Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Pumpkin Seed Oil 1000 mg Ingredients & Drug Interactions

by Nature's Harmony

Pumpkin Seed Oil 1000 mg label
See full label image
Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pumpkin Seed Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pumpkin Seed Oil 1000 mg is a dietary supplement by Nature's Harmony with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pumpkin (Cucurbita pepo) seed oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pumpkin Seed Oil 1000 mg by Nature's Harmony

Ask about any prescription or over-the-counter medication and we check it for interactions with Pumpkin Seed Oil 1000 mg by Nature's Harmony — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pumpkin Seed Oil 1000 mg by Nature's Harmony

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Pumpkin (Cucurbita pepo) seed oil” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Pumpkin Seed Oil 1000 mg gives you four active ingredients per softgel: oleic acid, linoleic acid, stearic acid, and palmitic acid. These are fatty acids naturally found in pumpkin seeds and similar plant oils.

The softgel itself also contains gelatin, glycerin, and water as inactive ingredients that hold everything together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Oleic Acid's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports prostate health and BPH urinary symptoms.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Overactive bladder, urinary retention, lower urinary tract symptoms.
  • The closest evidence on file: Oleic Acid is rated "Insufficient Reliable Evidence To Rate" for Bladder cancer (Natural Medicines).

Oleic acid, one of the fatty acids in this product, is rated possibly effective for high cholesterol (hypercholesterolemia) and coronary heart disease (CHD). That means there's some early research backing its use for these conditions, but we'd like to see more evidence before calling it fully established.

We don't hold effectiveness ratings for the other fatty acids in this formulation.

The evidence, ingredient by ingredient Pumpkin Oleic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid is generally recognized as safe in the amounts you'd get from eating foods like olive oil. However, concentrated supplement doses haven't been well studied, especially in pregnancy and during breastfeeding.

If you're pregnant, nursing, or planning to become pregnant, there isn't enough data to know whether supplement-level doses of this product are safe, so talk with your doctor or pharmacist before taking it. No serious adverse effects were recorded in the data we hold for this product.

Side effects, ingredient by ingredient Pumpkin Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (medications that lower blood sugar), double-check with your pharmacist or doctor before adding this product—oleic acid may increase their effect and raise your risk of low blood sugar. We could not check three other fatty acids in this supplement, so run your full medication list through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you take antidiabetes drugs, check with your doctor or pharmacist before starting—this product may boost their blood-sugar-lowering effect. It's generally well tolerated in food amounts, but concentrated supplement doses lack strong safety data, especially for pregnancy and nursing.

For any questions about whether this fits your situation, talk with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pumpkin Seed Oil 1000 mg, straight from the product label.

Brand Nature's Harmony
Barcode (UPC) 063047058175
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD May 24, 2013
DSLD ID 21801
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Adult Male (18-50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pumpkin Seed Oil 1000 mg by Nature's Harmony, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
UPC/BARCODE
063047058175
IngredientAmount% DV
Stearic Acid60 mg--
Linoleic Acid573 mg--
Oleic Acid234 mg--
Palmitic Acid122 mg--
Pumpkin (Cucurbita pepo) seed oil1000 mg--

Other ingredients: Gelatin, Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: Supports prostate health. Helps to relieve the urinary symptoms associated with BPH (Benign Prostatic Hyperplasia) Recommended Dose (Adults): Take 1 or 2 softgels three times daily with meals. Use for a minimum of three months.

Precautions

Risk Information: Consult a health care practitioner before use if pregnant or nursing.

If symptoms persist after six months, consult a health care practitioner.

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF SEAL UNDER CAP IS BROKEN.

Formulation

This product does not contain corn, dairy, egg, gluten, shellfish, soy, sulfites, or artificial colours, flavours or preservatives.

Storage

STORE IN A COOL, DRY PLACE.

Formula

Supports Prostate Health

General Statements

{Softgel} Actual Size

A Proud Canadian Company

Cold-Pressed

EN 124878

General

400448.01-04

Seals/Symbols

SunOpta A healthy products company

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pumpkin Seed Oil 1000 mg by Nature's Harmony label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pumpkin Seed Oil 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pumpkin Seed Oil 1000 mg by Nature's Harmony

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Pumpkin (Cucurbita pepo) seed oil

Interacts with
1 drug
1000 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin (Cucurbita pepo) seed oil monograph & interactions
  • › Stearic Acid
  • › Linoleic Acid
  • › Oleic Acid
  • › Palmitic Acid

Other (inactive) ingredients: Gelatin, Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pumpkin Seed Oil 1000 mg by Nature's Harmony Drug Interactions

Want to check YOUR meds against Pumpkin Seed Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Pumpkin (Cucurbita pepo) seed oil 1

Individual Drug Interactions

The ingredients in Pumpkin Seed Oil 1000 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pumpkin Seed Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Pumpkin (Cucurbita pepo) seed oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Pumpkin Seed Oil 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pumpkin (Cucurbita pepo) seed oil1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin (Cucurbita pepo) seed oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pumpkin Seed Oil 1000 mg, from the product label.

Nature's Harmony

See all Nature's Harmony products
Name
SunOpta Inc.
Street Address
6 Commerce Crescent
City
Acton
State
ON
ZipCode
L7J 2X3
Pharmacist Counseling Corner

Pumpkin Seed Oil 1000 mg by Nature's Harmony: Common Questions

Does Pumpkin Seed Oil 1000 mg by Nature's Harmony interact with any medications?
Yes. Based on its ingredients, Pumpkin Seed Oil 1000 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pumpkin Seed Oil 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my cholesterol or heart health?
Oleic acid, one of the fatty acids here, is rated possibly effective for high cholesterol and coronary heart disease. That means early research is promising, but we'd like to see more evidence. Talk with your doctor about whether it fits your heart health plan.
Is it safe to take while I'm pregnant or nursing?
We don't have enough data to know either way. Food amounts of oleic acid are considered safe, but concentrated supplements haven't been well studied in pregnancy and lactation. Check with your doctor or pharmacist for personalized advice.
What's in this softgel besides the pumpkin seed oil?
The softgel contains four fatty acids—oleic acid, linoleic acid, stearic acid, and palmitic acid—plus gelatin, glycerin, and water. The gelatin, glycerin, and water are inactive ingredients that form the capsule.
Can I take this if I'm on diabetes medication?
That's a question for your doctor or pharmacist. Oleic acid in this product may increase how well your diabetes drugs work, which could lower your blood sugar more than expected. Your provider can tell you if you need to monitor more closely or adjust your dose.
Are there any side effects I should know about?
We don't have records of serious adverse effects for this product. However, three of its fatty acid ingredients haven't been thoroughly checked in our database, so if you notice anything unusual after starting it, let your pharmacist or doctor know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pumpkin Seed Oil 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pumpkin Seed Oil 1000 mg label
Go deeper

The Full Monographs Behind Pumpkin Seed Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

Pumpkin Seed Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
  19. Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed

See these in context on the Oleic Acid monograph →

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team