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Dietary supplement

PS 150 Phosphatidylserine Ingredients & Drug Interactions

by Designs for Health

PS 150 Phosphatidylserine label
See full label image
Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PS 150 Phosphatidylserine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PS 150 Phosphatidylserine is a dietary supplement by Designs for Health with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PS 150 Phosphatidylserine by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with PS 150 Phosphatidylserine by Designs for Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PS 150 Phosphatidylserine by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylserine, a naturally occurring compound found in cell membranes. The capsule also holds microcrystalline cellulose, vegetable stearate, and silicon dioxide as inactive ingredients — these are binders and flow agents that help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Phosphatidylserine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Phosphatidylserine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Age-related cognitive decline — rated "Possibly Effective" (Natural Medicines).
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer's disease based on the evidence we hold. For athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia, the evidence isn't established — there isn't enough reliable data to rate it one way or the other.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated when taken by mouth. The most common side effects reported in studies are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Insomnia is more likely at higher doses (around 600 mg), and stomach upset can occur at 200–300 mg per day. Long-term safety is not fully established.

There isn't enough safety data during pregnancy, so it's best to avoid it while pregnant. Safety while breastfeeding is also unknown — talk with your doctor or pharmacist about whether this product is right for you if you're nursing or planning to become pregnant.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PS 150, check with your doctor or pharmacist if you're on anticholinergic drugs (used for muscle spasms, overactive bladder, or allergies) or cholinergic drugs (used for myasthenia gravis or Alzheimer's disease) — both are rated Moderate severity for this supplement. These medications might not work as well, or their effects could be intensified.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

PS 150 may be worth considering if you're interested in supporting age-related cognitive decline or Alzheimer's disease with supplement support. However, if you take anticholinergic or cholinergic medications, check with your doctor or pharmacist first — this product could theoretically affect how those drugs work.

The most common side effects are stomach upset and insomnia, especially at higher doses. Discuss this supplement with your healthcare provider, especially if you're pregnant, breastfeeding, or on any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PS 150 Phosphatidylserine, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452000643
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 22491
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PS 150 Phosphatidylserine by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
879452000643
IngredientAmount% DV
Phosphatidylserine150 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

General Statements

Notice: Color, size or shape may appear different between lots.

For Professional Use Only

Manufactured in an NSF GMP Registered Facility

Formulation

Does not contain gluten.

Soy-Free

General

PHS060

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Guaranteed GMP COMPLIANT Products

Sharp-PS(R) GREEN

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.

Brand IP Statement(s)

Sharp-PS(R) GREEN is a registered trademark of Enzymotec Ltd.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PS 150 Phosphatidylserine by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PS 150 Phosphatidylserine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PS 150 Phosphatidylserine by Designs for Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
150 mg per serving Form: Sharp PS(R) Green

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

PS 150 Phosphatidylserine by Designs for Health Drug Interactions

Want to check YOUR meds against PS 150 Phosphatidylserine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in PS 150 Phosphatidylserine interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in PS 150 Phosphatidylserine interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in PS 150 Phosphatidylserine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PS 150 Phosphatidylserine, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

PS 150 Phosphatidylserine by Designs for Health: Common Questions

Does PS 150 Phosphatidylserine by Designs for Health interact with any medications?
Yes. Based on its ingredients, PS 150 Phosphatidylserine has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PS 150 Phosphatidylserine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylserine and what does it do?
Phosphatidylserine is a natural compound found in cell membranes. It's thought to increase acetylcholine, a brain chemical involved in memory and cognition. The evidence shows it may help with age-related cognitive decline and Alzheimer's disease, though it's not proven for other conditions like ADHD or general brain fog.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data during pregnancy, so it's best to avoid it. Safety while breastfeeding is also unknown. Talk with your doctor or pharmacist for personalized advice before taking this product if you're pregnant or nursing.
What side effects should I watch for?
Most people tolerate it well, but common side effects include flatulence, stomach upset, headache, nausea, and insomnia — especially at higher doses or doses around 600 mg. Stomach upset can start at doses of 200–300 mg per day. If these bother you, mention it to your pharmacist or doctor.
Is this safe to take long-term?
Phosphatidylserine is generally well tolerated in studies, but long-term safety is not fully established. If you're thinking of taking it for months or years, it's a good idea to discuss that with your doctor or pharmacist to monitor how you respond.
Can I take this with my blood pressure or allergy medications?
Some allergy or over-the-counter cold medications have anticholinergic properties, and some blood pressure or other medications do too. Use the interaction checker on this page to look up your exact prescriptions, then confirm with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PS 150 Phosphatidylserine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PS 150 Phosphatidylserine label
Go deeper

The Full Monographs Behind PS 150 Phosphatidylserine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

PS 150 Phosphatidylserine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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