Pumpsurge Max Blue Raspberry Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pumpsurge Max Blue Raspberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pumpsurge Max Blue Raspberry is a dietary supplement by Jacked Factory with 7 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 594 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine A, Vitamin C, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pumpsurge Max Blue Raspberry by Jacked Factory
Ask about any prescription or over-the-counter medication and we check it for interactions with Pumpsurge Max Blue Raspberry by Jacked Factory — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pumpsurge Max Blue Raspberry by Jacked Factory
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Pumpsurge Max Blue Raspberry contains 7 active ingredients. Vitamin C supports immune function and collagen formation.
Setria is a form of glutathione, an antioxidant your cells produce naturally. Huperzine A is a compound derived from club moss that affects how your brain uses a chemical called acetylcholine.
L-citrulline and L-tyrosine are amino acids — building blocks your body uses to make proteins and other compounds. NO3-T and AstraGin are branded forms of ingredients added for nutrient absorption and blood flow support.
The powder also contains inactive ingredients like citric acid, silica, natural and artificial flavors, malic acid, sucralose, spirulina extract, and acesulfame potassium.
Does it work?
Moderate evidence
Vitamin C is effective for preventing and treating vitamin C deficiency, and possibly effective for anemia, atrial fibrillation, cataracts, and exercise-related respiratory infections, though the evidence is mixed. Setria (glutathione) is possibly effective for reducing nerve damage from the chemotherapy drug cisplatin; evidence for other uses like liver health and memory is insufficient to rate.
Huperzine A is possibly effective for Alzheimer's disease; evidence for memory, cognitive function, and athletic performance is insufficient. L-citrulline is possibly effective for athletic performance but possibly ineffective for muscle loss; evidence for heart health and diabetes is insufficient.
L-tyrosine is effective for a rare genetic condition called PKU and possibly effective for memory and thinking; it's possibly ineffective for athletic performance. We could not check AstraGin and NO3-T — effectiveness data isn't on file for those ingredients.
How safe is it?
Well-documented data
Vitamin C is generally well tolerated at normal doses, but very high doses can cause stomach cramping, diarrhea, heartburn, nausea, and kidney stones in people prone to them. Adverse effects are more likely above 2 grams daily.
In pregnancy, normal amounts from food and prenatal vitamins are fine, but avoid high-dose supplements unless your doctor advises it. Huperzine A is well tolerated orally but can cause dose-dependent side effects like blurred vision, dry mouth, diarrhea, nausea, and sweating; it's not safe in pregnancy and should be avoided while breastfeeding.
L-citrulline is generally well tolerated but may cause heartburn or stomach discomfort; safety data in pregnancy and breastfeeding is insufficient, so avoid supplements unless your doctor says otherwise. L-tyrosine is well tolerated in healthy adults with no serious side effects documented at normal doses; minor effects include fatigue, headache, and heartburn.
Safety data in pregnancy and breastfeeding is limited. Setria (glutathione) appears well tolerated short-term orally, but long-term safety is unclear.
Avoid it in pregnancy and breastfeeding unless your doctor advises otherwise. If you have asthma, inhaled glutathione may cause airway narrowing and shortness of breath.
Meds to double-check
Moderate interaction found
Check with your pharmacist before taking this if you use estrogen-containing birth control or hormone replacement therapy, blood thinners like warfarin, blood pressure medications, erectile dysfunction drugs, levodopa for Parkinson's disease, thyroid hormone medication, anticholinergic drugs, or cholinergic medications. These are Moderate-severity interactions — your doses may need adjustment or timing may matter.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This is a pre-workout supplement built around amino acids and compounds that affect blood flow and brain function. If you take estrogen, blood pressure medication, psychiatric medications, thyroid medication, or Parkinson's medication, check your exact drugs with the tool below before starting.
Talk to your pharmacist or doctor about whether this product fits your health situation, especially if you're pregnant, breastfeeding, or have asthma.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pumpsurge Max Blue Raspberry, straight from the product label.
| Brand | Jacked Factory |
|---|---|
| Net contents | 11.99 Ounce(s); 340 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2025 |
| DSLD ID | 337392 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pumpsurge Max Blue Raspberry by Jacked Factory, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 2.5 Calorie(s), 5 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s), 1 Gram(s) | 1%, 1% |
| Vitamin C | 125 mg, 250 mg | 139%, 278% |
| AstraGin | 25 mg, 50 mg | -- |
| Setria | 100 mg, 200 mg | -- |
| Huperzine A | 125 mcg, 250 mcg | -- |
| NO3-T | 1000 mg, 2000 mg | -- |
| L-Citrulline | 4500 mg, 9000 mg | -- |
| L-Tyrosine | 750 mg, 1500 mg | -- |
Other ingredients: Citric Acid, Silica, Natural & Artificial Flavors, Malic Acid, Sucralose, Spirulina Extract, Acesulfame Potassium
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
PUMPSURGE MAX provides unparalleled workout intensity, without the use of caffeine.
Stim-free Pre-Workout Powerful pumps Laser focus Improve performance Enhanced endurance
Stim-free Pre-Workout
Formula
Each 2 scoop serving is packed with 9 g OF L-Citrulline, 2 g of Arginine Nitrates, and 1.5 g of L-Tyrosine to optimize blood flow, intensify muscle pumps, and sharpen mental focus. It also includes 200 mg of Setria for robust antioxidant support, 250 mcg of Huperzine A for cognitive precision, and 50 mg of Astragin to tie it all together with enhanced nutrient absorption
9 g L-Citrulline per 2 Scoop serving 2 g Arginine Nitrate (No3T) per 2 Scoop serving 1.5 g L-Tyrosine per 2 Scoop Serving Naturally & artificially flavored Blue Raspberry
Precautions
Experience skin-splitting pumps, strength gains, and intense focus so that you perform at your max potential each and every workout.
Warning: This product is not intended for persons under the age of 18. Keep out of reach of children.
Do not use if pregnant or nursing.
Reduce or discontinue use if sleeplessness, dizziness, nervousness, headaches, or heart palpitations occur. Improper use of this product will not improve results and is potentially hazardous to a person's health. Do not use if safety seal is broken or missing.
Suggested/Recommended/Usage/Directions
Directions: Mix one scoop with 6-8 oz of water 30-40 minutes before a workout. If increased intensity is desired, mix two scoops with 12-16 oz of water 30-40 minutes before a workout. Do not exceed 2 scoops in a 24 hour period.
Storage
Store in a cool, dry place.
General Statements
Get Connected Facebook @jackedfactory Instagram @jackedfactory Jackedfactory.com
Servings per container: 40 20
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pumpsurge Max Blue Raspberry by Jacked Factory label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pumpsurge Max Blue Raspberry by Jacked Factory
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size8.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin C
Interacts with207 drugs
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...
Vitamin C monograph & interactionsAstraGin
Setria
No knowninteractions
Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...
Setria monograph & interactionsHuperzine A
Interacts with219 drugs
Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...
Huperzine A monograph & interactionsNO3-T
L-Citrulline
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline monograph & interactionsL-Tyrosine
Interacts with21 drugs
L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...
L-Tyrosine monograph & interactionsOther (inactive) ingredients: Citric Acid, Silica, Natural & Artificial Flavors, Malic Acid, Sucralose, Spirulina Extract, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.
Pumpsurge Max Blue Raspberry by Jacked Factory Drug Interactions
HelloPharmacist Interaction Report
Pumpsurge Max Blue Raspberry by Jacked Factory contains several ingredients with documented interactions.
Vitamin C, the most concerning, has Moderate-severity interactions with estrogens (including oral contraceptives and hormone replacement therapy) — it may increase blood levels of estrogen by up to 55% in some cases. Vitamin C also interacts with chemotherapy drugs, blood thinners like warfarin, certain psychiatric and thyroid medications, and aluminum-containing products.
Read the full breakdown — every affected drug type, severity by severity
Huperzine A carries Moderate interactions with anticholinergic drugs (like those for urinary incontinence or certain GI conditions) and cholinergic medications; it may decrease or increase their effects. L-citrulline has Moderate interactions with blood pressure medications and erectile dysfunction drugs (phosphodiesterase-5 inhibitors like sildenafil), potentially lowering blood pressure further.
L-tyrosine may reduce the effectiveness of levodopa (Parkinson's medication) and could have additive effects with thyroid hormone medications.
We could not check AstraGin and NO3-T for interactions — interaction data isn't on file for those ingredients. Setria (the branded form of glutathione) was checked and shows no interactions documented in our data.
Additionally, this doesn't mean interactions don't exist — just that we have no data for them. Run your exact medications through the search tool below before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pumpsurge Max Blue Raspberry?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pumpsurge Max Blue Raspberry interact with 594 drugs. Click any drug to see the details.
4 of the 7 ingredients in Pumpsurge Max Blue Raspberry interact with drugs. Each result below shows which ingredient is responsible. Huperzine A Vitamin C L-Citrulline L-Tyrosine
AcebutololRhotral, Sectral
How Acebutolol interacts with Pumpsurge Max Blue Raspberry — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Pumpsurge Max Blue Raspberry — through 1 ingredient. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acepromazine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Caffeine, Pyrilamine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Phenylephrine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Codeine, Doxylamine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Diphenhydramine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Doxylamine, Pseudoephedrine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Pamabrom, Pyrilamine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Pumpsurge Max Blue Raspberry — through 2 ingredients. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Phenylephrine, Chlorpheniramine interactionVitamin CAcetaminophen (tylenol, Others) Minor
Interaction Summary
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Pumpsurge Max Blue Raspberry — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Acetazolamide interactionAcetylcholineMiochol-E
How Acetylcholine interacts with Pumpsurge Max Blue Raspberry — through 1 ingredient. Tap an ingredient for the detail:
Huperzine ACholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Read the full Huperzine A + Acetylcholine interactionAclidinium BromideTudorza Pressair
How Aclidinium Bromide interacts with Pumpsurge Max Blue Raspberry — through 1 ingredient. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Aclidinium Bromide interactionAclidinium Bromide, Formoterol Fumarate DihydrateDuaklir Pressair
How Aclidinium Bromide, Formoterol Fumarate Dihydrate interacts with Pumpsurge Max Blue Raspberry — through 1 ingredient. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Aclidinium Bromide, Formoterol Fumarate Dihydrate interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Pumpsurge Max Blue Raspberry — through 1 ingredient. Tap an ingredient for the detail:
Huperzine AAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pumpsurge Max Blue Raspberry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Huperzine A
Anticholinergic Drugs
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.
Cholinergic Drugs
Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.
Vitamin C
Alkylating Agents
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Aluminum
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.
Antitumor Antibiotics
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.
Estrogens
Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.
Fluphenazine (Prolixin)
Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.
Indinavir (Crixivan)
Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.
Levothyroxine (Synthroid, Others)
Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.
Warfarin (Coumadin)
High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.
Acetaminophen (Tylenol, Others)
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.
Aspirin
Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.
Choline Magnesium Trisalicylate (Trilisate)
Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Niacin
Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.
Salsalate (Disalcid)
Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
L-Citrulline
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
L-Tyrosine
Levodopa
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.
Thyroid Hormone
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.
Brand information
Manufacturer and brand details for Pumpsurge Max Blue Raspberry, from the product label.
Pumpsurge Max Blue Raspberry by Jacked Factory: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Pumpsurge Max Blue Raspberry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin C
Interacts with 207 drugsVitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...
Read the full Vitamin C monograph → Herb & supplement monographGlutathione
Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefits. However, strong human evidence is lim...
Read the full Glutathione monograph → Herb & supplement monographHuperzine A
Interacts with 219 drugsHuperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...
Read the full Huperzine A monograph → Herb & supplement monographL-citrulline
Interacts with 178 drugsL-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...
Read the full L-citrulline monograph → Herb & supplement monographTyrosine
Interacts with 21 drugsL-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...
Read the full Tyrosine monograph →Sources & How We Checked
Pumpsurge Max Blue Raspberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 77 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin C 51 references
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- Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
- Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
- Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
- Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. PubMed
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
- Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
- Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
- Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. PubMed
- Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
- Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
- Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
- Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
- Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
- Dysken MW, Cumming RJ, Channon RA, Davis JM. Drug interaction between ascorbic acid and fluphenazine. JAMA 1979;241:2008. DOI
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
- Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed
- Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. PubMed
- Lee DH, Folsom AR, Harnack L, et al. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr 2004;80:1194-200. PubMed
- Taylor EN, Stampfer MJ, Curhan GC. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol 2004;15:3225-32. PubMed
- Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
- Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
- Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
- Fairweather-Tait S, Hickson K, McGaw B, et al. Orange juice enhances aluminium absorption from antacid preparation. Eur J Clin Nutr. 1994;48(1):71-3.
- Gruenwald, J., Graubaum, H. J., Busch, R., and Bentley, C. Safety and tolerance of ester-C compared with regular ascorbic acid. Adv.Ther. 2006;23(1):171-178.
- Rahimi, R., Nikfar, S., Rezaie, A., and Abdollahi, M. A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women. Hypertens.Pregnancy. 2009;28(4):417-434. PubMed
- Einerson, B., Nathorn, C., Kitiyakara, C., Sirada, M., and Thamlikitkul, V. The efficacy of ascorbic acid in suboptimal responsive anemic hemodialysis patients receiving erythropoietin: a meta-analysis. J Med.Assoc.Thai. 2011;94 Suppl 1:S134-S146.
- Li, G., Li, L., Yu, C., and Chen, L. Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis. Br.J Nutr 2011;106(11):1632-1637.
- Chen X, Shen L, Gu X, et al. High-dose supplementation with vitamin C--induced pediatric urolithiasis: the first case report in a child and literature review. Urology. 2014;84(4):922-4. PubMed
- Sattar A, Willman JE, Kolluri R. Possible warfarin resistance due to interaction with ascorbic acid: case report and literature review. Am J Health Syst Pharm. 2013;70(9):782-6. PubMed
- Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due to excess vitamin C intake: a cause of graft loss in a renal transplant recipient. Saudi J Kidney Dis Transpl. 2014;25(1):113-6. PubMed
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
- Rumbold A, Ota E, Nagata C, Shahrook S, Crowther CA. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev. 2015;(9):CD004072. PubMed
- Seo MS, Kim JK, Shim JY. High-dose vitamin C promotes regression of multiple pulmonary metastases originating from hepatocellular carcinoma. Yonsei Med J. 2015;56(5):1449-52. PubMed
- Skelin M, Lucijanic T, Amidzic Klaric D, et al. Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review. Clin Ther. 2017 Feb;39(2):378-403. PubMed
- Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z. Ascorbic acid supplements and kidney stones incidence among men and women: a systematic review and meta-analysis. Urol J. 2019;16(2):115-120.
- Thomas S, Patel D, Bittel B, et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2 PubMed
- Giffen MA, McLemore JL. Hyperoxalosis Secondary to Intravenous Vitamin C Administration as a Non-Allopathic Treatment for Cancer. Acad Forensic Pathol 2019;9(1-2):118-126. PubMed
- Maike A, Sturgill D, Gallan A. Oxalate Nephropathy in a Renal Transplant Recipient After Receiving High Dose Ascorbic Acid. Am J Med Sci 2021. PubMed
- Shen ZY, Chen YR, Wang MC, Chang SS. High-dose vitamin C-induced acute oxalate nephropathy in a renal transplant recipient: a case report and literature review. Asian J Surg 2022. PubMed
- Yanase F, Spano S, Maeda A, et al. Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial. Crit Care 2023;27(1):371. PubMed
- Sharma Y, Sumanadasa S, Shahi R, et al. Efficacy and safety of vitamin C supplementation in the treatment of community-acquired pneumonia: a systematic review and meta-analysis with trial sequential analysis. Sci Rep 2024;14(1):11846. PubMed
- Pejcic AV, Petrovic NZ, Djordjic MD, Milosavljevic MN. Vitamin C Levels in Pregnant Women and the Efficacy of Vitamin C Supplements in Preventing Premature Rupture of Membranes: A Systematic Review and Meta-Analysis. Balkan Med J 2024;41(4):248-260. PubMed
Glutathione 1 reference
- Marrades RM, Roca J, Barbera JA, et al. Nebulized glutathione induces bronchoconstriction in patients with mild asthma. Am J Respir Crit Care Med 1997;156(2 Pt 1):425-30. PubMed
Huperzine A 13 references
- Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer Disease therapy. JAMA 1997;277:776. DOI
- Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
- Wang T, Tang XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 1998;349:137-42. PubMed
- Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5.
- Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
- Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90.
- Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. PubMed
- Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82
- Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. PubMed
- Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
- Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
- Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
- Xing SH, Zhu CX, Zhang R, An L. Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med 2014;2014:363985. PubMed
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Tyrosine 4 references
- Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
- DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
- Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
- van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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