Interaction check not available yet — this product's ingredients haven't been matched to our database.
Dietary supplement

Probiotics + Prebiotics Settle & Restore Ingredients & Drug Interactions

by Renew Life

Probiotics + Prebiotics Settle & Restore label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotics + Prebiotics Settle & Restore against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotics + Prebiotics Settle & Restore is a dietary supplement by Renew Life with 3 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Probiotics + Prebiotics Settle & Restore by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotics + Prebiotics Settle & Restore by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Probiotics + Prebiotics Settle & Restore by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 8 active ingredients.
  • “Settle & Restore Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Total Bifido Probiotic Cultures” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Total Lacto Probiotic Cultures” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product contains 8 active ingredients: six different strains of live probiotic bacteria (Lactobacillus plantarum, Lactobacillus acidophilus, Bifidobacterium animalis lactis, Lactobacillus salivarius, Bifidobacterium bifidum, Lactobacillus casei, and Lactobacillus paracasei), plus organic xylooligosaccharides, which is a prebiotic — a type of fiber that feeds the good bacteria in your gut. The capsule itself is made from vegetable material, and the formula also contains organic rice hull concentrate as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support digestive health and immune function.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Inflammatory bowel disease (IBD), Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The probiotics in this product have the most evidence for irritable bowel syndrome (IBS), where they're possibly effective. Lactobacillus acidophilus is also possibly effective for antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection, while Bifidobacterium bifidum is possibly effective for respiratory tract infections.

For other conditions — like hay fever, anxiety, and Alzheimer disease — the evidence isn't established enough in our data to rate it. If you're considering this for a specific health concern, your pharmacist can talk through what the evidence shows for your situation.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Bifidobacterium bifidum is also generally well tolerated in healthy people, though those with weakened immune systems should check with their doctor first.

Both ingredients can cause uncommon gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea when used. There's a small theoretical concern with any live probiotic that in rare cases it could cause infection in people with severely compromised immunity, but this is not common.

No pregnancy or breastfeeding data is on file for the ingredients in this product — talk with your doctor if you're pregnant or nursing.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medication type to double-check before starting this product. Since both Lactobacillus acidophilus and Bifidobacterium bifidum can lose effectiveness if taken together with antibiotics, you'll want to time them separately — ask your pharmacist how many hours apart is best.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a solid choice if you're looking to support your gut with multiple probiotic strains and a prebiotic. If you're on antibiotics, space out when you take this — the two don't play well together at the same time.

People with weakened immune systems should check with their doctor first. Run your medication list through our tool to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotics + Prebiotics Settle & Restore, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257159823
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 203461
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotics + Prebiotics Settle & Restore by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
631257159823
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Lactobacillus plantarum0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium animalis lactis0 NP--
Lactobacillus salivarius0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus casei0 NP--
Lactobacillus paracasei0 NP--
organic Xylooligosaccharides1300 mg--
Settle & Restore Blend0 NP--
Total Bifido Probiotic Cultures0 NP--
Total Lacto Probiotic Cultures0 NP--

Other ingredients: Vegetable Capsule, organic Rice hull concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nourish your gut!

10 Strains 20 billion live cultures guaranteed

New!

Occasional diarrhea, plus digestive & immune support

20 billion live cultures

Quality, purity and potency guaranteed through expiration.

Is Settle & Restore right for me?

Formula

Renew Life Probiotics + Organic Prebiotics provide an effective and wholesome way to help support your health from the core every day.

Each daily formula is made with multiple strains of clinically studied probiotics to reflect the gut's natural diversity, plus an organic XOS prebiotic to help stimulate the growth of healthy bacteria, all in convenient vegetable capsules.

Contains 3 strains of Bifidobacterium lactis & 2 strains of Lactobacillus acidophilus.

Renew Life Settle & Restore is a clinically formulated daily probiotic with multiple strains of Bifidobacteria and Lactobacilli, plus prebiotics to: Support digestive and immune health Help reduce the incidence of occasional diarrhea Help calm and soothe an overstimulated gut Support a more stable and resilient healthy gut microbiome Help stimulate the growth of healthy bacteria in the gut

Formulation

Non-GMO No gluten, dairy or soy

Gluten, dairy & soy free

Made with organic Prebiotics

Certified organic by SCS Global Services.

Gluten free Dairy free Soy free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Non GMO project verified nongmoproject.org

Certified Organic SCS Global Services

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Directions: For best results, take two (2) capsules once a day, with or without food.

Storage

Store at 41(0)F (5(0)C) or below. Keep refrigerated.

Precautions

Keep out of reach of children.

Consult your healthcare professional before using this or any product if you are pregnant, nursing or under medical supervision.

Tamper Evident: Do not use if safety seal on bottle is broken or missing.

Brand IP Statement(s)

2017 Made in USA of global ingredients

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotics + Prebiotics Settle & Restore by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotics + Prebiotics Settle & Restore label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotics + Prebiotics Settle & Restore by Renew Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Xylooligosaccharides

1300 mg per serving

Settle & Restore Blend

0 NP per serving
  • › Total Bifido Probiotic Cultures
  • › Total Lacto Probiotic Cultures

Other (inactive) ingredients: Vegetable Capsule, Organic Rice hull concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotics + Prebiotics Settle & Restore by Renew Life Drug Interactions

Want to check YOUR meds against Probiotics + Prebiotics Settle & Restore?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Probiotics + Prebiotics Settle & Restore interact with 182 drugs. Click any drug to see the details.

0 of the 3 ingredients in Probiotics + Prebiotics Settle & Restore interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotics + Prebiotics Settle & Restore with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Probiotics + Prebiotics Settle & Restore, from the product label.

Renew Life

Name
Renew Life Formulas, Inc.
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Probiotics + Prebiotics Settle & Restore by Renew Life: Common Questions

Does Probiotics + Prebiotics Settle & Restore by Renew Life interact with any medications?
Yes. Based on its ingredients, Probiotics + Prebiotics Settle & Restore has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotics + Prebiotics Settle & Restore contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my irritable bowel syndrome?
Both Lactobacillus acidophilus and Bifidobacterium bifidum in this product are possibly effective for IBS. That means there's some evidence they can help, but it's not conclusive for everyone — it depends on your individual case. Talk with your doctor about whether a probiotic makes sense for you.
What's the prebiotic (xylooligosaccharides) doing in here?
Xylooligosaccharides is a type of fiber that acts as food for the good bacteria in your gut — that's what a prebiotic does. The idea is that it helps the probiotics thrive once they get to your colon.
Can I take this while I'm on an antibiotic?
Not at the same time. Antibiotics can kill off the live probiotic organisms, making this supplement less effective. Space them out — your pharmacist can tell you exactly how many hours apart to take them.
What side effects might I notice?
Most people tolerate this well, but some notice bloating, gas, stomach discomfort, or loose stools when they first start probiotics. These are usually mild and uncommon, and often settle down after a few days.
Is it safe if I have a weakened immune system?
People with weakened immune systems should check with their doctor before starting any probiotic. The live organisms are generally very safe, but in rare cases and in people with severely compromised immunity, there's a small theoretical risk — your doctor can advise what's right for you.
Can I take this while pregnant or breastfeeding?
We don't have pregnancy or breastfeeding safety data on file for these ingredients. Talk with your doctor or midwife about whether this product is right for you during pregnancy or while nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotics + Prebiotics Settle & Restore is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotics + Prebiotics Settle & Restore label
Sources

Sources & How We Checked

Probiotics + Prebiotics Settle & Restore's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team