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Dietary supplement

Pure D-Ribose Powder Ingredients & Drug Interactions

by Hard Rhino

Pure D-Ribose Powder label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure D-Ribose Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure D-Ribose Powder is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure D-Ribose Powder by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure D-Ribose Powder by Hard Rhino — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure D-Ribose Powder by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Hard Rhino's Pure D-Ribose Powder contains one active ingredient: D-Ribose, a five-carbon sugar your body makes naturally and uses to produce energy in muscle cells. The powder form is D-Ribose only — no added fillers or binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Ribose product and its label doesn't state a use — see Ribose's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold shows mixed results. D-Ribose is rated possibly ineffective for athletic performance and McArdle disease.

For restless legs syndrome, heart failure, muscle soreness, and recovery after bypass surgery, the evidence is insufficient — we simply don't have reliable data yet to say whether it works or doesn't. Talk with your doctor about whether this supplement makes sense for what you're trying to address.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-Ribose is generally well tolerated over the short term (up to about a month in the research we have), but long-term safety hasn't been well studied, so caution is warranted if you're thinking of using it regularly. The most common side effects are diarrhea, stomach discomfort, headache, nausea, and — because it lowers blood sugar — low blood sugar itself.

A small number of people also reported anxiety, lightheadedness, or increased appetite; in those cases, lowering the dose resolved the symptoms. During pregnancy and breastfeeding, there isn't enough safety information, so the data advises against use.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting D-Ribose, double-check with your doctor or pharmacist if you take insulin or any antidiabetes medication (such as metformin, sulfonylureas, or GLP-1 agonists). Both types carry a Moderate risk of low blood sugar when combined with ribose.

No interactions are documented for other medication types in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose might appeal to you if you're exploring options for athletic performance or certain muscle conditions, but the evidence of benefit is thin or missing. If you take insulin or blood-sugar-lowering medication, this product poses a moderate risk of dropping your blood sugar too far — check with your doctor or pharmacist first.

For anyone else, the main watch-outs are digestive upset and the possibility of low blood sugar if you take a higher dose.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure D-Ribose Powder, straight from the product label.

Brand Hard Rhino
Net contents 500 Gram(s); 1.1 lb
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34292
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure D-Ribose Powder by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1000 mg
Maximum serving Sizes:
1000 mg
Servings per container
500
IngredientAmount% DV
D-Ribose1000 mg--

Other ingredients: D-Ribose, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Storage: Store in a cool & dry place. Keep away from direct sunlight and heat.

Storage: Store in a cool & dry place. Keep away from strong light & heat.

Precautions

WARNING: A micro scale is required for accurate measurements.

WARNING: A scale is required for accurate measurements.

Keep away from children.

Do not take this or any other supplement if you are pregnant or nursing.

Do not take if you have high blood pressure or any medical complications.

Do not take this or any other supplement if you are pregnant or nursing, have high blood pressure or taking other prescription drugs.

Formulation

No added fillers No flow agents No driers No other ingredients

Allergens: This product contains NO Soy, Milk & Byproducts, Eggs, Fish, Shellfish, Wheat, Gluten, Tree Nuts, or Sesame Seeds.

Suggested/Recommended/Usage/Directions

Suggested Use: Commonly taken in large quanities initially during the loading phase while the body responds actively. The Recommended dosage can be as little as 3 grams to as much as 20 grams per day during the loading phase. Split the dosage into three equal portions through the day.

Suggested Use: Suggested dosage is 3g per day and up to 20g during load phase. Split dosage into three equal portions throughout the day.

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Always consult with your physician before taking any new dietary supplements.

Expiration date on back of pouch.

USP-FCC

This is a NON-GMO ingredient produced with organic material.

Quality Healthcare Worldwide

Always consult with a physician before taking any new dietary supplement.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure D-Ribose Powder by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure D-Ribose Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure D-Ribose Powder by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1000 mg Dosage formPowder Servings per container500 Amounts shown are per serving.

D-Ribose

Interacts with
86 drugs
1000 mg per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Other (inactive) ingredients: D-Ribose, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure D-Ribose Powder by Hard Rhino Drug Interactions

Want to check YOUR meds against Pure D-Ribose Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in Pure D-Ribose Powder interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure D-Ribose Powder interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure D-Ribose Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure D-Ribose Powder, from the product label.

Hard Rhino

See all Hard Rhino products
Name
GUARDIAN Biosciences
City
Phoenix
State
Arizona
Pharmacist Counseling Corner

Pure D-Ribose Powder by Hard Rhino: Common Questions

Does Pure D-Ribose Powder by Hard Rhino interact with any medications?
Yes. Based on its ingredients, Pure D-Ribose Powder has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure D-Ribose Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-Ribose if I'm pregnant or breastfeeding?
No — there isn't enough safety information, so it's best avoided during pregnancy and while breastfeeding. Talk with your doctor or pharmacist before taking it if either applies to you.
What are the most common side effects?
Diarrhea, stomach discomfort, headache, nausea, and low blood sugar are the most common. A few people also report anxiety, lightheadedness, or increased appetite — and lowering the dose often resolves those symptoms.
How long is it safe to use D-Ribose?
The research we have shows it's generally well tolerated for up to about a month. Long-term safety hasn't been well studied, so if you're thinking of using it regularly beyond that, talk it over with your doctor or pharmacist.
Does D-Ribose actually improve athletic performance?
The evidence suggests it's possibly ineffective for that use. If you're considering it for sports or exercise recovery, your doctor or pharmacist can help you weigh the data and explore other options.
Is this just D-Ribose powder with nothing else?
Yes — the powder form contains D-Ribose only, with no added fillers or binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure D-Ribose Powder is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure D-Ribose Powder label
Go deeper

The Full Monographs Behind Pure D-Ribose Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

Pure D-Ribose Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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