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Dietary supplement

Probiotic with Lactobacillus Rhamnosus GG Ingredients & Drug Interactions

by Well At Walgreens

Probiotic with Lactobacillus Rhamnosus GG label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic with Lactobacillus Rhamnosus GG against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic with Lactobacillus Rhamnosus GG is a dietary supplement by Well At Walgreens with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains two active probiotic ingredients: Lactobacillus rhamnosus GG and Lactobacillus acidophilus. These are beneficial live bacteria meant to support your gut health.

The product also contains other inactive ingredients that serve as fillers or capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Common cold, Constipation — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Necrotizing enterocolitis (NEC).

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's rated possibly ineffective for atopic disease (eczema and similar conditions), and we don't have enough reliable evidence to rate it for acute respiratory distress syndrome.

We hold no effectiveness data for Lactobacillus rhamnosus GG in our current records.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects like abdominal discomfort, bloating, gas, or diarrhea can occur when taking it with other probiotics, but these are uncommon.

In rare cases, the live bacteria have been linked to serious infections in people with compromised immune systems; most cases appear to stem from bacteria moving from their normal body locations. Check with your doctor before starting, especially if you have a weakened immune system or are hospitalized.

For pregnancy, Lactobacillus acidophilus is rated possibly safe. Lactation data aren't on file.

Talk with your doctor or pharmacist about whether this product is right for you during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern — they can reduce how well this probiotic works by killing off the live organisms. If you're on antibiotics, ask your pharmacist how to time your doses.

Altogether, these interactions span 182 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-related diarrhea, and a few other digestive and bacterial concerns, though the evidence is moderate. If you take antibiotics, you'll need to space them apart from this product.

It's generally well tolerated, but check with your doctor first if you have a weakened immune system. Run your medications through our tool and talk it over with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic with Lactobacillus Rhamnosus GG, straight from the product label.

Brand Well At Walgreens
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 239939
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus rhamnosus GG0 NP--
Lactobacillus acidophilus0 NP--
Probiotic Blend0 NP--

Other ingredients: Other Ingredients

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

New

100% Satisfaction guaranteed with all Walgreens products or your money back.

Formulation

Digestive & immune health Helps support the natural balance of good bacteria in your digestive tract

Promotes healthy intestinal microflora Supports healthy immune system function Restores digestive balance Supports digestive & immune health Beneficial Bacteria to Support Health & Wellness Our bodies need beneficial bacteria for supporting digestive and immune health Probiotics are the good bacteria that naturally promote a healthy intestinal microflora. This "friendly" bacteria is essential for numerous vital body functions, including healthy digestion and immune system function.

Supplement Facts: Probiotic Blend: Contains a minimum of 15 billion live bacteria when manufactured, and at least until the "Best Used By" date, provided proper handling and storage directions are followed.

This product does not contain any dairy, soy or gluten.

FDA Statement of Identity

Dietary Supplement

Formula

Walgreens Health and Wellness Probiotic is specially formulated with 15 billion live cultures of Lactobacillus rhamnosus GG in each capsule. By replenishing the good bacteria in your intestinal tract, our formula may help restore digestive balance and help promote gastrointestinal health.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Adults, take one capsule daily as a dietary supplement. Do not crush or chew.

Precautions

Do not crush or chew.

Warnings Keep out of reach of children.

We recommend you discuss the supplements and medications you take with your healthcare provider.

Consult your physician before taking this product if you have a medical condition, are pregnant or nursing.

Brand IP Statement(s)

Copyright 2015 Walgreen Co.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic with Lactobacillus Rhamnosus GG label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Probiotic Blend

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Other (inactive) ingredients: Other Ingredients. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens Drug Interactions

Want to check YOUR meds against Probiotic with Lactobacillus Rhamnosus GG?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Blend 182

Individual Drug Interactions

The ingredients in Probiotic with Lactobacillus Rhamnosus GG interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Probiotic with Lactobacillus Rhamnosus GG interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic with Lactobacillus Rhamnosus GG with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic with Lactobacillus Rhamnosus GG, from the product label.

Well At Walgreens

See all Well At Walgreens products
Phone Number
1-866-307-9794
Pharmacist Counseling Corner

Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens: Common Questions

Does Probiotic with Lactobacillus Rhamnosus GG by Well At Walgreens interact with any medications?
Yes. Based on its ingredients, Probiotic with Lactobacillus Rhamnosus GG has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic with Lactobacillus Rhamnosus GG contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
You can, but you need to space them apart. Antibiotics can kill the live bacteria in this probiotic, making it less effective. Ask your pharmacist how many hours to wait between your antibiotic and this supplement — usually it's a few hours either direction.
Does this really work for irritable bowel syndrome?
The Lactobacillus acidophilus in here is possibly effective for IBS, which means there's some evidence it may help, but it's not proven. Results vary from person to person. If you want to try it, give it a fair run and track whether your symptoms improve.
What are the live bacteria actually doing in my gut?
These are beneficial microorganisms meant to support your digestive health and the natural balance of bacteria in your gut. They may help with diarrhea, especially after antibiotics, and possibly with IBS and certain infections.
Are there any side effects I should know about?
Most people tolerate it well. Occasionally, when you combine it with other probiotics, you might notice bloating, gas, abdominal discomfort, or loose stool — but these are uncommon. Rarely, in people with very weak immune systems, there's a theoretical risk of infection, so check with your doctor first if that applies to you.
Is it safe to take this while I'm pregnant?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but we don't have complete safety data. Talk with your doctor about whether this is right for you before starting.
Can I take this if I'm breastfeeding?
We don't have lactation safety data on file for the ingredients in this product. Chat with your pharmacist or doctor about what's best for you and your baby.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic with Lactobacillus Rhamnosus GG is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic with Lactobacillus Rhamnosus GG label
Go deeper

The Full Monographs Behind Probiotic with Lactobacillus Rhamnosus GG’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic with Lactobacillus Rhamnosus GG's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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