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Dietary supplement

Pure Agmatine Sulfate Powder Ingredients & Drug Interactions

by Hard Rhino

Pure Agmatine Sulfate Powder label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Agmatine Sulfate Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure Agmatine Sulfate Powder is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Agmatine Sulfate Powder by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Agmatine Sulfate Powder by Hard Rhino — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure Agmatine Sulfate Powder by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: agmatine sulfate. Agmatine is a compound naturally produced in the body from the amino acid arginine.

The powder form lets you measure and mix the dose yourself.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Agmatine product and its label doesn't state a use — see Agmatine's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for agmatine isn't established yet. Studies have looked at how it might help with alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder, but the data so far is insufficient to rate it as effective for any of these.

If you're considering it for a specific reason, talk with your doctor about whether the current research supports its use.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated at typical doses. Long-term safety in humans hasn't been well studied, so caution is warranted if you're thinking about using it regularly.

The most common short-term side effects reported in small clinical trials are diarrhea, indigestion (dyspepsia), and nausea — these appeared within 2 to 3 days in a few participants and stopped when they stopped taking it. Avoid agmatine during pregnancy and while breastfeeding, as there isn't enough safety data to know it's okay.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist about any blood pressure medications (antihypertensives) or diabetes drugs you're on. Agmatine may increase the risk of low blood pressure or low blood sugar when combined with them.

Use the search tool on this page to look up your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine sulfate is a single-ingredient powder with limited established evidence for any use. If you take blood pressure or diabetes medications, you'll need to check your specific drugs before starting — agmatine may intensify their effects and drop your blood pressure or blood sugar too low.

Talk with your doctor or pharmacist about whether this product makes sense for you and your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Agmatine Sulfate Powder, straight from the product label.

Brand Hard Rhino
Net contents 125 Gram(s); 4.4 oz.
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34273
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Agmatine Sulfate Powder by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
750 mg
Maximum serving Sizes:
750 mg
Servings per container
166
IngredientAmount% DV
Agmatine Sulfate750 mg--

Other ingredients: Agmatine Sulfate powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

- No added fillers - No flow agents - No driers - No other ingredients

Allergens: This product contains NO Soy, Milk & Byproducts, Eggs, Fish, Shellfish, Wheat, Gluten, Tree Nuts, or Sesame Seeds.

This is a NON-GMO ingredient produced with organic material.

Suggested/Recommended/Usage/Directions

Suggested Use: Typical dosage is 750 mg & should be taken in cycles. For example 3 days on & 1 day off to prevent building a tolerance.

Suggested Use: Typical dosage is 750mg and should be taken in cycles. Example: 3 days on and 1 day off to prevent building a tolerance.

Storage

Storage: Store in a cool & dry place. Keep awayfrom strong light & heat.

Storage: Store in a cool & dry place. Keep away from direct sunlight and heat.

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Disclaimer: These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Precautions

WARNING: A scale is required for accurate measurements.

Keep away from children.

Do not take this or any other supplement if you are pregnant or nursing.

Do not take if you have high blood pressure or any medical complications.

Do not take this or any other supplement if you are pregnant or nursing, have high blood pressure or taking other prescription drugs.

WARNING: A micro scale is required for accurate measurements.

General Statements

Always consult with your physician before taking any new dietary supplements.

Expiration date on back of pouch.

USP-FCC

Quality Healthcare Worldwide

Always consult with a physician before taking any new dietary supplement.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Agmatine Sulfate Powder by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Agmatine Sulfate Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Agmatine Sulfate Powder by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size750 mg Dosage formPowder Servings per container166 Amounts shown are per serving.

Agmatine Sulfate

Interacts with
258 drugs
750 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Other (inactive) ingredients: Agmatine Sulfate powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Agmatine Sulfate Powder by Hard Rhino Drug Interactions

Want to check YOUR meds against Pure Agmatine Sulfate Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258

Individual Drug Interactions

The ingredients in Pure Agmatine Sulfate Powder interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure Agmatine Sulfate Powder interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Agmatine Sulfate Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Agmatine Sulfate Powder, from the product label.

Hard Rhino

See all Hard Rhino products
Name
GUARDIAN Biosciences
City
Phoenix
State
Arizona
Pharmacist Counseling Corner

Pure Agmatine Sulfate Powder by Hard Rhino: Common Questions

Does Pure Agmatine Sulfate Powder by Hard Rhino interact with any medications?
Yes. Based on its ingredients, Pure Agmatine Sulfate Powder has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Agmatine Sulfate Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Not without checking first. Agmatine may lower blood pressure further and raise your risk of excessively low blood pressure when combined with blood pressure drugs. Look up your specific medication in our search tool, and then talk with your doctor or pharmacist before you start.
What about diabetes medications — is this safe to combine?
That depends on which diabetes drug you take. Agmatine may lower blood sugar and increase the risk of low blood sugar when used alongside diabetes medications. Check your specific medication in our search tool and discuss it with your doctor or pharmacist before adding this product.
Are there any common side effects I should know about?
Diarrhea, indigestion, and nausea are the most common side effects reported in trials. They typically show up within a few days and go away when you stop taking it. If you experience any of these, discontinue use and talk with your pharmacist.
Is this safe to use long-term?
Short-term use appears generally well tolerated, but long-term safety in humans hasn't been well studied. If you're considering regular use, discuss it with your doctor to weigh the unknowns.
Can I take this while pregnant or breastfeeding?
No, not enough safety data exists. It's best to avoid agmatine during pregnancy and while breastfeeding. Talk with your doctor if you're considering it during these times.
Does agmatine actually work for anything?
The evidence so far is insufficient to say. Research has explored its potential for alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism, and bipolar disorder, but none have been established yet. Ask your doctor if the current research supports its use for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Agmatine Sulfate Powder label
Go deeper

The Full Monographs Behind Pure Agmatine Sulfate Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Pure Agmatine Sulfate Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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