contains Unique IS2 Bacillus Coagulans, a clinically tested form of bacteria that have a natural micro-encapsulation that allows up to 80% of the bacteria to survive the journey through the digestive tract and reach the large intestine.

Contains: Soy.

General Statements

Digestive support

Advisory board doctors Doctor Recommended “Probiotics are great because of their many beneficial health properties. The good bacteria in each serving help you break down and digest foods more efficiently, and they help eliminate bad bacteria that can weaken your immune system. In addition, the probiotics also inhibit cholesterol production to support a healthy heart.” –Robert Schiffer, M.D.

Contains a minimum of 3 billion live bacteria cells per softgel when manufactured and provides a minimum concentration of 500 million at expiration date.

Digestive health Doctor recommended 6 Billion beneficial microflora per day

Contains clinically tested ingredient Supports: Digestive health Natural body defenses Balance of good bacteria Normal range of cholesterol

Precautions

Contains: Soy.

Do not take this supplement within one hour of taking medications. Do not exceed the recommended dosage.

Warning: Women who are pregnant or lactating should consult a health care professional before using any nutritional product.

If any adverse reactions occur, discontinue use and consult a health care professional.

Not for use by children under the age of 18. Keep out of reach of children.

Do not use if seal under cap has been broken.

Formulation

Gluten and dairy free.

Gluten free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: For adults only. Take two (2) softgels daily with food and a full glass of water. Do not take this supplement within one hour of taking medications. Do not exceed the recommended dosage.

Seals/Symbols

Gluten free

cGMP

Made in U.S.A.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

General

Product No. USPB - No. 2

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic-6 by U.S. Doctors' Clinical label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic-6 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic-6 by U.S. Doctors' Clinical

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Unique IS2 Bacillus Coagulans

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Unique IS2 Bacillus Coagulans monograph & interactions

Other (inactive) ingredients: Flaxseed Oil, Gelatin, Purified Water, Glycerin, MCT Oil, Bees Wax, Soy Lecithin, Silicon Dioxide, FD&C Red #3. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic-6 by U.S. Doctors' Clinical Drug Interactions

Want to check YOUR meds against Probiotic-6?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Unique IS2 Bacillus Coagulans 182

Individual Drug Interactions

The ingredients in Probiotic-6 interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Probiotic-6 interact with drugs. Each result below shows which ingredient is responsible. Unique IS2 Bacillus Coagulans

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic-6 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Unique IS2 Bacillus Coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Unique IS2 Bacillus Coagulans full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic-6, from the product label.

U.S. Doctors' Clinical

See all U.S. Doctors' Clinical products
Name
U.S. Doctors' Clinical
Street Address
15568 Brookhurst St. Ste. 374
City
Westminster
State
CA
ZipCode
92683
Phone Number
1-800-914-0594
Web Address
www.usdoctorsclinical.com
Pharmacist Counseling Corner

Probiotic-6 by U.S. Doctors' Clinical: Common Questions

Does Probiotic-6 by U.S. Doctors' Clinical interact with any medications?
Yes. Based on its ingredients, Probiotic-6 has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic-6 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic help my IBS or constipation?
The data shows Bacillus coagulans is possibly effective for both constipation and irritable bowel syndrome. Results vary by person, so it may help, but it's not guaranteed.
Can I take this at the same time as my antibiotic?
No — antibiotics can kill the live organisms in this probiotic and make it less effective. Separate your doses and ask your doctor or pharmacist how far apart to take them.
Is this probiotic safe in healthy people?
It's generally well tolerated in healthy adults, but safety data is limited. Check with your doctor or pharmacist before starting, especially if you have any immune problems or serious illness — probiotics do carry a small theoretical risk in those groups.
Can I take this if I'm pregnant or breastfeeding?
The product facts don't include safety information for pregnancy or breastfeeding, so there isn't enough data to know either way. Talk with your doctor or pharmacist for personalized advice.
What's in this besides the probiotic?
The capsule contains flaxseed oil, gelatin, purified water, glycerin, MCT oil, beeswax, soy lecithin, silicon dioxide, and FD&C Red #3 as inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic-6 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic-6 label
Go deeper

The Full Monographs Behind Probiotic-6’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Probiotic-6's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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