Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Pumpsurge Max Blue Raspberry Ingredients & Drug Interactions

by Jacked Factory

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Pumpsurge Max Blue Raspberry is a dietary supplement by Jacked Factory with 7 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 594 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine A, Vitamin C, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Pumpsurge Max Blue Raspberry by Jacked Factory

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pumpsurge Max Blue Raspberry contains 7 active ingredients. Vitamin C supports immune function and collagen formation.

Setria is a form of glutathione, an antioxidant your cells produce naturally. Huperzine A is a compound derived from club moss that affects how your brain uses a chemical called acetylcholine.

L-citrulline and L-tyrosine are amino acids — building blocks your body uses to make proteins and other compounds. NO3-T and AstraGin are branded forms of ingredients added for nutrient absorption and blood flow support.

The powder also contains inactive ingredients like citric acid, silica, natural and artificial flavors, malic acid, sucralose, spirulina extract, and acesulfame potassium.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: workout intensity, muscle pumps, and mental focus.
  • We looked for evidence on: Athletic performance, Cognitive function, Exercise-induced muscle damage, Fatigue, Strength performance, Blood flow enhancement.
  • The strongest evidence on file: Tyrosine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.

Vitamin C is effective for preventing and treating vitamin C deficiency, and possibly effective for anemia, atrial fibrillation, cataracts, and exercise-related respiratory infections, though the evidence is mixed. Setria (glutathione) is possibly effective for reducing nerve damage from the chemotherapy drug cisplatin; evidence for other uses like liver health and memory is insufficient to rate.

Huperzine A is possibly effective for Alzheimer's disease; evidence for memory, cognitive function, and athletic performance is insufficient. L-citrulline is possibly effective for athletic performance but possibly ineffective for muscle loss; evidence for heart health and diabetes is insufficient.

L-tyrosine is effective for a rare genetic condition called PKU and possibly effective for memory and thinking; it's possibly ineffective for athletic performance. We could not check AstraGin and NO3-T — effectiveness data isn't on file for those ingredients.

The evidence, ingredient by ingredient Vitamin C Glutathione Huperzine A L-citrulline Tyrosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin C is generally well tolerated at normal doses, but very high doses can cause stomach cramping, diarrhea, heartburn, nausea, and kidney stones in people prone to them. Adverse effects are more likely above 2 grams daily.

In pregnancy, normal amounts from food and prenatal vitamins are fine, but avoid high-dose supplements unless your doctor advises it. Huperzine A is well tolerated orally but can cause dose-dependent side effects like blurred vision, dry mouth, diarrhea, nausea, and sweating; it's not safe in pregnancy and should be avoided while breastfeeding.

L-citrulline is generally well tolerated but may cause heartburn or stomach discomfort; safety data in pregnancy and breastfeeding is insufficient, so avoid supplements unless your doctor says otherwise. L-tyrosine is well tolerated in healthy adults with no serious side effects documented at normal doses; minor effects include fatigue, headache, and heartburn.

Safety data in pregnancy and breastfeeding is limited. Setria (glutathione) appears well tolerated short-term orally, but long-term safety is unclear.

Avoid it in pregnancy and breastfeeding unless your doctor advises otherwise. If you have asthma, inhaled glutathione may cause airway narrowing and shortness of breath.

Side effects, ingredient by ingredient Vitamin C Glutathione Huperzine A L-citrulline Tyrosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Huperzine A, Vitamin C, Tyrosine, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; Parkinson's medications.
  • For scale: 594 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you use estrogen-containing birth control or hormone replacement therapy, blood thinners like warfarin, blood pressure medications, erectile dysfunction drugs, levodopa for Parkinson's disease, thyroid hormone medication, anticholinergic drugs, or cholinergic medications. These are Moderate-severity interactions — your doses may need adjustment or timing may matter.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a pre-workout supplement built around amino acids and compounds that affect blood flow and brain function. If you take estrogen, blood pressure medication, psychiatric medications, thyroid medication, or Parkinson's medication, check your exact drugs with the tool below before starting.

Talk to your pharmacist or doctor about whether this product fits your health situation, especially if you're pregnant, breastfeeding, or have asthma.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pumpsurge Max Blue Raspberry, straight from the product label.

Brand Jacked Factory
Net contents 11.99 Ounce(s); 340 Gram(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 337392
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pumpsurge Max Blue Raspberry by Jacked Factory, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8.5 Gram(s)
Maximum serving Sizes:
17 Gram(s)
Servings per container
20
IngredientAmount% DV
Calories2.5 Calorie(s), 5 Calorie(s)--
Total Carbohydrates1 Gram(s), 1 Gram(s)1%, 1%
Vitamin C125 mg, 250 mg139%, 278%
AstraGin25 mg, 50 mg--
Setria100 mg, 200 mg--
Huperzine A125 mcg, 250 mcg--
NO3-T1000 mg, 2000 mg--
L-Citrulline4500 mg, 9000 mg--
L-Tyrosine750 mg, 1500 mg--

Other ingredients: Citric Acid, Silica, Natural & Artificial Flavors, Malic Acid, Sucralose, Spirulina Extract, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

PUMPSURGE MAX provides unparalleled workout intensity, without the use of caffeine.

Stim-free Pre-Workout Powerful pumps Laser focus Improve performance Enhanced endurance

Stim-free Pre-Workout

Formula

Each 2 scoop serving is packed with 9 g OF L-Citrulline, 2 g of Arginine Nitrates, and 1.5 g of L-Tyrosine to optimize blood flow, intensify muscle pumps, and sharpen mental focus. It also includes 200 mg of Setria for robust antioxidant support, 250 mcg of Huperzine A for cognitive precision, and 50 mg of Astragin to tie it all together with enhanced nutrient absorption

9 g L-Citrulline per 2 Scoop serving 2 g Arginine Nitrate (No3T) per 2 Scoop serving 1.5 g L-Tyrosine per 2 Scoop Serving Naturally & artificially flavored Blue Raspberry

Precautions

Experience skin-splitting pumps, strength gains, and intense focus so that you perform at your max potential each and every workout.

Warning: This product is not intended for persons under the age of 18. Keep out of reach of children.

Do not use if pregnant or nursing.

Reduce or discontinue use if sleeplessness, dizziness, nervousness, headaches, or heart palpitations occur. Improper use of this product will not improve results and is potentially hazardous to a person's health. Do not use if safety seal is broken or missing.

Suggested/Recommended/Usage/Directions

Directions: Mix one scoop with 6-8 oz of water 30-40 minutes before a workout. If increased intensity is desired, mix two scoops with 12-16 oz of water 30-40 minutes before a workout. Do not exceed 2 scoops in a 24 hour period.

Storage

Store in a cool, dry place.

General Statements

Get Connected Facebook @jackedfactory Instagram @jackedfactory Jackedfactory.com

Servings per container: 40 20

See for yourself

Pumpsurge Max Blue Raspberry by Jacked Factory label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pumpsurge Max Blue Raspberry by Jacked Factory

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size8.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin C

Interacts with
207 drugs
125 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

AstraGin

25 mg per serving Form: Astragalus membranaceus Root Extract, Panax notoginseng Root Extract

Setria

No known
interactions
100 mg per serving Form: L-Glutathione, Reduced

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...

Setria monograph & interactions

Huperzine A

Interacts with
219 drugs
125 mcg per serving Form: Huperzia serrata Whole Plant Extract

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

NO3-T

1000 mg per serving Form: Arginine Nitrate

L-Citrulline

Interacts with
178 drugs
4500 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

L-Tyrosine

Interacts with
21 drugs
750 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Other (inactive) ingredients: Citric Acid, Silica, Natural & Artificial Flavors, Malic Acid, Sucralose, Spirulina Extract, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pumpsurge Max Blue Raspberry by Jacked Factory Drug Interactions

Want to check YOUR meds against Pumpsurge Max Blue Raspberry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
594Drugs
514 Moderate 80 Minor

Ingredients driving the most interactions

Vitamin C 207

Each ingredient & the kinds of drugs it affects

For each ingredient in Pumpsurge Max Blue Raspberry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Pumpsurge Max Blue Raspberry, from the product label.

Jacked Factory

See all Jacked Factory products
Name
Jacked Factory
Web Address
jackedfactory.com
Pharmacist Counseling Corner

Pumpsurge Max Blue Raspberry by Jacked Factory: Common Questions

Does Pumpsurge Max Blue Raspberry by Jacked Factory interact with any medications?
Yes. Based on its ingredients, Pumpsurge Max Blue Raspberry has a known interaction with 594 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pumpsurge Max Blue Raspberry contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this affect my birth control pills?
Vitamin C in this product may increase estrogen levels from oral contraceptives by up to 55% in some cases. This is a Moderate interaction — talk to your doctor or pharmacist about whether it's safe for you, and whether your birth control dose needs adjusting.
Does this product have any side effects?
The main ingredients can cause stomach upset, heartburn, diarrhea, nausea, headache, and dry mouth at higher doses. Huperzine A may also cause blurred vision. Most people tolerate normal amounts well, but if you feel off, stop and talk to your pharmacist.
Is it safe to use while pregnant or breastfeeding?
Vitamin C in normal amounts from food is safe in pregnancy, but high-dose supplements should be avoided unless your doctor says it's okay. Huperzine A, L-citrulline, and L-tyrosine don't have enough safety data in pregnancy or breastfeeding — avoid them unless your doctor advises otherwise.
What is huperzine A used for in this product?
Huperzine A affects acetylcholine, a brain chemical involved in memory and thinking. It's possibly effective for Alzheimer's disease, but evidence for general memory and athletic performance isn't solid yet.
What does L-citrulline do?
Your body converts L-citrulline to L-arginine, which widens blood vessels and improves blood flow. It's possibly effective for athletic performance, but the evidence is still developing.
I take a blood pressure medication. Is this safe?
L-citrulline in this product may lower blood pressure further and increase the risk of dizziness or fainting when combined with blood pressure drugs. Talk to your doctor or pharmacist before starting — your dose may need to be adjusted.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pumpsurge Max Blue Raspberry label
Go deeper

The Full Monographs Behind Pumpsurge Max Blue Raspberry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Pumpsurge Max Blue Raspberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 77 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  4. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  5. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
  6. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  9. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  10. Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. PubMed
  11. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  12. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  13. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  14. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  15. Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. PubMed
  16. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
  17. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
  18. Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
  19. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
  20. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
  21. Dysken MW, Cumming RJ, Channon RA, Davis JM. Drug interaction between ascorbic acid and fluphenazine. JAMA 1979;241:2008. DOI
  22. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
  23. Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
  24. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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