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Dietary supplement

PS 100 mg Ingredients & Drug Interactions

by Health Resources

Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

PS 100 mg is a dietary supplement by Health Resources with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of PS 100 mg by Health Resources

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylserine 100 mg per capsule. Phosphatidylserine is a naturally occurring compound found in cell membranes, particularly in the brain.

The capsule also holds inactive ingredients — microcrystalline cellulose, gelatin, silicon dioxide, and magnesium stearate — which serve as binders, flow agents, and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, Mental performance — and 1 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

The evidence for phosphatidylserine is mixed. It's rated possibly effective for age-related cognitive decline and Alzheimer disease — meaning there's some research support, but it's not conclusive.

For athletic performance, cognitive function in general, attention deficit-hyperactivity disorder (ADHD), and dementia as a whole, the evidence we hold is insufficient to rate whether it works. If you're considering it for one of these uses, talk it over with your doctor to see if a trial makes sense for your situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated when taken by mouth, though long-term safety hasn't been fully studied. The most common side effects reported in trials are flatulence, gastrointestinal upset, headache, insomnia, and nausea — with gastrointestinal problems more likely at higher doses (200–300 mg daily) and insomnia more likely at 600 mg.

There isn't enough safety data for pregnancy or breastfeeding; the evidence advises against use in both situations. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor before taking this supplement.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications if you use anticholinergic drugs (used for overactive bladder, certain Parkinson's symptoms, and other conditions) or cholinergic drugs (used for some cases of Alzheimer's disease or myasthenia gravis). Both types have documented theoretical interactions with phosphatidylserine at Moderate severity.

Your doctor or pharmacist can review your specific medications and advise whether this supplement is appropriate for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may be worth considering if you're interested in supporting cognitive function in aging, but the evidence is strongest for age-related decline and Alzheimer disease — and even there it's only "possibly effective." If you take anticholinergic or cholinergic medications, check with your doctor or pharmacist first. Gastrointestinal upset and insomnia are possible, especially at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PS 100 mg, straight from the product label.

Brand Health Resources
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2012
DSLD ID 4761
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PS 100 mg by Health Resources, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Phosphatidylserine100 mg--

Other ingredients: Microcrystalline Cellulose, Gelatin, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take one capsule up to three times daily with meals or as directed by your healthcare professional.

Precautions

KEEP OUT OF REACH OF CHILDREN.

If you are taking medication or have a medical condition, consult with your healthcare professional before taking this or any other dietary supplement.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent and disease.

Storage

STORE IN A COOL, DRY PLACE.

General

300-HPFSS-B

General Statements

Contains the World’s Finest Ingredients.

This product is manufactured in a NSF GMP registered facility.

Ultimate Brain Food* 100 mg

Seals/Symbols

MADE IN USA

See for yourself

PS 100 mg by Health Resources label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in PS 100 mg by Health Resources

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Soy Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

PS 100 mg by Health Resources Drug Interactions

Want to check YOUR meds against PS 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in PS 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for PS 100 mg, from the product label.

Health Resources

See all Health Resources products
Name
Health Resources
Street Address
P.O. Box 3623
City
Hueytown
State
AL
ZipCode
35023
Phone Number
1-800-471-4007
Web Address
www.HealthResources.net
Pharmacist Counseling Corner

PS 100 mg by Health Resources: Common Questions

Does PS 100 mg by Health Resources interact with any medications?
Yes. Based on its ingredients, PS 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PS 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylserine, and what is it supposed to do?
Phosphatidylserine is a compound that's naturally found in your cell membranes, especially in the brain. This supplement is used in hopes of supporting memory and cognitive function, particularly in aging and Alzheimer disease — though the evidence is only "possibly effective" for those uses.
Can I take this if I'm pregnant or breastfeeding?
The safety data isn't there for either pregnancy or breastfeeding. The evidence advises against use in both situations. Talk with your doctor or pharmacist before taking it if you're pregnant, planning pregnancy, or nursing.
What side effects should I watch for?
The most common ones reported are flatulence, gastrointestinal upset, headache, insomnia, and nausea. Stomach upset is more likely at higher doses (200–300 mg daily), and insomnia more likely at 600 mg. This product is 100 mg, so side effects would be on the lower end of that risk.
Does phosphatidylserine really work for memory and thinking?
For age-related cognitive decline and Alzheimer disease, it's rated possibly effective — meaning there's some research support, but it's not conclusive. For other uses like general cognitive function or ADHD, the evidence we hold is insufficient to say whether it works.
Are there any fillers or other stuff in this capsule?
Yes — the capsule contains microcrystalline cellulose, gelatin, silicon dioxide, and magnesium stearate. These are standard inactive ingredients that help make the capsule and keep the powder flowing properly.
Should I take this if I'm on medication for Parkinson's disease or overactive bladder?
This product may interact with those types of drugs — check with your doctor or pharmacist first. Bring your exact medication list to the conversation so they can advise whether this supplement is safe for you to add.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PS 100 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PS 100 mg label
Sources

Sources & How We Checked

PS 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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