Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Probiotic Gummies Ingredients & Drug Interactions

by Schiff Digestive Advantage

Probiotic Gummies label
See full label image
Gummy Or Jelly Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Gummies against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Gummies is a dietary supplement by Schiff Digestive Advantage with 3 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BC30 Bacillus coagulans GBl-30, 6086. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Probiotic Gummies by Schiff Digestive Advantage

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Gummies by Schiff Digestive Advantage — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Probiotic Gummies by Schiff Digestive Advantage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

Schiff Digestive Advantage contains 2 active ingredients, both the same probiotic strain: BC30 Bacillus coagulans, a live beneficial bacteria that lives in your gut and is meant to support digestive health. The gummies also include inactive ingredients — corn syrup, water, gelatin, citric acid, natural flavors, lactic acid, and colors — which are the excipients that make it a gummy and keep it shelf-stable.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Constipation, Irritable bowel syndrome (IBS), Flatulence, Dyspepsia, Antibiotic-associated diarrhea, Travelers' diarrhea — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Inflammatory bowel disease (IBD), Diarrhea, Dyspepsia, and more.

The evidence here is mixed. BC30 Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS) based on available data.

For other uses listed — antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease — the evidence isn't established well enough for us to rate it one way or the other. If you're considering this for a specific digestive concern, your doctor or pharmacist can help you figure out whether the research matches your situation.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

BC30 Bacillus coagulans is generally well tolerated in healthy adults, though the evidence and quality of different probiotic products can vary. There isn't enough reliable safety data overall, so it's worth talking with your doctor before starting.

One concern with any live probiotic is the small risk of infection — mainly in patients with central lines, severe illness, or weakened immune systems. In relatively healthy people with intact immunity and no indwelling medical devices, this risk appears to be very low, but the data is still limited.

Talk with your doctor or pharmacist first, especially if you're unwell or immunocompromised.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Schiff Digestive Advantage, check with your doctor or pharmacist if you take antibiotics. Antibiotics can reduce how well these live bacteria work, so timing matters — they'll likely advise you to separate when you take them.

Run your complete medication list through the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

These gummies might help if you're dealing with constipation or IBS, but the evidence is not strong. They're generally well tolerated in healthy people, but there's a real interaction with antibiotics that you need to plan around.

If you take antibiotics, you'll want to space out when you take this probiotic. Talk with your doctor or pharmacist before starting, particularly if you have a weakened immune system or are on multiple medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Gummies, straight from the product label.

Brand Schiff Digestive Advantage
Barcode (UPC) 020525183637
Net contents 30 Gummie(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62611
Product type Non-nutrient/non-botanical
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Gummies by Schiff Digestive Advantage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gummy(ies)
Maximum serving Sizes:
4 Gummy(ies)
UPC/BARCODE
020525183637
IngredientAmount% DV
Calories25 Calorie(s), 10 Calorie(s)--
Total Carbohydrates6 Gram(s), 3 Gram(s)2%, 1%
Sugar4 Gram(s), 2 Gram(s)--
BC30 Bacillus coagulans GBl-30, 60860 NP--
BC30 Bacillus coagulans GBI-30, 60860 NP--

Other ingredients: Corn Syrup, Water, Gelatin, Citric Acid, Natural flavors, Lactic Acid, Colors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Digestive Advantage targets your specific digestive health needs and with continued use, gives you long-term digestive support.

Powered by Ganeden BC30 probiotic digestive & immune health

2015 RB

Formula

That's because Digestive Advantage contains BC30, a probiotic that survives 100x better than leading probiotics and yogurt so it can deliver good bacteria where you need it.

Contains soy

Ganeden BC30 probiotic

General Statements

Probiotics are beneficial bacteria that live in your digestive tract and promote digestive and immune health. Many other probiotics don't survive the harsh acidic stomach environment. The probiotic used in Digestive Advantage is protected by a hardened layer of proteins, which allows it to survive the harsh environment of the stomach better than other probiotics and reach the intestines to promote digestive and immune health. Digestive Advantage helps lessen minor abdominal discomfort, bloating and helps reduce occasional diarrhea.

Based on median % survivability of Digestive Advantage probiotic vs. leading probiotic supplements and 19 probiotic yogurts in simulated gastric pH for 2 hours. Survivability and delivery of probiotic cells to the small & large intestines is one of the several factors influencing overall product effect.

Since 1936

The probiotic that survives 100x better survivability vs. yogurt & leading probiotics

Great tasting natural fruit flavors

Health Hygiene Home

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults and children 4 years of age and older: Chew two (2) gummies daily to support digestive and overall health. Chew four (4) gummies daily to reduce occasional digestive upsets, lessen minor abdominal discomfort, and help relieve occasional diarrhea. Children 3 years of age: Chew one (1) gummy daily.

Chew thoroughly before swallowing.

Precautions

Not for children under 3 years of age due to the risk of choking.

Contains soy

Note: If pregnant, lactating or on prescribed medication, consult your physician before using this product.

Excessive consumption may have a laxative effect in children. Always consult your pediatrician before giving your child dietary supplements. Keep out of reach of children.

Storage

Store in a cool, dry place.

General

121714 8194597

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Gummies by Schiff Digestive Advantage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Gummies label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Gummies by Schiff Digestive Advantage

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Gummy(ies) Dosage formGummy Or Jelly Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

4 Gram(s) per serving

BC30 Bacillus coagulans GBl-30, 6086

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

BC30 Bacillus coagulans GBl-30, 6086 monograph & interactions

BC30 Bacillus coagulans GBI-30, 6086

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

BC30 Bacillus coagulans GBI-30, 6086 monograph & interactions

Other (inactive) ingredients: Corn Syrup, Water, Gelatin, Citric Acid, Natural flavors, Lactic Acid, Colors. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Gummies by Schiff Digestive Advantage Drug Interactions

Want to check YOUR meds against Probiotic Gummies?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

BC30 Bacillus coagulans GBl-30, 6086 182

Individual Drug Interactions

The ingredients in Probiotic Gummies interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Probiotic Gummies interact with drugs. Each result below shows which ingredient is responsible. BC30 Bacillus coagulans GBl-30, 6086

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Gummies with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BC30 Bacillus coagulans GBl-30, 60861 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
BC30 Bacillus coagulans GBl-30, 6086 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Gummies, from the product label.

Schiff Digestive Advantage

See all Schiff Digestive Advantage products
Name
Reckitt Benckiser
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.DigestiveAdvantage.com
Pharmacist Counseling Corner

Probiotic Gummies by Schiff Digestive Advantage: Common Questions

Does Probiotic Gummies by Schiff Digestive Advantage interact with any medications?
Yes. Based on its ingredients, Probiotic Gummies has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Gummies contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will these gummies help with my IBS?
BC30 Bacillus coagulans is possibly effective for irritable bowel syndrome based on the evidence we have. That doesn't guarantee it'll work for you — everyone's different — but there's enough research to suggest it's worth discussing with your doctor as part of your IBS plan.
Can I take this while I'm on antibiotics?
You shouldn't take them at the same time. Antibiotics kill bacteria, including the live organisms in this probiotic, so they work against each other. Space them out — ask your doctor or pharmacist exactly how far apart to take them for the best results.
Are there any side effects I should know about?
Most people tolerate these well. The main concern is for people who are severely ill, have a weakened immune system, or have central lines — there's a small risk of infection from live probiotics in those situations. If you're generally healthy, the risk is very low. Talk with your pharmacist if you have any health concerns.
Is it safe to take if I'm pregnant or breastfeeding?
The safety data for this product during pregnancy and lactation isn't established. Talk with your doctor or pharmacist before taking these if you're pregnant, trying to get pregnant, or breastfeeding — they can give you personalized advice based on your situation.
What's actually in these gummies?
The active ingredient is BC30 Bacillus coagulans, a live probiotic strain. The rest is the gummy base — corn syrup, gelatin, citric acid, natural flavors, lactic acid, water, and colors.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Gummies is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Gummies label
Go deeper

The Full Monographs Behind Probiotic Gummies’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Probiotic Gummies's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team