Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Probiotic Max Ingredients & Drug Interactions

by SimplySupplements

Probiotic Max label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Max against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Max is a dietary supplement by SimplySupplements with 2 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Probiotic Max by SimplySupplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Max by SimplySupplements — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Probiotic Max by SimplySupplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.

Probiotic Max contains two active ingredients. Lactobacillus acidophilus is a live probiotic bacterium intended to support your gut health.

Fructooligosaccharides (FOS) is a prebiotic fiber that may help feed beneficial bacteria already in your digestive system. The tablet also contains several inactive ingredients—dicalcium phosphate, microcrystalline cellulose, magnesium stearate, silicon dioxide, and maltodextrin—which serve as fillers, binders, and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and gut bacteria balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Helicobacter pylori — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation.

Lactobacillus acidophilus is rated Possibly Effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. For other conditions—acute respiratory distress syndrome and atopic disease—the evidence is either insufficient or suggests it's likely ineffective.

For fructooligosaccharides, the evidence we hold is not sufficient to establish its effectiveness for osteoporosis, constipation, diabetes, travelers' diarrhea, or high cholesterol. More research would be needed to make a confident call on any of those.

The evidence, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects—such as abdominal pain, bloating, flatulence, diarrhea, and burping—can occur, but they're uncommon.

There's also a theoretical concern that live organisms in the probiotic could cause infection in people with certain immune conditions or other risk factors; most reported cases have occurred in people with underlying health problems. Talk with your doctor before using if you have a weakened immune system or serious illness.

Fructooligosaccharides are generally well tolerated at food amounts but may cause gas, bloating, and abdominal pain—especially at higher doses. The evidence for safety at supplement-level doses is limited.

If you're new to FOS, start low and increase gradually to minimize digestive upset.

Side effects, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're taking any antibiotic drugs, make sure to separate them from this probiotic—take them several hours apart or finish your full antibiotic course before starting the supplement. Check your exact medications with the search tool on this page to confirm timing and dosing.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Probiotic Max may help if you have IBS, antibiotic-associated diarrhea, or certain other gut concerns—and Lactobacillus acidophilus is generally well tolerated. The main thing to watch is timing: if you're on an antibiotic, separate the doses to keep the medication effective.

If you have a weakened immune system or serious underlying illness, talk with your doctor or pharmacist before starting, since live probiotics carry a small theoretical risk in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Max, straight from the product label.

Brand SimplySupplements
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD May 24, 2013
DSLD ID 21698
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Max by SimplySupplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
IngredientAmount% DV
Fructooligosaccharides10 mg--
Lactobacillus acidophilus0 NP--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS Take one to two tablets daily preferably with a meal or as directed by a healthcare professional.

Precautions

Do not use if the seal is broken. Do not exceed stated dose.

Keep away from children at all times.

Pregnant and Lactating women should consult a Doctor before use.

Food supplement: This product should not be used as a substitute for a varied diet. Caution: If under medical supervision please consult a Doctor before use. Discontinue use if adverse reactions occur.

General

S493

General Statements

Each tablet provides over 5 billion colony forming units.

AUTODESPATCH Save 10% by having your supplements conveniently scheduled and delivered automatically. SAME DAY DESPATCH We will ensure your order is despatched on the day of receipt (before 12.30pm) and that all orders after 12.30pm are despatched within 24 hours. All sent 1st class!

BUY ONE GET ONE FREE on everything!

5 Billion Friendly Bacteria

PRICE MATCH GUARANTEE! Lowest Price in the UK or we will refund the difference plus 10%!

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Max by SimplySupplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Max label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Max by SimplySupplements

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fructooligosaccharides

No known
interactions
10 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Lactobacillus acidophilus

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Max by SimplySupplements Drug Interactions

Want to check YOUR meds against Probiotic Max?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Probiotic Max interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Probiotic Max interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Max with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Max, from the product label.

SimplySupplements

See all SimplySupplements products
Name
Simply Supplements
Street Address
PO Box 204
City
Guernsey
ZipCode
GY1 3NB
Pharmacist Counseling Corner

Probiotic Max by SimplySupplements: Common Questions

Does Probiotic Max by SimplySupplements interact with any medications?
Yes. Based on its ingredients, Probiotic Max has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Max contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Probiotic Max while I'm on antibiotics?
Not at the same time. Antibiotics can kill the live organisms in the probiotic, making it less effective. Talk with your pharmacist about spacing them out—typically a few hours apart or waiting until after your antibiotic course is done.
What side effects might I experience?
The most common are gas, bloating, and abdominal pain—especially when you first start or if you take a higher dose. These are usually mild and tend to settle down. Serious side effects are very rare but possible in people with weakened immune systems.
Is this safe during pregnancy?
Lactobacillus acidophilus is rated Possibly Safe in pregnancy. However, the safety data for fructooligosaccharides during pregnancy isn't on file, so there isn't enough information to say either way. Talk with your doctor or pharmacist for personalized advice if you're pregnant or planning to be.
Does Probiotic Max actually work for IBS?
Lactobacillus acidophilus is rated Possibly Effective for IBS, so there's some research support but it's not proven for everyone. Results vary from person to person—some find it helpful, others don't.
What is fructooligosaccharides (FOS) supposed to do?
FOS is a prebiotic fiber meant to feed the good bacteria in your gut. However, we don't have strong evidence yet for how well it works for specific conditions like constipation, diabetes, or high cholesterol.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Max is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Max label
Go deeper

The Full Monographs Behind Probiotic Max’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic Max's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team