Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Lactose Defense Formula Ingredients & Drug Interactions

by Schiff Digestive Advantage

Lactose Defense Formula label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lactose Defense Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lactose Defense Formula is a dietary supplement by Schiff Digestive Advantage with 2 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BC30 Bacillus coagulans GBI-30, 6086. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lactose Defense Formula by Schiff Digestive Advantage

Ask about any prescription or over-the-counter medication and we check it for interactions with Lactose Defense Formula by Schiff Digestive Advantage — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Lactose Defense Formula by Schiff Digestive Advantage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

This product contains two active ingredients. BC30 Bacillus coagulans is a probiotic — a beneficial live bacterium intended to support digestive health.

Lactase is an enzyme that breaks down lactose, the sugar found in milk and dairy products, making them easier to digest if you have trouble with them. The capsule also contains several inactive ingredients (maltodextrin, hypromellose, microcrystalline cellulose, dicalcium phosphate, stearic acid, titanium dioxide, and silicon dioxide) that serve as fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: break down lactose and defend digestive upset.
  • We looked for evidence on: Lactose intolerance, Diarrhea, Flatulence, Dyspepsia, Constipation, Irritable bowel syndrome (IBS) — and 3 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Diarrhea, Dyspepsia, Flatulence.

Lactase is Effective for lactose intolerance — it genuinely helps people digest dairy when they lack enough of the enzyme naturally. BC30 Bacillus coagulans is Possibly Effective for constipation and irritable bowel syndrome (IBS), though the evidence isn't definitive.

For other uses listed on the label (antibiotic-associated diarrhea, athletic performance, cancer, and fatty liver disease), the evidence we hold is Insufficient to rate it.

The evidence, ingredient by ingredient Bacillus Coagulans Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated and likely safe during pregnancy and lactation when used as directed. BC30 Bacillus coagulans is generally well tolerated in healthy adults, though evidence and product quality vary.

However, there isn't enough reliable safety data to make a blanket statement — talk to your doctor before starting, especially if you're pregnant, breastfeeding, or have a weakened immune system. Probiotics containing live organisms carry a theoretical risk of infection in severely ill or immunocompromised people, including those with central lines or premature infants, though this is uncommon in relatively healthy people with intact immune systems.

Side effects, ingredient by ingredient Bacillus Coagulans Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, check with your doctor or pharmacist about timing — you'll want to separate them from this product. The probiotic's live organisms can be killed by antibiotics, making the product less effective.

No other medication interactions are documented for the lactase ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a reasonable option if you have trouble digesting dairy or are looking for a probiotic to help with constipation or IBS — the evidence supports lactase, and BC30 has some support too. The key thing to watch is antibiotics: if you're on them, space out when you take this product so the antibiotic doesn't kill the live organisms.

Talk it over with your own doctor or pharmacist, especially if you have a weakened immune system or are pregnant.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lactose Defense Formula, straight from the product label.

Brand Schiff Digestive Advantage
Net contents 96 Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261794
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lactose Defense Formula by Schiff Digestive Advantage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
96
IngredientAmount% DV
BC30 Bacillus coagulans GBI-30, 60860 NP--
Lactase0 NP--

Other ingredients: Maltodextrin, Hypromellose, Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Titanium Dioxide, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Schiff Since 1936

Copyright 2017 RB Health, Hygiene, Home

Formulation

The Probiotic that survives

Helps break down lactose & defend against digestive upset

Probiotics are beneficial bacteria that live in your digestive tract and promote digestive and immune health. Many other probiotics don't survive the harsh acidic stomach environment. Because the probiotic in Digestive Advantage Lactose Defense Formula reaches your intestines alive, it is able to provide digestive and immune health benefits where you need it. Enjoy the Benefits Helps break down lactose and defend against digestive upset Simple and convenient to use Promotes long-term digestive health with continued use

Studies reveal that the single strain of probiotic used in Digestive Advantage survives 100x better than leading probiotics and yogurt so it can deliver good bacteria where you need it.

Schiff Quality Guarantee Guaranteed for purity, freshness and labeled potency.

Based on median % survivability of Digestive Advantage vs. leading probiotic supplements and 19 probiotic yogurts in simulated gastric pH for 2 hours. Survivability and delivery of probiotic cells to the small & large intestines is one of several factors influencing overall product effect.

FDA Statement of Identity

Dietary Supplement

Formula

Powered by Ganedon BC 30 Probiotic Digestive & Immune Health

Digestive Advantage targets your specific digestive health needs and, with continued use, gives you long-term digestive support. That's because Digestive Advantage contains BC30, a natural probiotic that survives 100X better that yogurt to deliver good bacteria where you need it. Digestive Advantage Lactose Defense Formula provides two powerful ingredients to support your digestive health: lactase and BC30, a natural probiotic. Lactase aids in the digestion of lactose. If not broken down, lactose can cause gas, bloating and occasional diarrhea. Lactase and BC30 help digest lactose and promote overall digestive health.

Fast acting enzymes

Suggested/Recommended/Usage/Directions

Directions: Adults: Take one (1) capsule with meals containing dairy. Some individuals may require two or more capsules daily, depending on frequency of dairy intake. Do not take more than three (3) capsules daily. Children 8 years and over: For children it is recommended that one capsule be opened and contents mixed into food or drink.

Precautions

Do not take more than three (3) capsules daily.

Contains wheat and soy.

If pregnant, breastfeeding, or on medication, consult your physician before using this product.

Keep out of reach of children. Always consult your pediatrician before giving your child dietary supplements.

Do not use if carton is damaged or if printed seal on blister is broken or missing.

Storage

Store in a cool, dry place and avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lactose Defense Formula by Schiff Digestive Advantage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lactose Defense Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lactose Defense Formula by Schiff Digestive Advantage

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container96 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

BC30 Bacillus coagulans GBI-30, 6086

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

BC30 Bacillus coagulans GBI-30, 6086 monograph & interactions

Lactase

No known
interactions
0 NP per serving Form: Beta-Galactosidase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Titanium Dioxide, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lactose Defense Formula by Schiff Digestive Advantage Drug Interactions

Want to check YOUR meds against Lactose Defense Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

BC30 Bacillus coagulans GBI-30, 6086 182

Individual Drug Interactions

The ingredients in Lactose Defense Formula interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lactose Defense Formula interact with drugs. Each result below shows which ingredient is responsible. BC30 Bacillus coagulans GBI-30, 6086

Each ingredient & the kinds of drugs it affects

For each ingredient in Lactose Defense Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BC30 Bacillus coagulans GBI-30, 60861 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
BC30 Bacillus coagulans GBI-30, 6086 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lactose Defense Formula, from the product label.

Schiff Digestive Advantage

See all Schiff Digestive Advantage products
Name
Reckitt Benckiser
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.digestiveadvantage.com
Pharmacist Counseling Corner

Lactose Defense Formula by Schiff Digestive Advantage: Common Questions

Does Lactose Defense Formula by Schiff Digestive Advantage interact with any medications?
Yes. Based on its ingredients, Lactose Defense Formula has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lactose Defense Formula contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help if I'm lactose intolerant?
Yes — the lactase in this product is Effective for lactose intolerance. It breaks down lactose so you can digest dairy without trouble.
Can I take this with antibiotics?
Not at the same time. Antibiotics kill the live beneficial bacteria in this product, making it less effective. Space them out several hours apart — your doctor or pharmacist can tell you the best schedule for your specific antibiotic.
Is this safe during pregnancy?
Lactase is likely safe during pregnancy. BC30 doesn't have enough safety data in pregnancy — talk to your doctor before using it if you're pregnant to decide what's best for you.
What should I do if I'm immunocompromised?
Check with your doctor or pharmacist first. Probiotics with live organisms carry a small risk of infection in people with weakened immune systems, especially those with central venous catheters.
Will this help my IBS?
BC30 Bacillus coagulans is Possibly Effective for IBS, but the evidence isn't definitive — it may help some people more than others. If you want to try it, talk it over with your doctor first.
Are there any fillers or other ingredients I should know about?
The capsule contains inactive ingredients like maltodextrin, cellulose, and dicalcium phosphate — common binders and fillers. If you have sensitivities to any of these, check the full ingredient list with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lactose Defense Formula is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lactose Defense Formula label
Go deeper

The Full Monographs Behind Lactose Defense Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Lactose Defense Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team