Probiotic Ingredients & Drug Interactions
by Onnit
What is this page for?
First and foremost: checking Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Probiotic is a dietary supplement by Onnit with 5 active ingredients. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum infantis, Lactobacillus acidophilus DDS-1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Probiotic by Onnit
Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic by Onnit — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Probiotic by Onnit
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Onnit Probiotic is a 5-ingredient blend of beneficial bacteria strains. The checked ingredients include Bifidobacterium longum infantis and Lactobacillus acidophilus DDS-1 — both live organisms that support digestive health.
The product also contains Lactobacillus plantarum, Bifidobacterium animalis lactis, and Lactobacillus rhamnosus, along with inactive ingredients like rice dextrin and medium-chain triglycerides that serve as carriers and stabilizers in the capsule.
Does it work?
Moderate evidence
Evidence for Lactobacillus acidophilus DDS-1 shows it may help with irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The data on Bifidobacterium longum infantis is not strong enough yet — we hold insufficient evidence to rate it for the conditions studied, including age-related cognitive decline, hay fever, antibiotic-associated diarrhea, generalized anxiety, asthma, and athletic performance.
Since we could not check the other three strains, their effectiveness data aren't on file here.
How safe is it?
Well-documented data
Bifidobacterium longum infantis is generally well tolerated in healthy people, but caution is needed if you're seriously ill or have a weakened immune system. Rare side effects include abdominal discomfort, flatulence, constipation, and in one case, a dry cough.
Lactobacillus acidophilus is also generally well tolerated in healthy adults and children; uncommon gastrointestinal side effects when combined with other probiotics may include bloating, gas, mild diarrhea, and abdominal pain. Both ingredients carry a small theoretical risk of bacteremia (bacteria entering the bloodstream) in critically ill or immune-compromised patients — cases have been documented in preterm infants and seriously ill adults, so check with your doctor before use if you fall into that group.
For pregnancy and breastfeeding, Bifidobacterium longum infantis is rated Possibly Safe; Lactobacillus acidophilus is Possibly Safe in pregnancy, though breastfeeding data aren't available. There isn't enough data to know about the other strains — talk with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
If you're on antibiotic drugs, hold off and ask your doctor or pharmacist when to take this probiotic — timing matters. Antibiotics can kill the live bacteria in this product and make it less effective, so you'll want to space them out.
Check your full medication list on this page to see if anything else applies.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This probiotic may be worth considering if you have IBS, antibiotic-associated diarrhea, or certain infections, based on the Lactobacillus acidophilus strain. If you're taking antibiotics, space out the doses — your doctor or pharmacist can help you time it right.
Be extra cautious if you're seriously ill, immune-compromised, or a critically ill infant. Talk with your doctor or pharmacist before starting, especially if you're pregnant, breastfeeding, or have any underlying health concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Probiotic, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Probiotic by Onnit, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bifidobacterium longum infantis | 0 NP | -- |
| Lactobacillus plantarum | 0 NP | -- |
| Bifidobacterium animalis lactis | 0 NP | -- |
| Lactobacillus acidophilus DDS-1 | 0 NP | -- |
| Lactobacillus rhamnosus | 0 NP | -- |
| Onnit Probiotic Blend | 450 mg | -- |
Other ingredients: Rice Dextrin, Hydroxypropyl Methylcellulose, Water, Nu-Flow, Medium Chain Triglyceride
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Probiotics - HCL - Enzymes
10 Probiotics Billion Colony Forming
Essential Prebiotics Prebiotics are essential to help support the probiotic colonies inside your gut. We included one of the best, Jerusalem artichoke, in our formula and complemented it with dandelion. Five Strains of Probiotics Probiotic bacteria are responsible for not only helping digestion, but also for optimizing mood and suppoering immune function. We added five of the most important acid-resistant probiotic strains: L. acidophilus DDS-1, L. plantarum, L. rhamnosus, B. infantis and B. lactis. Saccharomyces Boulardii S. boulardii is a unique non-pathogenic, non-colonizing probiotic yeast that supports gastrointestinal health by promoting the production of secretory immunoglobulin a. With five billion colony-forming units per capsule and its ability to survive stomach acid, this was an ingredient we just couldn't leave out. Digestive Enzymes Our flagship proteolytic enzyme blend, DigesTech, offers assistance with the digestion of all five major categories: fats, protein, dairy, fiber, and carbohydrates. Betaine HCL Hydrochloric acid is the stomach's innate way to assist with the breakdown of food. In combination with enzymes, our betaine HCI forms a potent 1-2 punch to support normal stomach acid function and to support digestion and nutrient absorption.
Formulation
Formulated to help support Healthy Gut Flora & Optimal Digestion
Unique formula designed to Break down food & absorb nutrients Support the immune system Help support healthy gut flora Digest Major macronutrients
Healthy Gut Biome A gut biome of friendly probiotic bacteria is not only important for digestion, it is also where a great deal of our important nutrients are produced. In addition, these all-important little allies are also responsible for maintaining a healthy immune system. In order to support the gut biome, we included five acid-resistant strains of probiotics, along with S. boulardii and prebiotic food to feed our little buddies.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use Adults, as a dietary supplement, take one packet with your largest meal of the day.
Precautions
Consult a medical doctor before taking this or any other nutritional supplement if you are pregnant, nursing, have or suspect a medical condition or are taking any medications.
Keep out of reach of children.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Probiotic by Onnit label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Probiotic by Onnit
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Onnit Probiotic Blend
- › Bifidobacterium longum infantis
- › Lactobacillus plantarum
- › Bifidobacterium animalis lactis
- › Lactobacillus acidophilus DDS-1
- › Lactobacillus rhamnosus
Other (inactive) ingredients: Rice Dextrin, Hydroxypropyl Methylcellulose, Water, Nu-Flow, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.
Probiotic by Onnit Drug Interactions
HelloPharmacist Interaction Report
Onnit Probiotic contains two ingredients with documented interactions: Bifidobacterium longum infantis and Lactobacillus acidophilus DDS-1.
Both interact with antibiotic drugs (a Moderate severity interaction). Since these probiotics contain live, active organisms, taking them at the same time as antibiotics may allow the antibiotic to kill off a significant portion of the beneficial bacteria, reducing the probiotic's effectiveness.
Read the full breakdown — every affected drug type, severity by severity
The interaction is straightforward to manage: separate when you take them. Your doctor or pharmacist can advise you on the right timing — generally spacing them several hours apart works, but it depends on which antibiotic you're on.
We could not check three other probiotic strains in this product: Lactobacillus plantarum, Bifidobacterium animalis lactis, and Lactobacillus rhamnosus. Altogether, these interactions span 182 individual medications.
Use the medication checker on this page to see if any of your prescriptions are affected, and talk with your doctor or pharmacist before starting this product if you're taking antibiotics.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Probiotic?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Probiotic interact with 182 drugs. Click any drug to see the details.
2 of the 5 ingredients in Probiotic interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum infantis Lactobacillus acidophilus DDS-1
CefotetanCefotan
How Cefotetan interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cefotetan interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cefotetan interactionCefoxitinMefoxin
How Cefoxitin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cefoxitin interactionLactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cefoxitin interactionCefpodoxime ProxetilVantin
How Cefpodoxime Proxetil interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cefpodoxime Proxetil interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cefpodoxime Proxetil interactionCefprozilCefzil
How Cefprozil interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cefprozil interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cefprozil interactionCeftazidimeCeftazidime, Ceptaz, Fortaz, Tazicef, Tazidime
How Ceftazidime interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Ceftazidime interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Ceftazidime interactionCeftibutenCedax
How Ceftibuten interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Ceftibuten interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Ceftibuten interactionCeftizoximeCefizox
How Ceftizoxime interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Ceftizoxime interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Ceftizoxime interactionCeftolozane Sulfate, Tazobactam SodiumZerbaxa
How Ceftolozane Sulfate, Tazobactam Sodium interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Ceftolozane Sulfate, Tazobactam Sodium interactionLactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Ceftolozane Sulfate, Tazobactam Sodium interactionCeftriaxoneRocephin
How Ceftriaxone interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Ceftriaxone interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Ceftriaxone interactionCefuroximeCeftin, Kefurox, Zinacef
How Cefuroxime interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cefuroxime interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cefuroxime interactionCephalexinCephalex, Keflex, Keftab, Lexin
How Cephalexin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cephalexin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cephalexin interactionCephapirinCefadyl
How Cephapirin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cephapirin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cephapirin interactionCephradineAnspor, Velosef
How Cephradine interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cephradine interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cephradine interactionChloramphenicolChloromycetin, Chloromycetin Injection, Chloromycetin Ophthalmic
How Chloramphenicol interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Chloramphenicol interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Chloramphenicol interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Chlortetracycline interactionLactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Chlortetracycline interactionCinoxacinCinobac
How Cinoxacin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cinoxacin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Ciprofloxacin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Ciprofloxacin interactionClarithromycinBiaxin, Biaxin XL
How Clarithromycin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Clarithromycin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Clarithromycin interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Clinafloxacin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Clinafloxacin interactionClindamycinCleocin, Cleocin T Gel, ClindaMax, Clindesse, Dalacin C
How Clindamycin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Clindamycin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Clindamycin interactionClofazimineLamprene
How Clofazimine interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Clofazimine interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Clofazimine interactionCloxacillin SodiumCloxapen, Cloxi, Tegopen
How Cloxacillin Sodium interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cloxacillin Sodium interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cloxacillin Sodium interactionColistimethateColy-Mycin M
How Colistimethate interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Colistimethate interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Colistimethate interactionCyclacillinCyclapen-W, Cylcapen
How Cyclacillin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cyclacillin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cyclacillin interactionCycloserineSeromycin
How Cycloserine interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Cycloserine interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Cycloserine interactionDalbavancin HydrochlorideDalvance
How Dalbavancin Hydrochloride interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Dalbavancin Hydrochloride interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Dalbavancin Hydrochloride interactionDapsoneAczone, Avlosulfon, Dapsone
How Dapsone interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Dapsone interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Dapsone interactionDaptomycinCubicin, Dapzura RT
How Daptomycin interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Daptomycin interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Daptomycin interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Demeclocycline interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Demeclocycline interactionDicloxacillin InjectionDynapen Injection
How Dicloxacillin Injection interacts with Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus Dds-1Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus Dds-1 + Dicloxacillin Injection interactionBifidobacterium Longum InfantisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Infantis + Dicloxacillin Injection interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bifidobacterium longum infantis
Antibiotic Drugs
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.
Lactobacillus acidophilus DDS-1
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
Brand information
Manufacturer and brand details for Probiotic, from the product label.
Onnit
See all Onnit products- Name
- Onnit Labs, LLC
- City
- Austin
- State
- Texas
- ZipCode
- 78744
- Phone Number
- (855) 666-4899
Probiotic by Onnit: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Probiotic’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Bifidobacterium Longum
Interacts with 182 drugsBifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...
Read the full Bifidobacterium Longum monograph → Herb & supplement monographLactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph →Sources & How We Checked
Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bifidobacterium Longum 21 references
- Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
- Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
- Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
- Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
- US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
- Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
- Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
- Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
- Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
- Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
- Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
- Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
- Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
- Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
- Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed
See these in context on the Bifidobacterium Longum monograph →
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
- Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
- Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
- Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
- Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
- Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
- Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.
See these in context on the Lactobacillus Acidophilus monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC